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インターロイキン インターロイキンは リンパ球や単球 マクロファージなどの免疫反応への寄与が知られる白血球から産生されることから 細胞間 ( inter-) 白血球 ( leukocyte -leukin) より Interleukin と名づけられました 現在までに 30 種類以上のインターロイキンが同定され 発見された順番に番号が付与されており 中にはケモカイン ( IL-8) やインターフェロン ( IL-28/29) など他のサイトカインにも分類されているインターロイキンもあります 各インターロイキンは 各々産生白血球から産生されると標的細胞の細胞表面に発現する受容体に結合します インターロイキン類は主に I 型サイトカイン受容体を選択します 受容体は γ c gp130 といったいくつかのサイトカインで共有される受容体や IL-6R といったそれぞれのサイトカインで選択される受容体とのヘテロ二量体 ヘテロ三量体 もしくはホモ二量体を形成し リガンドであるインターロイキンと相互作用します このような受容体を介し 標的細胞となる T 細胞 B 細胞などの活性化 さらに抗体産生亢進 分化 増殖誘導 炎症誘導 / 抑制などの生理作用を発現します

No. Interleukin-1, Human, recombinant (IL-1) -1,, IL-1 T (LAF) IL-1 IL-1 62 ICE 0.1ng/g ED 50 0.001ng/mL 110 9 units/mg D10S 094-04561 10g 39,000 090-04563 1mg / / -20 18.0kDa 1) March, C.J. et al.nature, 315, 641 (1985) 2) Kobayashi,Y. et al.j.immunol., 140, 2279(1988) 3) Dinarello, C.A et al.blood, 77, 1627(1991) Interleukin-1, Mouse, recombinant (IL-1) -1,, 097-04671 10g 39,000 0.1ng/g ED 50 0.002ng/mL 510 8 units/mg D10S 1) March, C. J. et al.nature, 315,641-647 (1985) 2) Kobayashi, Y. et al.j. Immunol., 140,2279-2287 (1988) 3) Rausch, U. P. et al.cytokine, 6,504-511 (1994) 4) Dinarello, C. A. et al.blood, 77,1627-1652 (1991) 5) Beuscher, H. U. et al.j. Exp. Med, 175,1793-1797 (1992) 6) Blumberg, B. M. et al.virus Res., 32,253-267 (1994) / / -20 17.9kDa Interleukin-1, Rat, recombinant (IL-1) -1,, 094-04941 10g 39,000 0.1ng/g ED 50 0.005ng/mL 210 8 units/mg D10S Interleukin-1, Human, recombinant (IL-1) -1,, IL-1 IL-1 Toll-like Receptor IL-1 IL-1 TypeI IL-1R IL-1R IL-1R AcP IL-1 IL-1 62% IL-1 IL-1 0.1ng/g ED 50 0.001ng/mL 110 9 units/mg D10S / / -20 17.7kDa 095-04611 10g 39,000 091-04613 1mg / / -20 1) March, C. J. et al.nature, 315, 641-647 (1985) 2) Thonberry, N. A. et al.nature, 356,768-774 (1992) 3) Rausch, U. P. et al.cytokine, 6, 504-511 (1994) 4) Dinarello, C. A. et al.blood, 77, 1627-1652 (1991) 5) Beuscher, H. U. et al.j. Exp. Med, 175,1793-1797(1992) 6) Blumberg, B. M. et al.virus Res., 32,253-267(1994) マウスラットヒト動物由来物フリー大入り包装をご希望の方は当社までお問合せ下さい

No. Interleukin-1, Human, recombinant, Animal-derived-free (IL-1) -1,,, 090-06121 10g 39,000 096-06123 1mg 0.1ng/g 17.3kDa ED 50 0.001ng/mL110 9 units/mg / D10S / -20 Interleukin-1, mouse, recombinant (IL-1) -1, 0.1ng/g ED 50 0.002ng/mL 510 8 units/mg D10S Interleukin-1, Rat, recombinant (IL-1) -1,, 0.1ng/g ED 50 0.1ng/mL D10S 1) Liu, C. et al.j. Interferon Res., 15, 985 (1995) Interleukin-2, Human, recombinant (IL-2) -2,, 094-04681 10g 39,000 090-04683 1mg / / -20 17.5kDa 092-04263 10g 39,000 IL-2 T T CD4 + T naive B in vitro CD4 + CD8 + T T in vivo CD4 + CD25 + Treg LAKNK T IL-2 IL-2 56% 66% 0.1ng/g ED 50 0.1ng/mL 110 7 units/mg CTLL-2 Interleukin-2, Human, recombinant, Animal-derived-free (IL-2) -2,,, / / -20 17.3kDa 097-03951 50g 39,900 093-03953 1mg / / -20 15.5kDa 1) Gillis, S. et al.j. Immunol., 120, 2027 (1978). 2) Fukuse, S. et al.int. Arch. Allergy Immunol., 99,411 (1992). 093-05751 50g 39,000 099-05753 1mg 0.1ng/g 15.5kDa ED 50 0.1ng/mL / CTLL-2 / -20 Interleukin-2, mouse, recombinant (IL-2) -2,, 090-04421 20g 39,000 0.1ng/g ED 50 0.2ng/mL 510 6 units/mg CTLL-2 / / -20 17.2kDa

