L- 11 12 13 15 15 17 17 18 21 23 25 25 27 29 29 30 31 32 32 33

36 36 36 37 37 37 38 39 39 40 42 42 45 46 48 10 48 11 49 11 50 50 50 51 51 51 51 52 52 53 53-54 12 55 55 57

28 3 6 4 8 7 6 100% 3 30 p.5760 12 10 11 8 9 1

2

OH 5000 p.4, 90 1994 10 1995, 3

4

R1=OH,R2=OH,R3=OH, 配糖体 = ブドウ糖 : デルフィニジングルコシド R1=OH,R2=OH,R3=H, 配糖体 = ブドウ糖 : シアニジングルコシド R1=OH,R2=OH,R3 =OCH 3, 配糖体 = ブドウ糖 : ペチュニジングルコシド R1= OCH 3,R2=OH,R3=H, 配糖体 = ブドウ糖 : ぺオニジングルコシド R1= OCH 3,R2=OH,R3 =OCH 3, 配糖体 = ブドウ糖 : マルビジングルコシド 5

DNA SOD OH, 100mg 12 140230ng/ml 1% - E 100 1 C 500 1 6

FDA Vol.34No.6p.21291999 Laura BravoNutrition ReviewsVol.56N0.11p.3173331998 19991999 No.216p.15191996 New Food industoryvol.40no.10p.39451998 p.6536691996 1993 No.264p.24312000 FRAGRANCE JOURNALVol.25No.4p.63691997 10New Food industoryvol.41no.7p.161999 11 1988 12 Vol.31No.2p.46471996 13Vol.73No.5p.5325341999 14 p.2382411991 15 10 1999 16 8 5 7

30 C () 100ml 100g Folin-Ciocalteu 660nm (+)- 1520% 100ml 5585mg 1.5 8

26.259.8mg/100ml 1 1 340ml 180290mg 100g 50540mg 10.8 1 5 1625g 1 15 110mg 100g 8501800mg 1750mg/100g 850mg/100g 2.1 1 2529g 200500 9

mg 100g 10503450mg 2000mg/100g 2700mg/100g 1300mg/100g 2.1 1 1 1323g 200 650mg 100ml 250450mg 2 4 300450mg/100ml 350mg/100ml 3 250mg/100ml 250mg/100ml 1.5 1 180ml 1 400 800mg 1 100ml 50320mg 100% 6.4 70320 mg/100ml 4 1 1 140300ml 90 100%450mg 5 10

11 8 9 10 100g 50mg 2 2 100ml 205mg C 47mg/100ml 2 1 180ml 370mg 1 1 1000mg 3703 1110mg 3050mg/100g - - C HPLC C 26.2 59.8 mg/100g 5.5 mg/100g029 mg/100g 4 7mg/100g 11

4565% HPLC 5 12

HPLC HPLC HPLC HPLC HPLC 73.9 74.3% 30.131.3%12.753.9% 11 HPLC HPLC 1 13

1.6 8.813.8mg/100ml 11.6 5.0 58.0mg/100g 41.5 44.7 mg/100ml 3 8 HPLC HPLC 2.6 240620mg/100g 2.3 390910mg/100g 14

34.940.8%9.815.1%1 2529g 8.7 11.4g 1 1323g 2.0 3.0g 30 HPLC 9 15

3 60.583.6% 36.0 50.1% 43.265.8%1 5 1625g 9.720.9 g 10.1 12.5g 1 6.9 15.1 g 0.35g/kg 7 8 17 mg/100ml0.080.17g/kg 17

O SOSA SOD SOD SOSA 720 960 units/g 170 4100units/g 580 2500units/g 490 18

2300units/g 4301300 units/g 90 100%770units/g 60 19

190units/g 1700 1900 units/g SOSA SOSA SOSA SOD SOSA SOSA unit/g 20

21

TBA 60 18 IC50g ml/ml50% Inhibitory concentration 12 1ml g ml log(ic50) 30 2 log(ic50) 5 1.03 1.16 22

0.07 2.00 2.592.84 2.57 2.93 0.96 2.03 0.34 100%1.59 log(ic50) SOSA TBA C E TBA -3 -- - 3 23

13 TBA - 2 24

30 19 14 19 14 3 2 4 4 1 15 25

26

10% 30 12 1 3 4 1 3 16 7 100% & 5 8 27

100% & 20% ウ 28

28 358 255 358 100g ml 32

30 33

34

63 13 1188 19 55 1288 6 50 5 2 1 1 3 2 1 20 38 10 77 35

28 4832 34.6% 51.2% 85.8% 20 48.7% 60 91.7% 36

66.6% 33.4%3 30 42.2% 13.5% 41.3% 43.6%36.1% 39.0% 81.7%41.5% 2442 50.5% 40.2% 37.8% 37

