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1) Roth, J., Glick, S. M., Yalow, R. S. and Berson, S. A.: Hypoglycemia: A potent stimulus to secretion of growth hormone. Science, 140, 987-988, 1963. 2) Ogawa, N.: Routine Ultramicro-Measurement of Human Growth Hormone in Plasma by Solid- Phase Radioimmunoassay. Endocrinol. Jap., 20, 587-594, 1973. 3) Cryer, P. E. and Daughaday, W. H.: Regulation of Growth Hormone Secretion in Acromegaly. J. Clin. Endocrinol., 29, 386-391, 1969. 4) Frantz, A. G. and Babkin, M. T.: Human growth hormone. New Engl. J. Med., 271, 1375-1381, 1964. 5) Ogawa, N.: Stimulation tests of human growth hormone secretion by insulin, lysine vasopr essin, pyrogen and glucagon. Acta Med. Okayama., 28, 181-197, 1974. 6) Hartog, M., Graafer, M. A., Meisser, B. and Fraser, R.: Immunoassay of serum growth hormone in acromegalic patients. Brit. Med. J., 2, 1229-1232, 1964. 7) Roth, J., Glick, S. M., Yallow, R. S. and Berson, S. A.: Secretion of human growth horm one: Physiologic and experimental modification. Metabolism., 12, 577-579, 1963. 8) Glick, S. M., Roth, J., Yalow, R. S. and Berson, S. A.: The regulation of growth hormone secretion. Recent Prog. Horm. Res., 21, 241-270, 1965. 9) Greenwood, F. C., Stewart, H. J., Forrest, A. P. M. and Wood, R. G.: Plasma growth-hormone levels in untreated acromegaly and after radioactive implants into the pituitary. Lancet, 2, 555-558, 1965. 10) Burgress, J. A., Smith, B. R. and Merimee, T. J.: Growth hormone in thyrotoxicosis: Effect of insulin-induced hypoglycemia. J. Clin. Endocr., 26, 1257-1260, 1966. 11) Rosenfeld, P. S., Wool, M. S. and Danforth, E. Jr.: Growth hormone response to insulininduced hypoglycemia in thyrotoxicosis. J. Clin. Endocr., 29, 777-780, 1969. 12) Giustina, G., Reschini, E., Valetini, F. and Cantalamessa, L.: Growth hormone and cortisol responses to insulin-induced hypoglycemia in thyrotoxicosis. J. Clin. Endocr., 32, 571-574, 1971. 13) Brauman, H. and Corvilainn, C.: Growth hormone response to hypoglycemia in myxedema. J. Clin. Endocr., 28, 301-304, 1968. 14) Katz, H. P., Youlton, R., Kaplan, S. L. and Grumbach, M. M.: Growth hormone. III. Growth hormone release in children with primary hypothyroidism and thyrotoxicosis. J. Clin. Endocr., 29, 346-351, 1969. 15) Hartog, M., Graafer, M. A. and Fraser, R.: Effect of corticosteroids on serum growth hor mone. Lancet, 2, 376-379, 1964.

Regulation of Human Growth Hormone Secretion in Patients with Various Endocrine and Metabolic Disorders Norio OGAWA, Jiro TAKAHARA and Tadashi OFUJI Third Department of Internal Medicine, Okayama University Medical School, Okayama, Japan. (Director: Prof. T. Ofuji) The basal plasma human growth hormone (HGH) levels and the plasma HGH response to insulin in 126 patients with various endocrine and metabolic disorders have been compared with the results found in 40 control subjects. In patients with acromegaly and anorexia nervosa, basal plasma HGH concentrations are high and fluctuated widely when measured frequently in their clinical courses. In all patients with panhypopituitarism, pituitary dwarfism, Cushing's syndrome and hypot hyroidism, an absent HGH response to insulin-induced hypoglycemia was obtained. The HGH response to insulin proved of value in differentiating patients with hypothalamic or pituitary hypofunction and those with anorexia nervosa.

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