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01. メ 0303060702 閨0309, 04. メ 04040707080ケ0, 6ム8. 6セ4 03 00 03 閨02090ケ0. 罍ッ 09 06000ク70206026ァ8 02 06 縺0ク707 06020803080906026ァ8 メ03060706026ァ8 09 0700apple06040209006ァ9080ク7 ゙0309070607, 09..03. 00 ゙6メ26メ2ヲミ メ フ0303. 0803076 5000ケ0 02080ク7 08apple0604036ァ9080ク7 6 5fi0303080ク7 ィCDandy Walker 046ヲ007 03080008 ゙03030903080903 086ァ9 : 066ァ900060706 1, 12462 01 0ク8 070306 6メ20903.: 210-5831000, 00040キ302. 2214 e-mail: debtobgyn@attikonhospital.gr メ 02 02 閨03090200 10.4.2005 0309060700 0002026ァ8 25.4.2005 0900036ァ903096 709 To 046ヲ007 03080008 Dandy Walker apple 03080ク7040607ィB0002 06 0000: 1) 06 08fi03080ク7 6 5 03-00086ヲ0 060702 0409 020キ307 02080603060607 02080ク7 00090200080703080ク7, 2) 06 020002 00 閨0709 000009070309 0001 0000076ァ8 02 06 3) 閨030300060000 040208 040206030902 02090ケ0 apple 030009020008 036ァ9 080ケ0 00-040キ3 02080ク7 08apple086ァ9080ク7 09 000009070309 0001 0000076ァ8 00apple06020806070キ307006ァ9 0000 020907 02 閨02 030209 020806036ァ9. 0307 000ク7036ヲ0 08070400 070キ300 03060607 02080ク7 08apple6ァ9040306080ク7 6 5fi0303080ク7 閨040006 apple0003060903 08006ァ9 040キ3036ァ90ケ0 07 0ク7apple070304080ク707 04 086ァ8 020306026ァ80306 060702030604090ケ0 000002 016ヲ0 02080ク70ケ0: 1) 09 0203 040406026ァ8 Dandy Walker 070キ300 036ァ9 apple080ク7 040ク7076ァ90402 02 06 0400 060702 0409 02080ク7 08apple6ァ9040306080ク7 6 5fi0303080ク7, apple036ァ80309 6ァ8 00000306026ァ8 09000700046ァ9 02080ク7 040206030902 02090ケ0 apple 030009020008 036ァ9 0ケ0 02 06 070ク76 70キ300 閨0708 040209076ァ9 0608, 2) 09 apple - 03 0303 096ァ8 02080ク7 Dandy Walker apple080ク7 000008 076ァ9ィB0006 apple0806026ァ90309 0ク7apple08apple03 046ァ9 02080ク7 040206030902 02090ケ0 apple 030009020008 036ァ9 0ケ0 0000 6ァ8 040キ3036ァ90ケ0 060702 0409 02080ク7 08apple6ァ9-040306080ク7 6 5fi0303080ク7), 3) 09 06 020002 00 閨0709 000009070309 0001 0000076ァ8 0000 02 閨03 0608 0208 040206030902 02 06 020907 02 閨02 030209 020806036ァ9. 6ム8apple6ァ904090ケ0 閨040006 apple0003060903 08006ァ9 09 080602080900076ァ80ケ0 09000700046ァ9 02080ク7 040206030902 02090ケ0 apple 030009020008 036ァ9 0ケ0,0208 046ヲ007 03080008 Joubert apple080ク7 040ク70708 006ヲ00002 06 applefi 00apple000604fi 06 0ク7apple000302 apple076ァ9 0ケ0, apple 03080308090602 閨0ケ0 0206076ァ80400060ケ0 020キ307 080803 03000607 02 016ァ9 02 06 0708090206026ァ8 0ク70402 閨03090409. 010キ3036ァ90ケ0 08060208090007 閨0ケ0 06040208030602fi 0208 046ヲ007-03080008 Joubert 0007 00apple0803006ァ9 07 06 02030603006ァ9 applefi 00000008070キ300 閨0709 Dandy Walker 06 02 03 046ァ8. ヌ 070キ300 036ァ9 Arnold Chiari 006ァ907 06 00apple6ァ904090ケ0 6 503076 509 02080ク7 08apple0604036ァ9080ク7 00090200080703080ク7 02 06 apple08020003006ァ902 06 applefi 6ヲ008 0402 閨0309. 6メ208 apple03060208 006ァ907 06 06-08fi03080ク7 6 5 0300086ヲ0 000002 02fiapple060409 060402086ヲ0 apple080ク7 apple0308 閨03040002 06 applefi 0208 02 02060200-0308 02006ァ800 02080ク7 040206030902 02090ケ0 apple 030009020008 036ァ9 0ケ0 040208 04apple0807 0ク7030602fi 0ク7-69

