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2 NPE EO NPE NPE 1 NPE NPE1 EO n NPE NPEn NP 1

3 10 CAS C H 0O 10 C H O (n = ) 1-0- (n = 10)

4 C 1H O CAS 0-- C 1H O CAS 10-- CAS C 1H O 1--

5 NPE 1) 11 ) MOE (00) ) MHLW, METI, MOE (01) ) EPI Suite (01) ) I ) ECHA 10) Canada (001) ) HSDB 11) AIST (00) ) NITE (00a) 1) Urano (1) ) MITI (1) 1) MITI (1) 1) Australia (01)

6 ) 11 ) EPI Suite(01) ) Kveštak (1) ) HSDB NA: NPE NPE logpow Koc 1) 11 ) Ahel (1)) EPI Suite (01)

7 ) 11 ) Ahel (1)) EPI Suite (01) 1) 11 ) SIDS (001)) Itokawa (1) ) Ahel (1)) PhysProp ) Canada (001)10) HSDB ) AIST (00)11) ECHA ) Mackay (00)1) EPI Suite (01) ) NITE (00b)

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15 PRTR PRAS-NITE Ver PRTR 1 PRTR 1 PRTR 1% PRTR H G-CIEMS ver.0. 1 NPE,0 H PRTR PRTR PRTR G-CIEMS PECwater/PNECwater NPE PRTR PRTR PECsed/PNECsed

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33 Ahel (1): Marijan Ahel. and Walter Giger (1) Partitioning of alkylphenols and alkylphenol polyethoxylates between water and organic solvents, Chemosphere, Vol., No., pp AIST (00):,,. 00. Australia (01): Environment Tier II Assessment for Nonylphenol Ethoxylates and their Sulfate and Phosphate Esters ( July 01). Canada (001): PRIORITY SUBSTANCES LIST ASSESSMENT REPORT, Nonylphenol and its Ethoxylates ECHA: Information on Chemicals Registered substances. ( ). EPI Suite (01): US EPA. Estimation Programs Interface Suite. Ver..11, 01. HSDB: US NIH. Hazardous Substances Data Bank. ( ). Itokawa (1): Itokawa, H., Totsuka, N., Hakahara, K., Meazuru, M., Takeya, K., Konda, M., Inamatsu, M., Morita, H (1) A quantitative structureactivity relationship for antitumor activity of long-chain phenols from Ginkgo biloba L, Chem. Pharm. Bull., Kveštak (1): R. Kveštak, M. Ahel (1) Biotransformation of nonylphenol polyethoxylate surfactants by estuarine mixed bacterial cultures, Archives of Environmental Contamination and Toxicology, (), 1-. Macky (00): Mackay, D., Shiu, W. Y., Ma, K. C., & Lee, S. C. Handbook of physical-chemical properties and environmental fate for organic chemicals. nd ed., CRC press, 00. MHLW, METI, MOE(01):, V.. Ver. 1.0, 01. MITI (1): ( ) ( No.K-A)., 1. MITI (1): ( ( 0) (C=) ) ( No.K-B)., 1. MOE (00): DB,. 00. NITE (00a):, ( ). Ver. 1.0, No., 00. NITE (00b):,. Ver. 1.0, No. 1, 00. PhysProp: Syracuse Research Corporation. SRC PhysProp Database. ( ). SIDS (001): SIDS INITIAL ASSESSMENT PROFILE, Phenol, -nonyl-, branched and Nonylphenol. 001 Urano (1): K. Urano, M. Saito, C. Murata (1) Adsorption of surfactants on sediments, Chemosphere,

