VarianIMRT IMRT MLC LMC VARIAN ONCOLOGY SYSTEMS
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1 1 VARIAN ONCOLOGY SYSTEMS
2 VarianIMRT IMRT MLC LMC VARIAN ONCOLOGY SYSTEMS
3 Varian装置によるIMRT 品質担保の為に必要な作業 Changes Over Time: ICRU 50 to 62 IRRADIATED VOLUME TREATED VOLUME PTV ITV CTV GTV PRV: Includes margin around the OAR to compensate for changes in shape and internal motion and for set-up variation. OAR IAEA 再現在のある患者固定法の選択 マージンの決定 近畿大学 奥村先生からの資料より VARIAN ONCOLOGY SYSTEMS PRV 必要な輪郭の指示 ICRU50/62 線量制約の統一
4 IMRT Contouring Field Setup (Optional) BAO Optimization Fluence Optimization Objectives Optimal Fluence VARIAN ONCOLOGY SYSTEMS
5 IMRT Optimal Fluence LMC Parameters Leaf Motion Calculation MLC Parameters AAA, PBC, Acuros XB algorithm Actual Fluence 3D dose calculation Leaf Motions Delivery VARIAN ONCOLOGY SYSTEMS
6 IMRT Only b5mm VARIAN ONCOLOGY SYSTEMS
7 IMRT IMRTRapidArc NTO IMRT Relative number (0 1000) Defines importance of the objective VARIAN ONCOLOGY SYSTEMS
8 IMRT Upper Objective Lower Objective Objectives on a Line VARIAN ONCOLOGY SYSTEMS
9 IMRT Objective - Function CF = N i=1 ( u( D min d i ) 2 + o( d i D max ) 2 ) 不足線量での評価 不足線量 過線量の項において指定線量の 範囲外は評価しないようにしておく 過線量での評価但し :i= 指定した腫瘍 N= 腫瘍内のボクセル数 d= 線量! u= アンダードーズの係数! p= 指定線量! Dmin= 腫瘍内最少線量 CF= 評価関数 o= オーバードーズの係数 Dmax= 腫瘍内最大線量 VARIAN ONCOLOGY SYSTEMS
10 IMRT Objective - Function CF = p k N k ( d i,k D max,k ) 2 i=1 臓器毎のペナルティー リスク臓器内のボクセルの線量 許容線量 ( 最大線量 ) 但し :k= 臓器! i= ボクセル数! p= ペナルティー係数! N= 登録臓器数! d= ボクセル線量! Dmax= 最大線量! VARIAN VARIAN ONCOLOGY SYSTEMS!10
11 IMRT Normal Tissue Objective VARIAN ONCOLOGY SYSTEMS
12 IMRT Normal Tissue Objective (NTO) f (r) = $ & % '& f 0 e k(r r start ) + f (1 e k(r r start ) ), r r start f 0, r < r start Where r = Distance from target border r start = start of fall off f 0 = start dose (%) f = end dose (%) k = Fall off VARIAN ONCOLOGY SYSTEMS
13 IMRT Smoothing Objectives XY XVarian MLCMU YMUTongue & Groove VARIAN ONCOLOGY SYSTEMS
14 IMRT Minimize Dose Objective Normal Tissue Objective VARIAN ONCOLOGY SYSTEMS
15 IMRT Optimization Parameters Beamlet (IMRT)! Base dose plan Maximum number of iterations Maximum optimization time VARIAN ONCOLOGY SYSTEMS
16 IMRT Point SamplingCalculation Grid IMRT VARIAN ONCOLOGY SYSTEMS
17 IMRT Point SamplingCalculation Grid VARIAN ONCOLOGY SYSTEMS
18 IMRT Optimization - Volume Representation EIP VARIAN ONCOLOGY SYSTEMS
19 IMRT Optimization - Field Representation Ray trace!!! row = leaf pair! Size of the beamlet Leaf width x 2.5 mm VARIAN ONCOLOGY SYSTEMS
