MAP MAP MAP MAPKKK /MAP MAPKK /MAP MAPK MAPK MAP Microtubule associated protein 2 MAP Dundee Sturgill MAP MAP ERK1 ERK2 MAP Nerve Growth Factor NGF MA

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1 四細胞生物学八月東京大学理学部生物化学科卒業すけ昭和二八年東京大学大学院理学系研究科博士課程修了介昭和五一年理学博士えい日本学術振興会奨励研究員栄東京大学理学部助手だ六月京都大学ウイルス研究所教授田五月京都大学大学院理学研究科教授にし五年京都大学大学院生命科学研究科教授現在に至る西平成九年京都大学大学院生命科学研究科長平成二一年まで受賞者専攻学科目一一年日本学術振興会学術システム研究センター主任研究員平成二七年まで日本学士院賞月一七年略年二四年生歴

2 MAP MAP MAP MAPKKK /MAP MAPKK /MAP MAPK MAPK MAP Microtubule associated protein 2 MAP Dundee Sturgill MAP MAP ERK1 ERK2 MAP Nerve Growth Factor NGF MAP MAP MAP MAP MAPKK MEK MAPKK MAPKK MAP MAPKK dual-specificity kinase MAP MAPKK MAPKK MAPKKK

3 MAPKKK MAPKK MAPK MAPK ERK1/ ERK2 JNK p38 ERK5 ERK7 MAPK MAPK MAPKK MAPKKK MAP MAPK MAPK nuclear export signal, NES MAPKK MAPKK MAPK MAPK MAPKK MAPK MAPK TV 1) Hoshi, M., Nishida, E. and Sakai, H. (1988) Activation of a Ca2+-inhibitable protein kinase that phosphorylates microtubule-associated protein 2 in vitro by growth factors, phorbol esters, and serum in quiescent cultured human

4 fibroblasts. J. Biol. Chem. 263, ) Gotoh, Y., Nishida, E., Yamashita, T., Hoshi, M., Kawakami, M. and Sakai, H. (1990) Microtubule-associated-protein (MAP) kinase activated by nerve growth factor and epidermal growth factor in PC12 cells. Eur. J. Biochem. 193, ) Gotoh, Y., Nishida, E., Matsuda, S., Shiina, N., Kosako, H., Shiokawa, K., Akiyama, T., Ohta, K. and Sakai, H. (1991) In vitro effects on microtubule dynamics of purified Xenopus M phase-activated MAP kinase. Nature 349, ) Gotoh, Y., Moriyama, K., Matsuda, S., Okumura, E., Kishimoto, T., Kawasaki, H., Suzuki, K., Yahara, I., Sakai, H. and Nishida, E. (1991) Xenopus M phase MAP kinase: isolation of its cdna and activation by MPF. EMBO J. 10, ) Matsuda, S., Kosako, H., Takenaka, K., Moriyama, K., Sakai, H., Akiyama, T., Gotoh, Y. and Nishida, E. ( 1992 ) Xenopus MAP kinase activator : identification and function as a key intermediate in the phosphorylation cascade. EMBO J. 11, ) Nishida, E. and Gotoh, Y. (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18, ) Kosako, H., Gotoh, Y. and Nishida, E. (1994) Requirement for the MAP kinase kinase/map kinase cascade in Xenopus oocyte maturation. EMBO J. 13, ) Gotoh, Y., Masuyama, N., Suzuki, A., Ueno, N. and Nishida, E. (1995) Involvement of the MAP kinase cascade in Xenopus mesoderm induction. EMBO J. 14, ) Fukuda, M., Gotoh, Y. and Nishida, E. (1997) Interaction of MAP kinase with MAP kinase kinase : its possible role in the control of nucleocytoplasmic transport of MAP kinase. EMBO J. 16, ) Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M. and Nishida, E. ( 1997 ) CRM 1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390, ) Tanoue, T., Adachi, M., Moriguchi, T. and Nishida, E. (2000) A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell Biol. 2, ) Harada, T., Morooka, T., Ogawa, S. and Nishida, E. (2001) ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat. Cell Biol. 3, ) Hanafusa, H., Torii, S., Yasunaga, T. and Nishida, E. (2002) Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat. Cell Biol. 4, ) Ebisuya, M., Yamamoto, T., Nakajima, M. and Nishida, E. (2008) Ripples from neighbouring transcription. Nat. Cell Biol. 10, ) Hanafusa, H., Matsumoto, K. and Nishida, E. (2009) Regulation of ERK activity duration by Sprouty contributes to dorsoventral patterning. Nat. Cell Biol. 11, ) Honjoh, S., Yamamoto, T., Uno, M. and Nishida, E. (2009) Signalling through RHEB-1 mediates intermittent fasting-induced longevity in C. elegans. Nature 457, ) Okuyama, T., Inoue, H., Ookuma, S., Satoh, T., Kano, K., Honjoh, S., Hisamoto, N., Matsumoto, K. and Nishida, E. (2010 ) The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J. Biol. Chem. 285, ) Sunadome, K., Yamamoto, T., Ebisuya, M., Kondoh, K., Sehara-Fujisawa, A. and Nishida, E. ( 2011 ) ERK 5 regulates muscle cell fusion through Klf transcription factors. Dev. Cell 20, ) Miyatake, K., Kusakaba, M., Takahashi, C. and Nishida, E. (2015) ERK7

5 regulates ciliogenesis by phosphorylating the actin regulator CapZIP in cooperation with Dishevelled. Nat. Commun. 6:6666.

研究成果報告書

研究成果報告書 21 5 28 2007 2008 CARElk CARPXR CAR CAR EST cdna CAR CAR 10FCS 96 SW480 HepG2 anti-lamin A/C anti-phospho-histone H3 anti-cyclin D1 G1 anti-cyclin A S CAR lamin A/C CAR Fig. 1 Lamin A/C /G1 lamin A/C G1