130803076 5000ケ0 02080ク7 08apple0604036ァ9080ク7 6 5fi0303080ク7 ィCDandy Walker 046ヲ007 03080008 メ 0303060702 閨0309 02 06 040ク707. 03fi. 6メ208 006ヲ002000308 006ァ907 06 006ァ9 fi000806 080ク703 6ァ9 000002 02fiapple06-0409 02090ケ0 09 閨080ク703 0ケ0, 02090ケ0 02 閨02 0302090ケ0 020806036ァ9 0ケ0 02 06 02080ク7 apple0308006ァ80209 000ク70003086ヲ0 06 00 閨04080ク7 02080ク7 060706 02086ヲ0 02036ァ800 02080ケ0 040208 04apple0807 0ク7030602fi 0ク703fi. 6セ40ク7076ァ8030キ30ケ0 040ク70708 006ヲ00002 06 0000 0ク7 030802 閨08 0308 02 06 00090706090908000ク7000308026ァ80309. 閨0100060ケ0-02030006 0607: 046ヲ007 03080008 Dandy Walker, 070キ300 036ァ9000ケ0 0607- apple03 04090ケ0 02080ク7 040206030902, 060702 0409 02090ケ0 020002070302090ケ0 020806036ァ9 0ケ0 6ム80604 090キ3096ァ8 ィC ゙07 0208006ァ9 6メ208 046ヲ007 03080008 Dandy Walker apple00030603 006 507070006 0006 0400060307 070キ300 03060607 0806 08apple086ァ9000ケ0 0808006ァ903080702 06 0400 apple 030803080906026ァ8 0707apple020ク70109 02090ケ0 apple 030009020008 036ァ9-0ケ0. 6メ208 046ヲ007 03080008 0ク702fi 006ァ907 06 apple08020003006ァ9 閨07 08070400 06 02 03 040607 apple080ク7 apple0308026ヲ0apple02080ク707 applefi 020907 0ク7apple08apple03 046ァ9 02090ケ0 apple 030009020008 036ァ9 0ケ0 02 06 0209 040ク70708 fi 02 026ァ8 0707apple020ク70109 02090ケ0 02 閨02 0302090ケ0 020806036ァ9 0ケ0. メ0ク7036ァ9 03-0408 006ヲ0030900 006ァ907 06 09 000009070309 060702 0409 02090ケ0 02 閨02 03-02090ケ0 020806036ァ9 0ケ0 02080ク7 00090200080703080ク7,09 08apple086ァ9 000009 0306-070006 02fi0408 apple08036ヲ0 06040200 02 02 03 006 507070006 02 06 06 02006ァ9-070006 020807 08apple6ァ904030608 6 5fi030308. 6セ40ク707 0ク707ィB0002 06 0000 06 08fi03080ク7 6 5 0300086ヲ0 060702 0409 020キ307 apple03 096ァ90キ307 02080603060607 0000 06 020002 00 閨0709 000009070309 0001 0000076ァ8 02 06 閨030300060000 02080ク7 040206030902 02090ケ0 apple - 030009020008 036ァ9 0ケ0 00 閨040キ3 02080ク7 08apple086ァ9080ク7 09 000009070309 00-01 0000076ァ8 00apple06020806070キ307006ァ9 0000 020907 02 閨02 030209 020806036ァ9. 1 6メ2 020003000ク702 6ァ9 0403fi0706 06070808030806 0803060400086ァ9 閨04080ク707 apple030802 03006ァ9 0906 07 09030604080ク707 020907 080007 020キ307 070キ300 03060607 02080ク7 08apple6ァ9040306080ク7 6 5fi0303080ク7 apple080ク7 00080607- ィB080ク707 0000 0208 0203 04040602fi 046ヲ007 03080008 Dandy Walker. フ06 apple0003060404fi0200030806 0803060400086ァ9 apple00030603 006 50707080ク707 02 02fi03080ク703 000ク7036ァ800 02 : 1) 020ク7040206026ァ8 060702 0409 02090ケ0 02 閨02 0302090ケ0 020806036ァ9 0ケ0,2) 0ク70409000700046ァ9 02080ク7 040206030902 02090ケ0 apple 030009020008 036ァ9 0ケ0 02 06 3) 0ク76 709036ァ8 03 閨0409 02080ク7 0402090706 6ァ9080ク7. 