Understanding Stem Cell Transplant 2007

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1 Understanding Stem Cell Transplant IMF International Myeloma Foundation Riverside Drive, Suite 206 North Hollywood, CA USA Telephone: CURE (2873) (USA & Canada) Fax: /07

2 David Vesole Brian Durie 2007, International Myeloma Foundation, North Hollywood, California

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7 36 50 PR 50% VGPR 90% CR ) VGPR CR VGPR CR VAD VGPR CR VGPR CR VGPR CR CR ) VGPR " "[] VGPR CR VGPR CR VGPR PR[] PR50% VGPR90% CR100%

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9 Neupogen Neulasta Leukine [PBSC] 1) 2) 1) 2)

10 "Tylenol " 2 DMSO 10 CD34+ CD34+ kg 200 CD34+ CD34+ CD34+ 2 kg 400 CD

11 AMD-3100 ("Mozobil ") 200mg (mg/) {} DMSO

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14 2 6 2 VGPR CR "Quadramet " Sm-153 "" GVHD 4 GVHD 26 27

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20 IMF 1 2 IMF. D. 75, ,000 20,000 IMF IMF 4 IMF 185,000 IMF IMF IMF 38 39

21 IMF IMF InfoPack IMF IMF 24 : CURE (2873) IMF IMF 100 IMF IMF Myeloma Minute BANK ON A CURE DNA ISS Myeloma Matrix IMF IMF Myeloma Today 40 41

22 DNA HLA (NMDP) 13 14g/dl 10g/dl CD34+ CD

23 CSF() "Neupogen" "Neulasta""Leukine" CR: CR CR ISS 20 M M M M M M PBSC "" PBSC PBSC CR CR 44 45

24 VGPR) 100 M Attal M, Harrousseau JL, Stoppa AM, et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med. 1996;335: Fermand JP, Ravaud P, Chevret S, et al. High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: up-front or rescue treatment? Results of a multicenter sequential randomized trial. Blood. 1998;92: Barlogie B, Jagannath S. Desikan KR< et al. Total therapy with tandem transplants for newly diagnosed multiple myeloma. Blood. 1999;93: Child JA, Morgan GJ, Davies FE, et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med. 2003;348: Attal M, Harousseau JL, Facon T, et al. Single versus double autologous stem-cell transplantation for multiple myeloma. N Engl J Med. 2003;349: Fassas AB, Van Rhee F, Tricot G. Predicting long-term survival in multiple myeloma patients following autotransplants. Leuk Lymphoma. 2003;44: Blade J. Transplantation for multiple myeloma: who, when, how often? High-dose therapy in multiple myeloma. Blood. 2003;15: Barlogie B, Tricot G, Anaissie E, et al. Thalidomide and menatopoietic-cell transplantation for multiple myeloma. N Engl J Med. 2006;354: Cavo M, Baccarani M. The changing landscape of myeloma therapy. N Engl J Med. 2006;354: Barlogie B, Tricot G. Complete response in myeloma: a Trojan horse? Blood. 2006;108:2134. IMF IMF

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