山形保健医療研究18/最終講義-1-内田勝雄(念校)

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1 Yamagata Journal of Health Sciences, Vol. 18, 2015 Katsuo UCHIDA Professor Emeritus, Yamagata Prefectural University of Health Sciences 260 Kamiyanagi, Yamagata, Yamagata, , Japan

2 GHz Hz 100 GHz KH2 PO Higasi K Higashi K Higasi I have become neither a proper experimentalist nor a proper theorist, but a middleman between experiment and theory and between chemistry and physics. R. S. Mulliken middleman S Robert Sanderson Mulliken middleman 7 Kramers- Kronig FORTRAN 8 Wiener-Khinchin s theorem X O2 CO2 CO2

3 CO2O2 S0 S1 T1 S PowerPoint 1 1 B5 2 2 C4N2H4 9 S/N S1 S0 10 emission spectrum excitation spectrum

4 S1 S1 T1 S1 1 serendipity 11 S1 S1 12 Xe S1 T1 T1 S1 T C4N2D4 S1 T

5 S S1 T1 S1 T Fick ph4-methylumbelliferone 4-MUHb CO2 ph CO2 HCO3 4-MU Hb 19 Hb 0 3 CO CO DLCO DLCO 1 single breath method 1 10 DLCO PhD O2 PaO Torr CO2 PaCO Torr 18 PaO Torr PaCO Torr

6 Langendorff s perfusion method rod-like pyrenebutyric acid PBA O2 O2 PBA Stern-Volmer O2 23 Stern-Volmer O2 24 Ca 2 Ca ATP ATP 27 ATP ATP Warburg effect 31 P- MRS ATP PCrPi MRS MRIin vivo MRS 31 P-MRS 28 in vivo 31 P-MRS 29 Ibrul Hassan Chowdhury in vivo MRS O2 31 P-MRS 30 MRS 30 in vivo MRS PCr Pi 31 P-MRS 31 P-MRS ATP PCr Chowdhury 24 G 95 PCr Lohmann s reaction ATP H ph phi PCr PCr Pi

7 phi 31 ATP phi PCr Pi PCr Pi ATP 31 P-MRS CO2 20 CO2 PACO2 3 1 CO2 PACO Mile High City1 600

8 SpO SpO SpO2 CvO2 37 CaO2 CvO2 vol h m CaO2 CvO h h h h CaO2 = CvO2 CaO2 CvO2 CvO2 38 CaO2 =CvO Boyer 4 Scholarship of DiscoveryScholarship of TeachingScholarship of Application Scholarship of Integration FD FD FD