20 IMRT Optimization - Target Masking 0.5cm 0.5cmY VARIAN ONCOLOGY SYSTEMS
21 IMRT Optimization - Dose Computation EclipseTarget Masking PointBeamlet Dose at point - d i, Beamlet Beamlet - x j VARIAN ONCOLOGY SYSTEMS
22 IMRT Penalty Calculation A C B 2 1 p1 > 40 w1 = 100 p2 < 20 w2 = 50 A C B 1 2 Next iteration A B C 1 2 d (d violate? penalty Σ A B C 1 2 d (d violate? penalty Σ Gain VARIAN ONCOLOGY SYSTEMS
23 IMRT Objective function ()! F obj = F PTV + F Critical + F NTO + F SmoothXY! allptvs allcs Fields! () + F Min.Dose Fields VARIAN ONCOLOGY SYSTEMS
24 Intermediate Dose Calculation MRDC VARIAN ONCOLOGY SYSTEMS
25 Segment Leaf Motion Calculator optimal fluenceactual fluence LMC Sliding Window Multiple Static Segments None Field size definition VARIAN ONCOLOGY SYSTEMS
26 Segment Large Field IMRT スプリットフィールド ( フィールド分割 ) 幅の広い照射野を左右二つの分割された照射野に変更をする その際 インテンシティーのつながりを考慮して分割する Paul Keall et. al. Virginia Commonwealth University Medical College of Virginia Hospital VARIAN VARIAN ONCOLOGY SYSTEMS
27 Segment Large Field IMRT LargeIMRT VARIAN ONCOLOGY SYSTEMS
28 RapidArc Contouring Auto adjust Field Setup Machine Parameters Optimization Leaf Motions MU per deg MRDC Objectives VARIAN ONCOLOGY SYSTEMS
29 RapidArc Leaf Motions MU per deg AAA or Acuros XB 3D dose calculation Delivery VARIAN ONCOLOGY SYSTEMS
30 VMAT Create Couch Structure Couch structures may be added to account for attenuation of the treatment couch. Numerous Varian couches are available Rails can be positioned in or out, for both left and right Couch position may be adjusted VARIAN ONCOLOGY SYSTEMS
31 VMAT Constraints - Varian Delivery Platforms RT Administration Dose rate / 0.1 MU/deg VARIAN ONCOLOGY SYSTEMS
32 VMAT Geometry 30 Avoidance sectors VMAT Field size Collimator, Couch rotation Isocenter Arc geometry tool VARIAN ONCOLOGY SYSTEMS
33 VMAT Avoidance Sectors VARIAN ONCOLOGY SYSTEMS
34 VMAT RapidArc - Arc Optimization Progressive Resolution Optimization (PRO) Starts with few directions (control points) Optimizes the MLC motion, Dose Rate, Gantry Speed for each control point Respects MLC, Gantry Speed Constraints () VARIAN ONCOLOGY SYSTEMS
35 VMAT Progressive resolution () Control Points resolution multi-resolution Calculation direction for arc segment VARIAN ONCOLOGY SYSTEMS
36 VMAT Steps PRO3 resolution level VARIAN ONCOLOGY SYSTEMS
37 (AcurosXB) Monte Calo f(x,v,t)x,vf(x,v,t)dxdv dxdv!"!" +!!"!" +!!!"!" =!!!!!!!!"Ω!!! v v VARIAN ONCOLOGY SYSTEMS
38 (AcurosXB) Monte Calo VARIAN ONCOLOGY SYSTEMS