6ム8apple6ァ9 02080ク7 apple 03fi0702080ケ0, 08 fi03080ケ0 Dandy Walker 04030904060008apple0806006ァ902 06 0906 07 006ァ9010006 閨07 08070400 070キ300 03060607 02080ク7 08apple6ァ9040306080ク7 6 5fi0303080ク7 0806 08apple086ァ9000ケ0 02 0106070800086ヲ00702 06 applefi 020907 01080706026ァ8 0ク7apple08-03080906040206026ァ8 020800080903 086ァ9 (CT scans) 0キ30ケ0 020803086ヲ0-030キ30ケ0: 1) 0203 040406026ァ8 Dandy Walker 070キ300 036ァ9, ( 060702 0409 02080ク7 08apple6ァ9040306080ク7 6 5fi0303080ク7, apple036ァ803090ケ0 6ァ8 0000-0306026ァ8 09000700046ァ9 02080ク7 040206030902 02090ケ0 apple 030009020008-036ァ9 0ケ0, 070ク76 70キ300 閨0708 040209076ァ9 0608) 2) apple 03 0303 096ァ8 02080ク7 Dandy Walker (apple0806026ァ90309 0ク7apple08apple03 046ァ9 02080ク7 040206030902 02090ケ0 apple 030009020008 036ァ9 0ケ0 0000 6ァ8 040キ3036ァ90ケ0 060702 0409 02080ク7 08apple6ァ9040306080ク7 6 5fi0303080ク7) 02 06 3) 06 0200-02 00 閨0709 000009070309 0001 0000076ァ8 0000 02 閨03 0608 0208 040206-030902 02 06 020907 02 閨02 030209 020806036ァ9 (mega-cisterna magna). 2 ゙07 02 06 08 0ク7 030802 閨08 03080ケ0 閨040006 03000キ3030903006ァ9 fi0206 006ァ9-07 06 閨07 080ク70406 04020602fi 06 09070キ304020602fi 0402080604006ァ908 040208 046ヲ007 03080008 Dandy Walker, apple0608 apple03fi0408 02000ケ0 0000-03 閨02000ケ0 07 08 閨03080ク707 fi0206 02 06 040208 0203 04040602fi 046ヲ007-03080008 09 060702 0409 020キ307 02080603060607 0007 006ァ907 06 apple030キ3-02 03040602fi 006ヲ0030900 02 0207 0209 09 閨0707090409 0402080ク70ケ0 apple00-03060404fi020003080ク70ケ0 04030007006ァ90ケ0 030307 07 apple026ヲ004040002 06 040ク7040707 02080ク70ケ0 apple030602080ク70ケ0 006ァ807000ケ0 02090ケ0 ィB0キ36ァ80ケ0. 3 ヌ 070キ300 036ァ9 Dandy Walker 000008 076ァ9ィB0002 06 0000 040ク70407fi020902 1/ 30000 090007076ァ80400060ケ0 02 06 000ク7036ァ904020002 06 0400 4% 閨0キ30ケ0 12% fi030キ307 020キ307 apple000306apple020604000キ307 070008-09070602086ヲ0 0ク7 030802 閨08 03080ク7. ヌ 040ク70407fi020902 020キ307 apple - 03 0303 090607 02080ク7 040ク707 03fi00080ク7 02 06 02090ケ0 06 020002 00-07090ケ0 0000090703090ケ0 0001 0000076ァ80ケ0 006ァ907 06 0709070キ3040209. 05000キ3-036ァ9000ケ0 0906 020907 apple 030809 閨07000409 apple00030603 006 50707080ク707 020309046ァ9 020キ307 0203090007020キ307 Luschka 02 06 Magendie 07 02 06 0ク70207 00apple0803006ァ9 07 apple 03080ク7040607- ィB080ク707 0207apple0806 06 6 5 02fi020902 02 06 08 6ァ9070002 06 07 0ク7apple0703040006 0ク7apple08apple03 046ァ9 02 06 0207apple0806080ク7 6 5 0300086ヲ0 apple - 030803080906026ァ8 0707apple020ク70109 02090ケ0 apple 030009020008 036ァ9 0ケ0. 