131234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 2016 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 0308ｨｨ05060302ｨｪｨｨ02 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 1234567890123456789012345678 00020304020504 0204010801060508000606 06 0601080204000806060508000606 050204080002020904080103010608 PROBLEMS OF PUBLIC HEALTH ORGANIZATION AND INFORMATIZATION ISSN 2219-6587 04020202ｨｪ04ｨｨ08ｨｮ02ｨｬ04ｨｦ ｨ ｨｪｨ 05ｨｨｨｰｨｨｨｺ06-ｨｨｨｪ000608ｨｬｨ 02ｨｨ06ｨｪｨｪ04ｨｦ ｨ 06050502ｨｰ02ｨｪｨｹ 00ｨｨｨｪｨｨ09ｨｰ020809ｨｰ0906 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 04020907ｨｮｨ 05ｨｨｨｺｨｨ 090205ｨ 08ｨｮ09ｨｹ t 060401ｨ 02ｨｰ0907 04020907ｨｮｨ 05ｨｨｨｺｨ ｨｪ09ｨｺｨｨｨｬ ｨｪｨ ｨｮ ﾂｨｪ06-0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨｨｬ 0202ｨｪｨｰ0806ｨｬ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ, ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ, ｨｮ0708ｨ 090502ｨｪｨｨ07 ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨｨｺｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 09 1995 001 7, 0904010601ｨｨｨｰ 4 08ｨ 04ｨ 09 000601 0105ｨ 09ｨｪ04ｨｦ 080201ｨ ｨｺｨｰ0608 001 7001 7 0508 ﾁ0308 040201ｨ ｨｺ02ｨｨ06ｨｪｨｪｨ 07 ｨｺ0605050200ｨｨ07: 061 7081 7 00ｨ 05ｨｹ ﾂｨｮｨｺ 061 7001 7 01ｨ 020909ｨｺｨｨｨｦ 001 7051 7 0105ｨｮ03ｨ ｨｪｨｺ06 081 7081 7 0108ｨ ｨｺ0609ｨｨ ﾂ 001 7061 7 04ｨ 08ｨｺ06 001 7081 7 09ｨ 07ｨｨ02ｨｺｨｨｨｦ 061 7061 7 09ｨｨ07ｨｪｨｨ02ｨｺｨｨｨｦ 061 7011 7 090609ｨｨ02ｨｺｨｨｨｦ 061 7001 7 00ｨ 05ｨ 010609ｨ (04ｨ ｨｬ1 7 0005ｨ 09ｨｪ060006 080201ｨ ｨｺｨｰ0608ｨ ) 081 7011 7 000806 ﾂ02ｨｺ 011 7011 7 03ｨｨ05ｨｨ07020209ｨｨ ﾂ 021 7091 7 03ｨｨｨｪ0209ｨｨ ﾂ 051 7001 7 03060507ｨｺ0609 001 7091 7 05ｨｬ04 ﾂ02ｨｺ (07080201090201ｨ ｨｰ0205ｨｹ 080201ｨ ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｺ0605050200ｨｨｨｨ) 031 7001 7 06ｨｨｨｴ02ｨｪｨｺ06 011 7031 7 0902ｨｦ000202 (06ｨｰ091 7 0902ｨｺ0802ｨｰｨ 08ｨｹ) 041 7081 7 ﾁｨ 09ｨｪ06ｨｦｨｰｨｹ 061 7001 7 01ｨ 0803ｨ ｨｺ0609ｨ 001 7031 7 010209 ﾂｨｮｨｺ 001 7021 7 01ｨｨ0506 0801080209 080201ｨ ｨｺ02ｨｨｨｨ: 220013, 001 7 00ｨｨｨｪ09ｨｺ, ｨｮ051 7031 7 09080609ｨｺｨｨ, 7ｨ 09ｨ ｨ 0608ｨ ｨｰ0608ｨｨ07 0609ｨｪ0609 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｨ04ｨ 02ｨｨｨｨ ｨｨ 060202ｨｪｨｺｨｨ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ 04010300 0006 0602051 7(017) 290-75-58; e-mail: infomed@belcmt1 7by 08 04020907ｨｮｨ 05ｨｨｨｺｨ ｨｪ09ｨｺｨｨｨｦ ｨｪｨ ｨｮ ﾂｨｪ06-0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨｨｨｦ 0202ｨｪｨｰ08 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨ01 ｨｰ0201ｨｪ06050600ｨｨｨｦ, ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ, ｨｮ0708ｨ 090502ｨｪｨｨ07 ｨｨ 05ｨｺ06ｨｪ06ｨｬｨｨｨｺｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 00ｨｨｨｪ040108ｨ 09ｨ 04020907ｨｮｨ 05ｨｨｨｺｨｨ 090205ｨ 08ｨｮ09ｨｹ (04010300 0006), 2016
1300ｨ ｨｰ0208ｨｨｨ 0504 III 030908ｨ 04ｨｨｨｦ09ｨｺ060006 ｨｺ06ｨｪ0008020909ｨ 080209ｨｬｨ ｨｰ060506000609 001 7 00ｨｨｨｪ09ｨｺ, 04020907ｨｮｨ 05ｨｨｨｺｨ 090205ｨ 08ｨｮ09ｨｹ, 26ｨC27 ｨｬｨ 07 2016 001 7 0205020903010102050606 08070108000606 0001030101030102 02040908010608 07 09020905010409 040300000806020602010400 0804060406060200 011 7091 708ｨ 01ｨｮｨ 04ｨｨ040609ｨ 06ｨ 03ｨｺ02ｨｪｨｰ09ｨｺｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨ 07 ｨ ｨｺｨ 0102ｨｬｨｨ07, 001 706ｨ 03ｨｺ02ｨｪｨｰ, 04020907ｨｮｨ 05ｨｨｨｺｨ 0704ｨ 02ｨｺｨｨ09ｨｰｨ ｨｪ 05080201ｨｨ 09ｨｪ0209ｨｮ09ｨｰｨ 09ｨｪ0401 07080607090502ｨｪｨｨｨｦ 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ 09ｨ 03ｨｪ0602 ｨｬ0209ｨｰ06 04ｨ ｨｪｨｨｨｬｨ 06ｨｰ 070608ｨ 0302ｨｪｨｨ07 050200ｨｺｨｨ011 7 0604ｨｮ ﾂ02ｨｪｨｨ02 ｨｺ05ｨｨｨｪｨｨｨｺ06-00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ 050200ｨｺｨｨ01, 07080609020102ｨｪｨｨ02 ｨｬｨｮ05ｨｹｨｰｨｨ0907ｨｨ08ｨ 05ｨｹｨｪ06ｨｦ ｨｺ06ｨｬ07ｨｹ06ｨｰ0208ｨｪ06ｨｦ ｨｰ06ｨｬ060008ｨ 00ｨｨｨｨ ｨｨ ｨｬ06ｨｪｨｨｨｰ0608ｨｨｨｪ0006090602 ｨｨ09090502010609ｨ ｨｪｨｨ02 ｨ 0806ｨｪ01ｨｨｨ 05ｨｹｨｪ06ｨｦ 070806010601ｨｨｨｬ0609ｨｰｨｨ ｨｮ ｨ 0605ｨｹｨｪ0401 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ06ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ 0706040906050706ｨｰ 09090602090802ｨｬ02ｨｪｨｪ06 09ｨｪ0609ｨｨｨｰｨｹ ｨｺ06080802ｨｺｨｰｨｨ0904 09 0502 ﾂ02ｨｪｨｨ021 7 080506 ﾂ02090402 09050609ｨ : 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ, 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨ, ｨｬｨｮ05ｨｹｨｰｨｨ0907ｨｨ08ｨ 05ｨｹｨｪｨ 07 ｨｺ06ｨｬ07ｨｹ06ｨｰ0208ｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07, 0907ｨｨ0806ｨｬ02ｨｰ08ｨｨ071 7 040209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ (0408) ｨC 0601ｨｪ06 ｨｨ04 ｨｪｨ ｨｨｨ 06050202 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｪ0401 09060907ｨ 05ｨｨｨｰ0205ｨｹｨｪ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ 09ｨｮ09ｨｰｨ 090609, 09 070607ｨｮ050702ｨｨｨｨ ﾂｨ 09ｨｰ06ｨｰｨ 01ｨ ｨｪｨｪ06ｨｦ 07ｨ ｨｰ06050600ｨｨｨｨ 090609ｨｰｨ 09050702ｨｰ 1ｨC2%1 7 020507 0408 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ06 0708060008020909ｨｨ08ｨｮ06ｨｴ0202 ｨｰ02 ﾂ02ｨｪｨｨ02 09 000608ｨｬｨｨ080609ｨ ｨｪｨｨ02ｨｬ 0102000608ｨｬｨ 02ｨｨｨｦ 09ｨｮ09ｨｰｨ 090609, 08ｨ 0409ｨｨｨｰｨｨ02ｨｬ ｨｰ070302050401 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｪｨ 08ｨｮ0302ｨｪｨｨｨｦ ｨｨ 070608ｨ 0302ｨｪｨｨ02ｨｬ 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ01 060800ｨ ｨｪ0609, 08ｨ ｨｪｨｪ02ｨｦ ｨｨｨｪ09ｨ 05ｨｨ01ｨｨ04ｨ 02ｨｨ02ｨｦ ｨ 0605ｨｹｨｪ0401, 0906ｨｺ08ｨ ｨｴ02ｨｪｨｨ02ｨｬ 07080601060503ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｨ 03ｨｨ04ｨｪｨｨ [1, 3, 4]1 7 0209ｨｪ0609ｨｮ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ01 07080607090502ｨｪｨｨｨｦ 0408 090609ｨｰｨ 09050702ｨｰ 09ｨｨｨｬｨｬ02ｨｰ08ｨｨ ﾂｨｪ04ｨｦ 010806ｨｪｨｨ ﾂ0209ｨｺｨｨｨｦ 05080604ｨｨ09ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺｨｨ01 09ｨｮ09ｨｰｨ 0906091 7 0201ｨｪｨ ｨｺ06, 0708ｨｨ 05ｨｰ06ｨｬ 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｨ ﾂｨ 09ｨｰ06 0909ｨｰ0802 ﾂｨ 06ｨｰ0907 ｨｨ 09ｨｨ09ｨｰ02ｨｬｨｪ0402 09060907ｨ 05ｨｨｨｰ0205ｨｹｨｪ0402 070608ｨ 0302ｨｪｨｨ07 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ01 060800ｨ ｨｪ06091 7 02ｨｪｨｨ ｨｬ0600ｨｮｨｰ 09ｨｰｨ ｨｰｨｹ 0708ｨｨ ﾂｨｨｨｪ06ｨｦ 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ060006 09ｨｪｨｨ0302ｨｪｨｨ07 ｨｺｨ ﾂ0209ｨｰ09ｨ 03ｨｨ04ｨｪｨｨ, ｨｰ08ｨｮ01060907060906ｨ ｨｪ0609ｨｰｨｨ ｨｨ 09 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ06ｨｦ ｨｬ020802 0607080201020507ｨｰｨｹ 07080600ｨｪ0604 [2, 6, 7]1 7 05080201ｨｨ 09ｨｪ0209ｨｮ09ｨｰｨ 09ｨｪ0401 07080607090502ｨｪｨｨｨｦ 0408 09ｨ 03ｨｪ0602 ｨｬ0209ｨｰ06 04ｨ ｨｪｨｨｨｬｨ 06ｨｰ 070608ｨ 0302ｨｪｨｨ07 050200ｨｺｨｨ01 ｨｨ ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ1 7 00 ｨｬｨｨ08060906ｨｦ 05ｨｨｨｰ0208ｨ ｨｰｨｮ0802 ｨｪｨ ｨｺ06070502ｨｪ ｨｪ02ｨｬｨ 0504ｨｦ 06ｨ ｨｲ02ｨｬ ｨｨｨｪ000608ｨｬｨ 02ｨｨｨｨ 06 070608ｨ 0302ｨｪｨｨｨｨ 060800ｨ ｨｪ0609 010401ｨ ｨｪｨｨ07 0708ｨｨ 0408 [8ｨC10], 0601ｨｪｨ ｨｺ06 09 05ｨｰ06ｨｦ 06ｨ 05ｨ 09ｨｰｨｨ 0609ｨｰｨ 02ｨｰ0907 080701 ｨｪ0208020302ｨｪｨｪ0401 070806ｨ 0502ｨｬ1 7 01ｨｮ0301ｨ 02ｨｰ0907 09 ｨｮｨｰ06 ﾂｨｪ02ｨｪｨｨｨｨ ﾂｨ 09ｨｰ06ｨｰｨ ｨ 0806ｨｪ010605020006 ﾂｨｪ0401 070608ｨ 0302ｨｪｨｨｨｦ ｨｮ ｨ 0605ｨｹｨｪ0401 04081 7 000205ｨｹ ｨｨ09090502010609ｨ ｨｪｨｨ07 ｨC ｨｨ04ｨｮ ﾂ02ｨｪｨｨ02 01ｨ 08ｨ ｨｺｨｰ0208ｨ ｨｨ 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｨ 070608ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ ｨｮ ｨ 0605ｨｹｨｪ0401 04081 7 00ｨ ｨｰ0208ｨｨｨ 0504 ｨｨ ｨｬ02ｨｰ0601041 7 05 020205ｨｹ06 ｨｨ04ｨｮ ﾂ02ｨｪｨｨ07 01ｨ 08ｨ ｨｺｨｰ0208ｨ ｨｨ 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｨ 070608ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ ｨｮ ｨ 0605ｨｹｨｪ0401 0408 07080609020102ｨｪ06 ｨｺ06ｨｬ070502ｨｺ09ｨｪ0602 ｨｺ05ｨｨｨｪｨｨｨｺ06-ｨｨｨｪ09ｨｰ08ｨｮｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0602 06ｨ 090502010609ｨ ｨｪｨｨ02 98 ｨ 0605ｨｹｨｪ0401 (ｨｨ04 ｨｪｨｨ01: 12 ｨｬｨｮ03 ﾂｨｨｨｪ ｨｨ 86 0302ｨｪｨｴｨｨｨｪ) 09 010609ｨｰ06090208ｨｪ04ｨｬ 01ｨｨｨ 00ｨｪ060406ｨｬ 0408 ｨｪｨ 0609ｨｪ0609ｨ ｨｪｨｨｨｨ ｨｺ08ｨｨｨｰ0208ｨｨ0209 08ｨｬ0208ｨｨｨｺｨ ｨｪ09ｨｺ06ｨｦ 080209ｨｬｨ ｨｰ06050600ｨｨ ﾂ0209ｨｺ06ｨｦ ｨ 09090602ｨｨｨ 02ｨｨｨｨ 1988001 7 05080201ｨｪ0707 07080601060503ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 090609ｨｰｨ 09ｨｨ05ｨ 10,5 ﾀ8,6 0502ｨｰ1 7 05020806070604ｨｨｨｰｨｨ09ｨｪ04ｨｦ 0408 ｨｨｨｬ0205 ｨｬ0209ｨｰ06 ｨｮ 64,45 ﾀ1,8, 09020806ｨｪ0200ｨ ｨｰｨｨ09ｨｪ04ｨｦ ｨC ｨｮ 72,88 ﾀ2,77 ｨ 0605ｨｹｨｪ04011 7 08ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0408, 09060005ｨ 09ｨｪ06 ｨｨｨｪ0102ｨｺ09ｨｮ DAS28, 090609ｨｰｨ 09ｨｨ05ｨ 5,8 ﾀ1,5 ｨ ｨ 050506091 7 02ｨ 090502010609ｨ ｨｪｨｨ02 ｨ 0605ｨｹｨｪ0401 