Candida Candida albicans Candida parapsilosis Candida glabrata Candida tropicalis C. albicans C. grabrata C. tropicalis µ Candida guilliermondii µc. parapsilosis µ Candida µcandida C. albicans µ µ µ µ C. parapsilosis Candida Candida
Fig. Annualchangesinpercentagesoffungiisolatedfrom bloodandvascularcatheters Fig. Frequenciesoffungiisolatedfrom bloodandvascularcatheters(99-) Malassezia C. albicans Candida dubliniensis C. albicans C. dubliniensis C. dubliniensis
Table Efectofantifungalactivityonincubationtimeofantifungalagentsinstandardorganisms Strain Incubation time AMPH-B -FC FLCZ ITCZ MCZ MCFG Candidaalbicans h..6. ATCC h.6. Candidaalbicans h.6.6. ATCC9 h.6. h ATCC9 h Candidakrusei h 6.6 ATCC6 h 6 Fig. ComparisonofcumulativeMICsfor6antifungalagentsbetweenhoursofincubationandhoursofincubation C. albicans C. parapsilosis C. glabrata C. tropicalis C. guilliermondii Candida Cryptococcus neoformans Trichosporon C. albicans C. albicans C. parapsilosis Candida krusei µ µ µ µ µ µ
Table MICsofmicafungin(MCFG)foryeast-likeorganisms..6 6 >6 6 9... >6 >6... >6 >6 Table MICsofamphotericinB(AMPH-B)foryeast-likeorganisms Cryptococcusneoformans 9 9 note:theverticaldashedlineshowsthemicbreakpoint. µ C. albicans C. albicans C. albicans C. parapsilosis C. glabrata C. tropicalis C. albicans C. parapsilosis C. glabrata C. tropicalis Candida Trichosporon Malassezia C. albicans C. glabrata C. tropicalis C. parapsilosis Trichosporon C. parapsilosis C. krusei
Table MICsoffluconazole(FLCZ)foryeast-likeorganisms 6 6 >6 Percentagesof resistant 6 9 >6 6. note:theverticaldashedlineshowsthemicbreakpoint. Table MICsofitraconazole(ITCZ)foryeast-likeorganisms..6 > Percentages ofresistant 6 6 6.6 >..6 note:theverticaldashedlineshowsthemicbreakpoint. C. albicans C. albicans Candida Trichosporon C. neoformans C. albicans C. glabrata C. tropicalis µ C. parapsilosis C. guilliermondii µ C. neoformans Trichosporon µ Candida C. neoformans Trichosporon µ C. albicans µ C. glabrata µ µc. neoformans Trichosporon µ C. albicans µ C. glabrata C. albicans C. parapsilosis C. grabrata C. tropicalis C. guilloermondii Candida C. neoformans µ Trichosporon µ C. albicans µ µµ Candida C. parapsilosis µ C. neoformans Trichosporon
Table6 MICsofmicronazole(MCZ)foryeast-likeorganisms.6 6 >6 6 Table MICsofflucytosine(-FC)foryeast-likeorganisms 6 6 >6 Percentages ofresistant 9 9 >6. note:theverticaldashedlineshowsthemicbreakpoint. µ C. parapsilosis µ C. albicans Candida Trichosporon µ C. neoformans Candida C. albicans C. parapsilosis µ µ C. albicans µ µ C. albicans C. glabrata C. tropicals C. krusei C. albicans
Table MICofantifungalagentsforfluconazole(FLCZ)-orflucytosine(-FC)-resistant CaseNo. Species AMPH-B -FC FLCZ ITCZ MCZ MCFG 6 9 9 / >6 >6 >6 >6 >6 >6 > > > > > >..... Yearof CaseNo. isolation 6 9 9 / 99 996 99 999 organism Table9 Patientprofilesofisolatedfluconazole-orflucytosine-resistant Patient Surgery Age Underlyingdisease gastriccancer Chemotherapy candidaisolate Complication Prognosis from othermaterial beforecandida aftercandida isolate isolate candida endophthalmitis Hematology malignantlymphoma oralcandidiasis Gastric enterology Nephrology *Alsubjectsweremale. Cardiology Surgery gastriccancer diabetesmelitus, renalfailure coloncancer, diabetesmelitus hypopharyngealcancer, esophagealcancer arterialblood, sputum venousblood IVH cathetel, bite arterialblood, sputum arterialblood, sputum cefpirome piperacilin, cefepime vancomycin, imipenem miconazole fluconazole fluconazole fluconazole recovered died died died died recovered C. albicans C. parapsilosis C. glabrata C. tropicalis C. albicans C. glabrata C. tropicalis C. parapsilosis Trichosporon C. albicans C. albicans C. glabrata Candida µ µ β Candida C. albicans C. glabrata C. tropicalis µ C. parapsilosis C. guilliermondii µ C. albicans
et al. et al. Candida in vitro et al. in vitro
Candida albicans Candida parapsilosis Candida glabrata Candida trophicalis C. albicans C. glabrata C. tropicalis Candida C. albicans C. parapsilosis