43 pdf 030720 8 8 15 10-18 00 WS1. Bio MBL
8 8 15 10-18 00 WS2. 80 1996 E-CELL (Tomita 1999) E-CELL E-CELL E-CELL
(metabolome) 13 ``E-CELL: Software environment for whole cell simulation'' Tomita, M., Hashimoto, K., Takahashi, K., Shimizu, T., Matsuzaki, Y., Miyoshi, F., Saito, K., Tanida, S., Yugi, K., Venter, J.C., Hutchison, C.; Bioinformatics, Volume 15, Number 1, 72-84 (1999) Whole cell simulation: A grand challenge of the 21 st century Tomita, M.: Trends in Biotechnology, 19:6, 205-210 (2001) Towards Computer Aided Design (CAD) of Useful Microorganisms Tomita, M.: Bioinformatics 17: 1091-1092 (2002) Computational challenges in cell simulation Takahashi, K., Yugi, K., Hashimoto, K., Yamada, Y., Pickett, C., and Tomita, M.: IEEE Intelligent Systems, Sept/Oct (2002) E-CELL2: Multi-platform E-CELL Simulation System Takahashi, K., Ishikawa, N., Sadamoto, Y., Sasamoto, H., Ohta, S., Shiozawa, A., Miyoshi. F., Naito, Y., Nakayama, Y., Tomita M.: Bioinformatics, in press. http://www.iab.keio.ac.jp http://www.bioinfo.sfc.keio.ac.jp [1]
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1) T. Funatsu, et al.: Nature. 374, 555 (1995). 2) R.D.Vale, et al.: Nature. 380, 451 (1996). 3) H. Taguchi, et al. : Nat Biotechnol. 19, 861 (2001). 4) A. Ishijima, et al.: Cell 92, 161 (1998). 5) Lu HP, et al. : Science 282, 1877 (1998). 8 9 9 00-12 WS5. NPO haklak@haklak.com 50 3 1 2 20 3 40 3 2 " " 3 " 40 40 10 NIH NIH NIH
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Adipose formation by cofactor proteins of nuclear receptors Steroids and related fat soluble hormones regulate complex programs of gene expression via nuclear receptor family of transcription factors. Recent studies have led to the identification of cofactor protein molecules that appear to play important roles in mediating transcription by members of the nuclear receptor family. The present research will investigate the biological roles of cofactor proteins, focusing on adipose (fat) tissue, an important organ for maintaining the energy balance in the human body. The results are expected to provide further insights into the molecular basis and possibility for new treatments of obesity and obesity-linked diseases, such as diabetes mellitus and hypertension.
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