No. Interleukin-2, Rat, recombinant (IL-2) -2,, 134 15.3k 0.1ng/g ED 50 0.4ng/mL 2.510 6 units/mg CTLL-2 Interleukin-3, Human, recombinant (IL-3) -3,, 091-04951 20g 39,000 IL-3 T - IL-3 29% 0.1ng/g ED 50 0.1ng/mL 110 7 units/mg TF-1 Interleukin-3, Human, recombinant, Animal-derived-free (IL-3) -3,,, / / -20 15.3kDa 092-04621 10g 39,000 098-04623 1mg / / -20 15kDa 1) Fung, M. C. et al.nature, 307,233 (1984) 2) Yokota, T. et al.proc. Natl. Acad. Sci. USA, 81, 1070 (1984) 3) Just, U. et al.cell, 64, 1163 (1991) 090-05761 10g 39,000 096-05763 1mg 0.1ng/g 15kDa ED 50 0.1ng/mL 110 7 units/mg / TF-1 / -20 Interleukin-3, Mouse, recombinant (IL-3) -3,, 0.1ng/g ED 50 0.05ng/mL 210 7 units/mg M-NFS-60 Interleukin-3, Mouse, recombinant, Animal-derived-free (IL-3) -3,,, 091-03971 10g 39,900 097-03973 1mg / / -20 15.1kDa 097-06131 10g 39,000 093-06133 1mg 0.1ng/g 15.1kDa ED 50 0.05ng/mL 210 7 units/mg / M-NFS-60 / -20 Interleukin-3, Rat, recombinant (IL-3) -3,, 098-04961 10g 39,000 144 16.3k 0.1ng/g ED 50 10ng/mL 1.010 5 units/mg MC-9 / / -20 16.3kDa マウスラットヒト動物由来物フリー大入り包装をご希望の方は当社までお問合せ下さい

No. Interleukin-4, Human, recombinant (IL-4) -4,, IL-4 T NK-T naive CD4 + T GA TA-3 Th2 IL-4,IL-5,IL-6,IL-10 IL-13 IgM IgG1 IgE Th2 IL-4 IgE IL-4 GATA-3 IL4 55% 39% 43% 0.1ng/g ED 50 0.2ng/mL 510 6 units/mg TF-1 Interleukin-4, Human, recombinant, Animal-derived-free (IL-4) -4,,, 098-03964 20g 39,000 090-03963 1mg / / -20 14.9kDa 1) Howard, M. et al.j. Exp. Med.,155, 914 (1982) 2) Yokota, T. et al.proc. Natl. Acad. Sci. USA, 83, 5894 (1986) 3) Ambrus, J. L., Jr. et al.j. Immunol., 141, 861 (1988) 4) Ryan, D. H. et al.j. Immunol., 152, 5250 (1994) 095-05733 20g 39,000 093-05734 1mg 0.1ng/g 14.9kDa ED 50 0.2ng/mL 510 6 units/mg / TF-1 / -20 Interleukin-4, Mouse, recombinant (IL-4) -4,, 0.1ng/g ED 50 2.0ng/mL 510 5 units/mg HT-2 Interleukin-4, Mouse, recombinant, Animal-derived-free (IL-4) -4,,, ED 50 2.0ng/mL 510 5 units/mg HT-2 Interleukin-4, Rat, recombinant (IL-4) -4,, 094-03944 20g 39,000 096-03943 1mg / / -20 13.5kDa 090-06621 20g 39,000 096-06623 1mg / / -20 13.5kDa 094-04463 20g 39,000 0.1ng/g LPS TNF- MIP-2 14.0kDa 1) Richter, G. et al.cytokine, 2, 221(1990) / 2) McKnight, A.J. et al.eur.j.immunol., 21, 1187(1991) / -20