0408 070806090601ｨｨ050609ｨｹ 09 0906070609ｨｰｨ 090502ｨｪｨｨｨｨ 09 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ070706ｨｦ, ｨｺ06ｨｰ0608ｨｮ06 090609ｨｰｨ 09ｨｨ05ｨｨ 20 07ｨ 02ｨｨ02ｨｪｨｰ06091 7 07 ｨ 0605ｨｹｨｪ0401 0408 ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨｺ06ｨｪｨｰ080605ｨｹｨｪ06ｨｦ 0008ｨｮ070704 0904070605ｨｪ0705ｨｨ09ｨｹ 06ｨ ｨｴ02ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ0602 06ｨ 090502010609ｨ ｨｪｨｨ02, 0907ｨｨ0806ｨｬ02ｨｰ08ｨｨ07, ｨｬｨｮ05ｨｹｨｰｨｨ0907ｨｨ08ｨ 05ｨｹｨｪｨ 07 ｨｺ06ｨｬ07ｨｹ06ｨｰ0208ｨｪｨ 07 ｨｰ06ｨｬ060008ｨ 00ｨｨ07 (00050806) 050200ｨｺｨｨ011 7 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ 06ｨ 09ｨｮ030102ｨｪｨｨ021 7 00 ｨｨ04ｨｮ ﾂ02ｨｪｨｨｨｨ 070608ｨ 0302ｨｪｨｨ07 060800ｨ ｨｪ0609 010401ｨ ｨｪｨｨ07 0708ｨｨ 0408 0702080906ｨｪｨ ﾂｨ 05ｨｹｨｪ06 060202ｨｪｨｨ09ｨ 05ｨｨ09ｨｹ 03ｨ 0506ｨ 04 ｨ 0605ｨｹｨｪ04011 7 090605ｨｹｨｪ0402 07080201ｨｲ0709ｨｨ05ｨｨ 03ｨ 0506ｨ 04 ｨｪｨ 08ｨ ｨｪｨｪ0202 ｨｨ 070609ｨｰ0607ｨｪｨｪ0602 070609020801ｨｪ0609ｨｰｨｪ0602 010401ｨ ｨｪｨｨ02, ﾂｨｮ0909ｨｰ0906 01ｨｨ09ｨｺ06ｨｬ000608ｨｰｨ 1 7 07 15,6% ｨ 0605ｨｹｨｪ0401 0408 ｨｨｨｬ0205 010806ｨｪｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｺｨ 030205ｨｹ1 7 02010403ｨｺｨ 0708ｨｨ 00ｨｨ04ｨｨ- ﾂ0209ｨｺ06ｨｦ ｨｪｨ 0008ｨｮ04ｨｺ02 ｨｨｨｬ0205ｨ 09ｨｹ ｨｮ 13,7% 07ｨ 02ｨｨ02ｨｪｨｰ0609, 09 ｨｰ06ｨｬ ﾂｨｨ090502 ｨｰ07030205ｨ 07 ｨｨ 06 ﾂ02ｨｪｨｹ ｨｰ07030205ｨ 07 ｨC ｨｮ 4%1 7 06ｨｰ06 090609ｨｰ0607ｨｪｨｨ02 0706ｨｺｨ 040409ｨ 02ｨｰ 09060907ｨ 0502ｨｪｨｨ02 ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪ06ｨｦ ｨｰｨｺｨ ｨｪｨｨ 05020006 ﾂｨｪ06ｨｦ 07ｨ 0802ｨｪ01ｨｨｨｬ041 7 04020907ｨｨ08ｨ ｨｰ0608ｨｪ0402 03ｨ 0506ｨ 04 ｨｮ ｨ 0605ｨｹｨｪ0401 0408 0909ｨｰ0802 ﾂｨ 05ｨｨ09ｨｹ 0708ｨｨ 09040906ｨｺ06ｨｦ ｨｨ 09080201ｨｪ02ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ1 7 02ｨ 06ｨ ｨｴｨ 07 03ｨ 0506ｨ 04 ｨ 0605ｨｹｨｪ0401, ｨｬ0603ｨｪ06 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ 09090704ｨｹ 09 09060408ｨ 09ｨｰｨｪ04ｨｬｨｨ 070208ｨｨ0601ｨ ｨｬｨｨ1 7 00 09060408ｨ 09ｨｰｨｪ06ｨｬ ｨ 090702ｨｺｨｰ02 ｨｪｨ ｨｨｨ 0605ｨｹ03ｨ 07 0909ｨｰ0802 ﾂｨ 02ｨｬ0609ｨｰｨｹ 06ｨｰｨｬ02 ﾂｨ 02ｨｰ0907 09 09060408ｨ 09ｨｰ02 50ｨC60 0502ｨｰ (07ｨ 02ｨｨ02ｨｪｨｰ0609 01ｨ ｨｪ- 2 00060708060904 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 2016 ｯ 0308ｨｨ05060302ｨｪｨｨ02
ｨｪ060006 09060408ｨ 09ｨｰｨ ｨC 1/3 06ｨ ｨｴ020006 ﾂｨｨ0905ｨ 06ｨ 090502010609ｨ ｨｪｨｪ0401)1 7 01ｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨｨｨ 09ｨｪ0203ｨｪ020006 010401ｨ ｨｪｨｨ07 (080002) 090407090502ｨｪ04 ｨｮ 47 ｨ 0605ｨｹｨｪ0401 04081 7 0308ｨｨ 00050806 050200ｨｺｨｨ01 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 0906 09ｨｰ060806ｨｪ04 050200ｨｺｨｨ01, 070502090804, ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ ｨｨ 060800ｨ ｨｪ0609 090802010609ｨｰ02ｨｪｨｨ07 090407090502ｨｪ04 ｨｮ 38 ｨ 0605ｨｹｨｪ0401 04081 7 0308ｨｨ 00050806 050200ｨｺｨｨ01 0708ｨｨ04ｨｪｨ ｨｺｨｨ 070608ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ ｨｪｨ ｨｮ080609ｨｪ02 0202ｨｪｨｰ08ｨ 05ｨｹｨｪ0401, 01060502090401, 090200ｨｬ02ｨｪｨｰｨ 08ｨｪ0401 ｨｨ 09ｨｮｨ 090200ｨｬ02ｨｪｨｰｨ 08ｨｪ0401 ｨ 0806ｨｪ010609 090407090502ｨｪ04 ｨｮ 34% ｨ 0605ｨｹｨｪ0401 04081 7 01ｨ ｨｨｨ 06050202 ﾂｨ 09ｨｰ06 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ 05ｨｨ09ｨｹ ｨｮｨｰ0605ｨｴ02ｨｪｨｨ02 09ｨｰ02ｨｪ06ｨｺ ｨ 0806ｨｪ010609 ｨｨ 0102000608ｨｬｨ 02ｨｨ07 ｨｨ01 070806090902ｨｰｨ (ｨｮ 25% ｨ 0605ｨｹｨｪ0401 0408)1 7 0308ｨｨ04ｨｪｨ ｨｺｨｨ 070608ｨ 0302ｨｪｨｨ07 01ｨｨ09ｨｰｨ 05ｨｹｨｪ0401 06ｨｰ0102050609 ｨ 0806ｨｪ01ｨｨｨ 05ｨｹｨｪ060006 0102080209ｨ (ｨ 0806ｨｪ01ｨｨ0605ｨｨｨｰ) 090407090502ｨｪ04 54% ｨ 0605ｨｹｨｪ0401 04081 7 02ｨ ｨｴｨ 07 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｹ 09090201 09ｨ 08ｨｨｨ ｨｪｨｰ0609 070608ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ ｨｮ 06ｨ 090502010609ｨ ｨｪｨｪ0401 ｨｪｨ ｨｬｨｨ ｨ 0605ｨｹｨｪ0401 0408 06ｨｺｨ 04ｨ 05ｨ 09ｨｹ ｨｪ0206ｨ 04 ﾂｨｪ06 09040906ｨｺ06ｨｦ 010507 09ｨｪ0209ｨｮ09ｨｰｨ 09ｨｪ060006 07080607090502ｨｪｨｨ07 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 030608ｨ 0302ｨｪｨｨ02 ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ 070806ｨｰ02ｨｺｨ 0506 ｨｬｨ 050609ｨｨｨｬ07ｨｰ06ｨｬｨｪ06 ｨｨ 06ｨ ｨｪｨ 08ｨｮ03ｨｨ09ｨ 050609ｨｹ 05ｨｨ03ｨｹ 0706 ｨｪｨ 05ｨｨ- ﾂｨｨ06 ｨｨ040605ｨｨ080609ｨ ｨｪｨｪ0401 01ｨｨ09ｨｰｨ 05ｨｹｨｪ0401 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ ｨ 0806ｨｪ010609, 09040709050702ｨｬ0401 09 0706ｨｬ06ｨｴｨｹ06 000508061 7 03060106ｨ ｨｪ0402 09ｨｮｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ02 070608ｨ 0302ｨｪｨｨ07, ｨｺｨ ｨｺ 0708ｨ 09ｨｨ0506, ｨｪ02 0708ｨｨ090502ｨｺｨ 06ｨｰ 09ｨｪｨｨｨｬｨ ｨｪｨｨ07 0908ｨ ﾂ02ｨｦ ｨｨ 09ｨ ｨｬｨｨ01 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨｨ 09 ｨｺ08ｨ ｨｰｨｺ06090806 ﾂｨｪ06ｨｬ ｨ 090702ｨｺｨｰ02 ｨｪ02 ｨｰ0802ｨ ｨｮ06ｨｰ 09070202ｨｨｨ 05ｨｹｨｪ060006 0502 ﾂ02ｨｪｨｨ071 7 050502010609ｨ ｨｰ0205ｨｹｨｪ06, 08ｨ ｨｪｨｪ0202 090407090502ｨｪｨｨ02 ｨｮ ｨ 0605ｨｹｨｪ0401 0408 070608ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ ｨｨ ｨｬ06ｨｪｨｨｨｰ0608ｨｨ080609ｨ ｨｪｨｨ02 ｨｮ ｨｪｨｨ01 01ｨｨｨｪｨ ｨｬｨｨｨｺｨｨ 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ06ｨｴｨｨ01 09ｨｰ08ｨｮｨｺｨｰｨｮ08ｨｪ0401 ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 09050201ｨｮ02ｨｰ 09 ﾂｨｨｨｰｨ ｨｰｨｹ 07080600ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺｨｨ 09ｨ 03ｨｪ04ｨｬ ｨｺ06ｨｬ0706ｨｪ02ｨｪｨｰ06ｨｬ 0106050006090806 ﾂｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺ06ｨｦ 0706ｨｬ06ｨｴｨｨ 0708ｨｨ 01ｨ ｨｪｨｪ06ｨｬ 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｨ1 7 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｪ0609ｨｰｨｹ ｨｨ ｨｺ05ｨｨｨｪｨｨ- ﾂ0209ｨｺｨ 07 04ｨｪｨ ﾂｨｨｨｬ0609ｨｰｨｹ 070608ｨ 0302ｨｪｨｨｨｦ 060800ｨ ｨｪ0609 010401ｨ ｨｪｨｨ07 0708ｨｨ 0408 090209ｨｹｨｬｨ 090205ｨｨｨｺｨｨ ｨｨ 08ｨ ｨｪ0202 06 ﾂ0209ｨｨ01ｨｪ06 ｨｪ020106060202ｨｪｨｨ09ｨ 05ｨｨ09ｨｹ1 7 0308ｨｨ04ｨｪｨ ｨｺｨｨ 0906090502 ﾂ02ｨｪｨｨ07 050200ｨｺｨｨ01, 070502090804 ｨｨ 070608ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ 09040709050706ｨｰ0907 09 08ｨ 04ｨｪ0401 0906 ﾂ02ｨｰｨ ｨｪｨｨ0701 ｨｮ 37,6% 07ｨ 02ｨｨ02ｨｪｨｰ06091 7 07 ｨ 0605ｨｹｨｪ0401 0408 0909ｨｰ0802 ﾂｨ 06ｨｰ0907 070608ｨ 0302ｨｪｨｨ07 09090201 06ｨｰ0102050609 08020907ｨｨ08ｨ ｨｰ0608ｨｪ060006 ｨｰ08ｨ ｨｺｨｰｨ ｨC 070806ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪ0401 ｨｨ 01ｨｨ09ｨｰｨ 05ｨｹｨｪ0401 ｨ 0806ｨｪ010609, ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨ07 ｨｨ 07ｨ 0802ｨｪ01ｨｨｨｬ04 050200ｨｺｨｨ01, ｨ ｨｰｨ ｨｺ0302 0705020908041 7 020906ｨ 02ｨｪｨｪ0609ｨｰｨｹ06 ｨｰ02 ﾂ02ｨｪｨｨ07 ｨ 0806ｨｪ010605020006 ﾂｨｪ0401 070608ｨ 0302ｨｪｨｨｨｦ ｨｮ ｨ 0605ｨｹｨｪ0401 0408 0709050702ｨｰ0907 ｨｨ01 ｨｬｨｪ060006ｨｮ080609ｨｪ020904ｨｦ 01ｨ 08ｨ ｨｺｨｰ0208, 0706040906050706ｨｴｨｨｨｦ 07080201070605ｨ 00ｨ ｨｰｨｹ ｨ ｨｪｨ ｨｰ06ｨｬｨｨ ﾂ0209ｨｺｨｮ06 ｨｪ02070802080409ｨｪ0609ｨｰｨｹ 09060907ｨ 05ｨｨｨｰ0205ｨｹｨｪ0609ｨｺ05020806ｨｰｨｨ ﾂ0209ｨｺ060006 070608ｨ 0302ｨｪｨｨ07 ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ1 7 07 ｨｬｨｪ0600ｨｨ01 ｨ 0605ｨｹｨｪ0401 0408 070608ｨ 0302ｨｪｨｨ07 050200ｨｺｨｨ01 ｨｨ ｨｪｨｨ03ｨｪｨｨ01 010401ｨ ｨｰ0205ｨｹｨｪ0401 07ｨｮｨｰ02ｨｦ, ｨｨｨｬ0206ｨｴｨｨ02 09ｨｮｨｴ0209ｨｰ0902ｨｪｨｪ0602 07080600ｨｪ0609ｨｰｨｨ ﾂ0209ｨｺ0602 04ｨｪｨ ﾂ02ｨｪｨｨ02, 070806ｨｰ02ｨｺｨ 06ｨｰ 09ｨｮｨ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ, ﾂｨｰ06 ｨｰ0802ｨ ｨｮ02ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0401 ｨｬ0208060708ｨｨ07ｨｰｨｨｨｦ 0706 ｨｨ01 090407090502ｨｪｨｨ061 7 01ｨ ｨｨｨ 0605ｨｹ030202 04ｨｪｨ ﾂ02ｨｪｨｨ02 010507 090407090502ｨｪｨｨ07 ｨｨ ｨｮｨｰ06 ﾂｨｪ02ｨｪｨｨ07 01ｨ 08ｨ ｨｺｨｰ0208ｨ 070608ｨ 0302ｨｪｨｨｨｦ 060800ｨ ｨｪ0609 010401ｨ ｨｪｨｨ07 ｨｮ ｨ 0605ｨｹｨｪ0401 0408 ｨｨｨｬ0202ｨｰ 0906 ﾂ02ｨｰｨ ｨｪｨｪ0602 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 00050806 050200ｨｺｨｨ01 ｨｨ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ1 7 02ｨ ｨｴ020708ｨｨｨｪ07ｨｰ0402 07060101060104 ｨｺ 0502 ﾂ02ｨｪｨｨ06 ｨ 0806ｨｪ010605020006 ﾂｨｪ0401 070608ｨ 0302ｨｪｨｨｨｦ ｨｮ ｨ 0605ｨｹｨｪ0401 0408 0106 ｨｪｨ 09ｨｰ0607ｨｴ020006 090802ｨｬ02ｨｪｨｨ ｨｪ02 09000608ｨｬｨｨ080609ｨ ｨｪ041 7 0308ｨｨ ｨｪ02ｨｨｨｪ0002ｨｺ02ｨｨ06ｨｪｨｪ0401 070608ｨ 0302ｨｪｨｨ0701 01ｨｨ09ｨｰｨ 05ｨｹｨｪ0401 ｨ 0806ｨｪ010609 ｨｰ08ｨ 01ｨｨ02ｨｨ06ｨｪｨｪ06 0708ｨｨｨ 0200ｨ 06ｨｰ ｨｺ ｨｨｨｬｨｬｨｮｨｪ0609ｨｮ0708020909ｨｨ09ｨｪ06ｨｦ ｨｨ 09ｨｨｨｬ07ｨｰ06ｨｬｨ ｨｰｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ1 7 07 ｨｪｨ ｨ 050601ｨ 0903ｨｨ010907 ｨｪｨ ｨｬｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609, 0708ｨｨ 0706ｨｰ0802ｨ ｨｪ0609ｨｰｨｨ 09 0502 ﾂ02ｨｪｨｨｨｨ, 0708ｨｨｨｬ02ｨｪ0705ｨｨ09ｨｹ ｨｨｨｪ00ｨ 050702ｨｨ06ｨｪｨｪ0402 ｨ 0806ｨｪ010605ｨｨｨｰｨｨｨｺｨｨ (ｨ 02ｨｰｨ 2-ｨ 0006ｨｪｨｨ09ｨｰ04 ｨｨ 00-010605ｨｨｨｪ0605ｨｨｨｰｨｨｨｺｨｨ) ｨｪｨ 