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労 働 Health Care Quality Indicators Project - 6 data collection update report (OECD Health Working Paper No. 29) 5-Oct-7 HPV-18 ( 99 HPV 8 HPV 9 B B C 8 5 >5 1 1 / 1.1.6 Baseline reference ( B 9.1 B 9 F.X. Bosch et all. in J. Clin Pathol 2 2
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HPV Assembly of Virus-Like ike Particle (VLP) HPV DNA L1 VLP HPV HPV mrna L1 19 HPV genotype 16 +18 +45 +31 +33 +52 +58 +35 +59 +56 +51 +39 +68 +73 +82 +Other 6.7 2.9 2.6 1.4 1.3 1.2 1..7.6.5.3 5.6 8 1 Global cervical cancer coverage by HPV high risk (cumulative) Adapted from Munoz N et al. Int J Cancer 4; 111: 21 278 85. 22 5 most common s in squamous cell carcinoma by region All all cases 16 18 45 31 33 Asia 16 18 58 52 45 North America and Australia Africa 16 18 45 33 31 Europe 16 18 33 31 45 South and Central America 16 18 31 33 45 16 18 31 45 33 23 Clifford et al, BJC, 3b 24 4
HPV8 6 (97.9 CI) HPV16 18 HPV45 31 33 52 6 Paavonen J et al. Lancet 7;369:2161-7 E. M. de Villiers et al., Virology 4. 1 8 15-25 26-35 36-45 46-55 rs HPV-16 GMC EU/ml 1 1 1 1 26 HPV-16 15-25 26-35 36-45 46-55 1 7 12 18 33-38 45-5 Schwarz TF et al. J Clin Oncol 6;24(18S) Harper et al. Lancet 6; 367: 1247-55 Schwarz TF et al. J Clin Oncol 6;24(18S) 25.. 15. 1. 5.. 29 5. 45.. 35. 3. 1987 199 1993 1996 1999 2 3 2 1 3 2 1 sexual debut in Japan Data source: Survey of consciousness and behavior about sex in children and students, 2. Metropolitan sexual education society of children and students in elementary schools, junior high schools and high schools, Tokyo. 2. 5
ACIP Recommendation 6111 GARDASIL H 4 6,11,16,18 CDC s Vaccine for Children, VFC 918 94 ( ) VFC 1994 18 CDC Advisory Committee for Immunization Practice, ACIP VFC 32 Ontario, Canada Government Will Offer HPV Vaccine To 8th Grade Girls August 3, 7 1: p.m. EST Valerie Chang - AHN News Writer Toronto, ON (AHN) - The province of Ontario will begin offering the human papillomavirus (HPV) vaccine to girls in the 8th grade, at no cost, starting this fall. HPV, which is sexually transmitted, causes cervical cancer. Girls in Ontario will have the option to get the Gardasil vaccine at no cost, but will not be required to do so. Public health nurses will provide the vaccine, which is comprised of a three-shot course of treatment, at schools. Gardasil prevents four strains of HPV that cause about 7 percent of cervical cancer cases. In announcing that it will provide HPV vaccines for girls, Ontario joins the province of Nova Scotia, which announced its vaccination program for 7th grade girls in June. Prince Edward Island also plans to offer the vaccine to 6th grade girls. Copyright AHN Media Corp - All rights reserved. Redistribution, republication. syndication, rewriting or broadcast is expressly prohibited without the prior written consent of AHN BCG B A HI b 2 6
711 771 1437 1 23 7 5 6 8 1 12 13 CDC 34 1 Outbreak 12 71 b Hib 5 3 7 1987 MMR* 1987 1 1 1 1971 4 7 1987 6 6 * MMR 3 1971 (Pw) (Pa) (Pa) B 1 BCG (<3) Hib Reference: Nature medicine Vo.11, No.4 S12(Table1) 7
83 11 12 Vaccine For Children Cervical Cancer Prevention Vaccinate your daughter, screen yourself! Dr.Kinny (USA) in EUROGIN 7, Monaco 45 46 Thank you for your attention! 8