50 60 43.8% 43.1% 21.3% 14.0% 8.4% 38

39 39.4% 37.5%22.3%20.5% 1691 23.0%10.7% 2 38.0%35.1%

39.5%20.2% 6 3.6%24.5% 5.3% 38.9%59.6% 20 40

41 30.3% 10% 42.0%17.2% 15.8%13.1%

5000 30 100g3000mg 100g 50mg 100ml 205mg 100g 30 100g 3000mg 1.5 5585mg/100ml 10.8 50 540mg/100g 42

1 340ml 180290mg5 1625g 15110mg 8501800mg/100g 10503450mg/100g 2.1 2.1 1 2529g 200500mg1 1323g 200650mg 250450mg/100ml 2 1.5 6.4 50320mg/100ml 4.6 70320mg/100ml 1 180ml 400800mg1 140300ml 90450mg 10105mg/100g 50mg/100g 2 205mg/100ml 1 400g 9 1 180ml 1 1300mg0.5 4002.0518031300 34.940.8%9.815.1% 8.711.4g 1 2.03.0g 36.0 50.1%43.265.8% 10.112.5g 1 6.915.1g 43

1.6 8.8 13.8mg/100g 11.6 5.058.0mg/100g 2.6 240 620mg/100g 2.3 390910mg/100g 1g 1g 1403units/g1350units/g 1303units/g907units/g 44

30 19 19 14 3 2 4 4 1 30 12 1 3 4 1 3 8 7 1 1 2 3 5 20% 28 358 255 100g ml 45

30 1288 6 50 38 1077 28 4832 3688 1052 92 66.6% 33.4% 81.7%41.5% 2442 50.5% 3218 40.2%37.8% 1.4% 46

43.8% 43.1% 14.0% 8.4% 1691 52.5% 35.0% 37.5%22.3%20.5% 5.3%38.9% 59.6%31.9% 22.2% 35.2%14.5% 50.6% 30.3%5.4% 2.2% 47

48

49

11 Folin-Ciocalteu Folin-Ciocalteu FC (+)- 1ml 5ml 10ml 1g 50% 8ml 30 10ml 0.5g 2ml 50% 30ml 30 50% 50ml 5g 50% 5ml 50% 5ml 5 3 50% 50ml 0.0010.1mg/ml 1ml2 FC 0.5ml0.4M Na2CO3 5ml 30 30 660nm 50% 1ml 0.0010.1mg/ml (+)- 50% 1ml FC F-L- 50

HPLC 10ml 40mM 40% ph310ml 1 20mM 20% ph320ml 0.45m HPLC 1g 7ml 30 10ml HPLC HPLC TSK-gelODS 80TS4.6mm250mm 20mM ph3.0 20mM 40% ph3.0 10 80201060 3070 205280nm 1.0ml/min4010l (+)- (-)-(-)-(-)- (-)- (-)- HPLC HPLC 30 51

F- 5,5- -1--N-(DMPO)(ESR) (SOD) SOD unit/g 515g 0.1M ph7.8 10ml 5g 0.1M ph7.8 100ml 60 1g Tween80 1g 0.1M ph7.8 0.1M ph7.8 100ml 1g 0.1M ph7.850ml 60 1335g 0.1M ph7.8 0.1M ph7.8 100ml 60 9.2M 5,5--1--N-(DMPO)15l 9.5mM -N,N,N,N,N -(DETAPAC)- 35l 2mM -50l SOD 50l 0.4units/ml -50l 160lESR 40 Mn 2+ 52

ESR JES-FR80 8mW335.2mT5mT100kHz0.790.1mT 21000.1 2 TBA 30 5ml 20ml 25ml 1g 80% 5ml 10 3 80% 25ml 1g 80% 5ml 80% 10ml 30 80% 10ml 10 3 80% 50ml (+)-10mg 80% 10ml 10.001mg/ml 10ml 1ml1.25mg/ml 1%SDS 0.25ml 60 18 60 18 0.5% BHT2,6-0.25ml 0.4% TBA 0.2M (ph3) 1ml 5 30 95 60 2.5ml n- (150:10) 4ml 3000rpm20 532nm IC5050% 53

IC50 3 - - - 0.1g/ml 0.1ml0.1mg/ml- 0.25ml20%w/v Tween40 0.5ml 45ml 0.2M ph6.85ml - 0.1ml 4.9ml - 470nm 50 60 0 60 TBA IC50 54

12 20 20 30 40 50 60 CM 10 55

56 10 111213 10 1112131415 1617 mg

57

58

59

60

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