4 02 6ァ9070002 06 fi0206 04020907 06026ァ9 0ク7026ァ80ケ0 02090ケ0 02 02070402-04090ケ0 apple 6ァ9ィB080ク707 040900 07020602fi 03fi0308 09000700020602086ァ9 apple 0307-09080702000ケ0. ヌ 070キ300 036ァ9 Dandy Walker 00apple0803006ァ9 07 0808006ァ9030002 06 0400 0000070200030602 閨0ケ0 06 02 03 04 閨0ケ0 02 06 0400 04030キ300 0208040キ300 020602 閨0ケ0 000002 0303070100060ケ0 6ム80707 0007 apple08020003006ァ9 00 閨03080ケ0 07 09070キ303060400 閨07080ク7 040ク707 03fi00080ク7, 08 026ァ907 0ク707080ケ0 00apple 0700000807070604090ケ0 006ァ907 06 1% 閨0キ30ケ0 5%.6セ400 04apple070706000ケ0 apple000306apple02060400060ケ0 09 0403 閨070006 020309-0308070800006ァ902 06 0000 0ク70208040キ300 020602fi 0ク7apple08030006applefi00000708 0203fiapple08. 5 090003066 5 03030807020602086ァ9 apple 030709080702000ケ0, 08030009000807 閨0ケ0 applefi 06086ヲ00ケ0, 036ァ86 709 030208fi03 02 06 06 6 56ァ802090ケ0 02090ケ0 000902 閨03 0ケ0 閨04080ク707 0007080408apple08060903006ァ9 0906 020907 0000080707060409 02080ク7 040ク707 03fi00080ク7. ヌ 02 010607fi00090409 02080ク7 040ク707 03fi00080ク7 閨09060700 02 036ヲ002000309 0000 020907 0008 030008096ァ8 02080ク7 MRI. 縺06 06 08fi03080ク70ケ0 03fi09080ク70ケ0 0806 030300apple0703030903000ケ0 020800 閨0ケ0 apple080ク7 apple 03 080406 0207 04030904060008apple0806086ヲ00702 06 04020907 CT 0007 閨04080ク707 020907 0602 07fi020902 07 00020206006ァ804080ク707 0000 02036ァ96 50006 0208 00 閨090003080ケ0 02080ク7 040206030902 02090ケ0 apple 0300-09020008 036ァ9 0ケ0 02 06 00apple0803086ヲ007 07 0ク7apple0800020206006ァ804080ク707 6ァ8 07 0ク7apple000300020206006ァ804080ク707 0208 00 閨090003080ケ0 0007fi0ケ0 000303006ァ900-00 02080ケ0. ヌ 0001 0603000206026ァ8 0707030ク70409 020キ307 00apple06006ァ8020キ307 00apple06apple - 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030009020008 036ァ9 0ケ0 00 閨04 040208 070602000308 04apple0807 0ク7030602fi 02036ァ800. 6メ208 006ヲ002000308 006ァ907 06 006ァ9 fi000806 080ク703 6ァ9 000002 02fiapple060409 02090ケ0 09 閨080ク703 0ケ0, 02090ケ0 02 閨02 0302090ケ0 020806-036ァ9 0ケ0 02 06 02080ク7 apple0308006ァ80209 000ク70003086ヲ0 06 00 閨04080ク7 02080ク7 0000090703080ク7 02036ァ800 02080ケ0 00 閨04 040208 04apple0807 0ク7030602fi 0ク7-03fi. ゙0ク702fi 040ク7076ァ8030キ30ケ0 040ク70708 006ヲ00002 06 0000 0ク7 030802 閨08-0308 02 06 0009070706090908000ク7000308026ァ80309. 21 ゙07 08 閨030002 06 fi0206 0806 apple0003060404fi020003000ケ0 apple000306apple02060400060ケ0 06040406 086ヲ00ケ0 0307-04090ケ0 00apple06apple03 閨02080702 06 applefi 020907 06 02 03 046ァ8 Arnold Chiari 02 06 fi0206 90 閨0キ30ケ0 95% 0ク7020607 020キ307 040300-070607 apple 03080ク7040607ィB080ク707 0ク7 030802 閨08 0308. 22,23 ヌ 06 02-03 046ァ8 Arnold Chiari apple08020003006ァ9 閨07 07 040900 07020602fi 006ァ9020209 0906 0209 06040406 6ァ8 03070409. 