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1 Title 1α,25-Dihydroxy vitamin D3 によるインスリ構 Author(s) 夏目, 佳幸 Citation [ 岐阜大学医学部紀要 = Acta scholae medicin Gifu] vol.[51] no.[1] p.[8]-[14] Issue Date Rights Version NII による電子化 URL この資料の著作権は各資料の著者学協会出版社等に帰属します

7 371 (1996) 2 ) Kadowaki S, Norman AW:Dietary VitaminD 3 is essen- tial for normal insulin secretion from the perfused rat pancreas. J Clin Invest 73, (1984) 3 ) D'Emden MC, Wark JD : 1,25-dihydroxy vitamin D 3 enhances thyrotropin releasing hormone-induced thy- rotropin secretion in normal pituitary cells. Endocrinol- ogy 121, (1987) 4 ) Wark JD, Tashjian Jr. AH : Vitamin D stimulates prolac- tin synthesis by GH4C1 cells incubated in chemically de- fined medium. Endocrinology 111, (1982) 5 ) Tsoukas CD, Provvedini D, Manolagas SC : 1,25- dihydroxy vitamin D 3 : A novel immunoregulatory hormone. Science 224, , (1984) 6 ) Henry HL, Norman AW:Studies on calciferol metabo- lism. J Biol Chem 249, (1974) 7 ) Falkenstein E, Norman AW, Wehling M:Classification of nongenomically initiated (rapid) steroid action (s). J Clin Endocrinol Metab 85, (2000) 8 ) Sylvia VL, Schwartz Z, Curry DB, Chang Z, Dean DD, Boyan BD : 1,25(0~)~D 3 regulates protein kinase C activity through two phospholipid-dependent pathways involving phospholipase A2 and phospholipase C in growth zone chondrocytes. J Bone Miner Res 13, (1998) 9 ) Boyan BD, Sylvia VL, Dean DD, Pedrozo H, Del Toro F, Nemere I, Posner GH, Schwartz Z : 1,25 (OH) 2D 3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2. Steroids 64, (1999) 10) Slater SJ, Kelly MB, Taddeo FJ, Larkin JD, Yeager MD, Mclane JA, Ho C, Stubbs CD:Direct activation of protein kinase C by 1 a, 25dihydroxy vitamin D3. J Biol Chem 270, (1995) 11) Chin JE, Dickens M, Tavare JM, Roth RA:Overexpression of protein kinase C isoenzymes a, PI, y and E in cells overexpressing the insulin receptor. Effects on receptor phosphorylation and signaling. J Biol Chem 268, (1993) 12) Stadtmauer L, Rosen 0M:Increasing the CAMP content of IM- 9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor. J Biol Chem 261, (1986) 13) Takayama S, White MF, Kahn CR:Phorbol ester-induced serine phosphorylation of the insulin receptor decreased its tyrosine kinase activity. J Biol Chem 263, (1988) 14) Standaert ML, Bandyopadhyay G, Galloway L, Sato J, Ono Y, Kikkawa U, Farese RV, Leitges M:Effects of knockout of protein kinase C P gene on glucose transport and glucose homeostasis. Endocrinology 140, (1999) 15) Olefsky, JM : Mechanisms of the ability of insulin to activate the glucose transport system in rat adipocytes. Biochem J 172, (1978) 16) Rodbell, M : Metabolism of isolated fat cells. J Biol Chem 239, (1964) 17) Ishizuka T, Cooper DR, Farese RV : Insulin stimulates the translocation of protein kinase C in rat adipocytes. FEBS Lett 257, (1989) 18) Ishizuka T, Cooper DR, Hernandez H, Buckley D, Standaert ML, Farese RV : Effects of insulin on diacylglycerol-protein kinase C signaling in rat diaphragm and soleus muscles and relationship to glucose transport. Diabetes 39, (1990) 19) Hayashi H, Kamohara S, Nishioka Y, Kanai F, Miyake N, Fukui Y, Shibasaki F, Takenawa T, Ebina Y : Insulin treatment stimulates the tyrosine phosphorylation of the a type 85-kDa subunit of phsphatidylinositol3 -kinase in vivo. J Biol Chem 267, (1992) 20) Kanai F, Ito K, Todaka M, Hayashi H, Kamohara S, Ishii K, Okada T, Hazeki 0, Ui M, Ebina Y:Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS- 1 and the activity of PI3-hnase. Biochem Biophys Res Commun 195, (1993) 21) Quon MJ, Butte AJ, Zarnowski M, Sesti G, Cushman SW, Taylor SI : Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT 4 translocation in transfected rat adipose cells. J Biol Chem 269, (1994) 22) Bouillon R, Okamura WH, Norman AW : Structurefunction relationships in the vitamin D endocrine system. Endocr Rev 16, (1995) 23) Vu D, Ong JM, Clemens TL, Kernet PA : 1,225- Dihydroxy vitamin D induces lipoprotein lipase expression in 3T3-L1 cells in association with adipocyte differentiation. Endocrinology 137, (1996) 24) Huang Y, Ishizuka T, Miura A, Kajita K, Ishizawa M, Kimura M, Yamamoto Y, Kawai Y, Morita H, Uno Y, Yasuda K:Effect of 1 a, 25-dihydroxy vitamin D 3 and vitamin E on insulin-induced glucose uptake in rat adipocytes. Diabetes Research and Clinical Practice 55, (2002) 25) Hirai H, Suzuki S, Hinokio Y, Hirai A, Chiba M, Arai H, Suzuki C, Toyota T : Variations in vitamin D-binding protein (group-specific component protein) are associated with fasting plasma insulin levels in Japanese with normal glucose tolerance. J Clin Endocrinol Metab 85, (2000) 26) Bennani-Kabchi N, Kehel L, El Bouayadi F, Fdhil H, A-

8 marti A, Saidi A, Marquie G : New model of atheroscle- rosis in insulin resistant sand rats : hypercholesterolemia combined with D 2 vitamin. Atherosclerosis 150, (2000) 27) Strack V, Hennige AM, Krutzfeldt J, Bossenmaier B, Klein HH, Kellerer M, Lammers R, Haring HU : Serine residue 994 and 1023/25 are important for insulin re- ceptor kinase inhibition by protein kinase C isoforms p 2 and 0. Diabetologia 43, (2000) 28) De Fea K, Roth RA : Protein kinase C modulation of in- sulin receptor substrate-1 tyrosine phosphorylation re- quires serine 612. Biochemistry 36, (1997)

第124回日本医学会シンポジウム

第124回日本医学会シンポジウム III γ γ γ α γ Molecular Mechanism of Insulin Resistance by Adipocytes TAKASHI KADOWAKI Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo Key words γ 110 124 TNFα FFA 1,2