Surgeons, Gastroenterologists and Oncologists) (September 23-26, 2009, Beijing) Fluorouracil intra-arterial infusion combined with systemic gemc

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1 1. Results of salvage esophagectomy after definitive chemoradiotherapy in patients with acrcinoma of the esophagus. Watanabe M, Yoshida N, Iwagami S, Toyama E, Hayashi N, Baba H ASCO GI Gastroentestinal Cancers Syposium ( January 15-17, 2009, San Francisco) 2. 5-fluorouracil intra-arterial infusion combined with systemic gemcitabine for unresectable pancreatic cancer -2nd report-. SakamotoY, Takamori H, Tanaka H, Ikuta Y, Nakahara O, Nakagawa S, Furuhashi S, Hashimoto D, Beppu T, Kanemitsu K, Baba H ASCO GI Gastroentestinal Cancers Syposium (January 15-17, 2009,San Francisco) 3. Indicator of cervical lymph node metastasis in thoratic esophageal squamous cell carcinoma. Imamura Y, Hayashi N, Satoh N, Karashima R, Hiyoshi Y, Nagai Y,Yoshida N, Toyama E,Watanabe M, Baba H 4 th Annual Academic Surgical Congress (February 4, 2009, Los Angels) 4. MicroRNA-21 regulates proliferation and invasion in esophagus squamous cell carcinoma. Hiyoshi Y, Kamohara H, Karashima R, Sato N, Imamura Y, Nagai Y, Hayashi N, Watanabe M, Baba H AACR 100th Annual Meeting 2009 ( April 18, 2009, Denver) 5. Identification of novel tumor-associated antigens, Cadherin3 (CDH3)/P-Cadherin and RAB6KIFL/KIF20A, as targets for anticancer Immunotherapy of pancreatic cancer. Imai K, Baba H AACR 100th Annual Meeting 2009 ( April 18, 2009, Denver) 6. Usefulness of endoscopic ultrasound-guided fine needle aspiration (eus-fna) for digestive organ diseases Nakahara O, Takamori H, Horino K, Tanaka H, Baba H Symposium :Nowadays Achievements in Cancer Diagnosis and Treatment (April 29-May2, Ulaanbaatar) 7. Analysis of the chronic pancreatitis model mice induced the choline-deficient with ethionine (CDE) diet. Ida S, Ohmuraya M, Tanaka H, Horino K, Takamori H, Baba H Symposium :Nowadays Achievements in Cancer Diagnosis and Treatment (April 29-May2, Ulaanbaatar) 8. Differential expression of basement membrane type IV collagen chains as a prognostic factor in extrahepatic bile duct carcinoma. Hirashima K, Iyama K, Baba Y, Sado Y, Ninomiya Y, Takamori H, Baba H 8th Pan-Pacific Connective Tissue Societies Symposium (June 4-7, 2009, Kanagawa) 9. Sequential methotrexate and 5-flouorouracil therapy for gastric cancer patients with bone-marrow metastasis. Iwagami S, Baba H, Iwasaki Y, Hayashi N,Toyama E,Watanabe M, Iwanaga T, Ohashi M 8th International Gastric Cancer Congress ( June 10-13, 2009, Krakow) 10. The clinical significance of the CEA/CA19-9measurement in advanced and recurrent gastric cancer patients. Nagai Y, Watanabe M, Ishikawa S, Imamura Y, Iwagami S, Hayashi N, Takamori H, Baba H 8th International Gastric Cancer Congress (June 10-13, 2009, Krakow) 11. Usefulness of early enteral feeding after total gastrectomy for gastric cancer in patients aged over 80. Watanabe M, Karashima R, Sato N, Hirashima K, Imamura Y, Hiyoshi Y, Nagai Y, Iwagami S, Hayashi N, Baba H 8th International Gastric Cancer Congress (June 10-13, 2009, Krakow) 12. Adenoviral oncolytic suicide gene therapy for peritoneal disseminated model of gastric cancer in mice. Imamura Y, Ishikawa S, Karashima R, Sato N, Hiyoshi Y, Nagai Y, Iwagami S, Hayashi N, Toyama E,Watanabe M, Baba H 8th International Gastric Cancer Congress (June 10-13, 2009, Krakow) 13. Autophagy process activates trypsinogen and the development of acute pancreatitis. Hirota M, Ohmuraya M, Hashimoto D,Yamamura K, Baba H The 41st European Meeting of the European Pancreatic Club (July3, 2009, Szeged) 14. Serine protease inhibitor kazal type 1 promptes proliferation of pancreatic cancer cells through the epidermal growth factor receptor. Ohmuraya M, Hirota M, Ozaki N, Baba H,Yamamura K The 41st European Meeting of the European Pancreatic Club (July3, 2009, Szeged) 15. Liver RFA with Endoscopic Approach. BeppuT, Ishiko T, Baba H 1th Japan korea Image guided Tumor Ablation Meeting (September 12-13, 2009, Tokyo) 16. The clinical significance of VIM expression in gastric cancer cells in bone marrow. Iwatsuki M, Mimori K, Baba H, Mori M 7th International Symposium on Minimal Residual Cancer (September 17, Athens) 17. FOLFOX in combination with hepatic resection and radio-frequency ablation for unresectable colorectal liver metastases. Beppu T, Baba H 19th IASGO (World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (September 23-26, 2009, Beijing) 18. Liver RFA with Endoscopic Approach. Ishiko T, Beppu T, Baba H 19th IASGO World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (September 23-26, 2009, Beijing) 19. Neoadjuvant and adjuvant chemotherapy. Takamori H, Baba H 19th IASGO (World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists) (September 23-26, 2009, Beijing) 20. Laparoscopic surgery for rectal cancer. Hayashi N, Baba H 19th IASGO (World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists) (September 23-26, 2009, Beijing) 21. Delta-shaped anastomosis in totally laparoscopic distal gastrectomy:safe and secure technique for intracorporeal billroth. Ikeda O, Watanabe M, Hayashi N, Baba H 19th IASGO (World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists) (September 23-26, 2009, Beijing) 22. New targeting agents for GI cancerd. Baba H 19th IASGO (World Congress of the International Association of

