1 2001 7 1 543( ) CAS 1309 64 4 1 25 ( ) Sb 2 O 3 291.52 1) 99 1. 2) 655 3) 1,425 3) ( ) 2) ( ) 2) ( ) 2) 5.2 ( ) 5.67 ( ) 3) 2)
2. 10 12,161 t ( 9,753 t 2,408 t) 4 2 1) 3. 1) 2) 3) 4. Selenastrum capricornutum 6 ) ( ) Selenastrum capricornutum 6 ) ( ) Skeletonema 7) costatum ( ) LC 50 (mg/ L) EC 50 (mg/l) ( ): *5) 67 (72-h,Sb 2 O 3, ): 3 0.61(96-h,SbCl 3, ): 1 > 4.2(96-h,Sb 2 O 3, ): < >
3 LC 50 (mg/ L) EC 50 (mg/l) ( ): Daphnia > 1,000(48-h,Sb 2 O 3, ): magna 6) ( ) Daphnia magna 6) ( ) 18.8(48-h,SbCl 3, ) Mysidopsis 6) bahia > 4.2 (96-h,Sb 2 O 3, ) ( ) Brachydanio > 1,000(96-h,Sb 2 O 3, ) rerio 6) ( ) Lepomis > 440 (96-h,Sb 2 O 3, ) macrochirus 8) ( ) Pimephales >80 (96-h,Sb 2 O 3, ) promelas 8) ( ) Pimephales 21.9 (96-h, SbCl 3, ) promelas 6) ( ) Pargus major 9) 12.4(96-h,SbCl 3, ) ( ) Pargus major 8) 0.93(96-h,SbCl 5, ) ( ) Pargus major 8) ( ) 6.9(96-h,K[Sb(OH) 6 ], ) * OECD 3 < > 3 < > < > < > 5. 3, 6,10, 11, 12) 1) LD 50 > 34,600 mg/kg LC 50 LD 50 > 2,000 mg/kg LD 50 172 mg/kg 3,250 mg/kg LD 50 7,904 mg/kg 2,760 mg/m 3 4 3) ( ) 3)
2) 4 100 mg 10) 3) 4) (1) 1.0 2.0 24 1.0 2.0 γ-gtp 3) (2) 3.1 mg/m 3 6 (T ) 5.6 mg/m 3 6 13) 0.2 1.0 5.0 25.0 mg/m 3 ( 0.25 1.08 4.92 23.46 mg/m 3 2.9 3.9 2.9 3.4 µm) 6 / 5 / 13 4.92 23.46 mg/m 3 AST NOAEL 1.08 mg/m 3 14) 45 mg/m 3 ( 37.8 mg/m 3 ) 36-40 mg/m 3 ( 17.5 mg/m 3 ) 7 / 5 / 52 3, 14) 1,700 mg/m 3 1 / 1-6 /2 ( 66-331 66-366 ) 3, 14) Wistar 1.9 5.0 mg/m 3 ( 0.3 0.9 mg/m 3 0.44, 0.40 µm) 6 / 5 / 13 1.9 mg/m 3 5.0 mg/m 3 14) 1.6 4.2 mg/m 3 ( 0.4 µm) 6 / 5 / 1 3) 0.05 0.50 5.00 mg/m 3 ( 0.06 0.51 4.50 mg/m 3 3.7 µm) 6 / 5 / 1
5 NOAEL 0.51 mg/m 3 14) 1,700 mg/m 3 (2,000 ppm 1,200 ppm ) 1 /2 1 3) 90-125 mg/m 3 100 / 14 3) 27.8 mg/m 3 5 13) 5) in vitro * TA100 TA98 S9 mix (+/-) 12) TA1535 TA1537 TA1538 TA98 TA100 WP2 13) V79 90 µg/l 10) DNA * 50 mmol/l 1, 10) M45(rec - ) H17(rec + ) 6,12 6) (1) Fischer 1.9 5.0 mg/m 3 6 / 5 / 13 12 5.0 mg/m 3 ( ) 13, 14) Wistar 45 mg/m 3 7 / 5 / 52 18-20 27 ( / 3, 10, 13, ) 14) 7) (1) 0.027 0.082 0.27 mg/m 3 24 / (21 ) 0.27 mg/m 3 0.082 mg/m 3 12, 13) 6. 1)
6 3) 3) 3) ( 2.88% ) 70 56 3 0.013 300 ml 36 mg 3) 12, 13) 2) 4.69-11.81 mg/m 3 0.36-1.10 mg/m 3 2 5 78 69 20% 11% 10% 8% 7% 5.5% 5.5% 4% 3.5% 11, 13) 2 600-3,000 µg/g 12) 3) 3) ( 38.73-88 0.82-4.72 2.11-7.82 ) 51 (31-54 45.23 9-31 17.91 ) 10 (60.8%) (35.3%) (34.5%) (27.3%) 3, (27.5%) (32/51) 14) ( ) 3) 78 69 5 6 X 4.69-11.81 mg/m 3 35-68% 2-5% 0.01-0.04% 0.04-0.30% 0.1-0.40% 14) 1-15 28 X 3 5 14)
7 274 18 22 37 mg/m 3 0.5-5.3 mg/m 3 13, 14, 15) ( ) 2 318 ( 12.5% 4.1%) ( 3.4% 1.2%) ( 77.5% 56%) 3 (70 ) 3, 12, 13, 1 14) 16, 17, 18) 3) EPA 2000 EU (1998 ) 3* NTP 2000 IARC(2000 ) 2B* ACGIH(2000 ) A2** 2 B*** (2000 ) * ** *** (Sb ) 1,081 56 10 (10 8) 110 9 5.7 9 8 45-64 4.5 2 15) 17, 18) 4) ACGIH (2000 ) 0.5 mg/m 3 * (2000 ) 0.1 mg/m 3** * (Sb ) ** (Sb )
8 7. 11, 14) 2% 8 1% 12 12 50% 75% 13) 11) 100-250 mg/m 3 2-14 13) 119 mg/m 3 80 4 40 µg 13) 0.2 g 8 3.2 % 2 % 8 13, 14) 5.5 mg/m 3 10 16-18 mg/l 13) ( ) 10 2.1-2.9 mg/100ml 3.3±2 mg/l 3.2-12.6 mg/100 ml 6.2±2.8 mg/100 ml 6.3±3 mg/100 ml 3) 425-680 µg/l 7 4 55 28 µg/l X 13) 8. (OECD ) * 5) * OECD