0006ｨｪ02 ｨ ｨ 04ｨｨ09ｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ1 7 0308ｨｨ ｨ 0806ｨｪ01ｨｨ0605ｨｨｨｰ02 ｨｰ07030205060006 0708060008020909ｨｨ08ｨｮ06ｨｴ020006 ｨｰ02 ﾂ02ｨｪｨｨ07 0408 0706050603ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ (09ｨｰｨ ｨ ｨｨ05ｨｨ04ｨ 02ｨｨ07 0706ｨｺｨ 04ｨ ｨｰ020502ｨｦ 080002, 04ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0602 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 090408ｨ 0302ｨｪｨｪ0609ｨｰｨｨ ｨｺｨ 030507 ｨｨ 06010403ｨｺｨｨ) 070605ｨｮ ﾂ02ｨｪ ｨｪｨ ｨｬｨｨ ｨｪｨ 0006ｨｪ02 ｨｺ06ｨｬｨ ｨｨｨｪｨｨ080609ｨ ｨｪｨｪ06ｨｦ ｨｨｨｬｨｬｨｮｨｪ0609ｨｮ0708020909ｨｨ09ｨｪ06ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ 0706 090102ｨｬ02: ｨ 04ｨ ｨｰｨｨ060708ｨｨｨｪ 100ｨｬ00/09ｨｮｨｰ + 07080201ｨｪｨｨ04060506ｨｪ 10ｨｬ00/09ｨｮｨｰ, ｨ ｨｰｨ ｨｺ0302 ｨｨｨｪ00ｨ 050702ｨｨ06ｨｪｨｪ060006 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ07 ｨ 0806ｨｪ010605ｨｨｨｰｨｨｨｺ06091 7 0902 ﾂ02ｨｪｨｨ02 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ0401 000608ｨｬ 0408 0708ｨｨ ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪ06ｨｬ 07ｨｪ0209ｨｬ06ｨｪｨｨｨｰ02 0802ｨｺ06ｨｬ02ｨｪ01ｨｮ02ｨｰ0907 ｨｪｨ ﾂｨｨｨｪｨ ｨｰｨｹ 09 0708ｨｨ02ｨｬｨ ｨｺ0608ｨｰｨｨｨｺ0609ｨｰ020806ｨｨ010609 09ｨｪｨｮｨｰ08ｨｹ (07080201ｨｪｨｨ04060506ｨｪ 0,5ｨｬ00/ｨｺ00/09ｨｮｨｰ 09 ｨｰ02 ﾂ02ｨｪｨｨ02 1ｨC3 ｨｬ020907020209)1 7 0308ｨｨ ｨｮ05ｨｮ ﾂ0302ｨｪｨｨｨｨ, 070601ｨｰ0902080301ｨ 02ｨｬ06ｨｬ 0706050603ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 01ｨｨｨｪｨ ｨｬｨｨｨｺ06ｨｦ 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ 0802ｨｪｨｰ0002ｨｪ06050600ｨｨ ﾂ0209ｨｺｨｨ01 0706ｨｺｨ 04ｨ ｨｰ020502ｨｦ, 010604ｨ 07080201ｨｪｨｨ04060506ｨｪｨ ｨｬ060302ｨｰ ｨ 04ｨｰｨｹ 09ｨｪｨｨ0302ｨｪｨ 0106 10ｨｬ00/09ｨｮｨｰ ｨｨ05ｨｨ 20ｨｬ00/09ｨｮｨｰ ﾂ02080204 0102ｨｪｨｹ1 7 0308ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨｨｨ 0706050603ｨｨｨｰ0205ｨｹｨｪ06ｨｦ 01ｨｨｨｪｨ ｨｬｨｨｨｺｨｨ 09 090609ｨｰ0607ｨｪｨｨｨｨ ｨ 0605ｨｹｨｪ060006 ｨｪｨ 0006ｨｪ02 ｨｮｨｬ020802ｨｪｨｪ0401 010604 0702080608ｨ 05ｨｹｨｪ0401 09ｨｰ020806ｨｨ010609, 02020502090606ｨ 08ｨ 04ｨｪ06 060202ｨｪｨｨｨｰｨｹ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ01 ｨｺ06ｨｬｨ ｨｨｨｪｨ 02ｨｨｨｨ 09 ｨｨｨｬｨｬｨｮｨｪ0601020708020909ｨ ｨｪｨｰｨ ｨｬｨｨ1 7 00 07060106ｨ ｨｪ0401 0905ｨｮ ﾂｨ 0701 0708ｨｨ 0502 ﾂ02ｨｪｨｨｨｨ ｨｨ01ｨｨ0607ｨ ｨｰｨｨ ﾂ0209ｨｺ060006 05020006 ﾂｨｪ060006 00ｨｨｨ 080604ｨ ｨｨ09070605ｨｹ04ｨｮ02ｨｰ0907 0906 ﾂ02ｨｰｨ ｨｪｨｨ02 07080201ｨｪｨｨ04060506ｨｪｨ (0,5ｨｬ00/ｨｺ00/09ｨｮｨｰ 0906 09ｨｪｨｨ0302ｨｪｨｨ02ｨｬ 04ｨ 3 ｨｬ02090702ｨ 0106 0,125ｨｬ00/ｨｺ00/09ｨｮｨｰ) ｨｨ ｨ 04ｨ ｨｰｨｨ060708ｨｨｨｪｨ (2ｨC3ｨｬ00/ｨｺ00/09ｨｮｨｰ, ｨｬｨ ｨｺ09ｨｨｨｬｨ 05ｨｹｨｪｨ 07 010604ｨ 150ｨｬ00/09ｨｮｨｰ)1 7 01ｨ 04ｨｪｨ ﾂ02ｨｪｨｨ02 09040906ｨｺｨｨ01 010604 09ｨｰ020806ｨｨ010609 09 09ｨｨ0102 ｨｬ06ｨｪ06ｨｰ0208ｨ 07ｨｨｨｨ ｨｪ02 0802ｨｺ06ｨｬ02ｨｪ01ｨｮ02ｨｰ0907, 060906ｨ 02ｨｪｨｪ06 ｨｮ ｨ 0605ｨｹｨｪ0401 09 090408ｨ 0302ｨｪｨｪ04ｨｬ 00ｨｨｨ 08060406ｨｬ (00ｨｨ09ｨｰ06050600ｨｨ ﾂ0209ｨｺｨｨ 090208ｨｨ00ｨｨ02ｨｨ080609ｨ ｨｪｨｪｨ 07 06ｨ 04 ﾂｨｪｨ 07 ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪｨ 07 07ｨｪ0209ｨｬ06ｨｪｨｨ07 ｨｨ05ｨｨ 0709ｨｪｨ 07 000906ｨｰ0609ｨ 0703 ｨｰ08ｨ ｨｪ09000608ｨｬｨ 02ｨｨ07 05020006 ﾂｨｪ06ｨｦ ｨｰｨｺｨ ｨｪｨｨ 0706 01ｨ ｨｪｨｪ04ｨｬ 00050806)1 7 00ｨ 03ｨｪｨｮ06 080605ｨｹ 09 09020102ｨｪｨｨｨｨ ｨ 0605ｨｹｨｪ0401 0408 09 ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪ04ｨｬ 070608ｨ 0302ｨｪｨｨ02ｨｬ 050200ｨｺｨｨ01 01060503ｨｪ04 ｨｨ0008ｨ ｨｰｨｹ 0607ｨｰｨｨｨｬｨ 05ｨｹｨｪｨ 07 07060101020803ｨｨ09ｨ 06ｨｴｨ 07 ｨｰ0208ｨ 07ｨｨ07, 09ｨｺ0506 ﾂｨ 06ｨｴｨ 07 0106050006090806 ﾂｨｪｨｮ06 ｨｺｨｨ09050608060106ｨｰ0208ｨ 07ｨｨ06, ｨｨ 05020006 ﾂｨｪｨ 07 0802ｨ ｨ ｨｨ05ｨｨｨｰｨ 02ｨｨ071 7 07 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 ｨｪ02ｨｮｨｺ0506ｨｪｨｪ06 0708060008020909ｨｨ08ｨｮ06ｨｴｨｨｨｬ ｨｰ02 ﾂ02ｨｪｨｨ02ｨｬ 0408 0708ｨｨ ｨｨｨｪｨｰ020809ｨｰｨｨ02ｨｨｨ 05ｨｹｨｪ06ｨｬ 07ｨｪ0209ｨｬ06ｨｪｨｨｨｰ02 0201ｨｨｨｪ09ｨｰ0902ｨｪｨｪ06ｨｦ 090604ｨｬ0603ｨｪ0609ｨｰｨｹ06 070806010502ｨｪｨｨ07 03ｨｨ04ｨｪｨｨ ｨｨ 070609040302ｨｪｨｨ07 0202 ｨｺｨ ﾂ0209ｨｰ09ｨ ｨｬ060302ｨｰ 06ｨｺｨ 04ｨ ｨｰｨｹ0907 ｨｰ08ｨ ｨｪ090705ｨ ｨｪｨｰｨ 02ｨｨ07 050200ｨｺｨｨ011 7 000409060104: 11 7020507 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 ｨ 0806ｨｪ010605020006 ﾂｨｪ04ｨｬ 070608ｨ 0302ｨｪｨｨ02ｨｬ 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04 ｨｪｨ 08ｨｮ0302ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨｨｨ 09ｨｪ0203ｨｪ020006 010401ｨ ｨｪｨｨ07 070802ｨｨｨｬｨｮｨｴ0209ｨｰ0902ｨｪｨｪ06 0706 09ｨｬ0203ｨ ｨｪｨｪ06ｨｬｨｮ ｨｰｨｨ07ｨｮ1 7 07 ﾂｨｨｨｰ0409ｨ 07 01ｨ 08ｨ ｨｺｨｰ0208 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨｨｦ 080002 (07080206ｨ 05ｨ 01ｨ 06ｨｴ0202 09ｨｪｨｨ0302ｨｪｨｨ02 000205 25-50-75 0708ｨｨ 08ｨ 09 ﾂ02ｨｰ02 ｨｨｨｪ0102ｨｺ09ｨ 06ｨｨ0000ｨｪ06), ｨｬ0603ｨｪ06 070802010706050603ｨｨｨｰｨｹ, ﾂｨｰ06 0708ｨｨ ｨ 0806ｨｪ- 00060708060904 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 2016 ｯ 0308ｨｨ05060302ｨｪｨｨ02 3
010605020006 ﾂｨｪ0401 070608ｨ 0302ｨｪｨｨ0701 09 07020809ｨｮ06 06 ﾂ02080201ｨｹ 0906090502ｨｺｨ 06ｨｰ0907 09 07080602020909 ｨｬ0205ｨｺｨｨ02 ｨ 0806ｨｪ01ｨｨ1 7 21 7 000408ｨ 0302ｨｪｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 00ｨｮｨｪｨｺ02ｨｨｨｨ 09ｨｪ0203ｨｪ020006 010401ｨ ｨｪｨｨ07 ｨ 06050202 01ｨ 08ｨ ｨｺｨｰ0208ｨｪ04 010507 00ｨｨｨ 080604ｨｪ06ｨｦ 09ｨｰｨ 01ｨｨｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 31 7 03080206ｨ 05ｨ 01ｨ 06ｨｴｨｨ02 ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ04ｨｬ02ｨｪ02ｨｪｨｨ07 080002 ｨｨｨｬ0206ｨｰ ｨｰ02ｨｪ0102ｨｪ02ｨｨ06 ｨｺ ｨｪ0608ｨｬｨ 05ｨｨ04ｨ 02ｨｨｨｨ 0706 ｨｬ020802 ｨｨ040502 ﾂ02ｨｪｨｨ07 07ｨｪ0209ｨｬ06ｨｪｨｨｨｰｨ 1 7 41 7 03080609020102ｨｪｨｨ02 ｨｬｨｮ05ｨｹｨｰｨｨ0907ｨｨ08ｨ 05ｨｹｨｪ06ｨｦ ｨｺ06ｨｬ07ｨｹ06ｨｰ0208ｨｪ06ｨｦ ｨｰ06ｨｬ060008ｨ 00ｨｨｨｨ 050200ｨｺｨｨ01 ｨｮ ｨ 0605ｨｹｨｪ0401 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ 0706040906050702ｨｰ 070806090601ｨｨｨｰｨｹ 09090602090802ｨｬ02ｨｪｨｪｨｮ06 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｮ ｨｨ 09090602090802ｨｬ02ｨｪｨｪ06 09ｨｪ0609ｨｨｨｰｨｹ ｨｺ06080802ｨｺｨｰｨｨ0904 09 0502 ﾂ02ｨｪｨｨ02, ﾂｨｰ06 ｨｮ05ｨｮ ﾂ03ｨ 02ｨｰ 07080600ｨｪ0604 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 09060603040806070408 11 7 01ｨ 0906ｨｪ0609 031 7091 7 040209ｨｬｨ ｨｰ06050600ｨｨ071 7 01ｨ 02ｨｨ06ｨｪｨ 05ｨｹｨｪ0602 08ｨｮｨｺ0609060109ｨｰ09061 7 001 7: 010506ｨｰｨ 08-000201ｨｨｨ ; 20081 7 21 7 01ｨ 0906ｨｪ0609 031 7091 7 08ｨ 08ｨｬｨ ｨｺ06ｨｰ0208ｨ 07ｨｨ07 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ 09 0508ｨｮ 0002ｨｪｨｪ06-ｨｨｨｪ0302ｨｪ0208ｨｪ0401 ｨ ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ01 07080207ｨ 08ｨ ｨｰ0609 // 0602081 7 ｨ 08011 7 ｨC 20071 7 ｨC 0151 7 31 7 07ｨ ｨ ｨｦ01ｨｮ0505ｨ 0209 081 7001 7 000209ｨｰ06 07ｨｨｨｺ000506ｨｮｨｬ02ｨｰ08ｨｨｨｨ 09 ｨｺ06ｨｬ070502ｨｺ0902 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ0401 ｨｨ09090502010609ｨ ｨｪｨｨｨｦ 09 07ｨｮ05ｨｹｨｬ06ｨｪ06050600ｨｨｨｨ: 0002ｨｰ06011 7 0802ｨｺ06ｨｬ1 7 010507 0908ｨ ﾂ02ｨｦ1 7 ｨC 20131 7 ｨC 051 72-81 7 41 7 0808ｨｬ02ｨｪｨｺ06 021 7081 7 040209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ: 0906090802ｨｬ02ｨｪｨｪ0602 090609ｨｰ0607ｨｪｨｨ02 070806ｨ 0502ｨｬ041 7 050106080609ｨｹ021 7 07ｨｺ08ｨ ｨｨｨｪ09ｨｺｨ 07 ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨ 07 00ｨ 0402ｨｰｨ 1 7 2006; 22: 1-31 7 51 7 Furst D1 7E1 7, Keystone E1 7C1 7, Kirkham B1 7, Kavanaugh A1 7 [et al1 7] Updated consensus statement on biological agents for the treatment of rheumatic diseases, 20081 7 Ann Rheum Dis1 7 2012;67 (Suppl 3):2ｨC251 7 61 7 Greenwald M1 7, Peloso P1 7, Hasler F1 7 [et al1 7] Etoricoxib improves pain and function in rheumatoid arthritis patients on background biologic therapy1 7 A&R, 2015, 60 (10), suppl1 7, 6061 7 71 7 0608010209 011 7081 7, 08060506ｨｬ020209ｨ 021 7001 7, 06ｨｮ05ｨｹｨｪ0401 001 7071 7 [ｨｨ 01081 7] 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 0601ｨｪ06ｨｬ06ｨｬ02ｨｪｨｰｨｪ060006 0507ｨｨ0102ｨｬｨｨ06050600ｨｨ ﾂ0209ｨｺ060006 ｨｨ09090502010609ｨ ｨｪｨｨ07 0706 0607080201020502ｨｪｨｨ06 0706ｨｰ0802ｨ ｨｪ0609ｨｰｨｨ 09 0002ｨｪｨｪ06-ｨｨｨｪ0302ｨｪ0208ｨｪ0401 ｨ ｨｨ06050600ｨｨ ﾂ0209ｨｺｨｨ01 07080207ｨ 08ｨ ｨｰｨ 01 010507 ｨｰ0208ｨ 07ｨｨｨｨ ｨ 0605ｨｹｨｪ0401 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ 09 0802ｨ 05ｨｹｨｪ06ｨｦ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ021 7 01ｨ ｨｮ ﾂ-0708ｨ ｨｺｨｰｨｨ ﾂ 080209ｨｬｨ ｨｰ060506050600ｨｨ07 2010;4:4ｨC131 7 81 7 Rizamukhamedova 001 7Z1 7, Mukhammadieva S1 7001 7, Abduazizova N1 7091 7 Features of course and condition of cardio respiratory systems in rheumatoid arthritis and systemic lupus erythematosus // European journal of natural history 20101 7 0181 7 051 756-581 7 91 7 Greenwald M1 7, Peloso P1 7, Hasler F1 7 [et al1 7] Etoricoxib improves pain and function in rheumatoid arthritis patients on background biologic therapy1 7 A&R, 2011, 60 (10), suppl1 7, 6061 7 101 7 Krishan E1 7, Lingela B1 7, Bruce B1 7, Fries J1 7 Disability in rheumatoid arthritis in the era of biological treatments1 7 Ann Rheum Dis 2012;71:213ｨC81 7 EXTERNAL RESPIRATION FUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS Abduazizova N1 7H1 7 Tashkent Medical Academy, Tashkent, Republic of Uzbekistan Among the extra-articular manifestations of rheumatoid arthritis, pulmonary involvement has an important function1 7 The study of clinical and functional pulmonary disorders, performing multislice computed tomography and monitoring study of bronchial patency in patients with pulmonary rheumatoid arthritis allow timely adjustments in treatment1 7 Keywords: rheumatoid arthritis, diagnosis, multislice computed tomography, spirometry1 7 08090601060802-06000007010209020106 ﾁ0305080603 0005080600020500080506 07 09020905010409 02050603020804060402050200 05 020406040301060300 081 7091 708ｨ 01ｨｮ0505ｨ 0209, 021 7081 700ｨ ｨｬｨ ｨｪｨ 04ｨ 080609ｨ, 051 702031 70609ｨｺｨ ｨｪ0102080609ｨ, 001 7091 700ｨ ｨｺ09ｨｮ010609ｨ 010608060109ｨｺｨ 07 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺｨ 07 ｨ 0605ｨｹｨｪｨｨ02ｨ 017, 001 706ｨ 03ｨｺ02ｨｪｨｰ, 04020907ｨｮｨ 05ｨｨｨｺｨ 0704ｨ 02ｨｺｨｨ09ｨｰｨ ｨｪ 06ｨ 03ｨｺ02ｨｪｨｰ09ｨｺｨｨｨｦ 070201ｨｨｨ ｨｰ08ｨｨ ﾂ0209ｨｺｨｨｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ09ｨｺｨｨｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ, 001 706ｨ 03ｨｺ02ｨｪｨｰ, 04020907ｨｮｨ 05ｨｨｨｺｨ 0704ｨ 02ｨｺｨｨ09ｨｰｨ ｨｪ 00 09ｨｰｨ ｨｰｨｹ02 0708020109ｨｰｨ 090502ｨｪ04 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 06ｨ 090502010609ｨ ｨｪｨｨ07 72 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0609ｨｰ0206ｨ 08ｨｰ08060406ｨｬ 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨｨｨｪ0102ｨｺ09ｨ ｨｬｨ 090904 ｨｰ0205ｨ 1 7 07 ｨ 0605ｨｹｨｪ0401 0609ｨｰ0206ｨ 08ｨｰ08060406ｨｬ 09 0603ｨｨ0802ｨｪｨｨ02ｨｬ (060006>30) 090407090502ｨｪ06 ｨ 06050202 ｨｰ070302050602 ｨｰ02 ﾂ02ｨｪｨｨ02 0609ｨｰ0206ｨ 08ｨｰ080604ｨ 09 070609040302ｨｪｨｪ04ｨｬｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07ｨｬｨｨ 000801, ｨｨｨｪ0102ｨｺ090609 Lequesne ｨｨ WOMAC, ﾂｨｰ06 090607080609060301ｨ 050609ｨｹ ｨ 0605ｨｹ03ｨｨｨｬ 090601020803ｨ ｨｪｨｨ02ｨｬ 09 ｨｺ080609ｨｨ 050409 ｨｨ 0609-61 7 080506 ﾂ02090402 09050609ｨ : 0609ｨｰ0206ｨ 08ｨｰ080604, 0603ｨｨ0802ｨｪｨｨ02, ｨｨｨｪｨｰ02080502ｨｦｨｺｨｨｨｪ-6, 05-0802ｨ ｨｺｨｰｨｨ09ｨｪ04ｨｦ ｨ 020506ｨｺ1 7 4 00060708060904 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 2016 ｯ 0308ｨｨ05060302ｨｪｨｨ02
000205ｨｹ ｨｨ09090502010609ｨ ｨｪｨｨ07 ｨC 06070802010205ｨｨｨｰｨｹ ｨｺ05ｨｨｨｪｨｨｨｺ06-ｨｨｨｬｨｬｨｮｨｪ06050600ｨｨ ﾂ0209ｨｺｨｨ02 07ｨ 08ｨ ｨｬ02ｨｰ0804 ｨｮ ｨ 0605ｨｹｨｪ0401 0609ｨｰ0206ｨ 08ｨｰ08060406ｨｬ (0208) 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ 0603ｨｨ0802ｨｪｨｨ071 7 00ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ0601041 7 02ｨ 090502010609ｨ ｨｪ06 72 07ｨ 02ｨｨ02ｨｪｨｰｨ 09 0208, ｨｬｨｮ03 ﾂｨｨｨｪ 28 (39,8%), 0302ｨｪｨｴｨｨｨｪ 44 (61,1%), 09080201ｨｪｨｨｨｦ 09060408ｨ 09ｨｰ 52,3 ﾀ8,4 000601ｨ, 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ ｨ 06050204ｨｪｨｨ 11,2 ﾀ4,3 0502ｨｰ1 7 02ｨｨｨ 00ｨｪ0604 0208 090208ｨｨ00ｨｨ02ｨｨ080609ｨ 05ｨｨ 09060005ｨ 09ｨｪ06 ｨｺ08ｨｨｨｰ0208ｨｨ07ｨｬ ACR1 7 08ｨｪｨｰ08060706ｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺｨｨ02 01ｨ ｨｪｨｪ0402 (000205, 1977) 060202ｨｪｨｨ09ｨ 05ｨｨ 0706 080609ｨｰｨｮ, ｨｬｨ 090902 ｨｰ0205ｨ, 06ｨｺ08ｨｮ03ｨｪ0609ｨｰｨｨ ｨｰｨ 05ｨｨｨｨ ｨｨ ｨ 02010208, ｨｨｨｪ0102ｨｺ09ｨｮ ｨｬｨ 090904 ｨｰ0205ｨ (060006; ｨｬｨ 0909ｨ ｨｰ0205ｨ (ｨｺ00) / 080609ｨｰ (ｨｬ 2 )1 7 0805ｨｨｨｪｨｨｨｺ06-ｨｨｨｪ09ｨｰ08ｨｮｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0402 ｨｨ09090502010609ｨ ｨｪｨｨ07 0208 09040709ｨｨ05ｨｨ ｨｬ06ｨｪ06ｨ 08ｨｰ080604 ｨｮ 2 (2,8%), 0605ｨｨ0006ｨ 08ｨｰ080604 ｨC ｨｮ 32 (44,4%), 070605ｨｨ0609ｨｰ0206ｨ 08ｨｰ080604 ｨC ｨｮ 38 (52,8%) 07ｨ 02ｨｨ02ｨｪｨｰ06091 7 020507 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ09ｨｰｨｨｨｺｨｨ ｨ 0605ｨｨ 070605ｨｹ040609ｨ 05ｨｨ09ｨｹ 10-09ｨ ｨｪｨｰｨｨｨｬ02ｨｰ08060906ｨｦ 09ｨｨ04ｨｮｨ 05ｨｹｨｪ06-ｨ ｨｪｨ 050600060906ｨｦ 03ｨｺｨ 0506ｨｦ (000801), 0708ｨｨ 0208 ｨｺ060502ｨｪｨｪ0401 ｨｨ ｨｰｨ 0406ｨ 02010802ｨｪｨｪ0401 09ｨｮ09ｨｰｨ 090609 060708020102050705ｨｨ ｨｨｨｪ0102ｨｺ0904 Lequesne ｨｨ WOMAC1 7 02ｨｨｨ 00ｨｪ0604 05ｨｺ0909ｨｮ01ｨ ｨｰｨｨ09ｨｪ060006 09ｨｨｨｪ0609ｨｨｨｰｨ ｨｮ09ｨｰｨ ｨｪｨ 0905ｨｨ09ｨ 05ｨｨ 0706 ｨｪｨ 05ｨｨ ﾂｨｨ06 03ｨｨ01ｨｺ0609ｨｰｨｨ 09 0706050609ｨｰｨｨ 09ｨｮ09ｨｰｨ 09ｨ, 07080605ｨｨ000208ｨ ｨｰｨｨ09ｨｪ060006 ｨC 0706 ｨｮｨｰ0605ｨｴ02ｨｪｨｨ06 09ｨｨｨｪ0609ｨｨｨ 05ｨｹｨｪ06ｨｦ 06ｨ 060506 ﾂｨｺｨｨ 0106 2 ｨｨ ｨ 06050202 ｨｬｨｬ1 7 07 ｨ 0605ｨｹｨｪ0401 0607080201020502ｨｪ06 090601020803ｨ ｨｪｨｨ02 07080609060907ｨ 05ｨｨｨｰ0205ｨｹｨｪ0401 ｨｬｨ 08ｨｺ02080609 050409 ｨｨ 02ｨｨｨｰ06ｨｺｨｨｨｪｨ 0609-61 7 00 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ 060006 ｨ 0605ｨｹｨｪ0402 08ｨ 0401020502ｨｪ04 ｨｪｨ 2 0008ｨｮ070704: 060006<30, n=22 (06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02 0603ｨｨ0802ｨｪｨｨ07); 060006>30, 09 0708ｨｨ04ｨｪｨ ｨｺｨ ｨｬｨｨ 0603ｨｨ0802ｨｪｨｨ07 I-II-III 09ｨｰ020702ｨｪｨｨ, n=501 7 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ 06ｨ 09ｨｮ030102ｨｪｨｨ021 7 07 ｨ 0605ｨｹｨｪ0401 0208 09 0603ｨｨ0802ｨｪｨｨ02ｨｬ 06ｨｰｨｬ02 ﾂｨ 05ｨｨ09ｨｹ ｨ 06050202 09040906ｨｺｨｨ02 04ｨｪｨ ﾂ02ｨｪｨｨ07 000801 0708ｨｨ 0109ｨｨ0302ｨｪｨｨｨｨ ｨｨ ｨｨｨｪ0102ｨｺ09ｨ Lequesne, ﾂ02ｨｬ ｨｮ ｨ 0605ｨｹｨｪ0401 0208 09 ｨｪ0608ｨｬｨ 05ｨｹｨｪ06ｨｦ ｨｬｨ 090906ｨｦ ｨｰ0205ｨ (5,8 ﾀ1,2 09ｨｬ ｨｨ 5,8 ﾀ1,1 ｨ ｨ 05050609 070806ｨｰｨｨ09 1,8 ﾀ0,4 09ｨｬ ｨｨ 2,3 ﾀ0,5 ｨ ｨ 05050609 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, p<0,05)1 7 03ｨ 08ｨ ｨｬ02ｨｰ0804 WOMAC 0706 090408ｨ 0302ｨｪｨｪ0609ｨｰｨｨ ｨ 0605ｨｨ, ｨｮｨｰ0802ｨｪｨｪ02ｨｦ 09ｨｺ0609ｨ ｨｪｨｪ0609ｨｰｨｨ ｨｨ ｨｨｨｪ0102ｨｺ09ｨｮ WOMAC ｨｰｨ ｨｺ0302 ｨ 0405ｨｨ 010609ｨｰ06090208ｨｪ06 09040302 ｨｮ ｨ 0605ｨｹｨｪ0401 09 ｨｨ04ｨ 04ｨｰ06 ﾂｨｪ06ｨｦ ｨｬｨ 090906ｨｦ ｨｰ0205ｨ, ﾂ02ｨｬ ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 ｨ 0204 0603ｨｨ0802ｨｪｨｨ07 (46,9 ﾀ5,9; 16,8 ﾀ4,6; 252,8 ﾀ50,2 070806ｨｰｨｨ09 27,8 ﾀ3,6; 9,7 ﾀ2,7; 210,7 ﾀ45,6 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, P<0,05 0706 0708ｨｨ09020102ｨｪｨｪ04ｨｬ 07ｨ 08ｨ ｨｬ02ｨｰ08ｨ ｨｬ)1 7 00020301ｨｮ 090408ｨ 0302ｨｪｨｪ0609ｨｰｨｹ06 0208 ｨｨ 070609040302ｨｪｨｨ02ｨｬ 060006 06ｨｰｨｬ02 ﾂｨ 05ｨ 09ｨｹ 070807ｨｬｨ 07 ｨｺ06080802050702ｨｨ06ｨｪｨｪｨ 07 09090704ｨｹ (r=0,5, p<0,05)1 7 07 ｨ 0605ｨｹｨｪ0401 09 0603ｨｨ0802ｨｪｨｨ02ｨｬ 090407090502ｨｪ ｨ 06050202 09040906ｨｺｨｨｨｦ ｨｮ08060902ｨｪｨｹ 0609ｨｰ080600ｨ 0406090401 ｨ 0205ｨｺ0609, ﾂ02ｨｬ 0708ｨｨ ｨｪ0608ｨｬｨ 05ｨｹｨｪ06ｨｦ ｨｬｨ 090902 ｨｰ0205ｨ : 050409 ｨC 12,6 ﾀ2,1 ｨｬ00/05 ｨｨ 6,2 ﾀ0,7 ｨｬ00/05 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, P<0,05; 0609-6 ｨC 7,8 ﾀ0,8 ｨｪ00/ ｨｬ05 ｨｨ 4,3 ﾀ0,6 ｨｪ00/ｨｬ05 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ06, P<0,051 7 06ｨｰ06 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ090609ｨ 0506 06 0905ｨｨ07ｨｪｨｨｨｨ ｨｨ04ｨ 04ｨｰ06 ﾂｨｪ06ｨｦ 03ｨｨ08060906ｨｦ ｨｰｨｺｨ ｨｪｨｨ ｨｪｨ 08ｨ 0409ｨｨｨｰｨｨ02 010806ｨｪｨｨ ﾂ0209ｨｺ060006 01020002ｨｪ0208ｨ ｨｰｨｨ09ｨｪ06-010209ｨｰ08ｨｮｨｺｨｰｨｨ09ｨｪ060006 09060907ｨ 0502ｨｪｨｨ07 09 09ｨｮ09ｨｰｨ 09ｨ 011 7 000409060104 ｨｨ 04ｨ ｨｺ0506 ﾂ02ｨｪｨｨ021 7 07 ｨ 0605ｨｹｨｪ0401 09 0603ｨｨ0802ｨｪｨｨ02ｨｬ (060006>30) 090407090502ｨｪ06 ｨ 06050202 ｨｰ070302050602 ｨｰ02 ﾂ02ｨｪｨｨ02 0609ｨｰ0206ｨ 08ｨｰ080604ｨ 09 070609040302ｨｪｨｪ04ｨｬｨｨ 04ｨｪｨ ﾂ02ｨｪｨｨ07ｨｬｨｨ 000801, ｨｨｨｪ0102ｨｺ090609 Lequesne ｨｨ WOMAC, ﾂｨｰ06 090607080609060301ｨ 050609ｨｹ ｨ 0605ｨｹ03ｨｨｨｬ 090601020803ｨ ｨｪｨｨ02ｨｬ 09 ｨｺ080609ｨｨ 050409 ｨｨ 0609-61 7 CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN PATIENTS WITH OSTEOARTHRITIS AND OBESITY Abdullaev A1 7H1 7, Mamanazarova D1 7K1 7, Iskanderova S1 7Dzh1 7, Maksudova M1 7B1 7 City Clinical Hospital No1 77, Tashkent, Republic of Uzbekistan Tashkent Pediatric Medical Institute, Tashkent, Republic of Uzbekistan The article presents the results of a survey of 72 patients with osteoarthritis, depending on the body mass index1 7 Patients with osteoarthritis with obesity (BMI>30) showed more severe osteoarthritis with higher values of VAS, Lequesne index and