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やすはるはかまや
9 years ago
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1 CO2 Laser Treatment of Tinea Pedis Masahiro UEDA:,' Kiyotaka KITAMURA** and Yukihiro GOKOH***

4 Table I Specifications 1. Kind of Laser 2. Wavelength of Lasers. Power of Laser. Radiation Mode. Pulse Duration. Exposure Area 7. Gas Mixture 8. Air 9. Manipulator 10. Electric 11. Weight Power Remarks : The ; of the Melase environment onment for installation of this syste shot should be 0"C temperature re and 10-90% relative humidity. CO2 Laser 10.u m 2 J/cm2 Pulsed 10 - second 2-7mm2 Mix mode of CO2, N2, He and CO. One gas cylinder (good for approximately 70 hours' continuous operation at 2.7 J average power) Clean air for clinical use. One gas cylinder (good for approximately 28 hours' continuous operation at 2.7 J average power) Multi-articulated arm type by mirror reflectiont Number of joints : Horizontal reach : 2000 mm AC 100V± 10%, 0/Hz, 700 VA Approximately 20 kg Fig. Cure rate judged from culture test. These results were attained after 2 consecutive treatment: once a week for two weeks.

u m 2 J/cm2 Pulsed 10 - second 2-7mm2 Mix mode of CO2, N2, He and CO. One 10. 1 gas cylinder (good for approximately 70 hours' continuous operation at 2.7 J average power) Clean air for clinical use.

5 EXCELLENT 18. GOOD 2. FAIR.8 POOR WORSE. 0.0 "GOOD" OR BETTER RATE.% Fig. 7 10% 20% 0% Final overall effect of the treatment judged from KOH and skin findings. These attained after consecutive twice a week for weeks. 0% 0% CO2 laser test results results were treatment VERY USEFUL 18. USEFUL FAIRLY USEFUL USELESS HARMFUL A. 0.0 "USEFUL" OR BETTER RATE.2% Fig. 8 10% 20% 0% Usefulness judged from degrees of the CO2 laser 0% 0% usefulness treatment.

These attained after consecutive twice a week for weeks.

6 Clinical examples of tinea pedis. (a) For plantar lesions, and (b) for lesions between toes. The left corresponds to the one prior to laser treatment and the right to the one after laser treatment. ' b Fig.10 Structure of human plantar skin after exposure to laser beam of this laser treatment system. (a) For prior to laser light exposure (X100), and (b) for exposure to pulses of laser light (X100). Laser light exposure condition: light power of.j/cm' and pulses with an interval of 1 second.

10 Structure of human plantar skin after exposure to laser beam of this laser treatment system.

7 Tabl e Di Data for the skin temperature by LASER LIGHT I aser irradiation. EYE REFLECTED ' SKIN SAMPLE HEAT SENSITIVE PAPER SILICONE Interval between Pulses (second) Thickness of the Sample (inm) 0. Temperature (t Number Laser Pulses of MIRROR Fig.11 IMAGE OF THE PAPER Set-up for the measurement of skin temperature rise by pulsed CO2 laser irradiation U LJ Fig NUMBER OF 2 LASERPULSES N 7 8 Relation between the skin temperature T (=-AT+0t, AT; temperature rise) and the number of laser pulses N. (a) For the time interval between laser pulses, =1 second, and (b) for S=-- 0. second. In the figure, shows the data for d=0.7 mm, 0 for 0.7mm, ^ for 0.7 mm and A for 0.91mm , 7

11 IMAGE OF THE PAPER Set-up for the measurement of skin temperature rise by pulsed CO2 laser irradiation. 1 0.7 0.7 0.70 0.8 0.8 0.92 U 0.9 0.89 8 LJ Fig.

8 <120 - Cr LJ Cr Ce U-1 10 Lai 1 Fig. 1 ZAT THICKNESS OF THE SKIN d (rnm) Temperature rise zat calculated from Eq. (1) as a function of skin thickness d for R , p =1 g/cm'and C cal/gt. In the figure, I shows the light fluence (light power) Vein' and I' the light energy per unit area absorbed for evaporation of water in the horny layer. E (1 R) E'.18XSdp C xi ( c) (1)

In the figure, I shows the light fluence (light power) Vein' and I' the light energy per unit

9 1) 2) ) ) )

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study

CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study VOL. 41 S 1 Table 2. Levels (ƒêg/ml or ƒêg/g) of S-1006 in serum, bile, and tissue (gallbladder) after oral administration

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