Understanding Stem Cell Transplant 2007
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- つねとき さわなか
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1 Understanding Stem Cell Transplant IMF International Myeloma Foundation Riverside Drive, Suite 206 North Hollywood, CA USA Telephone: CURE (2873) (USA & Canada) Fax: /07
2 David Vesole Brian Durie 2007, International Myeloma Foundation, North Hollywood, California
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24 VGPR) 100 M Attal M, Harrousseau JL, Stoppa AM, et al. A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma. Intergroupe Francais du Myelome. N Engl J Med. 1996;335: Fermand JP, Ravaud P, Chevret S, et al. High-dose therapy and autologous peripheral blood stem cell transplantation in multiple myeloma: up-front or rescue treatment? Results of a multicenter sequential randomized trial. Blood. 1998;92: Barlogie B, Jagannath S. Desikan KR< et al. Total therapy with tandem transplants for newly diagnosed multiple myeloma. Blood. 1999;93: Child JA, Morgan GJ, Davies FE, et al. High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma. N Engl J Med. 2003;348: Attal M, Harousseau JL, Facon T, et al. Single versus double autologous stem-cell transplantation for multiple myeloma. N Engl J Med. 2003;349: Fassas AB, Van Rhee F, Tricot G. Predicting long-term survival in multiple myeloma patients following autotransplants. Leuk Lymphoma. 2003;44: Blade J. Transplantation for multiple myeloma: who, when, how often? High-dose therapy in multiple myeloma. Blood. 2003;15: Barlogie B, Tricot G, Anaissie E, et al. Thalidomide and menatopoietic-cell transplantation for multiple myeloma. N Engl J Med. 2006;354: Cavo M, Baccarani M. The changing landscape of myeloma therapy. N Engl J Med. 2006;354: Barlogie B, Tricot G. Complete response in myeloma: a Trojan horse? Blood. 2006;108:2134. IMF IMF
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トピックス Ⅵ. 多発性骨髄腫に対する標準治療 多発性骨髄腫に対する標準治療 要旨 多発性骨髄腫 (multiple myeloma:mm) の治療成績は, 新規薬剤の導入により深い奏効が得られるようになったことや, 再発難治例にも有効な治療薬が登場したことにより改善している. 若年者の初回標準治療は, 新規薬剤を組み込んだ寛解導入療法に続く自家移植併用大量化学療法である. この10 年の骨髄腫の治療成績向上は,
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