I 89 16 3 130 ab c AMPcAMP a 1 --- b c --- 2 --- --- 3 --- --- 4 --- --- 5 --- --- camp camp Ca 2+ β1 camp A camp camp A β1 p.156 β p.146 b. p.157 p135 (ANP) p157 c PDE-III p.157 p.157, 183 PDE C Ca PDE-III Ia Na + p.161 ACE p.145 131 a b c d --- Na + --- --- ß --- --- Ca 2+ --- --- K + --- e --- Na + K + -ATPase ---
1abc2abe3ade4bcd5cde a. (p.161)ib Na+ (p.119) b. (p.163)ii β c. (p.163) Ca IV d. (p.163)k + III e. (p.163, p.152) Na + /K + -ATPase Ca 2+ a b c d e 133 a Na + K + b Na + cd- Na + d K + 1ab2ac3ad4bc5bd6cd a. (p.176) Na + /Cl - b. Na + (p.177) c. D- (p.178) Na + d. (p.178) Na + Na+ K + K + 134 al- -S-S- b c d ß2 e d 1 2 3 4 5 a. L- (p.188) SS b. (p.188) c. (p.189) d. (p.185) β2 β1 e. (p.87)
187 a b ACE c ACE II d II II e ß 1abc2abe3acd4bde5cde a. II NaCl K + b. ACE ACE ACE ACE c. p.150 4-13 ACE II d. II II II ACE e. β (p.148) 188 33 100/ a bna + Ia c dna + Ib e 1abd2abe3acd4bce5cde a. β (p.156) p.163 4-6 II β III K+ IV Ca I Ia Ib bce 189 62 1 23 1 1 3 ST-T a ß b c ß dca 2+ e 1abc2abe3acd4bde5cde p.133 p.134 4-2 ST-T p.135p.141 cde
190 40 42/ 198/100 mmhg K + a ß bca 2+ c d ACE e II 1abc2abe3acd4bde5cde p.143 4-1 Ca 2+ ACE II ACE II II K+ K + bde 193 a b c d e d 1 2 3 4 5 a. b. c. (p.188) d. e. 194 a b ß2 c d e 1abe2acd3ace4bcd5bde
a. (COPD) b. 2 Gs camp Ca 2+ camp Ca 2+ c. d. e. COPD ace 88 15 3 121 a b c d ( ) e 1(abc)2(abe)3(acd)4(bde)5(cde) a. b. c. d. e. acd a b c d e ---- ß1 ---- Gs ---- M3 ---- C ---- GABAA ---- Cl - ---- 5-HT2 ---- Gi ---- ---- 1(ab)2(ad)3(bc)4(ce)5(de) a. Gs camp b. M3 Gq C c. GABAA GABAA Cl - d. e. - ab
123 - B C B C 10 B C BC 1 2 3 4 5 H1 H1 H2 (p.66)ssri PDE 132 ah +,K + -ATPase Na + Ca 2+ b c d e 1(ab)2(ae)3(bc)4(cd)5(de) a. Na + /K + -ATPase b. c. d, e. d, e de
a ß2 b c d e 1(abc)2(abe)3(ade)4(bcd)5(cde) 1 p.106, p. 137, p.146, p.163 a. b c d a b c D1 d 1(ab)2(ad)3(bc)4(bd)5(cd) a b cna + -K + -2Cl - d e 1(abc)2(abe)3(acd)4(bde)5(cde) a b AMP (camp) c ß2 ß1 d A2 e 1(abc)2(ace)3(ade)4(bcd)5(bde) 66 0.25 mg/ 40 mg/ ST K + a b (ACE) c ß d 1(ab)2(ac)3(ad)4(bd)5(cd)
55 5 45/ 180/100 mmhg, a b Ca 2+ c ß d a1 e II 1(abc)2(abd)3(ace)4(bde)5(cde) a b c ß2 d 1(ab)2(ac)3(bc)4(bd)5(cd) aca 2+ b c d e 1 2 3 4 5 87 14 3 121 GLP GLP 123 -
) 126 24 133 Ca 2 ß1 II a1
134 Na K + -ATPase Ca 2 camp ß1 Gi a 135 I2 136 ß K + Ca 2 Na ß1 137 138 ß2 L-
GFJ GFJ CYP3A4 GFJ GFJ GFJ Cmax GFJ 3 AMPcAMP ß Ca2 86 13 3 K +
ß Na + QT ß1 Ca 2+ D- II Cockcroft-Gault
ß ST ß CO2 O2 ß2 (NSAID) 85 12 3 - A B
a pd2 6.O7.O b A c A pa2 8.0 d B pa2 7.0 e 3 10-6 M A 10-8 M 90% 1(a, b, c) 2 (a, b, e) 3(a, c, d)4(b, d, e) 5 (c, d, e) a ß1 b ß1 c a1 d a1 a2 a2 e aß 1(a, b)2(a, d)3(b, e)4(c, d)5(c, e) a b c d e AMP(cAMP) 1(a, c)2(a, d)3(b, d)4(b, e)5(c, e) Ca2+ a L Ca2+ b c d e 1(a, b, c) 2 (a, b, e) 3(a, c, d)4(b, d, e) 5 (c, d, e) a +
b Na + - K + c H + - K + d Na + - K + -2Cl - e Na + K + 1(a, b)2(a, d)3(b, c)4(c, e)5(d, e) a b c d e T 1(a, b)2(a, e)3(b, c)4(c, d)5(d, e) a b 5 c Ca 2+ d ß 1(a, b)2(a, c) 3(a, d)4(b, c)5(b, d) 6(c, d) a -------- b a1 ---------- c ß1 ----- d Ca 2+ ------------------ e -----------------Na + K + 1(a, b,c) 2 (a, b, e) 3(a, c, d)4(a, d,e) 5 (b, c,d) 6(c, d, e) 84 11 3 A-D 1 2 a A intrinsic activity1 b B A1/10 0.1 c0.5
d100µm B 30µM e100µm B D a b c d e 1abc 2abe3ade 4bcd 5cde a100 b c d ST T a ---------- a1 ---------- b ------- -------- c ------------ ----- d -------- a1 ---------- e -----a1 ---------- a a1 b a2 c ß1 dß1
e ß2 1ab2ae3bc4cd5de a ------------ b ---------------------- c ------------ d ------------ e -------------------- 1ab2ad3bc4ce5de a K b c a dß e 1ab2ad3be4cd5ce a b c d e Na Cl - 1ab2ae3bc4cd5de ae aa bbd cc B dba ec 1abd2a cd3 ace 4bce5bde a b IgE
c d e a b c 1 10 L d Vaughan Williams ana Ia b Ib Ic cß II I dk III eca 2 IV a GFR b Na K c Na d e 1ac2ae3bd4be5cd a b c d
60 120 170100 mmhg 140 mgdlna 145 meqlk 3.8 meq LCl 104 meql 17 17-OHCS6.5 mg 38 mg CT 131 I-metaiodobenzylguanidineMIBG a ß 83 10 3 122 ß2 7 G G ADP G ADP GTPase G camp IP3 135 1ac2ae3bd4be5cd 136 - II v I II 1ac2ae3bd4be5cd 137 ß1 a1 M1 NN
ß1 138 139 ß2 a1 191 ST ß 203 26 60 mg 1 2 2 100 mgday 3 QT 580 msec 67min torsades de pointes 2 3 QT QT
CYPIA2 CYPIA2 CYPIA2 CYP2D6 CYP2D6 CYP2D6 CYP3A4 CYP3A4 CYP3A4 207 ß- TDM 20 µgml 1abc2abd3ace 4bcd5bce6cde