046ヲ008 apple 030809070キ30006-0207 0ク7apple00030904080903 08060207 040900006ァ9 閨04080ク707 apple0003060903-08006ァ9 0906 0209 06 02 03 046ァ8 Arnold Chiari 02 06 006ァ907 06 0208 040900006ァ908 02080ク7 030000080706086ヲ0 fiapple080ク7 00006 507030ク7070409 020キ307 0000020キ3apple06 6ァ90キ307 0804020607 00apple0803006ァ9 07 06040006 006ァ9 04046ァ8-00 02080ケ0 030000080706086ヲ0 06 00fi03080キ30409 040208 0203 076ァ908 02080ク7 apple0308046 5006 5030900 閨07080ク7 00006 5036ヲ0080ク7 0400 00090207030406 0208006ァ8 040209 060703020006 02080ク7 000ク702 閨03080ク7 020306006ァ807080ク7. ヌ 080ク7-03 6ァ9 000002 02fiapple060409 02080ク7 0009020008 030602086ヲ0 060402086ヲ0 08 6ァ9-070002 06 07 apple 0307090006 0ク7026ァ8 020907 00006 507030ク7070409. ヌ 0000-02 02fiapple060409 02090ケ0 apple 030009020008 036ァ9 080ケ0 apple 03 0008030806-070006 02 0900060408 6ァ90306 02090ケ0 (02 08apple086ァ9 040707080ク707 0208 0408 06030602fi 02080ク70ケ0 04046ァ800 ) 096ァ907080702 06 00apple6ァ9apple00, 09 0000-09070309 0001 0000076ァ8 040ク700apple06 險B0002 06 02 06 0208 0007026ヲ0apple0キ300 02080ク7 040206030902 08 6ァ9070002 06 apple0003060404fi02000308 040ク7070004 閨0ケ0 02 06 apple0308026ヲ0apple020006 0208 040900006ァ908 02090ケ0 00apple 070707 0ケ0, 0208 08apple086ァ908 00apple0803006ァ9 07 08 07006ァ9 applefi 0208 apple03060208 02036ァ90009-0708. 24 6セ400 0203 6ァ9000ケ0 apple000306apple02060400060ケ0 02 apple 030009020008-0306 060207 0900060408 6ァ90306 00apple0803006ァ9 07 000907 000008 076ァ9ィB08-0702 06 02 0207 0209 060703020006 02080ク7 0ク7apple00030904080903 080602086ヲ0 0003 閨0904080ク7 02090ケ0 020008 036ァ80ケ0 02080ク7 00006 5036ヲ0080ク7. ゙0ク7026ァ8 09 04 03 0202090306040206026ァ8 0ク7apple00030904080903 0806026ァ8 0000080707060409 73

130803076 5000ケ0 02080ク7 08apple0604036ァ9080ク7 6 5fi0303080ク7 ィCDandy Walker 046ヲ007 03080008 メ 0303060702 閨0309 02 06 040ク707. apple03 鐶pple0006 07 020607090208apple08066ァ8040006 020807 0ク7apple00030904080903 0806-04026ァ8 0906 07 6 707010006 0906 06040406 6ァ8 03070409. 25-28 Posterior fossa abnormalities ィC Dandy Walker Syndrome Ch. メallideri, D. メassanos, 6ム8. 6セ4alamalekis 3rd Department of Obstetrics and Gynaecology, University of Athens P.G.N. アAttikon ア, Athens, Greece A03030903080903 086ァ9 : D. Kassanos 1 Rimini str., 12462 Chaidari, Greece 6メ2el.: 210-5831000, direct: 2214 E-mail: debtobgyn@attikonhospital.gr Summary Dandy Walker syndrome indicates the association of 1) ventriculomegaly of variable degree 2) a large cisterna magna 3) a defect in the cerebellar vermis through which the cyst communicates with the fourth ventricle. A wide spectrum of anomalies of the posterior fossa have been described but there are no clear criteria of distinction between them 1) classic Dandy Walker malformation, (enlarged posterior fossa, complete