竹森 重 ９‐３１／９‐３１
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2 成城 経済研究 第１ ９ ５号 ２ ０ １ ２年１月 働きかけたりするためにこの骨格筋の収縮を利用します 骨格筋は私たち の頭脳とともに 私たち動物をして動物たらしめる欠くことのできない装 置であり このことが骨格筋を私たちにとってそもそも魅力的な存在にし ています 筋節の構造に見られますように 骨格筋は収縮を実現する主役のアクチ ンとミオシンという二種類のタンパク質を高い濃度でお行儀よく配列し 筋肉の長さ方向に縮もうとする強い力を発生しながら 許されれば実際に 筋肉の長さを縮ませます 長さ変化する素材として私たちの身の回りには ゴムやバネがありますが しっかりした力を支えられるゴムやバネは長さ 変化をさせにくく 伸び縮み自由なゴムやバネが支える力は頼りないこと をご存じでしょう 骨格筋はゴムやバネとは全く趣の異なる筋節構造のお かげで 力強さと自由な長さ変化とを両立させる性質を備えています ど 図１ 骨格筋細胞中の筋節構造の電子顕微鏡写真 ウシガエル縫工筋 図の一つの 筋節の長さは一ミリメートルの１０ ０ ０分の２ ５ ２ ５ミクロン に相当する １０
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21 Bresadola M (1998) Medicine and science in the life of Luigi Galvani ( ). Brain Res. Bull 46: Bernstein J (1902) Untersuchungen zur Thermodynamik der bioelektrischen Ströme. Pflügers Arch 92: (2008) 123: Hodgkin A, Huxley A (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117: Watson JD, Crick FH (1953) Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature 171: Schneider MF, Chandler WK (1973) Voltage dependent charge movement in skeletal muscle: a possible step in excitation-contraction coupling. Nature 242: Endo M (2007) Calcium-induced release of calcium from the sarcoplasmic reticulum. In: Advances in experimental medicine and biology. Vol. 592,
22 Regulatory mechanisms of striated muscle contraction. EditedbyEbashiS, Ohtsuki I. Springer, Japan, pp (2007) Ca 122: (1993) 8: Huxley AF, Niedergerke R (1954) Structural changes in muscle during contraction; interference microscopy of living muscle fibers. Nature 173: Huxley H, Hanson J (1954) Changes in cross-striations of muscle during contraction and stretch and their structural interpretation. Nature 173: Maruyama K, Matsubara S, Natori R, Nonomura Y, Kimura S, Ohashi K, Murakami F, Handa S, Eguchi G (1977) Connectin, an elastic protein of muscle: Characterization and function. J Biochem 82: Vibert PJ, Haselgrove JC, Lowy J, Poulsen FR (1972) Structural changes in actin-containing filaments of muscle. J Mol Biol 71: Chalovich JM, Yu LC, Brenner B (1991) Involvement of weak binding crossbridges in force production in muscle. J Muscle Res Cell Motil 12: Huxley AF (1957) Muscle structure and theories of contraction. Prog Biophys Biophys Chem 7: Einstein A (1905) Über die von der molekularkinetischen Threorie der Wärme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen. Annalen der Physik (Germany) 17, Meyerhof O (1920) Die Energieumwandlungen im Muskel. III. Kohlehydrat und Milchsäure umsatz im Froschmuskel. Pflügers Arch ges Phsiol. Menschen und Tiere 185: Lundsgaard E (1930) Untersuchungen über Muskelkontraktion ohne Milchsäure. Biochem Z 217: Lohmann K (1934) Über die enzymatische Aufspaltung der Kreatinephosphorsäure; zugleich ein Beitrag zum Chemismus der Muskelkontraction. Biochem Z 271: Makino K (1935) Über die Konstitution der Adenosin-Triphosphorsäure. Biochem Z 278: Engelhardt WA, Ljubimowa MN (1939) Myosin and adenosine triphosphate.
23 Nature 144: Lipmann F (1941) Metabolic generation and utilization of phosphate bond energy. In: Advances in enzymology and related subjects. Vol. 1. Edited by Nord FF, Werkman CH. Interscience Publishers. N.Y., pp Cain DF, Davies RE. (1962) Breakdown of adenosine triphosphate during a single contraction of working muscle. Biochem Biophys Res Commun 8: (1989) 34: Sun Y, Goldman YE (2011) Lever-arm mechanics of processive myosins. Biophys J 101: 1-11.
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![Title ドイツにおける高齢者看護師 (AltenpflegerIn) の職関する判決とその理由 ( 本文 (Fulltext) ) Author(s) 高木, 和美 Citation [ 社会医学研究 ] vol.[23] p.[63]-[73] Issue Date Ri](/thumbs/99/142332172.jpg "Title ドイツにおける高齢者看護師 (AltenpflegerIn) の職関する判決とその理由 ( 本文 (Fulltext) ) Author(s) 高木, 和美 Citation [ 社会医学研究 ] vol.[23] p.[63]-[73] Issue Date Ri")
Title ドイツにおける高齢者看護師 (AltenpflegerIn) の職関する判決とその理由 ( 本文 (Fulltext) ) Author(s) 高木, 和美 Citation [ 社会医学研究 ] vol.[23] p.[63]-[73] Issue Date 2005-12-01 Rights Japan Society for Social Medicine Version 出版社版
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