化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]

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1 p,p -DDT 1 p,p -DDT 1,1,1- -2,2- (4- ) CAS C 14 H 9 Cl ) 260 2) 1.5 1) mmhg (20 ) 3) 1ppm=14.50 mg/m 3 at 25, n- / ) 1) 3 4) BOD 0 % ( mg/l 30 mg/l) 4) BCF5,10024,400 ( 10 1 µg/l), 6,08025,900 ( µg/l) 4) ) ) 5)

2 95 (1) EUSES 2.1 2,400km ),2) () (2) g/m 3 µg/l µg/l µg/g µg/g µg/l µg/l ( ) µg/g ( ) µg/g < < 0.05 < < 0.01 < < < < < 0.05 < < 0.01 < < < < * /10 0/42 0/4 57/57 4/94 0/20 0/76 0/90 0/ ) µg/m 3 7) 2) 0.05 µg/l(1994) (1984) 8) 3) 0.2 µg/g (1998) 9) 4)* 5%

3 (3) m 3 2L2,000g 0.15g 50kg µg/m 3 (2001) 0.05 µg/l (1999) 0.05 µg/l (1998) µg/l (2001) µg/kg/day µg/kg/day µg/kg/day µg/kg/day µg/g (1998) µg/kg/day 0.01 µg/g (1998) µg/m 3 (2001) µg/kg/day µg/l (2001) 0.05 µg/l (1999) 0.05 µg/l (1998) µg/g (1998) µg/kg/day µg/kg/day µg/kg/day µg/kg/day 0.16 µg/kg/day µg/g (1998) µg/kg/day µg/kg/day µg/m µg/kg/day 0.16 µg/kg/day 0.16 µg/kg/day

4 2.4 (µg/kg/day) (0.002) (0.002) (µg/kg/day) ( ) ( ) ) 2) (4) PEC 2.5 PEC µg/l µg/l µg/l (2001) µg/l (1995) µg/l (2001) µg/l (1995)

5 1 3.1 TDLo16 mg/kg 2.5 mg/kg/day LD mg/kg LD 50 2,500 mg/kg LD mg/kg ppm mg/kg/day 27 5 ppm 1 ppm 1 ppm 0.05 mg/kg/day NOEL JMPR1984 NOAEL 6.25 mg/kg/day 10 mg/kg/day 0.25 mg/kg/day ADI GDWQ1996 NOAEL ADI Sprague-Dawley mg/kg mg/kg/day mg/kg 10 mg/kg/day NOEL p,p'- DDT 80 %o,p-ddt 17 %p,p'-dde 2 % JMPR mg/kg/day NOAEL 0.06 mg/kg/day

6 2 2 mg/kg/day IARC 2B 3 NOAEL NOAEL 0.05 mg/kg/day NOEL NOAEL 0.25 mg/kg/day 0.06 mg/kg/day MOE µg/kg/day 0.16 µg/kg/day 0.06 mg/kg/day µg/kg/day mg/kg/day MOE Margin of Exposure 380

7 (1) Ref. No. [ µg/l] / [] Cyclotella nana 14 C uptake ,000 Spirulina platensis LC 50 MOR *0.36 Daphnia pulex EC 50 IMM * Corophium insidiosum LC 50 MOR Daphnia magna EC 50 IMM Daphnia magna EC 50 REP Daphnia magna EC 50 REP Bosmina longirostris EC 50 IMM Daphnia magna EC 50 REP Daphnia magna EC 50 IMM Daphnia magna EC 50 REP Daphnia magna EC 50 IMM Gammarus lacustris LC 50 MOR Daphnia magna EC 50 IMM Cancer magister EC 50 IMM Daphnia magna EC 50 IMM Gammarus lacustris LC 50 MOR Bosmina longirostris EC 50 IMM Gammarus lacustris LC 50 MOR Daphnia pulex EC 50 IMM Gammarus lacustris LC 50 MOR Gammarus lacustris LC 50 MOR Gammarus lacustris LC 50 MOR Gammarus lacustris LC 50 MOR Gammarus lacustris LC 50 MOR Daphnia magna EC 50 IMM Daphnia magna EC 50 IMM Daphnia magna EC 50 IMM Daphnia magna EC 50 IMM

