第124回日本医学会シンポジウム
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1 IV β Therapeutic approaches to obesity HIRONOBU YOSHIMATSU Department of Internal Medicine 1, Faculty of Medicine, Oita University Key words
2 1,2 BAT uncoupling protein 1UCP1 1,3 A 1 α-fluoromethylhistidinefmh 1 B 1 H1 H1KO 1C 4 BAT UCP1 H1KO 4 dbdb AB 3 2B 3 BAT UCP 1 2C 3 dbdb 2D 3 3,5 125
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8 1Yoshimatsu H, Itateyama E, Kondou S, et al :Hypothalamic neuronal histamine as a target of leptin in feeding behavior. Diabetes 1999 ; 48 : Hidaka S, Yoshimatsu H, Kondou S, et al :Chronic central leptin infusion restores hyperglycemia independently of food intake and insulin level in streptozotocin-induced diabetic rats. FASEB J 2002 ; 16 : Masaki T, Yoshimatsu H, Chiba S, et al : Central infusion of histamine reduces fat accumulation and upregulates UCP family in leptin-resistant obese mice. Diabetes 2001 ; 50 : Masaki T, Yoshimatsu H, Chiba S, et al : Targeted disruption of histamine H1-receptor attenuates regulatory effects of leptin on feeding, adiposity, and UCP family in mice. Diabetes 2001 ; 50 : Masaki T, Chiba S, Yoshimichi G, et al : Neuronal histamine regulates food intake, adiposity, and uncoupling protein expression in agouti yellowa y aobese mice. Endocrinology 2003 ; 144 : Fujise T, Yoshimatsu H, Kurokawa M, et al : Hypothalamic histamine modulates mastication and satiation in rats. Proc Soc Exp Biol Med 1998 ; 217 : ; 90 : Yoshimatsu H, Chiba S, Tajima D, et al : Histidine Suppresses Food Intake through Its Conversion into Neuronal Histamine. Exp Biol Med 2002 ; 227 : Yoshimatsu H, Tsuda K, Niijima A, et al : Histidine induces lipolysis through sympathetic nerve in white adipose tissue. Eur J Clin Invest 2002 ; 32 : Masaki T, Chiba S, Yasuda T, et al : Peripheral, but not central, administration of adiponectin reduces visceral adiposity and upregulates the expression of uncoupling protein in agouti yellowa y aobese mice. Diabetes 2003 ; 529:
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第124回日本医学会シンポジウム
III γ γ γ α γ Molecular Mechanism of Insulin Resistance by Adipocytes TAKASHI KADOWAKI Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo Key words γ 110 124 TNFα FFA 1,2
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日本皮膚科学会第121巻第9号
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Effects of Diet Class on Overweight Middle-aged Women Analysis of Nutritional Intake Pattern YAMAGUCHI Shizue*, MATSUMOTO Tomoko**, MIMURA Kan-ichi***, ASAI Hitoshi****, OKUDA Toyoko***** * O saka Shin-ai
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VOL.39 S-1 CHEMOTHERAPY FEB. 1981 Table 1. Activity of cefpirome and others against clinical isolates VOL.39 S-1 CHEMOTHERAPY FEB. 1991 72 M, 55.5 kg 66 F, 53 kg Chronic bronchitis Bronchopneumonia Peak
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