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47) Kinersly T. Yale J. Biol. med., 26, 211, 1953. 48) Grassmann W. Nuturwiss, 38, 496, 1950. 49) Grassmann W. Nuturwiss, 38, 200, 1950. 50) Grassmann W.. Dtsch. med. Wschr., 76, 333, 1951. 51) Kendel M.: med. Mschr., 76, 707, 1951. 52) Eisenreich F.: Kl. Wschr., 29, 60, 1951. 53) Sucker T.: Kl. Wschr., 325, 1952. 54) Esser H. Kl. Wschr., 30, 228, 1952. The P. H. and Proteins in the Saliva of Patients with Cervical Carcinoma By Kenji Kawada Department of Obstetrics and Gynecology Okayama University (Director: Prof. Hideo Yagi) Medical School As the auxiliary diagnosis for carcinoma of the cervix the author evaluated the ph, whole proteins. and protein fractions in the saliva; and obtained the following results: 1) The ph of the saliva in patients with cervical carcinoma is lower than that in the case of normal non-pregnant women, and it becomes more marked with the lapse of time. In 25.6 per cent of the patients in Stage I an abnormally low ph of under 6.2 can be observed, showing a significant difference as compared with the normal non-pregnant women; but as the percentage is low, it can not be so useful for an early diagnosis. 2) In 9.6 per cent of those whose improvement is good at follow-up examinations after treatment such an abnormally low ph can be found, and in them ph returns to the normal level only after one year. In 33.3 per cent of those whose prognosis is poor, an abnormally low ph value can be recognized. In the follow-up examinations sur e;sively abnormally low ph can be found in 8.0 per cent of those with a good improvement, and in 66.6 per cent of

those with a poor improvement. Sixty per cent of those showing abnormally low ph succes sively are those with a poor prognosis. 3) The amount of whole protein in the saliva of patient with cervical carcinoma shows a slight increase over 46.2mg/dl in the case of normal non-pregnant women. Statistically a significant difference at 79.0mg/dl can only be recognized in those at Stage IV. As for the percentage of those showing as abnormally high as 72.26mg/dl, 28.9 per cent of those in Stage II show abnormally high value as compared with normal non-pregnant women, but it has little value for diagnosis. 4) An increase in whole protein can be recognized in the anemic patient showing sahli value of under 59 per cent. 5) No significant difference can be recognized in the protein fractions of the saliva in the patients with cervical carcinoma as compared with normal non-pregnant women. From these data it is assumed that the evaluations of the whole protein content and protein fractions in the saliva are not so useful as an auxiliary diagnosis of cervical carcinoma, but the continuous follow-up estimations of ph of the saliva for the purpose of discovering the recurrence of cervical carcinoma at an early stage enable us to foresee it, and such follow up examinations will offer us an important criterion for the judging of the conditions after treatment.