Key words: EBV-VCA, gastric cancer, B lymphocytes, CR2/C3d receptor Cell, B lymphocytes stimulated with SAC

Key words: EBV-VCA, gastric cancer, B lymphocytes, CR2/C3d receptor Cell, B lymphocytes stimulated with SAC

Fig. 1 Distribution of negative rate of antibody to herpes viruses in patients with gastric cancer and normal persons VZV : varicella-zoster virus, HSV : herpes simplex virus, CMV : cytomegalovirus, EBV : Epsten-Barr virus (VCA-IgG) ranged from 40 to 80 years old normal persons : healthy voluntears ( ), gastric cancers ( )

Fig. 2 Distribution of high titer rate antbody to of herpesviruses in patients with gastric cancer and normal persons The lanes are the mean of normal persons ( ) and gastric cancers ( )

Fig. 3 Geometrical means of antibody titers to EBV according to stages of gastric cancer and normal persons normal persons of age : young personnel between 20 and 30 years of age and elderly personnel between 60 and 80 years of age : VC A-IgG EA-IgG

Fig. 4 Relationship between the percentage of B lymphocytes (CR2/B7) and EBV-VCA antibody titers in patient with gastric cancers and normal persons gastric canser healthy Fig. 5 Relationship between the percentage of B lymphocytes stimulated by SAC and antibody titers to EBV-VCA patient with gastric cancer and normal persons gastric canser healthy

Fig. 6 Alternation of OKT4+ cell and OKT8+ cell ratio in peripheral blood with gastric cancers Fig. 7 Relationship between the percentage of T lmphocytes stimulated by PHA and antibody titers to EBV-VCA patient with gastric cancers

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Human Herpesviruses Infections (I) EBV Infection and Immunity in Cancer Patients Masako TAJIMA1), Fumiko TAKEDA1), Toshio TAKESHIMA2), Tokuyuki YOKOHATA2) & Kouta OKINAGA2) 1)Division of Virology, Central Laboratory for Clinical Examination, Teikyo University School of Medicine 2)Second Department of Surgery, Teikyo University School of Medicine Human herpesviruses have been known to be reactivated from latent infection in immunosuppressed individuals. To asses the immunity, antibodies to human herpesviruses (VZV, HSV, CMV and EBV) were measured in patients with gastointestinal cancer and normal persons ranging from 40 to 80 in age. CF antibodies to herpesviruses except for EBV were negative in normal persons below the age of 60 and cancer patients aged 60 and over. The CF antibody titer higher than 1:64 occurred only in young cancer patients and older normal persons. The titer of VCA antibody to EBV ranged from 1:40 to 1:160 in more than 80% of normal persons and was higher than 1:640 in less then 7%. The ratio those with antibody negative or below 1:40 increased with the age. In contrast, the titer was higher than 1:320 in 70% of the cancer patients, and the antibody was negative in none of them. In addition, the low titer occurred only in less than 5%. The rate of patients having higher VCA antibody titers increased with age, and the titer was high in more than 50% of patients in the 8th decade. In cancer patients, the higher the VCA antibody titer was, the less number of mature B cells, target cells of EBV, and the B cell functions were observed. This suggests that reactivation of EBV in hosts bearing carcinomas results in a fall of production of the specific antibody.