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1 (Received September 15, 1958.)

3 Fig. 2. Thyroid gland, 2 days after the adrenalectomy. Follicular epithelial cells are generally hypertrophied chiefly at the center of the gland, where cell proliferation is promoted. The cross-section of a mass of proliferating cells whose lumina is negligible is presented here and there, but its internal structure is the same to the normal cell. LEVI, PAS-iron-

4 Fig. 3. Thyroid gland, 10 days after the adrenalectomy. any PAS-possitive granules are seen to be disposed as the cellular mantle enclosing the inner thin epithelial layer.

Fig. 15. Thyroid gland, adrenalectomized, treated with DOCA 2.5mg/day for 7 days. Histological picture resembles that of the adrenalectomiezd rats.

9 Fig. 15. Thyroid gland, adrenalectomized, treated with DOCA 2.5mg/day for 7 days. Histological picture resembles that of the adrenalectomiezd rats. In spite of the chemical administration, the proliferation which may be originated from the parafollicular cells still remains, as well as the colloidal substances in the cell-body of com-

13 Author's Abstract. The adult male rats of WISTAR strain were devided into three experimental groups. The first consisted of 25 adrenalectomized rats which were decapitated 2, 5, 10, 15 and 20 days respectively after the removal; the second of 5 intact and 5 adrenalectomized with the administrations of 2.5mg of cortisone per day for 7 days; the third of the same number of intact and operated with the injections of 2.5mg of DOCA per day for 7 days. The changes in thyroid glands were histologically investigated. Within 2 days the alterations were not profound yet in adrenalectomized animals. However, in 5 days the proliferation took places in follicles principally located at the center of the gland, being probably based on the augementation in hyperplasia of parafollicular cells whose enlarged cytoplasm usually contain, under the normal condition, a number of PAS-positive granules or vacuoles. Such a regeneration developed gradually in 10 and 15 days, finally ceased to advance to gain a subsequent fixed configuration. It was an information in the present observation as to the particular changes caused by the adrenalectomy that the huge colloidal substances of various sizes frequently appeared at manifold areas of the cell-bodies, especially accumulated at the luminal surface lacking the secretory cytoplasmic processes. These substances tended to be vacuolized at the basal part of the cell, associated with the vacancy or extraordinary reduction in amount of the intrafollicular colloid. With regard to their functional significance, an assumption may be drawn that they are not any indices to the intracellular synthesis of thyroglobulin, but rather accounted as the reabsorption picture (YOSHIMURA, IRIYE and YAGI 1958). The frequency in occurrence of these substances was the highest in 5, 10

and 15 days. Following the prolonged administration of cortisone the follicles of intact rats were proliferous because of the advanced differentiation in the common glandular cells.

14 and 15 days. Following the prolonged administration of cortisone the follicles of intact rats were proliferous because of the advanced differentiation in the common glandular cells. Intrafollicular colloid faintly stained included abundant circumference vacuoles and at the periphery of the lumina the cytoplasmic processes indicating a possible apocrine secretion were often detected. With the administration of cortisone the thyroid glands of the adrenalectomized rats resulted in the serious disorder in the cell arrangement, which was presumably originated in their malignant hyperplasia, although it is impossible for us to determine whether this proliferous phenomenon is ascribed to the activity of the common follicular cells or that of parafollicular ones. The huge colloidal substances following the adrenalectomy completely disappeared with the chemical introduction. The effect of DOCA upon the thyroid glands of intact and adrenalectomized rats were so delicate or minute, but take a moderate action to disperse the huge colloidal substances induced by the adrenalectomy, and also to make a slight proliferation of follicles. The mode of action of coritcoids upon the thyroid gland was discussed on the basis of present morphological aspects.

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date URL

Title 泌尿器科領域に於ける17-Ketosteroidの研究 17-Ketosteroidの臨床的研究第 III 篇 : 尿 Author(s) 卜部, 敏入 Citation 泌尿器科紀要 (1958), 4(1): 3-31 Issue Date 1958-01 URL http://hdl.handle.net/2433/111559 Right Type Departmental Bulletin