9 Journal 43 Journal of the Physical Society of Japan Be Gentleman! AI

10 Uchida K, Takahashi H, Higasi K. Polarized Raman spectra of (NH4)2SO4 single crystals. Bulletin Chem Soc Jpn. 1974; 47: Uchida K. Far-infrared Reflection Spectra and Polarized Raman Spectra of Ammonium Sulfate. Waseda University (Mater Thesis); Yamazaki I, Uchida K, Baba H. Fluorescence spectrum of pyrimidine vapor from the zero-point vibrational level of 1 B1(n, π*) state. Chem Lett.1974; 3: Uchida K, Yamazaki I, Baba H. Fast and slow fluorescence emissions from pyrimidine vapor. Chem Phys Lett. 1976; 38: Uchida K, Yamazaki I, Baba H. Effects of methyl substitution on electronic relaxation processes of pyrimidine vapor. Chem Phys.1978; 35: ; 26: Uchida K. Spectroscopic Studies on Electronic Relaxation Processes in Pyrimidine and Its Derivatives in the Vapor Phase. Hokkaido University (PhD Dissertation); Baba H, Fujita M, Uchida K. Rotational effects on fluorescence quantum yields of pyrazine and pyrimidine in the vapor phase.chem Phys Lett. 1980; 73: Baba H, Ohta N, Sekiguchi O, Fujita M, Uchida K. Effects of molecular rotation on electronic relaxation processes in pyrazine and pyrimidine with particular regard to pressure dependence. J Phys Chem. 1983; 87: Takemura T, Uchida K, Fujita M, Shindo Y, Suzuki N, Baba H. Phosphorescence from pyrimidine vapor. Chem Phys Lett. 1980; 73: Mochizuki M, Tamura M, Shimasaki T, Niizeki K, Shimouchi A. A new indirect method for measuring arteriovenous O2 content difference and cardiac output from O2 and CO2 concentrations by rebreathing air. Jpn J Physiol,1984; 34: Uchida K, Mochizuki M, Niizeki K. Diffusion coefficients of CO2 molecule and bicarbonate ion in hemoglobin solution measured by fluorescence technique. Jpn J Physiol,1983; 33: Uchida K, Shibuya I, Mochizuki M. Simultaneous measurement of cardiac output and pulmonary diffusing capacity for CO by a rebreathing method. Jpn J Physiol, 1986; 36: Takahashi H, Iwabuchi K, Kudo Y, Tomoike H, Niizeki K, Uchida K, Takahashi K. Simultaneous measurement of pulmonary diffusing capacity for CO and cardiac output by a rebreathing method in patients with pulmonary diseases. Int Med,1995; 34: Uchida K, Shibuya I, Doi K. Difference in the mode of acute cold-induced hypothermia between rat and hamster. Jpn J Physiol,1987; 37: Uchida K, Matsuyama K, Tanaka K, Doi K. Diffusion coefficient for O2 in plasma and mitochondrial membranes of rat cardiomyocytes. Respir Physiol. 1992; 90: ; 45: Kuroda M, Kaminishi T, Uchida K, Miyazawa K, Tomoike H, Doi K. Ca 2+ increase and ph decrease induced by hypochlorous acid in single quiescent myocytes isolated from rat ventricles. Jpn J Physiol,1995; 45: Uchida K, Tanaka K, Doi K. Effects of cardioplegic reperfusion on ATP recovery of rodshaped myocytes isolated from rat ventricles.jpn J Physiol,1993; 43: Uchida K, Doi K. Glycolysis vs. respiration as ATP source for the shape of quiescent cardiomyocytes. Respir Physiol : P-MRS 1995; 13 2 : Sasagawa I, Nakada T, Kubota Y, Ishigooka M,

11 Uchida K, Doi K. In vivo 31 P magnetic resonance spectroscopy for evaluation of testicular function in cryptorchid rats. JUrol.1995; 154: Chowdhury IH, Uchida K, Amagasa S, Sakai M, Ogino T, Horikawa H, Doi K. 31 P magnetic resonance spectroscopy of perfused rat skeletal muscle. Yamagata J Health Sci. 2002; 5: Uchida K. Kinetics of energy metabolism in skeletal muscle during ischemia. Yamagata J Health Sci. 1998; 1: A Journal Uchida K. Estimation of mixed venous CO2 tension and QRS electrical axis from simple mathematical considerations. Yamagata J Health Sci. 2001; 4: Uchida K. Some mathematical issues in the relationship between respiratory exchange ratio and carbon dioxide pressure during rebreathing. Yamagata J Health Sci. 2009; 12: ; ; Uchida K. Mixed venous oxygen content estimated from oxygen saturation and heart rate measured for healthy students during a study tour in Colorado. Yamagata J Health Sci. 2013; 16: Uchida K. Noninvasive estimation of mixed venous oxygen content. J Phys Fitness Sports Med. 2014; 3: Boyer EL. Scholarship Reconsidered: Priorities of the Professoriate. The Carnegie Foundation for the Advancement of Teaching, ; 13; 1-6

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$00.\...ec5$ Yamagata Journal of Health Science, Vol. 6, 23 Kyoko SUGAWARA, Junko GOTO, Mutuko WATARAI Asako HIRATUKA, Reiko ICHIKAWA Recently in Japan, there has been a gradual decrease in the practice of community