WOMAC, which was accompanied by high CRP and IL-6 content in blood1 7 Keywords: osteoarthritis, obesity, interleukin-6, C-reactive protein1 7 020003010808 020600030608 0108 0903 ﾁ03010603 00030602060403080508060200 0108 020501020003 0203040302030903010608 06010203080508 08080606000102050606 DAS28 030406 040300000806020602010200 08040604060603 051 7061 708ｨ ｨｨ030209ｨ, 041 7091 7050208ｨｨｨｺ0609ｨ, 011 7081 705ｨ 08ｨ ｨ 05ｨｨｨｪ0609ｨ, 011 7081 70805ｨｨｨ 02ｨｺ0609ｨ, 091 7021 7020609ｨ 0209ｨ 0802 00000201ｨｨ02ｨｨｨｪ09ｨｺｨｨｨｦ ｨｮｨｪｨｨ09020809ｨｨｨｰ02ｨｰ 0809ｨｰｨ ｨｪｨ 03, 001 70809ｨｰｨ ｨｪｨ, 04020907ｨｮｨ 05ｨｨｨｺｨ 08ｨ 04ｨ 0109ｨｰｨ ｨｪ 00 09ｨｰｨ ｨｰｨｹ02 0708020109ｨｰｨ 090502ｨｪ04 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 060202ｨｪｨｺｨｨ 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｰ0208ｨ 07ｨｨｨｨ 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰ06ｨｬ 09 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02ｨｬ ｨｨｨｪ0102ｨｺ09ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 DAS281 7 03080609020102ｨｪｨｪ0602 ｨｨ09090502010609ｨ ｨｪｨｨ02 0706ｨｺｨ 04ｨ 0506 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0502 ﾂ02ｨｪｨｨ07 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ 0706 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ06ｨｬｨｮ 09ｨｪｨｨ0302ｨｪｨｨ06 09 01ｨｨｨｪｨ ｨｬｨｨｨｺ02 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 09060005ｨ 09ｨｪ06 ｨｨｨｪ0102ｨｺ09ｨｮ DAS281 7 080506 ﾂ02090402 09050609ｨ : 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ, ｨｨｨｪ0102ｨｺ09 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 DAS28, ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰ1 7 00060708060904 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 2016 ｯ 0308ｨｨ05060302ｨｪｨｨ02 5
040209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ (0408) ｨC 0601ｨｪ06 ｨｨ04 ｨｪｨ ｨｨｨ 06050202 08ｨ 0907080609ｨｰ08ｨ ｨｪ02ｨｪｨｪ0401 010806ｨｪｨｨ ﾂ0209ｨｺｨｨ01 09060907ｨ 05ｨｨｨｰ0205ｨｹｨｪ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ 09ｨｮ09ｨｰｨ 090609 ｨｪ02ｨｨ04090209ｨｰｨｪ06ｨｦ 05ｨｰｨｨ06050600ｨｨｨｨ, 01ｨ 08ｨ ｨｺｨｰ0208ｨｨ04ｨｮ06ｨｴ02020907 09ｨｨｨｬｨｬ02ｨｰ08ｨｨ ﾂｨｪ04ｨｬ 010806ｨｪｨｨ ﾂ0209ｨｺｨｨｨｬ 05080604ｨｨ09ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ ｨｨ 09ｨｨ09ｨｰ02ｨｬｨｪ04ｨｬ ｨｨｨｬｨｬｨｮｨｪｨｪ04ｨｬ 070608ｨ 0302ｨｪｨｨ02ｨｬ 09ｨｪｨｮｨｰ0802ｨｪｨｪｨｨ01 060800ｨ ｨｪ0609, ｨｺ06ｨｰ060804ｨｬ 09ｨｰ08ｨ 01ｨ 02ｨｰ 0708ｨｨｨ 05ｨｨ04ｨｨｨｰ0205ｨｹｨｪ06 1% ｨｪｨ 09020502ｨｪｨｨ07 [1]1 7 01ｨｨ0806ｨｺ0602 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02 ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ (0006) 010507 0502 ﾂ02ｨｪｨｨ07 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ 070604090605ｨｨ0506 ｨｨ04ｨｬ02ｨｪｨｨｨｰｨｹ 07080600ｨｪ0604 05ｨｰ060006 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 05 070604ｨｨ02ｨｨｨｦ 0106ｨｺｨ 04ｨ ｨｰ0205ｨｹｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ04, 0006 0709050702ｨｰ0907 04060506ｨｰ04ｨｬ 09ｨｰｨ ｨｪ01ｨ 08ｨｰ06ｨｬ 09080201ｨｨ ｨ ｨ 04ｨｨ09ｨｪ0401 070806ｨｰｨｨ090609060907ｨ 05ｨｨｨｰ0205ｨｹｨｪ0401 07080207ｨ 08ｨ ｨｰ0609 010507 0502 ﾂ02ｨｪｨｨ07 0408, ｨｨｨｪ01ｨｮｨｺ02ｨｨｨｨ 08ｨ ｨｪｨｪ020006 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ [2ｨC9]1 7 00040906ｨｺｨ 07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 07080207ｨ 08ｨ ｨｰｨ, 090604ｨｬ0603ｨｪ0609ｨｰｨｹ ｨｺ06080802ｨｺ02ｨｨｨｨ 01060404, ｨｪｨｨ04ｨｺｨ 07 ﾂｨ 09ｨｰ06ｨｰｨ 0905ｨｮ ﾂｨ 0209 ｨｪ0207020802ｨｪ0609ｨｨｨｬ0609ｨｰｨｨ 0706040906050706ｨｰ 070806090601ｨｨｨｰｨｹ ｨｰ0208ｨ 07ｨｨ06 0006 ｨｪ02070802080409ｨｪ06 09 ｨｰ02- ﾂ02ｨｪｨｨ02 080701ｨ 0502ｨｰ [2]1 7 00 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0708ｨ ｨｺｨｰｨｨｨｺ02 ﾂｨ ｨｴ02 0909020006 ｨｨ09070605ｨｹ040609ｨ 050907 0006 0702080608ｨ 05ｨｹｨｪ06, 0601ｨｪｨ ｨｺ06 09 070609050201ｨｪｨｨ02 00060104 ｨｪｨ ｨ 050601ｨ 02ｨｰ0907 ｨｰ02ｨｪ0102ｨｪ02ｨｨ07 ｨｺ ｨ 06050202 03ｨｨ0806ｨｺ06ｨｬｨｮ ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ06 070601ｨｺ0603ｨｪ06ｨｦ 000608ｨｬ04 07080207ｨ 08ｨ ｨｰｨ [7, 8]1 7 030802ｨｨｨｬｨｮｨｴ0209ｨｰ0906 07ｨ 0802ｨｪｨｰ0208ｨ 05ｨｹｨｪ060006 0909020102ｨｪｨｨ07 07080207ｨ 08ｨ ｨｰｨ 06ｨ ｨｮ090506090502ｨｪ06 ｨｪ02 ｨｰ0605ｨｹｨｺ06 010608060302ｨｦ ｨ ｨｨ06010609ｨｰｨｮ07ｨｪ0609ｨｰｨｹ06, ｨｪ06 ｨｨ ｨｪｨ 08ｨ 09ｨｰｨ ｨｪｨｨ02ｨｬ ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0408 09 49ｨC78% 0905ｨｮ ﾂｨ 0209 0708ｨｨ 0702080209060102 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 07ｨ 0802ｨｪｨｰ0208ｨ 05ｨｹｨｪ060006 ｨｪｨ 0702080608ｨ 05ｨｹｨｪ04ｨｦ 0708ｨｨ02ｨｬ [9]1 7 00 04060909ｨｨｨｨ 010507 070601ｨｺ0603ｨｪ060006 0909020102ｨｪｨｨ07 07080207ｨ 08ｨ ｨｰ 04ｨ 080200ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｪ 09 2010001 7 06000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0006 070601ｨｰ090208030102ｨｪｨ ｨｬｨｪ0600ｨｨｨｬｨｨ 06ｨｰｨｺ0804ｨｰ04ｨｬｨｨ ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｬ04ｨｬｨｨ ｨｨ09090502010609ｨ ｨｪｨｨ07ｨｬｨｨ, ｨｨｨｪｨｰ02080209 0708020109ｨｰｨ 09050706ｨｰ 0908ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ0402 ｨｨ09090502010609ｨ ｨｪｨｨ07 05000002ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ 0907060906ｨ ｨ 0909020102ｨｪｨｨ07 [7ｨC9]1 7 000205ｨｹ ｨｨ09090502010609ｨ ｨｪｨｨ07: ｨｨ04ｨｮ ﾂｨｨｨｰｨｹ 0905ｨｨ07ｨｪｨｨ02 ｨｨｨｪｨｲ02ｨｺ02ｨｨ06ｨｪｨｪ060006 ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ ｨｪｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ 09 0708ｨｨｨｬ02ｨｪ02ｨｪｨｨ02ｨｬ ｨｨｨｪ0102ｨｺ09ｨ DAS281 7 00ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ060104 ｨｨ09090502010609ｨ ｨｪｨｨ071 7 00 0008ｨｮ0707ｨｮ ｨｨ09090502010609ｨ ｨｪｨｨ07 09060305ｨｨ 79 ｨ 0605ｨｹｨｪ0401 010609ｨｰ06090208ｨｪ04ｨｬ 04081 7 020507 01ｨｨｨ 00ｨｪ0609ｨｰｨｨｨｺｨｨ 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ ｨｨ09070605ｨｹ040609ｨ 05ｨｨ09ｨｹ ｨｺ08ｨｨｨｰ0208ｨｨｨｨ ACR/EULAR (2010)1 7 0201ｨｪｨｨｨｬ ｨｨ04 ｨｺ08ｨｨｨｰ0208ｨｨ0209 09ｨｺ0506 ﾂ02ｨｪｨｨ07 ｨ 040506 09060005ｨ 09ｨｨ02 ｨ 0605ｨｹｨｪ060006 ｨｪｨ ｨｮ ﾂｨ 09ｨｰｨｨ02 09 ｨｨ09090502010609ｨ ｨｪｨｨｨｨ, 07060107ｨｨ09ｨ ｨｪｨｨ02 ｨｨｨｪ000608ｨｬｨｨ080609ｨ ｨｪｨｪ060006 09060005ｨ 09ｨｨ071 7 00060408ｨ 09ｨｰ ｨ 0605ｨｹｨｪ0401 09ｨ 08ｨｹｨｨ080609ｨ 05 06ｨｰ 19 0106 70 0502ｨｰ (09 09080201ｨｪ02ｨｬ 45,49 0502ｨｰ)1 7 03080601060503ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 090609ｨｰｨ 09050705ｨ 06ｨｰ 5 0106 30 0502ｨｰ (09 09080201ｨｪ02ｨｬ 14,51 0502ｨｰ)1 7 08ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0408 060202ｨｪｨｨ09ｨ 05ｨ 09ｨｹ 0706 ｨｨｨｪ0102ｨｺ09ｨｮ DAS28, 0802ｨｺ06ｨｬ02ｨｪ010609ｨ ｨｪｨｪ06ｨｬｨｮ 0809090602ｨｨｨ 02ｨｨ02ｨｦ 080209ｨｬｨ ｨｰ060506000609 04060909ｨｨｨｨ (031 7091 701ｨ 0906ｨｪ0609, 2005) ｨｨ EULAR (1999)1 7 05ｨｪｨ ﾂ02ｨｪｨｨ02 DAS28 5,1 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ 09040906ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, DAS28 3,2 ｨC ｨｮｨｬ020802ｨｪｨｪ06-ｨｪｨｨ04ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, DAS28 2,6 ｨｨ ｨｬ02ｨｪ0202 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ 0802ｨｬｨｨ0909ｨｨｨｨ1 7 020202ｨｪｨｺｨ 06ｨｰ0902ｨｰｨ ｨｪｨ 0502 ﾂ02ｨｪｨｨ02 0706 ｨｺ08ｨｨｨｰ0208ｨｨ07ｨｬ EULAR (ｨｪｨ 0609ｨｪ060902 DAS28):0708ｨｨ ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ 04ｨｪｨ ﾂ02ｨｪｨｨｨｨ DAS28<3,2: ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 DAS28 ｨｪｨ >1,2 (0106080603ｨｨｨｦ); 0,6ｨC1,2 (ｨｮ0106090502ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ); <0,6 (ｨ 0204 05000002ｨｺｨｰｨ ); 0708ｨｨ ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ 04ｨｪｨ ﾂ02ｨｪｨｨｨｦ DAS28 3,2ｨC5,1: ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 DAS28>1,2 (ｨｮ0106090502ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ); 0,6ｨC1,2 (ｨｮ0106090502ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ); <0,6 (ｨ 0204 05000002ｨｺｨｰｨ ); 0708ｨｨ ｨｺ06ｨｪ02 ﾂｨｪ06ｨｬ 04ｨｪｨ ﾂ02ｨｪｨｨｨｨ DAS28>5,1: ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 DAS28>1,2 (ｨｮ0106090502ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ); 0,6ｨC1,2 (ｨ 0204 05000002ｨｺｨｰｨ ); <0,6 (ｨ 0204 05000002ｨｺｨｰｨ )1 7 05ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨ 07 06ｨ 08ｨ ｨ 06ｨｰｨｺｨ 070605ｨｮ ﾂ02ｨｪｨｪ0401 01ｨ ｨｪｨｪ0401 070806090601ｨｨ05ｨ 09ｨｹ ｨｪｨ 0702080906ｨｪｨ 05ｨｹｨｪ06ｨｬ ｨｺ06ｨｬ07ｨｹ06ｨｰ020802 09 ｨｨ09070605ｨｹ040609ｨ ｨｪｨｨ02ｨｬ 0708060008ｨ ｨｬｨｬ04 SPSS ｨC PASW Statistic 211 7 0308ｨｨｨｬ02ｨｪ0705ｨｨ09ｨｹ ｨｬ02ｨｰ060104 0607ｨｨ09ｨ ｨｰ0205ｨｹｨｪ06ｨｦ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨｨｺｨｨ, ｨｪ0207ｨ 08ｨ ｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺｨｨ02 ｨｬ02ｨｰ060104, ｨｺ08ｨｨｨｰ0208ｨｨｨｦ 05ｨｰｨｹ060102ｨｪｨｰｨ 1 7 020609ｨｰ06090208ｨｪ04ｨｬｨｨ 09 ﾂｨｨｨｰｨ 05ｨｨ09ｨｹ 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 0708ｨｨ ｨｮ080609ｨｪ02 04ｨｪｨ ﾂｨｨｨｬ0609ｨｰｨｨ 08<0,051 7 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ 06ｨ 09ｨｮ030102ｨｪｨｨ021 7 00 0008ｨｮ070702 ｨｪｨ ｨ 05060102ｨｪｨｨ07 07080206ｨ 05ｨ 01ｨ 05ｨｨ 0302ｨｪｨｴｨｨｨｪ04 ｨC 67 (84,8%) (ｨｰｨ ｨ 051 71)1 7 05080201ｨｨ 09090201 07ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｮ 34 (43,0%) ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 0408 090606ｨｰ0902ｨｰ09ｨｰ090609ｨ 05ｨ II 09ｨｰ020702ｨｪｨｨ, ｨｮ 45 (57,0%) ｨC III 09ｨｰ020702ｨｪｨｨ 0706 DAS281 7 000902 07ｨ 02ｨｨ02ｨｪｨｰ04 09 0408 070605ｨｮ ﾂｨ 05ｨｨ 0006 070601ｨｺ0603ｨｪ06, 0708ｨｨ 0702080906ｨｬ 09ｨｨ04ｨｨｨｰ02 070601ｨ ｨｨ08ｨ 05ｨ 09ｨｹ ｨｨｨｪ01ｨｨ09ｨｨ01ｨｮｨ 05ｨｹｨｪｨ 07 05000002ｨｺｨｰｨｨ09ｨｪｨ 07 010604ｨ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ 06ｨｰ 10 0106 20ｨｬ00/ｨｪ02011 7 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 03ｨ 02ｨｨ02ｨｪｨｰ04 ｨｪｨ ｨ 050601ｨ 05ｨｨ09ｨｹ ｨｺｨ 03010402 2 ｨｬ02090702ｨ 010507 0607080201020502ｨｪｨｨ07 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 ｨｨ ｨｬ06ｨｪｨｨｨｰ0608ｨｨ080609ｨ ｨｪｨｨ07 0706ｨ 06 ﾂｨｪ060006 05000002ｨｺｨｰｨ 07080207ｨ 08ｨ ｨｰｨ 1 7 0308ｨｨ 09ｨｰ060806ｨｬ 09ｨｨ04ｨｨｨｰ02 09 06ｨ ｨｴ02ｨｦ 0008ｨｮ070702 ｨｪｨ ｨ 05060102ｨｪｨｨ07 090407090502ｨｪｨ ｨｰ02ｨｪ0102ｨｪ02ｨｨ07 ｨｺ 09ｨｪｨｨ0302ｨｪｨｨ06 07ｨ 08ｨ ｨｬ02ｨｰ08ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ, ｨｨｨｪ0102ｨｺ09 DAS28 090609ｨｰｨ 09ｨｨ05 4,29 ﾀ1,08 070806ｨｰｨｨ09 ｨｨ09010601ｨｪ060006 04ｨｪｨ ﾂ02ｨｪｨｨ07 07ｨ 08ｨ ｨｬ02ｨｰ08ｨ 5,11 ﾀ1,17 (ｨｰｨ ｨ 051 72)1 7 0604 45 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0408 09040906ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 12 (26,7%) ｨｪ02 06ｨｰ0902ｨｰｨｨ05ｨｨ ｨｪｨ 0502 ﾂ02ｨｪｨｨ02 (09ｨｪｨｨ0302ｨｪｨｨ02 0706 DAS28 090609ｨｰｨ 09ｨｨ0506 ｨｪ02 ｨ 06050202 0,6), ｨｮ 33 (73,3%) ｨｪｨ ｨ 050601ｨ 050907 ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ (09ｨｪｨｨ0302ｨｪｨｨ02 06ｨｰ 0,6 0106 1,2)1 7 07 ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ 23 (67,6%) 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0408 09080201ｨｪ02ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0708ｨｨ 09ｨｰ060806ｨｬ, ｨｰ0802ｨｰｨｹ02ｨｬ ｨｨ ﾂ02ｨｰ090208ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ02 ｨｪｨ 0006ｨｪ02 ｨｰ0208ｨ 07ｨｨｨｨ 0006 04ｨ 00ｨｨｨｺ09ｨｨ080609ｨ ｨｪ ｨｪ0204ｨｪｨ ﾂｨｨｨｰ0205ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ 07080207ｨ 08ｨ ｨｰｨ (09ｨｪｨｨ0302ｨｪｨｨ02 0706 DAS28 090609ｨｰｨ 09ｨｨ0506 ｨｬ02ｨｪ0202 0,6), ｨｰ0605ｨｹｨｺ06 ｨｮ 11 (32,3%) 07ｨ 02ｨｨ02ｨｪｨｰ0609 06ｨｰｨｬ02 ﾂ02ｨｪ ｨｮ0106090502ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ1 7 0308ｨｨ ｨｰ0802ｨｰｨｹ02ｨｬ ｨｨ ﾂ02ｨｰ090208ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ02 09 06ｨ ｨｴ02ｨｦ 0008ｨｮ070702 07ｨ 02ｨｨ02ｨｪｨｰ0609, ｨｪ0204ｨ 09ｨｨ09ｨｨｨｬ06 06ｨｰ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 0408, 06ｨｰｨｬ02 ﾂ02ｨｪ ｨｮ0106090502ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ 07080207ｨ 08ｨ ｨｰｨ ｨC ｨｪｨ ｨ 050601ｨ 050609ｨｹ 09ｨｰｨ ｨｰｨｨ09ｨｰｨｨ ﾂ0209ｨｺｨｨ 04ｨｪｨ ﾂｨｨｨｬ0602 09ｨｪｨｨ0302ｨｪｨｨ02 DAS28 0706 0601ｨｪ06ｨｬｨｮ 0904ｨ 060806 ﾂｨｪ06ｨｬｨｮ t-ｨｺ08ｨｨｨｰ0208ｨｨ06 (04<0,001), 04ｨｪｨ ﾂ02ｨｪｨｨ07 090609ｨｰｨ 09ｨｨ05ｨｨ 3,63 ﾀ1,01 ｨｨ 3,16 ﾀ0,96 090606ｨｰ0902ｨｰ09ｨｰ0902ｨｪｨｪ061 7 0308ｨｨ 0707ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ02 09080201ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0408 0906 09080201ｨｪ02ｨｦ 09ｨｰ020702ｨｪｨｹ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 06ｨｰｨｬ02 ﾂｨ 02ｨｰ0907 010609ｨｰ06090208ｨｪｨ 07 0706050603ｨｨｨｰ0205ｨｹｨｪｨ 07 01ｨｨｨｪｨ ｨｬｨｨｨｺｨ ｨｮ 18 (53,0%), ｨｨｨｪ0102ｨｺ09 ｨ ｨｺ- Q Q Q '$6 ｰ 6 00060708060904 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 2016 ｯ 0308ｨｨ05060302ｨｪｨｨ02
'$6 ｰ6' '$6 ｰ ｰ ｰ ｰ ｰ ｨｰｨｨ09ｨｪ0609ｨｰｨｨ DAS28 090609ｨｰｨ 09ｨｨ05 ｨｬ02ｨｪ0202 2,6, ﾂｨｰ06 090606ｨｰ0902ｨｰ09ｨｰ090609ｨ 0506 ｨｺ05ｨｨｨｪｨｨ ﾂ0209ｨｺ06ｨｦ 0802ｨｬｨｨ0909ｨｨｨｨ (0706 ｨｺ08ｨｨｨｰ0208ｨｨ07ｨｬ 030908060702ｨｦ09ｨｺ06ｨｦ 05ｨｨ00ｨｨ 080209ｨｬｨ ｨｰ060506000609), ｨｮ 16 (47%) 07ｨ 02ｨｨ02ｨｪｨｰ0609 04ｨ 00ｨｨｨｺ09ｨｨ080609ｨ ｨｪｨ ｨｮｨｬ020802ｨｪｨｪ06-ｨｪｨｨ04ｨｺｨ 07 09ｨｰ020702ｨｪｨｹ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 05080201ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0408 09 09040906ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｹ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ ｨｮ 31 (68,9%) ｨｪｨ 09ｨｰｨｮ07ｨｨ05ｨ ｨｪ02070605ｨｪｨ 07 0802ｨｬｨｨ0909ｨｨ07 (ｨｨｨｪ0102ｨｺ09 ｨ 06050202 2,6), ｨｰ0605ｨｹｨｺ06 ｨｮ 14 (31,1%) 07ｨ 02ｨｨ02ｨｪｨｰ0609 06ｨｰｨｬ02 ﾂ02ｨｪ ｨｨｨｪ0102ｨｺ09 DAS28 ｨｬ02ｨｪ0202 2,61 7 01ｨ 0707ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ02 09 06ｨ ｨｴ02ｨｦ 0008ｨｮ070702 ｨｪｨ ｨ 05060102ｨｪｨｨ07 DAS28 090609ｨｰｨ 09ｨｨ05 2,74 ﾀ0,79, ﾂｨｰ06 090606ｨｰ0902ｨｰ09ｨｰ09ｨｮ02ｨｰ ｨｪｨｨ04ｨｺ06ｨｦ 09ｨｰ020702ｨｪｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ (0708ｨｨ 0908ｨ 09ｨｪ02ｨｪｨｨｨｨ 09 07ｨ 08ｨ ｨｬ02ｨｰ0806ｨｬ 0708ｨｨ ﾂ02ｨｰ090208ｨｰ06ｨｬ 09ｨｨ04ｨｨｨｰ02 04ｨ 080200ｨｨ09ｨｰ08ｨｨ080609ｨ ｨｪ06 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｪｨ 0,42)1 7 05050201ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｨｨｪ0102ｨｺ09ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 DAS28 ｨｪｨ 2,37 06ｨｰ ｨｨ09010601ｨｪ060006 ｨｮ080609ｨｪ07 0706ｨｺｨ 040409ｨ 02ｨｰ ｨｮ0106090502ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ04ｨｦ 05000002ｨｺｨｰ 07080207ｨ 08ｨ ｨｰｨ 1 7 06ｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ, 080204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｪｨ 03020006 ｨｨ09090502010609ｨ ｨｪｨｨ07 0706ｨｺｨ 04ｨ 05ｨｨ, ﾂｨｰ06 ｨｮ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｬ ｨ 08ｨｰ08ｨｨｨｰ06ｨｬ ﾂ02080204 2 ｨｬ02090702ｨ ｨｰ0208ｨ 07ｨｨｨｨ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰ06ｨｬ ｨｪｨ ｨ 050601ｨ 050609ｨｹ 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｨｨｪ0102ｨｺ09ｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ DAS28, ﾂ02080204 8 ｨｬ020907020209 ｨｮ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ09ｨ ｨ 0605ｨｹｨｪ0401 04ｨ 00ｨｨｨｺ09ｨｨ080609ｨ ｨｪｨ ｨｪｨｨ04ｨｺｨ 07 09ｨｰ020702ｨｪｨｹ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ, 0909ｨｨ0102ｨｰ0205ｨｹ09ｨｰ09ｨｮ06ｨｴｨ 07 06ｨ ｨｮ0106090502ｨｰ090608ｨｨｨｰ0205ｨｹｨｪ06ｨｬ 05000002ｨｺｨｰ02 07080207ｨ 08ｨ ｨｰｨ, ﾂｨｰ06 070604090605ｨｨｨｰ ｨｮ05ｨｮ ﾂ03ｨｨｨｰｨｹ 07080600ｨｪ0604 05ｨｰ060006 ｨｰ07030205060006 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 09060603040806070408 11 7 040209ｨｬｨ ｨｰ06050600ｨｨ07: 0805ｨｨｨｪｨｨ ﾂ0209ｨｺｨｨ02 0802ｨｺ06ｨｬ02ｨｪ01ｨ 02ｨｨｨｨ / 070601 0802011 7 031 7091 701ｨ 0906ｨｪ0609ｨ, 001 7: 010602060804-000201ｨｨｨ, 2011, 752091 7 21 7 01ｨ 0906ｨｪ0609 E1 7091 7 0902 ﾂ02ｨｪｨｨ02 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ060006 ｨ 08ｨｰ08ｨｨｨｰｨ 2012: ｨｬ0209ｨｰ06 ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ 1 7 01ｨ ｨｮ ﾂｨｪ06-0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨ 07 080209ｨｬｨ ｨｰ06050600ｨｨ071 7 2012;2 (0708ｨｨ05060302ｨｪｨｨ02 1):1-241 7 31 7 Weslake S1 7L1 7, Imamura F1 7, Wyler von Ballmoos M1 7 [et al1 7] The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review1 7 Rheumatology (Oxford)1 7 2010;49(2):295ｨC3071 7 DOI: 101 71093/rheuma- tology/ kep3661 7 Epub 2009 Nov 271 7 41 7 Halla J1 7T1 7, Hardin J1 7G1 7 Under-recognized post-dosing reactions to methotrexate in patients with rheumatoid arthritis1 7 J Rheumatol1 7 1994;21(7):1224ｨC61 7 51 7 Aydintung A1 7O1 7, D ｯCruz D1 7, Cervera R1 7 [et al1 7] Lowdose methotrexate treatment in adult Still ｯs disease1 7 J Rheumatol1 7 1992;19(3):431ｨC51 7 61 7 Kraus A1 7, Alarcon-Segovia D1 7 Fever in adult onset Still ｯs disease1 7 Response to methotrexate1 7 J Rheumatol1 7 1991;18(6):918ｨC201 7 71 7 Hoekstra M1 7, Haagsma C1 7, Neef C1 7 [et al1 7] Bioavailability of high dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis1 7 J Rheumatol1 7 2004;31:645ｨC81 7 81 7 Stamp L1 7K1 7, Barclay M1 7L1 7, O ｯDonnell J1 7L1 7 [et