Phase II clinical trials for patients with cancer
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- みずき さわまつ
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1 II II
2 I 1
3 I III
4
5 CI
6 (π B π A ) 1.96 [π A (1 π A )/n A + π B (1 π B )/n B ] π A = probability of response rate by treatment A π B = probability of response rate by treatment B n A = number of sample treated by A n B = number of sample treated by B 95
7 95 10
8 2 phase II trial (1 arm) 95 CI
9
10 π one arm 1.96 [π (1 - π)/n] = 0.1 When π = 0.8, n = 62 When π = 0.7, n = 81 When π = 0.6, n = 93 When π = 0.5, n = 96 When π = 0.4, n = 93 When π = 0.3, n = 81 When π = 0.2, n = 62 When π = 0.1, n =
11 55% 42 95% 55% 15%
12 .Therefore, achievement of a response rate of more than 55% was considered treatment results worthy of further development of this dose and schedule of rituximab. Accrual of 42 assessable patients to this trial allowed adequate assessment of treatment toxicity and provided a response rate with 95% confidence intervals of plus minus 15%. Modified: J Clin Oncol 2003; 21:
13 = % 42
14 P 1.96 P(1-P) N 0.15 = (1-0.55) N N = 42; but we should recruit a little bit more patients to consider drop out of intensified therapy.
15 30% 95% 30%
16 O O O X Required activity; e.g., 30% The treatment would be rejected as of little interest.
17 20% STATA ( % 10 10%
18 Binomial distribution Immediate test Patients enrolled Success True probability Rejection error (β) (%) = 10.7%
19 30% 9 95%
20 Therapeutic Effectiveness (%) β (%) For example, if the study produced no responses among the first 9 patients, one would have 95% confidence in rejecting the treatment as being less than 30% active.
21 95% % 95% 12% 54% 10%
22 95% CI In 20 patients, 6 will succeed. With 95% confidence, true response rate is more than 10%.
23 9 1 95% III 35 phase II clinical trial
24 If more than one response is seen among the first 9 patients The accrual is continued until a study group is reached that is large enough to provide an estimate of response rate with a specified precision. This estimate will be helpful in planning the further investment of resources in a phase III study and in determining whether this step is justified. The minimum total size for a phase II study is typically 35 subjects, which allows for a maximum standard error of approximately 8%.
25 S/N
26 Evaluation of tumor regression N: evaluable patients accrue S: tumor regression P: estimated probability of regression: S/N P 0 : required probability of regression P A : expected probability of regression H 0 : P P 0 H A : P A P
27 10% 10% 10 10% 100% 10% 30% 20% 10% 10% 20% 30% 30% 20%
28 O X Expected activity; e.g., 30%: beta=20% Required activity; e.g., 10%; alpha = 5% The treatment would be rejected as of little interest.
29 :80% 1.96,
30 N = {[Z α x P 0 (1-P 0 )] 1/2 + [Z β x P A (1-P A )] 1/2 } 2 [P 0 P A ] 2 Assuming Zα = 1.96 (α = 0.05), Zβ = 0.84 (β = 0.2) N = {1.96 x [0.1(1-0.1)] 1/ x [0.3(1-0.3)] 1/2 } 2 [ ] 2 = 23.5 < 24 participants will be required.
31 S {N x P 0 + Z α [NP 0 (1-P 0 )] 1/2 }+1 Nearest integer of {x} 24 x [24x0.1(0.9)] 1/2 +1 = = 6 = 6 responses are required to pass in 24 patients.
32 24 6
33 STATA 10% % p= % % p=0.77
34 α error = Power (1 β error) = 0.771
35 20% 40% % 20% 73% 40%
36 P 0 P A N R* + 1 a 1-b
37 5% 20% 2nd nd 30 20% 86% 5%
38 A two-stage sample size design The response rate of interest was 20% or greater, and a response rate of less than 5% would be interpreted as poor efficacy. A lack of any response in the first 14 response-assessable patients would have resulted in termination of the study. Because at least one response occurred in the first 14 response-assessable patients, an additional 16 response-assessable patients were recruited, for a planned total of 30 patients. The estimated power of this design is 0.86, when the true response probability is 20%, given a type I error of J Clin Oncol 2003; 21:
39 1st 14 20% 5% 14
40 A lack of any response in the first 14 response-assessable patients would have resulted in termination of the study.
41 10 3 7% 65% 95% 7% 65% 10 7% 65% % 10
42 95% CI = p(1-p)/n %CI %CI %CI %CI %CI
43 % % 20%
44
45 STATA 5% 20% 30 5% 84%
46
47 % 1st 2 nd 20%
48 A two-stage statistical design was used to permit early termination if preliminary results indicated minimal efficacy. A target response rate of 20% was deemed sufficient to warrant further study, whereas a response rate 5% was insufficient for further investigation. This trial design therefore called for 15 assessable patients to be entered onto the first stage of the trial. If one or more responses were observed among these initial patients, an additional 20 assessable patients, would be entered. If five or more responses were observed among 35 assessable patients would be entered. If
49 % %
50 This trial was designed to test the null hypothesis that the true treatment success rate is at most The smallest treatment success proportions that would indicate that this regimen warrants further study is The planned accrual for this Simon-design study was 50 assessable patients. An interim analysis was conducted after the first 21 patients had been followed for 6 months. If two or fewer responses were observed during the interim analyses, the treatment arm was to be closed permanently. If three or more confirmed responses were observed during the interim analyses, accrual was to continue. At the time of final analyses, a confirmed response among eight or more of the 50 evaluable patients would indicate that this regimen merits further investigation. J Clin Oncol 2003; 21:
51 % % % % % %
52 Reject *1 Desire *2 1 st stage 2 nd stage *2 N1 *3 R1 *4 N2 *5 R2 *6 *6 Max SS * *1: drug not of interest if true response rate *2: desirable true response rate, *3: accrue n1 patients *4: reject if r1 response, *5: add n2 patients, *6: reject if r total response, *7: maximum sample size (n) Simon R. Optimal two-stage designs for phase II clinical trials. Controlled Clin Trials 1989; 71:
53 %
54 If two or fewer responses were observed during the interim analyses, the treatment arm was to be closed permanently. If three or more confirmed responses were observed during the interim analyses, accrual was to continue.
55 % % -
56 At the time of final analyses, a confirmed response among eight or more of the 50 evaluable patients would indicate that this regimen merits further investigation.
57 % %
58 If tumors of 10 in 50 patients regress, true response rate will be no less than 0.10 with 95% confidence.
59 peer reviewed journal
60 Fleming single-stage procedure and tested the following H0: p 15% and H1: p 30%, with a=2.5% (one-sided) and a power of 90%. To allow for premature withdrawals from the study, the planned sample size was 100 patients with CML in blast crisis. ; this sample size was based on practical considerations rather than a formal sample-size calculation.
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