Permeability of Formocresol into Root Dentin and its Effects on the Periodontium in Dogs Kouji Araki Department of Endodontics, Faculty of Dentistry, Tokyo Medical and Dental University ( Director: Prof. Imao Sunada) The purpose of this study was to investigate the permeability of formocresol into the root dentin and its effects on the periodontium in beagle dogs. The fourth upper and lower premolar pulp of 9 dogs were removed and formocresol containing 3H-formaldehyde or 3H-cresol was dressed in the root canal. After a given period, the amount of tritium radioactivity permeating into the blood was measured by a liquid scintillation counter. The periapical periodontium and lateral periodontium were evaluated histologically and autoradiographically. The results obtained were as follows: 1) Both 3H-formaldehyde and 3H-cresol were present in the blood within half an hour postoperatively. There was more 3H- cresol than 3H-formaldehyde in the blood within 4 hours but after 24 hours more 3H-formaldehyde than 3H-cresol. 2) In the periapical periodontium, the inflammatory cell infiltration was observed in 12 (50%) of 24 roots and hyperemia and dilatation of the vessels were observed in 16 (66.7%) of 24 roots after 3 days. In the lateral periodontium, several specimens showed inflammatory cell infiltration and more than half of the whole specimens showed hyperemia and dilatation of the vessels after 3 and 7 days. 3) Grains of 3H-formaldehyde and 3H-cresol were found distributed from the pulpal side of the dentin to the cemento-dentinal junction after 3 and 7 days. There were more grains of 3H-formaldehyde than those of 3H-cresol throughout the root dentin.
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