1 2 3 4
5 6 7 Che E, in Cancer: Principles & Practice of Oncology (7th ed) in Devita, 2005 Marangolo M, Oncol Rep, 2006 hryniuk WM, Important Adv Oncol, 1988 8 Cancer: Principles & Practice of Oncology 5th Ed. Devita, 1997
9 Rassnick KM, Vet Comp Oncol, 2010 Vaughan A, JVIM, 2007 Frimberger AE, JVIM, 2006 10 IIIVn= 66 L-CHOP-CCNU-MOPP p= 0.05 L-CHOP Rassnick KM, Vet Comp Oncol, 2010 11 IIIVn= 62 34 Vaughan A, JVIM, 2007 12 IIIVn= 28 VELCAP p= 0.027 Frimberger AE, JVIM, 2006
13 14 CCNU (70mg/m 2 ) CCNU(60mg/m 2 ) CCNU (60mg/m 2 ) CCNU (60mg/m 2 ) SD PR CR Grade4 Seg= 37 Grade4 Seg= 34 Grade4 Seg= 251 Grade4 Seg= 169 821kg 16
17 Ogilvie GK, JAVMA, 1993 18 19!20 PDGFR= VEGFR= PDGF PDGF & PDGFR-β binding VEGF PDGFR-β トセラニブ VEGF & VEGFR-2 binding VEGFR-2 トセラニブ
21 London CA, Vet Compar Oncol, 2011 22 n= 85 % n=32 n=23 n=15 n=8 n=7 London CA, Vet Compar Oncol, 2011 23 n= 85 London CA, Vet Compar Oncol, 2011 24
25!26 27 Samm, 2010 Phillips, 2009 Kow, 2008-13295CI: -211 to -52) Boerman I, BMC Vet Res, 2012 28
!29!30 286 Give Up? Yeah, used to be...!32 286
!33 363!34 412!35 440!36 475
!37 501!38 574 39 40 Lee KW et al., Cancer, 2003
41 Lee KW et al., Cancer, 2003 42 43 44
45 46 n CR CR 9 50% 5 Jeglum KA, JAVMA, 1987 28 32% 7.1 Mahony OM, JAVMA, 1994 50-7.6 Vail DM, JVIM, 1998 21 38% 4.7 Zwahlen CH, JAVMA, 1998 11 64% 8.2 Teske E, JVIM, 2002 10 40% 34.8 Limmer S, VCO, 2014 75 30% 1.7PFI Collette SA, VCO, 2015 * CHOP 47!48 n=20 Gouldin ED, VCO, 2015
49 Rassnick KM, JAVMA, 2001 50 Dank G, Vet Comp Oncol, 2012 51 % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J. 2014 52 % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J. 2014
53 % 1. Moore AS, J Vet Intern Med. 1990, 2. Chun R, J Am Vet Med Assoc. 1996, 3. Knapp DW, Cancer Chemother Pharmacol. 2000, 4. Chun R, Vet Intern Med. 1997, 5. Knapp DW, J Vet Intern Med. 1994, 6. Mutsaers AJ, J Vet Intern Med. 2003, 7. Knapp DW, J Vet Intern Med. 2013, 9. Arnold EJ, J Vet Intern Med. 2011, 12. Robat C, J Small Anim Pract. 2013, 13. Mohammed SI, Cancer Res. 2002, 14. Mohammed SI, Mol Cancer Ther. 2003, 15. Boria PA, Vet Comp Oncol. 2005, 16. Greene SN, J Am Vet Med Assoc. 2007, 18. Marconato L, J Am Vet Med Assoc. 2011, 19. Kaye ME, Vet Comp Oncol. 2013, 20. Schrempp DR, J Am Vet Med Assoc. 2013, 21. Henry CJ, Clin Cancer Res. 2003, 22. Knapp DW, Small Animal Clinical Oncology (5 th ed), 2013, 23. Perazella MA, Semin Nephrol. 2010, 24. Rao P, J Pharm Pharm Sci. 2008, 25. Allstadt SD, J Vet Intern Med 2015, 26. Knapp DW, ILAR J. 2014 55 56
!57!58 60
61 Berg J, Cancer, 1997 62 n= 102) 2 10 15-20mg/m 2 IV 60mg/m 2 ) IV 23 x 3 Berg J, Cancer, 1997 63 n vs. P<0.000012 vs. 10p=0.727 Berg J, Cancer, 1997 64 Berg J, Cancer, 1997
65 Berg J, Cancer, 1997 66 67 adriamycin@mac.com