39 (AcurosXB) Monte Calo VARIAN ONCOLOGY SYSTEMS
40 (AcurosXB) Monte Calo q γ prim q γ sec q e cont Initial Phase Space q γγ unc q γe unc q ee unc Modified Phase Space VARIAN ONCOLOGY SYSTEMS
41 (AcurosXB) Monte Calo VARIAN ONCOLOGY SYSTEMS
42 より正確な線量計算(AcurosXB) Monte Calo等価な線量計算 不均質層での結果 Monte Carlo計算と同等の結果 5cm 2cm 8cm 6MV, 5x5cm 4cm 11cm 5cm(Water) 8cm(Lung) 2cm(Titanium) VARIAN ONCOLOGY SYSTEMS 11cm(Water) 4cm(Bone)
43 IMRT VARIAN ONCOLOGY SYSTEMS
44 2 VARIAN ONCOLOGY SYSTEMS
45 3 VARIAN ONCOLOGY SYSTEMS
46 4 VARIAN ONCOLOGY SYSTEMS
47 270 3 MLC COPYRIGHT 2010 VARIAN MEDICAL SYSTEMS
48 Clinac Beam Stand Gantry
49 Clinac Beam 4 7 VARIAN ONCOLOGY SYSTEMS Stand Gantry
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51 9 VARIAN ONCOLOGY SYSTEMS
52 10 VARIAN ONCOLOGY SYSTEMS
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55 0 0 0
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58 16 VARIAN ONCOLOGY SYSTEMS
59 x E E x =E 0 sin { (z / c t)} H y =H 0 sin { (z / c t)} z E 0 /H 0 = / (376.7 c=1 / y H EH S = E H z E x =E 0 sin { (z / c + t)} B y = B 0 sin { (z / c + t)} 17 VARIAN ONCOLOGY SYSTEMS
60 TM 010 Ez 2b z 2b E 0 Ez d r Ez z r =b 0 d V=E 0 d/2 d/2 d/2 d/2 cos t dz =E 0 cos z/v+ t 0 dz =V 0 T cos t 0 t=t 0 z=0 V 0 =E 0 d T =sin d d <1 2v 2v T 18 VARIAN ONCOLOGY SYSTEMS
61 1/2 (1) (2) (3) (4) (1) 19 VARIAN ONCOLOGY SYSTEMS
62 2/2 (5) (2) (7) (8) (1) Z 20 VARIAN ONCOLOGY SYSTEMS
63 1 1 1/4/2 /2 1/32/3 2/3 21 VARIAN ONCOLOGY SYSTEMS
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69 1 Z=E 02 P 2 ZT 2 (E 0 T) 2 P 2 E 0 T P 27 VARIAN ONCOLOGY SYSTEMS
70 2 (1) (2) T 5060 M/m 100 M/m 28 VARIAN ONCOLOGY SYSTEMS
71 29 VARIAN ONCOLOGY SYSTEMS
72 1 10MeV 6MeV 4MeV 1 V= 1+ 2 LPZT 2 ilzt 2 L m ZT 2 /m P 1 P 2 P 3 A 30 VARIAN ONCOLOGY SYSTEMS
73 2 Buncher Section RF Regular Section ~0.4m ~1m 31 VARIAN ONCOLOGY SYSTEMS
74 2 Buncher Section RF Regular Section ~0.4m ~1m 32 VARIAN ONCOLOGY SYSTEMS
75 33 VARIAN ONCOLOGY SYSTEMS
76 Achromatic Bending Magnet System 34 VARIAN ONCOLOGY SYSTEMS
77 270 C-Series HE Clinac X
78 270 TrueBeam X
79 e 2a B 2b 2d z 37 VARIAN ONCOLOGY SYSTEMS
80 B F = e B B 2 = B(z) d z 1 dz 1 P / e 1 = B(z)dz P / e - 8 = P / e 1 2 abni a 2 +d 2 e z 1 z 2 B z E = 10 (MeV) a = 0.1(m)b = 0.1(m) d = 0.1(m)nI = 100(A) B = P / e = 0.035(Tm) B y (0) = (T) 2.3mrad 38 VARIAN ONCOLOGY SYSTEMS
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82 40 VARIAN ONCOLOGY SYSTEMS
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