or partial agenesis of the cerebellar vermis and elevated tentorium) 2) the Dandy Walker variant (variable hypoplasia of the cerebellar vermis with or without enlargement of the posterior fossa) and 3) megacisterna magna (enlarged cisterna magna with integrity of both cerebellar vermis and fourth ventricle). Familial agenesis of the cerebellar vermis with episodic hypercapnia, abnormal eye movements, ataxia and early death define Jouberts syndrome. Without a family history of Jouberts syndrome, familial agenesis of cerebellar vermis would not be distinguishable sonographically from an isolated Dandy Walker malformation. The Arnold Chiari malformation is an anomaly of the hindbrain, with two components. The first a variable displacement of tissue derived from the inferior cerebellar vermis into the upper cervical canal. The second a similar caudal dislocation of the pons, the fourth ventricleand mededulla oblonganda to the spinal canal. Usually is associated with hydrocephalus and spina bifida. Key words: Dandy Walker syndrome, abnormalities of the vermis, enlargement of the fourth ventricle 08066 50306080903 086ァ9 1) Nyberg, D.A, Cyr, D.R., and Mack, L.A. The Dandy Walker malformation: prenatal sonographic diagnosis and its clinical significance. J Ultrasound Med.1988., 7:65. 2) Harwood Nash D, Fitz C: Neuroradiology in infants and Children, 1976 vol.3 St Louis CV Mosby. 3) Hirsch JF, Pierre-Kahn A, Renier D, et al,: The Dandy Walker malformation: A review of 40 cases.1984.j Neurosurg61:515. 4) Warkany, J., Lemire, R.J., and Cohen., M.M: Mental retardation and Congenital Malformations of the central Nervous System. Chicago: Year Book1981.Pp61-63. 5) Ecker JL, Shipp TD, Bromley B, Benacerraf B: The sonographic diagnosis of Dandy Walker and Dandy Walker variant: associated findings and outcomes. Prenat Diagn.2000 Apr;20(4):328-32. 6) Murray JC, Johnson JA, Bird TD: Dandy Walker malformation: Etiologic heterogeneity and empiric recurrence risks.1985.clin.genet28:272. 7) Pilu G, Goldstein I, ReeceE, et al: Sonography of fetal Dandy Walker malformations: A reappraisal. UltrasoundObstetGynecol1992., 2:151. 8) Archiron R, Archiron A: Transvaginal ultrasonic assessment of the early fetal brain. Ultrasound Obstet Gynecol.1991.,1:336. 9) Russ,P. D. Pretorius, D.H., and Johnson, M.J. Dandy Walker syndrome: a review of fifteen cases evaluated by prenatal sonography. Am.J ObstetGynecol1989.,161:401 10) Pilu, G., et al Antenatal diagnosis and Obstetric management of Dandy Walker syndrome J Reprod. Med.1986.,31:1017. 11) Nyberg DA, Mahony BS, Heegge FN, et al: Enlarged 74

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