2 Surgeons, Gastroenterologists and Oncologists) (September 23-26, 2009, Beijing) Fluorouracil intra-arterial infusion combined with systemic gemcitabine for pancreatic cancer. 130 patients. Takamori H, Baba H 40th Anniversary Joint Meeting of the American Pancreatic Association & Japan Pancreas Society (November 3-4, 2009, Honolulu) 24. Laparoscopic surgery and multimodal therapy for hepatocellular carcinoma. Beppu T, Baba H 17th International Postgraduate Course New Frontiers in the Management of Abdominal Diseases (December 4-5, 2009, Athens) 25. Surgery in combination with chemotherapy for unresectable colorectal liver metastases. Beppu T, Baba H 17th International Postgraduate Course New Frontiers in the Management of Abdominal Diseases (December 4-5, 2009, Athens) H2 H3 mfolfox6+bevacizumab) FOLFOX) Kagoshima GI Cancer Forum Kumamoto Clinical Oncology Meeting FU Gemcitabine induction chemotherapy DCF Docetaxel/CDDP/5-FU FOLFOX Current status of SL study in Japan S-1/L FD

3 CEA,CA19-9 CRP oncolytic suicide gene therapy GIST CDCA S-1/LV(1W on 1W off) S-1/L FOLFOX ACHIEVE Symposium FOLFOX HMGA ID1 mrna microrna mcea pre-coagulation hanging manenuer SM MP E-PASS C5a receptor IL-6 microrna

4 Pancreatic intraetpthelial neoplasia(panin) Serine protease inhibitor Kazal type1(spink1) IPMN CT PET-CT FOLFOX FOLFOX FOLFOX CR cm SPARC cancer-associated fibroblast(caf) WISP SBT(spontaneous breathing trial) SSpPD (PpPD)

5 69. TEPP E-PASS scoring system pagetoid spread RAB6KIFL KIF20A myofibroblast Gastrointestinal cancer SPARC GIST cm

6 IVR FOLFOX RFA ICGR15 ICGR15 LHL15, EUS-FNA) E-PASS Estimation of physiologic ability and surgical stress) SPECT CT fusion cm hanging maneuver high volume center Solid-pseudopapillary neoplasm (SPN) Avastin Chugai Implemental Evolution of Expert GIST

7 AFP H3stage S GIST solid-pseudopapillary neoplasm Docetaxel+TS Salvage RAD DCF PDCD GIST - Glivec - 4 GIST up to date SPECT CT-fusion

8 Non-T4 StageII-III DCF (70 )IPMN FOLFOX Salvage pre-coagulation (PSE) E-PASS p12cdk2-ap

9 160. mtor Quality control Wnt/ -catenin HMGA CA C5a C5a (80 ) FDG PET CT HGF, TGF-beta AFP PIVKA-II doubling time STAT SPINK1 EGFR (80 ) E-PASS

10 DCF cstage a DCF pcr SUGT MAP GIST UP to DATE 3 GIST E-PASS E-PASS ocetaxel+ts Oncolytic Suicide Gene Therapy Wnt/ -catenin HMGA E cadherin ZEBI Micro RNA CD microrna, fstage Grade

11 Achieve in NAGANO Pre-coagulation 28 Microwave Surgery UV cut #5, 7, 8a, Docetaxel/Cisplatin/5-FU CR FOLFOX) IPMN Hiroshima Oncology Group of Gastric Cancer (HOG-GC) Liver cell adenoma CDE PDCD SPARC CD cetuximab cn CT PET/CT D

12 228. DCF Salvage SPECT CT-fusion 51 JDDW JDDW JDDW DCF CTL T CD57 NKT PSK PET UP TO DATE GIST CRT DCF p MRI

13 250. PET CT modified DCF Pre-coagulation Hanging maneuver Quality control p SSI (EUS-FNA) cn(+) modified DCF Taxotere S

14 Pre-coagulation Hanging maneuver R EUS-FNA IPMA < (PSE) XELOX XELODA SYMPOSIUM IN OKAYAMA GOF) KSCC ACHIEVE Symposium in Kyushu

15 KSCC Gastroentistinal Oncology Forum GIST

食道がん化学放射線療法後のsalvage手術

食道がん化学放射線療法後のsalvage手術 2006 2 17 52 Daly JM, et al. J Am Coll Surg 2000;190:562-573 Esophageal Cancer: Results of an American College of Surgeons Patient Care Evaluation Study Daly JM, et al. J Am Coll Surg 2000;190:562-573