8 Mugil cephalus LC 50 MOR Mugil cephalus LC 50 MOR Micrometrus minimus TL 50 MOR Gambusia affinis TL 50 MOR Cymatogaster aggregata LC 50 MOR Morone saxatilis TL 50 MOR Oncorhynchus kisutch LT 50 MOR Oncorhynchus clarki TLmMOR Rasbora heteromorpha LC 50 MOR Mystus gulio LC 50 MOR Rasbora heteromorpha LC 50 MOR Leiostomus xanthurus EC Poecilia reticulata TL 50 MOR Lepomis macrochirus LC 50 MOR Kuhlia sandvicensis TL 50 MOR Pteronarcella badia LC 50 MOR Claassenia sabulosa LC 50 MOR Aedes cantans LC 50 MOR Pteronarcys california LC 50 MOR Culex pipiens molestus LC 50 MOR Crassostrea madrasensis LC 50 MOR Katelysia opima LC 50 MOR Meretrix casta LC 50 MOR Hydropsyche sp. LC 50 MOR Hydropsyche recurvata LC 50 MOR Hydropsyche morosa LC 50 MOR PNEC PNEC PNEC EC 50 Median Effective Concentration): LC 50 Median Lethal Concentration): TLmMedian Tolerance Limit): TL 50 Median Tolerance Limit): LT 50 Mean Survival Time): IMMImmobilization): MORMortality): REPReproduction): (2) PNEC Cyclotella nana 14 C 24 EC µg/l Daphnia magna 48 EC µg/l Mugil cephalus 5 LC µg/l Pteronarcella badia 96 LC 50

9 1.9 µg/l µg/l PNEC µg/l PNEC µg/l (3) 4.2 PEC µg/l (2001) µg/l (2001) < µg/l (1995) µg/l (1995) µg/l <1 1) µg/g dry µg/g dry (1998) µg/g dry µg/g dry (1998) (1998) (1998) 1) 0.05 µg/l(1994) (1984) µg/l µg/l PEC µg/l µg/l PEC PNEC 0.1 PEC/PNEC 1

10 1 1IPCS (1995) International Chemical Safety Cards 2Chemfinderhttp://Chemfinder.Camsoft.com/ 3BIDLEMAN, TF & FOREMAN, WT (1987) [SRC MPBPWIN v1.40] 4() (1992) 5,,,, (1988), (2) 1 () 10 2 () SPEED'98 (1999) 5 () 10 () 6 8, p , R.M.Hoff et al:atmospheric Deposition of Toxic Chemicals to the Great Lakes:A Review of data through 1994,Atmospheric Environment,30(20), (1994) 8Yang Y.,Sheng G et al:organochlorinated Compounds in Water of the Pearl River Delta Region, Environ.Monit.Assess.,44(1), (1990) , 2Laug, E. P. et al.1950j. Pharmacol. Exp. Ther., 98: Joint FAO/WHO Meeting on Pesticide Residues1985FAO Plant Production and Protection Paper 67. 4Ottoboni, A.1969Toxicol. Appl. Pharmacol., 14: Tomatis, L. et al.1972int. J. Cancer, 10: Joint FAO/WHO Meeting on Pesticide Residues2000Pesticide residues in food 2000 : DDT Environmental Health Criteria 9, DDT and its derivatives, IPCS1979. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 51974; Supplement 71987; Volume IRIS Integrated Risk Information System, No.0147, DDT, U.S. EPA1997.

