Review Essentials 痛みの伝導路 歴史から学ぶ Pain Pathway Learning from History 小山なつ等誠司滋賀医科大学生理学講座 Key words ascending nociceptive pathways anterolateral tract spi
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1 Review Essentials 痛みの伝導路 歴史から学ぶ Pain Pathway Learning from History 小山なつ等誠司滋賀医科大学生理学講座 Key words ascending nociceptive pathways anterolateral tract spinothalamic pathway spinobulbar projections descending modulatory control Spinal Surgery International Association for the Study of Pain IASPpain An unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. IASP 1 3 Herophilos BC Galen Galen 642 Amr ibn al As Avicenna Friedrich Leonardo da Vinci ,2 19 Charles Bell Bell Natsu Koyama, Ph.D., Seiji Hitoshi, M.D., Ph.D Address reprint requests to Natsu Koyama, Ph.D., Department Physiology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu shi, Shiga , Japan VOL. 29 NO
2 Galen Charles Édouard Brown Séquard Victor Horsley Avicenna Charles Bell Moritz Schiff William Gowers Joseph Jules Dejerine Gustave Roussy François Magendie Ludwig Edinger Henry Head Fig. 1 痛みの伝導路探索の先駆者 Wikipedia の肖像画を使用 Public Domain Horsley と Head は Wellcome Library, London より引用 文の挿絵に使用していた François Magendie 1783 いては言及していなかった Magendie の弟子である 1855 フランスの生理学者 Fig. 1 が 4,000 頭のイヌの Moritz Schiff ドイツの生理学者 Fig. 1 神経を切断した実験から同様の報告をしたのは Bell の はイヌやネコの求心性神経の刺激に対する反応が切断後 報告から 10 年以上も後であるにもかかわらず この法則 にどのように変化するかを調べ 触圧覚の伝導路と温痛 に は Magendie の 名 前 が 加 え ら れ て い る Charles 覚 の 伝 導 路 が 異 な る こ と を 発 表 し た 1858 年 Édouard Brown Séquard フランスの生理 Magendie は Galen Brown Séquard と Schiff は Avicenna 学者 Fig. 1 は 1846 年の学位論文で 動物の後索の切 の観察を検証したわけである 1846 年に Benedikt Still- 断では痛覚は保たれ 脊髄半側切断では切断側の 対側 ing ドイツの解剖学者 がミクロトームを の痛覚が消失することを報告したが 触覚の伝導路につ 開発し 脳の連続切片が作成できるようになった 脊髄外科 VOL. 29 NO 年 12 月
3 Augustus Volney Waller Camillo Golgi Vittorio Marchi William Gowers Gowers Ludwig Edinger F.W. Mott 1895 Quensel Walter Ranson Edinger Heinrich Lissauer Ranson 1 4 William Gibson Spiller Victor Horsley Joseph Jules Dejerine Gustave Roussy Henry Head Gordon Morgan Holmes Artur Schüller chordotomie Spiller Edward Martin Anterolateral tractotomycordotomy Otfrid Foerster William Raphael Mehler David R Bowsher VOL. 29 NO
4 2 A C AC 1 2, ,6 9 5 Textbook of Pain 1 1 2, ,6 8 VB IL VB VB VB VMpoIL 1 2,6 8,10 6 8, VOL. 29 NO
5 a b ,9 periaqueductal gray PAG A6 A7 A6 A7 1 2,6 8 3 Horsley Head Holmes Wilder Graves Penfield ,6 7,11 12 VOL. 29 NO
6 1 2,4,6 7,11 12 fmri DMN DMN 4,7,11 12 文献 1 Perl ER Pain mechanism A commentary on concepts and issues. Prog Neurobiol20 38, Perl ER Ideas about pain, a historical view. Nat Rev Neurosci 71 80, Lenz FA, Casey KL, Jones EG, et al Discovery of the anterolateral system and its role as a pain. The Human Pain System Experimental and Clinical Perspectives. Cambridge, Cambridge University Press, 2010, pp Apkarian AV, Bushnell MC, Schweinhardt P Representation of pain in the brain. in McMahon SB, Koltzenburg M, Tracey I, et al ed Wall and Melzack s Textbook of Pain 6th. Elsevier Saunders, 2013, pp kindle pp pp pp Thomas M, Jessell JM Kandel ER, Schwartz JH, Siegelbaum SA, et al ed pp Todd AJ, et al Neuroanatomical substrates of spinal nociception. in McMahon SB, Koltzenburg M, Tracey I, et al ed Wall and Melzack s Textbook of Pain 6th. Elsevier Saunders, 2013, pp kindle 10 Dostrovsky JO, Bud Craig AD Ascending projection systems. in McMahon SB, Koltzenburg M, Tracey I, et al ed Wall and Melzack s Textbook of Pain 6th ed, Elsevier Saunders, 2013, pp kindle 11 Lenz FA, Casey KL, Jones EG, et al Organization of the central pain pathway. The Human Pain System Experimental and Clinical Perspectives. Cambridge, Cambridge University Press, 2010, pp Brooks J, Tracey I From nociception to pain perception imaging the spinal and supraspinal pathways. J Anat 19 33, VOL. 29 NO
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Attendance Demand for J-League õ Shinsuke KAWAI* and Takeo HIRATA* Abstract The purpose of this study was to clarify the variables determining the attendance in J-league matches, using the 2,699 J-league
Title Author(s) Kobe University Repository : Kernel 公務員の経験学習と人材育成 (Experiential Learning and Development in Public Organizations) 松尾, 睦 Citation 国民経済雑誌,204(5):31-41 Issue date 2011-11 Resource Type Resource
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77 1 1 1 Comparative analysis of training regimens between top European and Japanese women s youth handball teams with a focus on shooting Eiko Yamada 1 Hiroshi Aida 1 and Akira Nakagawa 1 Abstract In
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