VOL. 21 NO. 2 CHEMOTHERAPY 395

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1 394 CHEMOTHERAPY MAR. 1973

2 VOL. 21 NO. 2 CHEMOTHERAPY 395

3 396 CHEMOTHERAPY MAR. 1973

4 VOL. 21 NO. 2 CHEMOTHERAPY 397

5 398 CHEMOTHERAPY MAR. 1973

6 VOL. 2 1 NO. 2 CHEMOTHERAPY 399

7 400 CHEMOTHERAPY MAR. 1973

8 VOL. 21 NO. 2 CHEMOTHERAPY 401 1) BURCHALL, J. J. & G. H. HITCHINGS: Inhibitor binding analysis of dihydrofolate reductases from various species. Mol. Pharmacol. 1: 126, ) BUSHBY, S.R.M. & G. H. HITCHINGS: Trimethoprim, a sulfonamide potentiator. Brit. J. Pharmacol. 33:72, ) HITCHINGS, G. H. & J. J. BURCHALL: Inhibi-

9 402 CHEMOTHERAPY MAR tion of folate biosynthesis and function as a basis for chemotherapy. Advances in Enzymology. Ed. F. F. Nord 27: 417, New York: WILEY, J. and E. M. LANSFORD Jr. Reinhold Publi shing Corp., New York, p ) BUSHBY, S. R. M. & M. BARNETT : Trimethoprim-Sulfonamides. In vitro sensitivity of 384 strains of bacteria. Proceedings, 5th International Congress of Chemotherapy, Vienna, June 25-July 2, A 1-6/11, 753, ) WATERWORTH, P. M.: Practical aspects of testing sensitivity to trimethoprim and sulfonamide. Postgrad. Med. J. 45, Suppl. (Nov): 21, ) BOEHNI, E.: Chemotherapeutic activity of the combination of trimethoprim and sulfamethoxazole in infections of mice. The synergy of trimethoprim and sulfonamides. Proceedings. of a Conference at the Royal College of Pysicians, London, held on Friday, May 9, ) REEVES, D. S.; M. C. FAIERS, R. E. PURSELL, & W. BRUMFITT : Trimethoprim-sulfamethoxazole, comparative study in urinary infection in hospital. Brit. Med. J. 1: 541, ) NOALL, E. W. P. & H. F. G. SEWARDS : Successful treatment of a case of Proteus septicemia. Brit. Med. J. 2: 1101, ) DREW, C. D. M.; D. T. D. HUGHES, A. S. E. FOWLE & M. A. CASSELL : Effective treatment of chronic bronchitis with short term trimethoprim and sulfa methoxazole. Proceed. of 5th International Congress of Chemotherapy, Vienna, June 25-July 2, 1: 293, ) PINES, A.; H. RAAFAT, K. PLUCINSKI, J. S. B. GREENFIELD & M. SOLARI : Antibiotic regimes in severe and acute purulent exacerbation of chronic bronchitis. Brit. Med. J. 2: 735, 1968 A REPORT ON TRIAL OF SULFAMETHOXAZOLE-TRIMETHOPRIM SYRUP PREPARATION IN CHILDREN MAKOTO HORI and SABURO KOHNO Department of Infectious Diseases, National Children's Hospital YOSHIO AOKI Clinical Laboratory, National Children's Hospital A syrup preparation of sulfamethoxazole-trimethoprim combination was given to a total of 24 pediatric patients, consisting of 3 children with acute upper respiratory tract infection, 4 patients with acute bronchitis, 3 patients with pyoderma, 1 patient with periproctal abscess, 6 patients with infantile diarrhea, 1 patient with acute infantile diarrhea and 6 patients with acute urinary tract infection. The overall effective response was seen in 18 patients, an effective rate being 75%. No significant untoward reactions have been seen clinically. Tests of the liver and kidney function and blood counts remained within the normal limits throughout the therapy.

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