al1 7] Effects of changing from oral to subcutaneous methotrexate on red blood cell methotrexate polyglutamate concentrations and disease activity in patients with rheumatoid arthritis1 7 J Rheumatol1 7 2011;38(12):2540ｨC 71 7 DOI: http://dx1 7doi1 7org/101 73899%2Fjrheum1 71104811 7 91 7 00ｨｮ08ｨ 09ｨｹ0209 071 7001 7, 0202ｨｪｨｨ090609 091 7011 7, 080502ｨｺ09020209ｨ 091 7061 7 [ｨｨ 01081 7] 02ｨｰｨｺ0804ｨｰ0602 ｨｺ06ｨｪｨｰ080605ｨｨ08ｨｮ02ｨｬ0602 08ｨ ｨｪ0106ｨｬｨｨ04ｨｨ080609ｨ ｨｪｨｪ0602 24-ｨｪ02010205ｨｹｨｪ0602 0908ｨ 09ｨｪｨｨｨｰ0205ｨｹｨｪ0602 ｨｨ09090502010609ｨ ｨｪｨｨ02 ｨｨｨｪｨｲ02ｨｺ02ｨｨ06ｨｪｨｪ06ｨｦ ｨｨ ｨｰｨ ｨ 0502ｨｰｨｨ080609ｨ ｨｪｨｪ06ｨｦ 0502ｨｺｨ 0809ｨｰ0902ｨｪｨｪ0401 000608ｨｬ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰｨ 0708ｨｨ 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ06ｨｬ ｨ 08ｨｰ08ｨｨｨｰ021 7 01ｨ ｨｮ ﾂｨｪ06-0708ｨ ｨｺｨｰｨｨ ﾂ0209ｨｺｨ 07 080209ｨｬｨ ｨｰ06050600ｨｨ071 7 2011;5:58-611 7 ASSESSMENT OF RESPONSE TO TREATMENT WITH METHOTREXATE BASED ON ACTIVITY INDEX DAS28 IN RHEUMATOID ARTHRITIS Abisheva S1 7T1 7, Serikova Zh1 7B1 7, Sarbalinova G1 7K1 7, Alibekova G1 7A1 7, Dosaeva L1 7O1 7 Astana Medical University JSC, Astana, Republic of Kazakhstan The article presents the results of evaluating the effectiveness of treatment of rheumatoid arthritis with methotrexate using DAS28 disease activity index1 7 This study demonstrated the effectiveness of the treatment of patients with rheumatoid arthritis as to statistically significant reduction in the dynamics of the disease activity according to DAS28 activity index1 7 Keywords: rheumatoid arthritis, DAS28 disease activity index, methotrexate1 7 00060708060904 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 2016 ｯ 0308ｨｨ05060302ｨｪｨｨ02 7
0005080600020500080505 070402000108 06 0803010206060308 FOXP3+ 040301070908060204010409 06-080903060208 05 0808060600010205060507 0508090209030008010608 06 07040200010300 020506040208080502000409 0302080805080603090307 07 030800060301060200 05 040801010600 040300000806020602010400 0804060406060200 1 081 7051 7080901020209ｨ, 2 071 7031 704ｨｮｨ 020609, 1 061 7001 7030607ｨｺ0609ｨ, 2 021 7061 70204ｨｦｨｺｨ ｨｪ0609, 1 031 7011 7080502ｨｺ09ｨ ｨｪ01080609ｨ, 1 031 7091 701ｨ 0906ｨｪ0609 1 0802010208ｨ 05ｨｹｨｪ0602 000609ｨｮ01ｨ 0809ｨｰ0902ｨｪｨｪ0602 ｨ 06010302ｨｰｨｪ0602 ｨｪｨ ｨｮ ﾂｨｪ0602 ｨｮ ﾂ0802030102ｨｪｨｨ02 0001ｨ ｨｮ ﾂｨｪ06-ｨｨ09090502010609ｨ ｨｰ0205ｨｹ09ｨｺｨｨｨｦ ｨｨｨｪ09ｨｰｨｨｨｰｨｮｨｰ 080209ｨｬｨ ｨｰ06050600ｨｨｨｨ ｨｨｨｬ02ｨｪｨｨ 001 7081 701ｨ 0906ｨｪ060906ｨｦ03 (0801090107 01060604 ｨｨｨｬ1 7 001 7081 701ｨ 0906ｨｪ060906ｨｦ), 001 7000609ｨｺ09ｨ, 04060909ｨｨｨｦ09ｨｺｨ 07 0802010208ｨ 02ｨｨ07 08ｨ ｨｺｨｮ05ｨｹｨｰ02ｨｰ 00ｨｮｨｪ01ｨ ｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ06ｨｦ ｨｬ0201ｨｨ02ｨｨｨｪ04 000107 ｨｨｨｬ1 7 001 7001 70906ｨｬ06ｨｪ06090609ｨ, 001 7000609ｨｺ09ｨ, 04060909ｨｨｨｦ09ｨｺｨ 07 0802010208ｨ 02ｨｨ07 FoxP3+ 080200ｨｮ0507ｨｰ0608ｨｪ0402 06 ｨｺ0502ｨｰｨｺｨｨ (06-080200) ｨｨ0008ｨ 06ｨｰ ｨｺ0506 ﾂ0209ｨｮ06 080605ｨｹ 09 07060101020803ｨ ｨｪｨｨｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ06050208ｨ ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ 0906ｨ 09ｨｰ0902ｨｪｨｪ04ｨｬ ｨ ｨｪｨｰｨｨ0002ｨｪｨ ｨｬ1 7 06-080200 ｨｺ0502ｨｰｨｺｨｨ 0907060906ｨ ｨｪ04 070601ｨ 090507ｨｰｨｹ 06-ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ ｨｨｨｬｨｬｨｮｨｪｨｪ04ｨｦ 06ｨｰ0902ｨｰ ｨｨ ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ 080200ｨｮ05ｨｨ080609ｨ ｨｰｨｹ ｨｨｨｬｨｬｨｮｨｪｨｪ0402 0802ｨ ｨｺ02ｨｨｨｨ, 09 080204ｨｮ05ｨｹｨｰｨ ｨｰ02 ﾂ020006 ｨｨｨｬ 06ｨｰ090601ｨｨｨｰ0907 090201ｨｮｨｴｨ 07 080605ｨｹ 09 07ｨ ｨｰ060002ｨｪ020402 ｨ ｨｮｨｰ06ｨｨｨｬｨｬｨｮｨｪｨｪ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ1 7 0308ｨｨ 08ｨ ｨｪｨｪ02ｨｬ 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ06ｨｬ ｨ 08ｨｰ08ｨｨｨｰ02 (0408) 090407090502ｨｪ06 09ｨｪｨｨ0302ｨｪｨｨ02 ｨｮ080609ｨｪ07 06-080200 ｨｺ0502ｨｰ06ｨｺ 09 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｬ ｨｺ08060906ｨｰ06ｨｺ02, ｨ ｨｰｨ ｨｺ0302 ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 ｨｮ080609ｨｪ07 ｨｬｨ 08ｨｺ02080609 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪ06-ｨ ｨｺｨｰｨｨ09ｨｪ0401 06-080200, ﾂｨｰ06 ｨ 09090602ｨｨｨｨ080609ｨ 050609ｨｹ 09 ｨ 06050202 09040906ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 080506 ﾂ02090402 09050609ｨ : 080209ｨｬｨ ｨｰ06ｨｨ01ｨｪ04ｨｦ ｨ 08ｨｰ08ｨｨｨｰ, 06-080200ｨｮ0507ｨｰ0608ｨｪ0402 ｨｺ0502ｨｰｨｺｨｨ, ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ 04ｨ ｨ 06050209ｨ ｨｪｨｨ071 7 FoxP3+ 080200ｨｮ0507ｨｰ0608ｨｪ0402 06 ｨｺ0502ｨｰｨｺｨｨ (06-080200) ｨｨ0008ｨ 06ｨｰ ｨｺ0506 ﾂ0209ｨｮ06 080605ｨｹ 09 07060101020803ｨ ｨｪｨｨｨｨ 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｰ06050208ｨ ｨｪｨｰｨｪ0609ｨｰｨｨ ｨｺ 0906ｨ 09ｨｰ0902ｨｪｨｪ04ｨｬ ｨ ｨｪｨｰｨｨ0002ｨｪｨ ｨｬ1 7 06-080200 ｨｺ0502ｨｰｨｺｨｨ 0907060906ｨ ｨｪ04 070601ｨ 090507ｨｰｨｹ 06-ｨｺ0502ｨｰ06 ﾂｨｪ04ｨｦ ｨｨｨｬｨｬｨｮｨｪｨｪ04ｨｦ 06ｨｰ0902ｨｰ ｨｨ ｨｰｨ ｨｺｨｨｨｬ 06ｨ 08ｨ 0406ｨｬ 080200ｨｮ05ｨｨ080609ｨ ｨｰｨｹ ｨｨｨｬｨｬｨｮｨｪｨｪ0402 0802ｨ ｨｺ02ｨｨｨｨ, 09 080204ｨｮ05ｨｹｨｰｨ ｨｰ02 ﾂ020006 ｨｨｨｬ 06ｨｰ090601ｨｨｨｰ0907 090201ｨｮｨｴｨ 07 080605ｨｹ 09 07ｨ ｨｰ060002ｨｪ020402 ｨ ｨｮｨｰ06ｨｨｨｬｨｬｨｮｨｪｨｪ0401 04ｨ ｨ 06050209ｨ ｨｪｨｨｨｦ [1, 2]1 7 040200ｨｮ0507ｨｰ0608ｨｪ0402 06-ｨｺ0502ｨｰｨｺｨｨ 05ｨｺ090708020909ｨｨ08ｨｮ06ｨｰ 03ｨｨ0806ｨｺｨｨｨｦ 090702ｨｺｨｰ08 ｨｬ02ｨｬｨ 08ｨ ｨｪｨｪ0401 ｨｬ060502ｨｺｨｮ05, ｨｺ06ｨｰ06080402 060708020102050706ｨｰ ｨｨ01 00ｨｮｨｪｨｺ02ｨｨ06ｨｪｨ 05ｨｹｨｪｨｮ06 ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ ｨｨ 0706040906050706ｨｰ ｨｨ0102ｨｪｨｰｨｨ00ｨｨ02ｨｨ080609ｨ ｨｰｨｹ 05ｨｰｨｨ ｨｺ0502ｨｰｨｺｨｨ 09 ｨｺ08060906ｨｰ06ｨｺ02 [3, 4], 0601ｨｪｨ ｨｺ06 0106 09ｨｨ01 070608 090201ｨｮｨｰ0907 0907060804 0706 0706090601ｨｮ ｨｮｨｪｨｨ09020809ｨ 05ｨｹｨｪ060006 070609020801ｨｪ0609ｨｰｨｪ060006 ｨｬｨ 08ｨｺ0208ｨ, 0706040906050706ｨｴ020006 0904010205ｨｨｨｰｨｹ 01ｨ ｨｪｨｪｨｮ06 ｨｺ0502ｨｰ06 ﾂｨｪｨｮ06 09ｨｮｨ 070607ｨｮ050702ｨｨ06 ｨｨ04 07ｨｮ05ｨ 06-05ｨｨｨｬ000602ｨｨｨｰ06091 7 01ｨ ｨｨｨ 06050202 09070202ｨｨ00ｨｨ ﾂ0209ｨｺｨｨｨｬ 09ｨｪｨｮｨｰ08ｨｨｨｺ0502ｨｰ06 ﾂｨｪ04ｨｬ ｨｬｨ 08ｨｺ020806ｨｬ 06-080200 ｨｺ0502ｨｰ06ｨｺ 0709050702ｨｰ0907 07010208ｨｪ04ｨｦ 00ｨ ｨｺｨｰ0608 ｨｰ08ｨ ｨｪ09ｨｺ08ｨｨ0702ｨｨｨｨ Foxp3, ｨｺ06ｨｰ060804ｨｦ ｨｨｨｬ0202ｨｰ 00ｨｮｨｪ01ｨ ｨｬ02ｨｪｨｰｨ 05ｨｹｨｪ0602 04ｨｪｨ ﾂ02ｨｪｨｨ02 09 08ｨ 0409ｨｨｨｰｨｨｨｨ 06-080200 ｨｺ0502ｨｰ06ｨｺ ｨｨ ｨｨ01 ｨｨｨｪ00ｨｨｨ ｨｨｨｰ0608ｨｪ06ｨｦ 00ｨｮｨｪｨｺ02ｨｨｨｨ [3]1 7 00 ｨｺｨ ﾂ0209ｨｰ0902 070609020801ｨｪ0609ｨｰｨｪ0401 ｨｬｨ 08ｨｺ02080609 06-080200 ｨｺ0502ｨｰ06ｨｺ ｨｬ0600ｨｮｨｰ ｨｨ09070605ｨｹ040609ｨ ｨｰｨｹ0907 CD25 (a-020207ｨｹ 0802020207ｨｰ0608ｨ IL-2), CTLA-4 (CD152, cytotoxic T lymphocyte antigen 4), CD95 (Fas), CD127 low ｨｨ 080701 0108ｨｮ00ｨｨ011 7 07 ﾂ0205060902ｨｺｨ 06-080200 ｨｺ0502ｨｰｨｺｨｨ 06ｨｰｨｪ060907ｨｰ0907 ｨｺ 09ｨｮｨ 070607ｨｮ050702ｨｨｨｨ CD4+Foxp3+06 ｨｺ0502ｨｰ06ｨｺ ｨｨ 06ｨｰ05ｨｨ ﾂｨ 06ｨｰ0907 09040906ｨｺ06ｨｦ 05ｨｺ090708020909ｨｨ02ｨｦ CD25 ｨｨ ｨｪｨｨ04ｨｺ06ｨｦ 05ｨｺ090708020909ｨｨ02ｨｦ CD127 [5, 6]1 7 00 ｨｪｨ 09ｨｰ0607ｨｴ0202 090802ｨｬ07 09 05ｨｨｨｰ0208ｨ ｨｰｨｮ0802 0708020109ｨｰｨ 090502ｨｪ06 ｨ 0605ｨｹ030602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 08ｨ ｨ 06ｨｰ, 0706090907ｨｴ02ｨｪｨｪ0401 060202ｨｪｨｺ02 ﾂｨｨ0905ｨ ｨｨ 0002ｨｪ06ｨｰｨｨ07ｨ 06-080200 ｨｺ0502ｨｰ06ｨｺ 0708ｨｨ 04081 7 00 070601ｨ 09050706ｨｴ02ｨｬ ｨ 0605ｨｹ03ｨｨｨｪ09ｨｰ0902 ｨｨ04 ｨｪｨｨ01 09040709050702ｨｰ0907 ｨｮ090205ｨｨ- ﾂ02ｨｪｨｨ02 090601020803ｨ ｨｪｨｨ07 06-080200 ｨｺ0502ｨｰ06ｨｺ 09 09ｨｨｨｪ0609ｨｨｨ 05ｨｹｨｪ06ｨｦ 03ｨｨ01ｨｺ0609ｨｰｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0408 [7, 8], 0601ｨｪｨ ｨｺ06 01ｨ ｨｪｨｪ0402 06ｨ ｨｮ080609ｨｪ02 01ｨ ｨｪｨｪ06ｨｦ ｨｺ0502ｨｰ06 ﾂｨｪ06ｨｦ 09ｨｮｨ 070607ｨｮ050702ｨｨｨｨ 09 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺ080609ｨｨ 090209ｨｹｨｬｨ 070806ｨｰｨｨ09060802 ﾂｨｨ09041 7 090605ｨｹ03ｨｨｨｪ09ｨｰ0906 ｨｨ09090502010609ｨ ｨｰ020502ｨｦ ｨｪｨ ｨ 050601ｨ 05ｨｨ ｨｮｨｬ02ｨｪｨｹ0302ｨｪｨｨ02 0708060202ｨｪｨｰｨｪ060006 ﾂｨｨ0905ｨ 02ｨｨ08ｨｺｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 06-080200 ｨｺ0502ｨｰ06ｨｺ [9, 10], 09 ｨｰ06 090802ｨｬ07 ｨｺｨ ｨｺ 09 0108ｨｮ00ｨｨ01 08ｨ ｨ 06ｨｰｨ 01 090407090502ｨｪ06 ｨｮ090205ｨｨ ﾂ02ｨｪｨｨ02 [11] ｨｨ05ｨｨ 06ｨｰ09ｨｮｨｰ09ｨｰ09ｨｨ02 06ｨｰ05ｨｨ ﾂｨｨｨｦ 09 ｨｮ080609ｨｪ02 06-080200 ｨｺ0502ｨｰ06ｨｺ 06ｨｰ 0401060806090401 0106ｨｪ06080609 [12]1 7 030605ｨ 00ｨ 06ｨｰ, ﾂｨｰ06 ｨｺ0605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ04ｨｦ 01020002ｨｺｨｰ CD4+CD25+Foxp3+CD127-080200ｨｮ0507ｨｰ0608ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ 060906ｨ 02ｨｪｨｪ06 01ｨ 