No. Interleukin-5, Human, recombinant (IL-5) -5,, Th2 IL-5 c c IL-3, GM-CSF IL-5 IL-5 0.1ng/g ED 50 0.15ng/mL 6.610 6 units/mg TF-1 Interleukin-6, Human, recombinant (IL-6) -6,, 096-06341 10g 39,000 IL-6 IL-1 TNF- IL-6 T T B B IL-3 IL-6 gp130 IL-6 (PCT-GF)IFN- 2 B B (BSF-2) (HSF)/ 1(IL-HP1) IL-6 41% 0.1ng/g ED 50 0.1ng/mL 110 7 units/mg 7TD1 Interleukin-6, Human, recombinant, Animal-derived-free (IL-6) -6,,, / / -20 26.0kDa(homodimer) 099-04631 20g 39,000 095-04633 1mg / / -20 20.9kDa 1) Hirano, T. et al.nature, 324:73-76 (1986) 2) Van Snick, J.Annu. Rev. Immunol.,, 8:253-278(1990) 3) Muraguchi, A. et al.j. Exp. Med., 167:332-344(1988) 098-06041 20g 39,000 094-06043 1mg 0.1ng/g 20.9kDa ED 50 0.1ng/mL 110 7 units/mg / 7TD1 / -20 Interleukin-6, Mouse, recombinant (IL-6) -6,, 0.1ng/g ED 50 0.02ng/mL 510 7 units/mg IL-6 7TD1 1) Ikebuchi,K. et al.proc.natl.acad.sci.usa, 84, 9035 (1987) 2) Muraguchi,A. et al.j.exp.med., 167, 332 (1988) 3) Suematsu,S. et al.proc.natl.acad.sci.usa, 86, 7547 (1989) 4) Van Snick, J. et al.annu.rev.immunol., 8, 253 (1990) 5) Poli,V. et al.embo J., 13, 1189 (1994) 6) Kopf,M. et al.nature, 368, 339 (1994) 093-04433 10g 39,000 091-04434 1mg 21kDa / / -20 マウスラットヒト動物由来物フリー大入り包装をご希望の方は当社までお問合せ下さい

No. Interleukin-6, Rat, recombinant (IL-6) -6,, 0.1ng/g ED 50 0.01ng/mL 110 8 units/mg IL-6 7TD1 1) Northemann, W. et al.j. Biol. Chem., 264, 16072(1989) Interleukin-7, Human, recombinant (IL-7) -7,, IL-7 B sig B T CD4 + CD8 + CTL( T) LAK() (IL-1,IL-6,TNF-,MIP-1) IL-2 IL-7 IL-2 IL-7 65% 0.1ng/g ED 50 0.5ng/mL 210 6 units/mg 2E8 Interleukin-7, Human, recombinant, Animal-derived-free (IL-7) -7,,, 093-04271 10g 39,000 / / -20 21.7kDa 096-04641 10g 39,000 / / -20 17.4kDa 1) Namen, A. E. et al.nature, 333, 571-573 (1988) 2) Chazen,G.D.et al.proc. Natl. Acad. Sci. USA, 86:5923-5927 (1989) 3) Colon, P. J. et al.blood, 74, 1368-1373 (1989) 4) Muegge, K. et al.science, 261,93-95 (1993) 5) Grabstein, K. H. et al.j. Exp. Med, 178:257-264 (1993) 094-06641 10g 39,000 090-06643 1mg 0.1ng/g 17.4kDa ED 50 0.5ng/mL 210 6 units/mg / 2E8 / -20 Interleukin-7, Mouse, recombinant (IL-7) -7,, 090-04443 10g 39,000 0.1ng/g ED 50 0.2ng/mL 510 6 units/mg 2E8 / / -20 15.0kDa Interleukin-8 (endothelial cell-derived), Human, recombinant (IL-8) -8(),, 091-04331 25g 39,000 IL-8 CXCin vitro Tcell 77 0.1ng/g 25.0-150.0ng/mL 1) Gimbron, Jr. et al.science, 246, 1601 (1989) 2) Schroder, J. et al.j.immunol., 144, 2223 (1990) / / -20 8.9kDa