9 OECD 9. 1) in vitro IARC 2B 2) (1) (2) 13 6
10 1) ( ) (2001). 2) IPCS, International Chemical Safety Cards (1995). 3) Hazardous Substances Data Bank (HSDB), U.S. National Library of Medicine (1998). 4) 10, (1999). 5) OECD, Harmonised Integrated Classification System for Human Health and Environmental Hazards of Chemical Substances and Mixtures. OECD Series on Testing and Assessment No. 33 (2001). 6) IUCLID (International Uniform Chemical Information Data Base) Data Set, EU (2000). 7) US EPA, Ambient Water Quality Criteria for Antimony, EPA 440/5-80-020, October (1980). 8) AQUIRE (US EPA ECOTOX Database System). 9) Kazufumi Takayanagi, Bull. Environ. Contam. Toxicology. (in press) 10) Registry of Toxic Effects of Chemical Substances (RTECS), US NIOSH (1998). 11),,,, (1994). 12) Sharat Gangolli, The Dictionary of Substances and their Effects, 2nd. Ed., The Royal Society of Chemistry (1999). 13) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans,47 (1989). 14) Cooper, david A., The American Journal of Roentgenology, Radium Therapy and Nuclear Medicine, 103(3), 495-508 (1968). 15) ACGIH, Documentation of the Threshold Limit Values and Biological Exposure Indices (1991). 16) JETOC,,, 4 (1999). 17) ACGIH, Booklet of the Threshold Limit Values and Biological Exposure Indices (2000). 18),, 42, 130-154 (2000). 1) 2) 3)
(mg/ll) 10,000 藻類 甲殻類 セレナストラムスケレトネマオオミシ ンコ 1,000 1,000 (48-h,Sb2O3(III)) 100 67 (72-h,Sb2O3(III)) 10 18.8 (48-h,SbCl3(III)) 1 0.61 (96-h,SbCl3(III)) 4.2 (96-h,Sb2O3(III)) 4.2 (96-h,Sb2O3(III)) LC50 EC50 0 (96-h,SbCl 3 (III)) 1) IUCLID (International Uniform Chemical Information Data Base) Data Set, EU (2000). 2) US EPA, Ambient Water Quality Criteria for Antimony, EPA 440/5-80-020, October (1980).
(mg/l) 10,000 魚類 セ フ ラフィッシュフ ルーキ ルファットヘット ミノーファットヘット ミノーマタ イマタ イマタ イ 1,000 1,000 (96-h,Sb2O3(III)) 440 (96-h,Sb2O3(III)) 100 80 (96-h,Sb2O3(III)) 10 21.9 (96-h,SbCl3(III)) 12.4 (96-h,SbCl3(III)) 6.9 (96-h,K[Sb(OH)6](ⅴ)) 1 LC50 0.93 (96-h,SbCl5(ⅴ)) 0 1) IUCLID (International Uniform Chemical Information Data Base) Data Set, EU (2000). 2) US EPA, Ambient Water Quality Criteria for Antimony, EPA 440/5-80-020, October (1980). 3) AQUIRE (US EPA ECOTOX Database System). 4) Kazufumi Takayanagi, Bull. Environ. Contam. Toxicology. (in press)
(Fischer ) 1.9 5.0 mg/m 3 1), 2) 6 / 5 / 13 0/13 0/17 3/18 12 0/13 1/17 0/18 0/13 0/17 9/18 0/13 0/17 2/18 1) IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, 47 (1989). 2) Integrated Risk Information System (IRIS), U.S. Environmental Protection Agency (1998).
( 三酸化二アンチモン ) 反復発がん生殖 6 w 6 h/d 5 d/w 13 w7 h/d 5 d/w 52 w6 h/d 5 d/w 1 year6 h/d 5 d/w 1 year6 h/d 5 d/w 13mont6 h/d 5 d/w 13mon 24 h/d 21 d 1000 mg/m3 100 10 37.8 体重減少 肺線維化 肺胞壁細胞肥大 過形成 4.5-125 ヘモグロビン濃度増加 結膜炎 白内障 間質性肺炎 肉芽腫 1 0.1 3.1 1.08 NOAEL 1.6-4.2 肺の線維化 腺腫様過形成 0.51 NOAEL 5.0 間質性肺炎 5.0 肺腫瘍肉芽腫性炎 1.9 LOAEL 肺重量増加 線維化 腺腫 肺細胞過形成 ( 腺腫 扁平上皮癌 硬癌 ) 0.27 吸収胚増加 0.082 吸収胚の増加 胎児の発育遅延 0.01