34 (), Dorn,P.B., J.P. Salanitro, S.H. Evans, and L. Kravetz 1 Assessing the Aquatic Hazard of Some Branched and Linear Nonionic Surfactants by Biodegradation and Toxicity.Environ. Toxicol. Chem.1(10): ECOTOX no.01 ECHA 010 Exp Key Toxicity to aquatic algae and cyanobacteria /AGGR-fc1--aeb-a0-bc1cd1_DISS-db-0-0ff-e0-001fd 01.html#AGGR-fc1--aeb-a0-bc1cd1 ECHA 1 Long-term toxicity to aquatic invertebrates00key Experimental result.. ECHA 00 Short-term toxicity to aquatic invertebrates 00 Supporting.( UID=ffe1ab-1b-e-b-cbdcded 0110 ) Ward,T.J., and R.L. Boeri 10 Acute Static Toxicity of Nonylphenol to the Marine Alga Skeletonema costatum.envirosystems Study No.0-CMA, EnviroSystems Div.Resour.Anal.Inc., Hampton, NH: p.. ECOTOX no.0 Ward,T.J., and R.L. Boeri 10 Acute Static Toxicity of Nonylphenol to the Freshwater Alga Selenastrum capricornutum.envirosystems Study No.-CMA, EnviroSystems Div.Resour.Anal.Inc., Hampton, NH:1 p.. ECOTOX no. ECHA 10 Toxicity to aquatic algae and cyanobacteria 00 Supporting. UUID=0e-a1-fb-a0-e1ca 0110>. ECHA 1 Toxicity to aquatic algae and cyanobacteria001 Key. d0d1-e11-dd-0a-d0fa 0110>. Ward,T.J., and R.L. Boeri 11 Chronic Toxicity of Nonylphenol to the Mysid, Mysidopsis bahia.envirosystems Study No.-CMA, EnviroSystems Div.Resour.Anal.Inc., Hampton, NH:1 p.. ECOTOX no.0 10Sun and Gu 00 Comprehensive Toxicity Study of Nonylphenol and Short-Chain Nonylphenol Polyethoxylates on Daphnia magna.bull. Environ. Contam. Toxicol. :. ECOTOX no. 11Brooke,L.T. 1 Acute and Chronic Toxicity of Nonylphenol to Ten Species of Aquatic Organisms.Contract No.-C1-00, U.S.EPA, Duluth, MN: p.. ECOTOX no.00 1Comber,M.H.I., T.D. Williams, and K.M. Stewart 1 The Effects of Nonylphenol on Daphnia magna.water Res.(): -. ECOTOX no.1 1ECHA 10 Short-term toxicity to aquatic invertebrates01 Supporting Experimental result. =fcef-ea-ac-fd-d0ddbac 0110>.

35 Lussier,S.M., D. Champlin, J. LiVolsi, S. Poucher, and R.J. Pruell 000 Acute Toxicity of para-nonylphenol to Saltwater Animals.Environ. Toxicol. Chem.1(): 1-1. ECOTOX no.1 1ECHA 1 Short-term toxicity to aquatic invertebrates00 Key Experimental result. =c0c-de-ae-a1ca0cdc# 01/0/0. 1ECHA 1 long-term toxicity to aquatic invertebrates00 Supporting Experimental result. =afaf0-1ef--a00e-1fcedb# 01/0/0. 1ECHA 1 Short-term toxicity to aquatic invertebrates001 Key Experimental result. 01/0/ , 0 :1-.. 1Zhang,L., R. Gibble, and K.N. Baer 00 The Effects of -Nonylphenol and Ethanol on Acute Toxicity, Embryo Development, and Reproduction in Daphnia magna.ecotoxicol. Environ. Saf.(): 0-. ECOTOX no , 0 :-0.. 1Watanabe, H., Y. Horie, H. Takanobu, M. Koshio, K. Flynn, T. Iguchi, and N. Tatarazako 01 Medaka Extended One-Generation Reproduction Test Evaluating -Nonylphenol. Environmental Toxicology and Chemistry, (1):.Ward,T.J., and R.L. Boeri 11 Early Life Stage Toxicity of Nonylphenol to the Fathead Minnow, Pimephales promelas.final Rep., Chem.Manuf.Assoc., Washington, DC: p.. ECOTOX no.0 Ward,T.J., and R.L. Boeri 11 Early Life Stage Toxicity of Nonylphenol to the Fathead Minnow, Pimephales promelas.final Rep., Chem.Manuf.Assoc., Washington, DC: p.. ECOTOX no.0 Seki,M., H. Yokota, M. Maeda, H. Tadokoro, and K. Kobayashi 00 Effects of -Nonylphenol and -tert-octylphenol on Sex Differentiation and Vitellogenin Induction in Medaka (Oryzias latipes).environ. Toxicol. Chem.(): ECOTOX no.1 00c 00 1 ELS. 00a 1 00b 1 00a : 0. Holcombe,G.W., G.L. Phipps, M.L. Knuth, and T. Felhaber 1 The Acute Toxicity of Selected

36 Substituted Phenols, Benzenes and Benzoic Acid Esters to Fathead Minnows Pimephales promelas.environ. Pollut. A.(): -1. ECOTOX no.10 0Geiger,D.L., C.E. Northcott, D.J. Call, and L.T. Brooke 1 Acute Toxicities of Organic Chemicals to Fathead Minnows (Pimephales promelas), Volume II.Center for Lake Superior Environmental Studies, University of Wisconsin, Superior, WI: p. ECOTOX no b 0 ECHA 10 Short-term toxicity to Fish010 Supporting Experimental result.< D=ddbaf0a-1-af-b-0ddb0e0> 01 1 Bettinetti R and Provini A 00 Toxicity of -nonylphenol to Tubifex tubifex and Chironomus riparius in -day whole-sediment tests.ecotoxicol. Environ. Safety. :11-11.

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