No. Interleukin-8 (monocyte-derived), Human, recombinant (IL-8) -8(),, 098-04341 25g 39,000 72 0.1ng/g 10-100ng/mL 8.4kDa 1) Gimbrone, Jr. et al.science, 246, 1601 (1989) / 2) Schroder, J. et al.j. Immunol., 144, 2223 (1990) / -20 Interleukin-9, Human, recombinant (IL-9) -9,, 098-06161 10g 39,000-9 Th T T- IL-9 IL-9 0.1ng/g ED 50 0.2ng/mL 510 6 units/mg MO7e / / -20 14.0kDa Interleukin-10, Human, recombinant (IL-10) -10,, 093-04651 10g 39,000 IL-10 CD4 + T T B B 18.6kDa / T B IgG / -20 IL-10 72%86% IL-10 IL-10 0.1ng/g 1) Moore, K. W. et al.annu. Rev. Immunol., 11:165-190 (1993) 2) Viere, P. et al.proc. Natl. Acad. Sci. USA, 88:1172-1176 (1991) ED 50 2ng/mL 510 5 units/mg IL-4 MC/9 Interleukin-10, Mouse, recombinant (IL-10) -10,, 0.1ng/g ED 50 2ng/mL 510 5 unit/mg IL-4 MC/9 / Interleukin-10, Rat, recombinant (IL-10) -10,, 0.1ng/g ED 50 10ng/mL T 091-04691 10g 39,000 097-04693 500g / -20 18.7kDa 092-04981 10g 39,000 / / -20 18.7kDa マウスラットヒト動物由来物フリー大入り包装をご希望の方は当社までお問合せ下さい

No. Interleukin-11, Human, recombinant (IL-11) -11,, IL-11 IL-3 IL-6 IL-3 0.1ng/g ED 50 2.0ng/mL 510 5 units/mg T11 1) Paul,S.R.et al.proc.natl.acad.sci.usa,87,7512 (1990) 2) Mckinley,D.et al.genomics,13,814 (1992) 090-04281 10g 39,000 096-04283 1mg / / -20 19.5kDa Interleukin-12, Human, recombinant (IL-12) -12,, 096-05361 10g 39,000 IL-12 p40( 40,000) p35( 35,000) 2 /B IL-12 NK,CD4 + CD8 + INF- IL-12 p40 70%p35 60% IL-12 0.1ng/g ED 50 1.0ng/mL 110 6 units/mg IL-18 NK IFN- CHO / / -20 75.0kDa(heterodimer) Interleukin-12, Mouse, recombinant (IL-12) 12,, 095-05331 10g 39,000 0.1ng/g ED 50 0.1ng/mL 110 7 units/mg CHO IL-18 INF- / Interleukin-12 p40, Human, recombinant (IL-12 p40) -12 p40,, IL-12 p40( 40,000) P40 p35 IL-12 p19 IL-23 0.1ng/g Interleukin-12 p40, Mouse, recombinant (IL-12 p40) -12 p40,, 0.1ng/g / -20 75.0kDa 095-05191 10g 39,000 CHO / / -20 40.0kDa 098-05201 10g 39,000 CHO / / -20 40.0kDa

No. Interleukin-13, Human, recombinant (IL-13) -13,, IL-13 IL-13 57% 59% / 114 12.5kDa / -20 0.1ng/g ED 50 1.0ng/mL 110 6 units/mg TF-1 091-05171 10g 39,000 097-05173 1mg 12.5kDa Interleukin-13, Mouse, recombinant (IL-13) -13,, 111 12.3kDa 0.1ng/g ED 50 4.0ng/mL 2.510 5 units/mg TF-1 098-05181 10g 39,000 094-05183 1mg 12.3kDa / / -20 Interleukin-13 Variant, Human, recombinant (IL-13 Variant) -13,, 091-05051 10g 39,000 IL-13 112 114 0.1ng/g IL-13 IL-13 2 STAT6 in vitro A201.1 IL-13 / / -20 Interleukin-16, Human, recombinant, Animal-derived-free (IL-16) -16,,, 094-06141 10g 39,000 090-06143 1mg IL-16 HIV-1 CD8 + T CD4 + T CD4 + 0.1ng/g 50.0-1,000.0ng/mL / / -20 12.4kDa Interleukin-17, Human, recombinant (IL-17) -17,, 099-05091 25g 39,000 IL-17 AF 6 IL-17 136 15.5kDa CD4 + T 0.1ng/g ED 50 2.0ng/mL 510 5 units/mg IL-6 / / -20 31.0kDa(homodimer) マウスラットヒト動物由来物フリー大入り包装をご希望の方は当社までお問合せ下さい

