ExTEND2005 2005 3
ExTEND2005 Enhanced Tack on Endocrine Disruption
10 (1998 )5 - SPEED'98-12 (2000 )11 2000 11 ( SPEED'98 ) 14 (2002 )8 (WHO)/ (ILO)/ (UNEP) Global Assessment of the State-of-the-Science of Endocrine Disruptors( WHO ) (OECD) 15 (2003 )5 15 (2003 ) 2 SPEED'98 ( ) 2005 3-1 -
1 3 SPEED 98 3 SPEED 98 4 (1) 4 (2) 5 (3) 8 (4) 12 13 13 16 (1) 16 (2) 18 (3) 20 (4) 24 (5) 27 (6) 27 (7) 28 33 35 36 38 43 58 WHO 65 71 73 SPEED 74 82-2 -
SPEED 98 10 (1998 ) ( ) 67 2000 11 65-3 -
SPEED 98 10 (1998 ) SPEED 98 (1) ( ) 10 15 1 ( ) 2 11 16 14 15 POPs 1 ( ) 2 : : : ( ) - 4 -
SPEED 98 (in vitro ) 3 4 5 ( ) 28 4- ( )4-t- 23 (o,p -DDT p,p -DDE 2004 12 ) OECD ( ) 3 21 4 5-5 -
(1421 ) (HSI) ( 70 ) (G SI) (H S I) (F 0 : 100 ) (F 1 : 70 ) (G SI) (HSI) 0-30 31-60 61-90 91-120 121-150 151-180 1 (F 0 ) 2 (F 1 ) 21 70 2 (180 ) 90 120-6 -
- 7 - -2-4-t- ( ) cis- 2,4-4- trans- 4- ( ) ( ) A ( ) ( ) -2- -n- - ( ) p,p - p,p - ( ) o,p - ( ) p,p - http://www.env.go.jp/chemi/end/speed98/speed98-20.pdf
SPEED 98 28 28 ( ) 6 12 16 (Hershberger ) 28 28-8 -
- 9 - -2- ( ) ( ) ( ) ( ) ( ) 4-t- ( ) cis- ( ) 2,4- ( ) 4- ( ) trans- ( ) 4- ( ) ( ) A ( ) ( ) -2- ( ) ( ) -n- ( ) ( ) ( ) ( ) ( ) - ( ) ( ) ( ) ( ) p,p - ( ) p,p - E ( ) o,p - ( ) p,p - ( ) http://www.env.go.jp/chemi/end/speed98/speed98-19.pdf
(4-14-2) 4-1 (1) A ( ) PCB DDT (HCB) (HCH) PCB ( ) 80% Total PCB / PCB ( ) 16 1 2-10-
4-2 (2) 10 3 (20 60 ) 16 1 2 10 (2000).,70:113-118. - 11-
(4) 10 (1998 ) OECD WHO ( ) H10 H11 H12 H13 H14 H15 H16 500 1 (http://www.env.go.jp/chemi/end/index3.html) 11 13 16 ( 16 ) (OECD) OECD ( enhanced TG211 enhanced TG206) OECD (http://www.oecd.org/home) (WHO)WHO/ILO/UNEP 14 WHO WHO (http://www.env.go.jp/chemi/end/index4.html) - 12-
() - 13-
OECD - 14-
(1) (2) (3) (4) (5) (6) (7) WHO 11 WHO 12 IUPAC EC 14 13 11 WHO (2002) Global assessment of the state-of-the-science of endocrine disruptors, WHO/IPCS/EDC/02.2. 12 WHO/UNEP/ILO (2004) Report of the joint IPCS-Japan workshop on Endocrine disruptors: Research needs and future directions, WHO/IPCS/EDC/01/04. 13 J. Miyamoto and J. Burger (2003) Implication of Endocrine Active Substances for Human and Wildlife, Scope/IUPAC. 14 EC (2001) Communication from the Commission to the Council and the European Parliament on the implementation of the Community Strategy for Endocrine Disrupters- A range of substances suspected of interfering with the hormone systems of humans and wildlife (COM(1999)706), COM(2001)262final. - 15-
(1) 15 11 ( ) (4 ) - 16-
- - 17 ( )
(2) 10 (1998 ) SPEED 98 ( ) 49 (1973 ) ( ) ) ) ) ) ) - 18-
- - 19 ( ) ( )
- - 20 (3) 10 (1998 ) () OECD
( ) (in vivo ) 15 ) ) (in vitro ) ( ) 15 15 USEPA(1998)Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC) Final Report - 21-
) DNA DNA () ) ) / / ) ) in vivo - 22-
) ) ) in vitro in vivo in vitro in vivo ) OECD - 23-
(4) (6) ( ) - 24-
- 25-
OECD OECD 20 OECD in vivo - 26-
(5) ( ) ( ) (6) - 27-
(7) 10 (1998 ) ( ) ) - 28-
) 1) 2) - 29-
- - 30 3) ( )
- - 31 16 http://www.env.go.jp/chemi/entaku/index.html
- 32-
- - 33 11 LC/MS