08ｨ ｨｺｨｰ020802ｨｪ 010507 08ｨ ｨｪｨｪ020006 0408 ｨｨ ｨ 09090602ｨｨｨｨ08ｨｮ02ｨｰ0907 09 08ｨｨ09ｨｺ06ｨｬ 08ｨ 0409ｨｨｨｰｨｨ07 0408 ｨｮ ｨ 020909ｨｨｨｬ07ｨｰ06ｨｬｨｪ0401 07ｨ 02ｨｨ02ｨｪｨｰ0609, 070604ｨｨｨｰｨｨ09ｨｪ0401 0706 08000003 [13]1 7 06ｨ ｨｺ0302 09 05ｨｨｨｰ0208ｨ ｨｰｨｮ0802 0708020109ｨｰｨ 090502ｨｪ04 070806ｨｰｨｨ09060802 ﾂｨｨ090402 01ｨ ｨｪｨｪ0402 06 0904ｨ ｨｨｨｬ0609090704ｨｨ ｨｮ080609ｨｪ07 06-080200 ｨｺ0502ｨｰ06ｨｺ 09 ｨｺ05ｨｨｨｪｨｨｨｺ0605ｨ ｨ 0608ｨ ｨｰ0608ｨｪ04ｨｬｨｨ 0706ｨｺｨ 04ｨ ｨｰ020507ｨｬｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04081 7 06ｨ ｨｺ 09 08070102 08ｨ ｨ 06ｨｰ 090407090502ｨｪｨ 06ｨ 08ｨ ｨｰｨｪｨ 07 ｨｺ06080802050702ｨｨ06ｨｪｨｪｨ 07 0904ｨ ｨｨｨｬ0609090704ｨｹ ｨｬ020301ｨｮ DAS 28 ｨｨ 0708060202ｨｪｨｰ06ｨｬ 02ｨｨ08ｨｺｨｮ05ｨｨ08ｨｮ06ｨｴｨｨ01 Foxp3+ 080200ｨｮ0507ｨｰ0608ｨｪ0401 ｨｺ0502ｨｰ06ｨｺ [9]; 09 0108ｨｮ0006ｨｦ 09ｨｰ060806ｨｪ04 09080201ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 09040906ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 ｨ 09ｨｰ060804 080200ｨｨ09ｨｰ08ｨｨ08ｨｮ06ｨｰ 09040906ｨｺ0602 090601020803ｨ ｨｪｨｨ02 CD25+Foxp3+ 06-ｨｺ0502ｨｰ06ｨｺ [14]1 7 06ｨ ｨｺ0302 09050201ｨｮ02ｨｰ 06ｨｰｨｬ02ｨｰｨｨｨｰｨｹ, ﾂｨｰ06 ｨｪｨｨ 09 0601ｨｪ06ｨｦ 08ｨ ｨ 06ｨｰ02 ｨｪ02 09040709050705ｨ 09ｨｹ ｨ 09090602ｨｨｨ 02ｨｨ07 ｨｬ020301ｨｮ 0708060202ｨｪｨｰｨｪ04ｨｬ 090601020803ｨ ｨｪｨｨ02ｨｬ 06-080200 ｨｺ0502ｨｰ06ｨｺ, ｨ ｨｰｨ ｨｺ0302 09060408ｨ 09ｨｰ06ｨｬ, 07060506ｨｬ, 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ06 04ｨ ｨ 06050209ｨ ｨｪｨｨ07, 09020806070604ｨｨｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 0706 0408 ｨｨ 08000003 ｨｨ 05080604ｨｨ09ｨｪ04ｨｬ 070608ｨ 0302ｨｪｨｨ02ｨｬ 09ｨｮ09ｨｰｨ 090609 [10]1 7 000205ｨｹ06 ｨｪｨ 0302ｨｦ 08ｨ ｨ 06ｨｰ04 07090507050609ｨｹ: 070806ｨ ｨｪｨ - 8 00060708060904 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 2016 ｯ 0308ｨｨ05060302ｨｪｨｨ02
05ｨｨ04ｨｨ080609ｨ ｨｰｨｹ 0708060202ｨｪｨｰｨｪ0602 ｨｨ ｨ ｨ 09060506ｨｰｨｪ0602 090601020803ｨ ｨｪｨｨ02 06-080200 ｨｺ0502ｨｰ06ｨｺ 09 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺ080609ｨｨ 0401060806090401 0106ｨｪ06080609 ｨｨ 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 08ｨ ｨｪｨｪｨｨｨｬ 0408 ｨｬ02ｨｰ060106ｨｬ 070806ｨｰ06 ﾂｨｪ06ｨｦ 02ｨｨｨｰ06ｨｬ02ｨｰ08ｨｨｨｨ; 060202ｨｪｨｨｨｰｨｹ 0904ｨ ｨｨｨｬ0609090704ｨｹ ｨｬ020301ｨｮ ｨｺ0605ｨｨ ﾂ0209ｨｰ0906ｨｬ ｨｨ 0002ｨｪ06ｨｰｨｨ0706ｨｬ 06-080200 ｨｺ0502ｨｰ06ｨｺ ｨｨ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 04081 7 00ｨ ｨｰ0208ｨｨｨ 05 ｨｨ ｨｬ02ｨｰ060104: 00 ｨｨ09090502010609ｨ ｨｪｨｨ02 ｨ 040506 09ｨｺ0506 ﾂ02ｨｪ06 39 07ｨ 02ｨｨ02ｨｪｨｰ0609(5 ｨｬｨｮ03 ﾂｨｨｨｪ ｨｨ 34 0302ｨｪｨｴｨｨｨｪ04) 09 08ｨ ｨｪｨｪｨｨｨｬ 0408 (ｨｺ08ｨｨｨｰ0208ｨｨｨｨ ACR/EULAR 2010 001 7), ｨｪ02 070605ｨｮ ﾂｨ 0903ｨｨ01 07080201030209ｨｰ09ｨｮ06ｨｴ02ｨｦ ｨｰ0208ｨ 07ｨｨｨｨ ｨ ｨ 04ｨｨ09ｨｪ04ｨｬｨｨ 070806ｨｰｨｨ090609060907ｨ 05ｨｨｨｰ0205ｨｹｨｪ04ｨｬｨｨ 07080207ｨ 08ｨ ｨｰｨ ｨｬｨｨ ｨｨ 000506ｨｺ06ｨｺ0608ｨｰｨｨｨｺ06ｨｨ01ｨ ｨｬｨｨ, 09080201ｨｪｨｨｨｦ 09060408ｨ 09ｨｰ 50 (32-58) 0502ｨｰ, 0105ｨｨｨｰ0205ｨｹｨｪ0609ｨｰｨｹ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 5 (4-6) ｨｬ020907020209, ｨｬ0201ｨｨｨ ｨｪｨ DAS 28 5,1 (4,3-5,8)1 7 0408 070604ｨｨｨｰｨｨ09ｨｪ0401 ｨC 26 (66,7%), 08000003 070604ｨｨｨｰｨｨ09ｨｪ0401 ｨC 34 (87,2%))1 7 000902ｨｬ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬ 09 ｨｺｨ ﾂ0209ｨｰ0902 07020809060006 09030003 ｨ 0405 ｨｪｨ 04ｨｪｨ - ﾂ02ｨｪ ｨｬ02ｨｰ06ｨｰ0802ｨｺ09ｨ ｨｰ (0006) 09 ｨｪｨ ﾂｨ 05ｨｹｨｪ06ｨｦ 01060402 10 ｨｬ00/ｨｪ02011 7 0207080201020502ｨｪｨｨ02 050206 0609ｨｮｨｴ0209ｨｰ09050705ｨｨ 09ｨｰｨ ｨｪ01ｨ 08ｨｰｨｪ04ｨｬ ｨｬ020301ｨｮｨｪｨ 080601ｨｪ04ｨｬ ｨｬ02ｨｰ060106ｨｬ 0706 000209ｨｰ0208000802ｨｪｨｮ (ｨｪ0608ｨｬｨ 0530 ｨｬｨｬ/ ﾂ)1 7 050409060806ｨｰ06 ﾂｨｪｨｮ06 ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ06 050409 ｨｨ IgM 0408 ｨｨ04ｨｬ02080705ｨｨ ｨｨｨｬｨｬｨｮｨｪ06ｨｪ0200020506ｨｬ02ｨｰ08ｨｨ ﾂ0209ｨｺｨｨｨｬ ｨｬ02ｨｰ060106ｨｬ ｨｪｨ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ060802 BN ProSpec (00Siemens03, 010208ｨｬｨ ｨｪｨｨ07)1 7 010608ｨｬｨ 05ｨｹｨｪ04ｨｦ ｨｮ08060902ｨｪｨｹ 050409 09 090409060806ｨｰｨｺ02 ｨｺ080609ｨｨ 090609ｨｰｨ 09050705 055,0 ｨｬ00/051 7 0306 ｨｨｨｪ09ｨｰ08ｨｮｨｺ02ｨｨｨｨ 00ｨｨ08ｨｬ04-ｨｨ040006ｨｰ0609ｨｨｨｰ020507 04ｨ 09020801ｨｪ0606 0008ｨ ｨｪｨｨ02ｨｮ ｨｪ0608ｨｬ04 IgM 0408 ｨ 0405ｨ 0708ｨｨｨｪ07ｨｰｨ ｨｺ06ｨｪ0202ｨｪｨｰ08ｨ 02ｨｨ07, 08ｨ 09ｨｪｨ 07 15,0 0003/ｨｬ051 7 080605ｨｨ ﾂ0209ｨｰ0902ｨｪｨｪ0602 0607080201020502ｨｪｨｨ02 08000003 09 090409060806ｨｰｨｺ02 ｨｺ080609ｨｨ 070806090601ｨｨ05ｨｨ 050502ｨｺｨｰ08060102ｨｬｨｨ0506ｨｬｨｨｨｪｨｨ090202ｨｪｨｰｨｪ04ｨｬ ｨｬ02ｨｰ060106ｨｬ ｨｪｨ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ060802 Cobas e411 (00Roche03, 010902ｨｦ02ｨ 08ｨｨ07) (09020801ｨｪ0707 0008ｨ ｨｪｨｨ02ｨ ｨｪ0608ｨｬ04 17,0 0302/ｨｬ05), ｨ ｨｰｨ ｨｺ0302 ｨｬ02ｨｰ060106ｨｬ ｨｨｨｬｨｬｨｮｨｪ06000208ｨｬ02ｨｪｨｰｨｪ060006 ｨ ｨｪｨ 05ｨｨ04ｨ 09 0706ｨｬ06ｨｴｨｹ06 ｨｺ06ｨｬｨｬ0208 ﾂ0209ｨｺ060006 ｨｪｨ ｨ 0608ｨ 0802ｨ 0002ｨｪｨｰ0609 (00Axis-Shield03, 000205ｨｨｨｺ06ｨ 08ｨｨｨｰｨ ｨｪｨｨ07), 09020801ｨｪ0707 0008ｨ ｨｪｨｨ02ｨ ｨｪ0608ｨｬ04 ｨC 5,0 0301/ｨｬ051 7 02ｨｰｨｪ0609ｨｨｨｰ0205ｨｹｨｪ0602 ｨｨ ｨ ｨ 09060506ｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 06-080200 ｨｺ0502ｨｰ06ｨｺ (FoxP3+CD25+; CD152+surface; CD152+intracellular; FoxP3+CD127-; CD25+CD127-; FoxP3+ICOS+; FoxP3+CD154+; FoxP3+CD274+) 0607080201020507050609ｨｹ ｨｬ02ｨｰ060106ｨｬ ｨｬｨｪ060006020902ｨｰｨｪ06ｨｦ 070806ｨｰ06 ﾂｨｪ06ｨｦ 02ｨｨｨｰ060005ｨｮ0608ｨｨｨｬ02ｨｰ08ｨｨｨｨ ｨｪｨ ｨ ｨｪｨ 05ｨｨ04ｨ ｨｰ060802 BD LSR Fortessa Special Order Research Product (BD)1 7 0806ｨｪｨｰ080605ｨｹｨｪｨｮ06 0008ｨｮ0707ｨｮ 090609ｨｰｨ 09ｨｨ05ｨｨ 20 0401060806090401 0106ｨｪ06080609, 0906070609ｨｰｨ 09ｨｨｨｬ0401 0706 070605ｨｮ ｨｨ 09060408ｨ 09ｨｰｨｮ 09 06ｨ 090502010609ｨ ｨｪｨｪ04ｨｬｨｨ 07ｨ 02ｨｨ02ｨｪｨｰｨ ｨｬｨｨ1 7 040204ｨｮ05ｨｹｨｰｨ ｨｰ04 ｨｨ 06ｨ 09ｨｮ030102ｨｪｨｨ021 7 07 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 08ｨ ｨｪｨｪｨｨｨｬ 0408 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 0906 04010608060904ｨｬｨｨ 0106ｨｪ0608ｨ ｨｬｨｨ 080200ｨｨ09ｨｰ08ｨｨ080609ｨ 050609ｨｹ ｨ 06050202 ｨｪｨｨ04ｨｺ0602 0708060202ｨｪｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 FoxP3+CD25+ ｨｺ0502ｨｰ06ｨｺ ((5,53 (4,09-6,48 ｨｨ 6,92 (5,84-7,96)), 0708060202ｨｪｨｰｨｪ0602 ｨｨ ｨ ｨ 09060506ｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 FoxP3+ICOS+ ｨｺ0502ｨｰ06ｨｺ ((6,91 (2,14-11,47) ｨｨ 10,83 (9,27-13,7); 0,0035 (0,0013-0,0067) ｨｨ 0,0068 (0,0039-0,009)), 0708060202ｨｪｨｰｨｪ0602 ｨｨ ｨ ｨ 09060506ｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 FoxP3+CD154+ ｨｺ0502ｨｰ06ｨｺ ((0,47 (0,19-0,83) ｨｨ 1,51 (1,12-2,08); 0,0002 (0,00009-0,0005) ｨｨ 0,00087 (0,00047-0,0014)) ｨｨ FoxP3+CD274+ 06-ｨｺ0502ｨｰ06ｨｺ (0,63 (0,34-1,49) ｨｨ 1,94 (1,16-2,25); 0,0003 (0,0002-0,00065) ｨｨ 0,001 (0,0006-0,0016), p<0,05 0906 09090201 0905ｨｮ ﾂｨ 0701) (08ｨｨ091 7 1)1 7 040200ｨｨ09ｨｰ08ｨｨ080609ｨ 05ｨ 09ｨｹ 06ｨｰ08ｨｨ02ｨ ｨｰ0205ｨｹｨｪｨ 07 ｨｺ06080802050702ｨｨ06ｨｪｨｪｨ 07 0904ｨ ｨｨｨｬ0609090704ｨｹ: 0708060202ｨｪｨｰｨｪ060006 ｨｺ0605ｨｨ ﾂ0209ｨｰ09ｨ FoxP3+CD25+ 09 050409 (r = -0,4) ｨｨ 050206 (r = -0,43); 0308 CD152+ intracellular 09 DAS 28 (r = -0,4), 050206 (r = -0,52) 050409 (r = -0,55); 0308 FoxP3+CD127-09 050206 (r = -0,41), 050409 (r = -0,48); 0308 CD25+CD127-09 DAS28 (r = -0,53), SDAI (r = -0,5), CDAI (r = -0,44), 050206 (r = -0,56), 050409 (r = -0,53), 08<0,05 0906 09090201 0905ｨｮ ﾂｨ 07011 7 00 0008ｨｮ070702 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 09040906ｨｺ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 (DAS 28>5,1 SDAI>26 CDAI>22, n=27) 080200ｨｨ09ｨｰ08ｨｨ080609ｨ 050609ｨｹ ｨ 06050202 ｨｪｨｨ04ｨｺ0602 0708060202ｨｪｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 CD25+CD127-06-ｨｺ0502ｨｰ06ｨｺ 0706 0908ｨ 09ｨｪ02ｨｪｨｨ06 09 ｨ 0605ｨｹｨｪ04ｨｬｨｨ 09 ｨｪｨｨ04ｨｺ06ｨｦ/ｨｮｨｬ020802ｨｪｨｪ06ｨｦ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｹ06 07ｨ ｨｰ06050600ｨｨ ﾂ0209ｨｺ060006 07080602020909ｨ (5,1; 4,9-5,6 ｨｨ 6,9; 6,4-7,9, P<0,05) (08ｨｨ091 7 2)1 7 04ｨｨ091 7 11 7 0308060202ｨｪｨｰｨｪ0602 090601020803ｨ ｨｪｨｨ02 09ｨｮｨ 070607ｨｮ050702ｨｨｨｦ 06-080200 ｨｺ0502ｨｰ06ｨｺ 09 070208ｨｨ000208ｨｨ ﾂ0209ｨｺ06ｨｦ ｨｺ080609ｨｨ ｨ 0605ｨｹｨｪ0401 0408 ｨｨ 0401060806090401 0106ｨｪ06080609 04ｨｨ091 7 21 7 0308060202ｨｪｨｰｨｪ0602 ｨｺ0605ｨｨ ﾂ0209ｨｰ0906 CD25+CD127-06 ｨｺ0502ｨｰ06ｨｺ 09 0008ｨｮ0707ｨ 01 07ｨ 02ｨｨ02ｨｪｨｰ0609 09 0408 09 04ｨ 09ｨｨ09ｨｨｨｬ0609ｨｰｨｨ 06ｨｰ ｨ ｨｺｨｰｨｨ09ｨｪ0609ｨｰｨｨ 04ｨ ｨ 06050209ｨ ｨｪｨｨ07 00060708060904 060800ｨ ｨｪｨｨ04ｨ 02ｨｨｨｨ ｨｨ ｨｨｨｪ000608ｨｬｨ ｨｰｨｨ04ｨ 02ｨｨｨｨ 040108ｨ 0906060108ｨ ｨｪ02ｨｪｨｨ07 2016 ｯ 0308ｨｨ05060302ｨｪｨｨ02 9