Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 389( 15 ) 1. MDS collagenase 2. 1 3. 4. /
390( 16 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. 4 4 2004 10 2 1 NTT
Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 391( 17 ) 1 MDS collagenase Matrix metalloproteinases (MMP)-2, MMP-9 IV collagenase MMP-2, MMP-8, MMP-9 (Myelodysplastic syndrome: MDS) collagenase MDS collagenase Collagenase MDS 50 29 21 22 81 39 23 16 22 54 collagenase MDS FAB RA (refractory anemia) 31 RARS (refractory anemia with ringed sideroblast) 4 RAEB (refractory anemia with excess of blasts) 5 RAEBt (refractory anemia with excess of blasts in transformation) 1 CMML (chronic myelomonocytic leukemia) 2 post-mds AML (acute myeloid leukemia) 2 5 collagenase CellProbe (Beckman Coulter, Fullerton, CA, USA) CellProbe MMP-2, MMP-8, MMP-9 II IV collagenase CellProbe collagenase collagenase CellProbe collagenase MDS collagenase MDS collagenase (p 0.05) FAB (Table 1) Table 1. Collagenase
392( 18 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. IPSS (International Prognostic Scoring System) collagenase (Table 2) MDS NAP (Neutrophil Alkalyne Phosphatase Score) NAP collagenase (Table 3) collagenase MDS collagenase MDS 1,000/ml 37.5 C 7 MDS 50 6 collagenase (p 0.01) MDS ( p 0.01) (Table 4) collagenase (SD) 26.9 6 5 37 2 (p 0.0005) Collagenase 26.9 5 (Table 5) 1 Table 2. IPSS collagenase Table 3. NAP collagenase Table 4. collagenase Table 5. Collagenase *
Aug. MDS collagenase MDS collagenase collagenase MDS collagenase NAP collagenase THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 393( 19 ) NAP G-CSF G-CSF G-CSF collagenase collagenase collagenase 6
394( 20 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. 2 1 1) 2) 1) 1) 2) 1 27 1999 7 38 C 7 13 30 40 / 9 730/ml 510/m l 210/m l 10/ml 1.84 10 6 / ml 5.8g/dl 17.3% 6,600/ml 6.3 /ml CRP 5.27mg/dl M/E 0.54 5% (Myelodysplastic syndrome: MDS) CD4 53.4% (32 48), CD8 32.2% (21 33) PHA 956 cpm (26,000 53,000), ConA 1,230 cpm (20,000 48,000) Gaffky Mycobacterium avium 3 3mm G-CSF ciclosporin (CyA) (Fig. 1) M. avium isoniazid (INH), ethambutol (EB) CRP rifampicin (RFP), clarithromycin (CAM) 2000 1 CRP 1.20 mg/dl ciclosporin 2000 8 9 ethambutol, clarithromycin 2000 10 ciclosporin, ethambutol, clarithromycin 2002 2 4 2001 8 2002 7 8 10 cm (Fig. 2) 10
Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 395( 21 ) Fig. 1. Fig. 2. 12 MRI L2 T2 L4 (Fig. 3) 3,950/m l 3,349/ml
396( 22 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. Fig. 3. MRI 2002 12 Fig. 4. MRI 2003 4 Cryptococcus neoformans ( ) 2003 1 Fluconazole (FLCZ) 200 mg/ 6 2 7 CRP 2.81 mg/dl 2003 4 MRI L2 L4 (Fig. 4) Fluconazole 200 mg 1 1 6 568/m l 20/m l 9.6 g/ dl CRP 4.91 mg/dl 2001 9 MRI
Aug. Cryptococcus neoformans THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 397( 23 )
398( 24 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. 3 Fluconazole (FLCZ) (ITCZ) FLCZ 10 14 ITCZ FLCZ 10 2 13 10 3 9 7 180 92 227 88 186 FLCZ ITCZ 4 FLCZ 200 400 mg/ ITCZ 200 mg/ 100 mg/ 4 10 413 (None) 181 FLCZ (FLCZ) 71 ITCZ (ITCZ) 91 FLCZ ITCZ (FLCZÆITCZ) 8 ITCZ FLCZ (ITCZÆFLCZ) 62 51 61.0 24.3 1 (Table 1) (Fig. 1) FLCZ 27.9 ITCZ 40.2 14.1% (10/71) ITCZ 4.4% (4/91) (Table 1) ITCZ ITCZ FLCZ p 0.01: c 2 ITCZ FLCZ 62 14 FLCZ 29 10 ITCZ FLCZ 1
Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 399( 25 ) Table 1. Fig. 1. (non-hodgkin s lymphoma: NHL) 98 (acute myeloid leukemia: AML) 67 (acute lymphoblastic leukemia: ALL) 20 (multiple myeloma: MM) 15 (Table 2) ITCZ 0% (0/34) FLCZ 19.4% (7/ 36) p 0.02: c 2 ITCZ FLCZ p 0.004: c 2
400( 26 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. Table 2. Table 3.
Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 401( 27 ) Table 4. 1 15 30 (Table 3) 15 30 31 60 p 0.009: c 2 FLCZ AMPH-B ITCZ 3.3% (3/91) ITCZ FLCZ 16.1% p 0.01: c 2 (Table 4) FLCZ ITCZ ITCZ FLCZ ITCZ b-d-
402( 28 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. 4 / Fluconazole (FLCZ) (ITCZ) Fluconazole (oral solution) Fluconazole 500/ml Fluconazole 200 mg/ 1 1 H 2 Fluconazole 1,000/ml 7 B 300 mg/ 1 8 2 15 b -D- 1,000/ml 7 Fluconazole 14 (Table 1) 14 4 (28.6%)
Aug. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 403( 29 ) Table 1. Table 2. Fig. 1. Fluconazole 14 5 (35.7%) (Table 2) Fluconazole 2 (possible) 1 1 500/ml CT Micafungin 250 ng/ml 500 ng/ml 250 ng/ml (Fig. 1) (OH- ITCZ) Fig. 2.
404( 30 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 4 Aug. (Fig. 2) Fluconazole 200 mg/ Fluconazole MIC 90 250 ng/ml 1) 250 500 ng/ml 2), 500 ng/ml 3) 250 ng/ml Fluconazole in vitro (OH-ITCZ) 14 Fluconazole 2 b-d- 2 b-d- Fluconazole Fluconazole 1 1) BOOGAERTS, M. A., et al.: Mycoses, 1989 2) BOYLE, B. M., et al.: Transplant Infection Disease, 2000 3) GLASMACHER, A., et al.: Mycoses, 1999