No. Interleukin-17F, Human, recombinant (IL-17F) -17F,, IL-17F 134 30.1kDa T PBMC 0.1ng/g Interleukin-19, Human, reocmbinant (IL-19) -19,, 098-05061 10g 39,000 / / -20 30.1kDa(homodimer) 092-05101 10g 39,000 IL-19 154 17.9kDa IL-10 21% IL-19 IL-19 69% IL-19 / IL-19 / -20 0.1ng/g IL-19 STAT- 17.9kDa Interleukin-20, Human, recombinant (IL-20) -20,, 099-05111 10g 39,000 IL-20 153 17.6kDa IL-20 IL-10 28% IL-20 77% IL-20 0.1ng/g IL-20 STAT- Interleukin-22, Human, recombinant (IL-22) -22,, IL-22 147 16.8kDa IL-22 in vitro in vivo IL-22 IL-22 79% 0.1ng/g IL-22 STAT / / -20 17.6kDa 096-05121 10g 39,000 / / -20 16.8kDa Interleukin-23, Human, recombinant (expressed in Insect Cells), Solution (IL-23) -23,, (), 092-06441 10g 39,000 098-06443 200g p40 (IL-12p40) p19 (IL-23p19) p40 p35 IL-12 Sf+ IL-23 IL-12 IL-12 Th1 IL-23 Th17 / IL-23 T CD4 + T / -80 Th17 10EU/mL ED 50 0.3ng/mL IL-17 60kDa

No. Interleukin-23, Mouse, recombinant (expressed in Insect Cells), Solution (IL-23) -23,, () 10EU/mL ED 50 0.3ng/mL IL-17 Interleukin-31, Mouse, recombinant (IL-31) -31,, 099-06451 10g 39,000 095-06453 200g Sf+ / -80 / 65kDa 099-05471 10g 39,000 T IL-31 IL-6,Oncostatin M,LIF Cardiotrophin-1 IL-31 GPLgp130-like,IL-31RA OSMRM / GPL/OSMR / -20 STAT3 STAT5 STAT1,Jak1 Jak2 IL-31 31% 63% 0.1ng/g 15.8kDa Interleukin-33, Human, recombinant (IL-33) -33,, 099-05611 10g 39,000 IL-33 IL-1 IL-1 ST2 NFB MAP IL-33 IL-4IL-5 IL-13 Th2 / / -20 IL-33 52% 58% IL-33 IL-1 20% 0.1ng/g ED 50 0.05ng/mL 210 7 units/mg D10S 17.9kDa No. Interleukin-1Receptor Antagonist, Human, recombinant (IL-1R) -1,, 093-05991 100g 39,000 IL-1RIL-1 IL-1 (type I/II IL-1R) IL-1 IL-1 IL-1 0.1ng/g ED 50 20-40ng/mL IL-1 50pg/mL D10S IL-1 / / -20 17.2kDa マウスラットヒト動物由来物フリー大入り包装をご希望の方は当社までお問合せ下さい

No. Interleukin-2 Receptor soluble, Human, (expressed in Insect Cells) (sil-2r) -2,, 096-06081 25g 39,000 IL-2 B NK IL-2 IL-2R,IL-2R IL-2R IL-2R IL-2R IL-2R IL-2R IL-2R IL-2 IL-2 IL-2R T B 0.1ng/g ED 50 0.5-1.5g/mL 1ng/mL Il-2 CTLL-2 IL-2 Hi-5 / / -20 31kDa Interleukin-4 Receptor soluble, Human, recombinant (sil-4r) -4,, 099-06071 15g 39,000 IL-4 B T IL-4 c IL-4R IL-13R IL-4R 2 2 IL-4RIL-4 CD4 + T IgM IgG1IgE 0.1ng/g ED 50 5.0ng/mL 210 5 units/mg 0.5ng/mL IL-4 IL-4 TF-1 Interleukin-6 Receptor soluble, Human, recombinant (sil-6r) -6,, HEK293 / / -20 45.0kDa 090-06001 20g 39,000 IL-6 IL-6 IL-6 (IL-6R)gp130 IL-6 IL-6R gp130 IL-6 gp130 IL-6RIL-11,IL-27,IL-31, M,LIF, (CNTF) IL-6 0.1ng/g ED 50 5.0ng/mL rhil-6 20ng/mL M1 IL-6 HEK293 / / -20 37.6kDa