11 Documentation of the Threshold Limit Values and Biological Exposure Indices, Sixth Edition, DDT, ACGIH1991. (4) U.S.EPAAQUIRE Ref. No. 276:Goodman,L.R., G.M.Cripe, P.H.Moody, and D.G.Halsell (1988): Acute Toxicity of Malathion, Tetrabromobisphenol-A, and Tributyltin Chloride to Mysids (Mysidopsis bahia) of Three Ages. Bull. Environ. Contam. Toxicol. 41(5): :Goodman,L.R., G.M.Cripe, P.H.Moody, and D.G.Halsell (1988): Acute Toxicity of Malathion, Tetrabromobisphenol-A, and Tributyltin Chloride to Mysids (Mysidopsis bahia) of Three Ages. Bull. Environ. Contam. Toxicol. 41(5): :Korn,S. and R.Earnest (1974): Acute Toxicity of Twenty Insecticides to Striped Bass, Morone saxatilis. Calif. Fish Game 60(3): :Goodman,L.R., G.M.Cripe, P.H.Moody, and D.G.Halsell (1988): Acute Toxicity of Malathion, Tetrabromobisphenol-A, and Tributyltin Chloride to Mysids (Mysidopsis bahia) of Three Ages. Bull. Environ. Contam. Toxicol. 41(5): :Butler,P.A. (1964): Commercial Fishery Investigations. In: Pesticide-Wildlife Studies, U.S.D.I Fish and Wildl. Serv. Circular 199:28 p. 885:Vigano,L. (1993): Reproductive Strategy of Daphnia magna and Toxicity of Organic Compounds. Water Res. 27(5): :Sanders,H.O. and O.B.Cope(1966): Toxicities of Several Pesticides to Two Species of Cladocerans. Trans. Am. Fish. Soc. 95(2): :Jensen,L.D. and A.R.Gaufin(1964): Effects of Ten Organic Insecticides on Two Species of Stonefly Naiads. Trans. Am. Fish. Soc. 93(1): :Post,G. and T.R.Schroeder(1971): Toxicity of Four Insecticides to Four Salmonid Species. Bull. Environ. Contam. Toxicol. 6(2): :Randall,W.F., W.H.Dennis, and M.C.Warner(1979): Acute Toxicity of Dechlorinated DDT, Chlordane and Lindane to Bluegill (Lepomis macrochirus) and Daphnia magna. Bull. Environ. Contam. Toxicol. 21(6): :Dinnel,P.A., J.M.Link, Q.J.Stober, M.W.Letourneau, and W.E.Roberts(1989): Comparative Sensitivity of Sea Urchin Sperm Bioassays to Metals and Pesticides. Arch. Environ. Contam. Toxicol. 18(5): :Halter,M.T. and H.E.Johnson (1974): Acute Toxicity of a Polychlorinated Biphenyl (PCB) and DDT Alone and in Combination to Early Life Stages of Coho Salmon (Oncorhynchus kisutch). J. Fish. Res. Board Can. 31(9): :Menzel, D.W., J. Anderson, and A. Randtke (1970): Marine Phytoplankton Vary in Their Response to Chlorinated Hydrocarbons. Science 167: :Tyler-Schroeder,D.B.(1979): Use of the Grass Shrimp (Palaemonetes pugio) in a Life-Cycle Toxicity Test. In: L.L.Marking and R.A.Kimerle (Eds.). Aquatic Toxicology and Hazard Assessment, 2nd Symposium, ASTM STP 667, Philadelphia, PA: :Bowling,J.W., G.J.Leversee, P.F.Landrum, and J.P.Giesy (1983): Acute Mortality of Anthracene-Contaminated Fish Exposed to Sunlight. Aquat. Toxicol. 3: :Passino-Reader,D.R., J.P.Hickey, and L.M.Ogilvie(1997): Toxicity to Daphnia pulex and QSAR Predictions for Polycyclic Hydrocarbons Representative for Great Lakes Contaminants. Bull. Environ. Contam. Toxicol. 59(5): :Mills,W.L. (1977): Bioassay Procedure to Evaluate the Acute Toxicity of Salinity and Geothermal Pollutants (Pesticides) to Gambusia affinis. North Carolina Central University, Durham, NC:20 p. (U.S. NTIS UCRL-13832). 6038:Gersich,F.M., F.A.Blanchard, S.L.Applegath, and C.N.Park (1986): The Precision of Daphnid (Daphnia magna Straus, 1820) Static Acute Toxicity Tests. Arch. Environ. Contam. Toxicol. 15(6): :Reish,D.J. (1993): Effects of Metals and Organic Compounds on Survival and Bioaccumulation in Two Species of Marine Gammaridean Amphipod, Together with a Summary of Toxicological Research on this Group. J. Nat. Hist. 27(4): :Passino-Reader,D.R., J.P.Hickey, and L.M.Ogilvie (1997): Toxicity to Daphnia pulex and

12 QSAR Predictions for Polycyclic Hydrocarbons Representative for Great Lakes Contaminants. Bull. Environ. Contam. Toxicol. 59(5): :Passino-Reader,D.R., J.P.Hickey, and L.M.Ogilvie (1997): Toxicity to Daphnia pulex and QSAR Predictions for Polycyclic Hydrocarbons Representative for Great Lakes Contaminants. Bull. Environ. Contam. Toxicol. 59(5): :Bednarz, T. (1981): The Effect of Pesticides on the Growth of Green and Blue Green Algae Cultures. Acta. Hydrobiol. 23(2):

化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質]

化学物質の環境リスク初期評価（平成９～１２年度）結果[39物質] (1) CAS 302-01-2 N 2 H 4 32.0 CAS 7803-57-8 2 1) 2.0 2,3) 113.5 2,4) 1.011 (15 ) 2,3) 1.0036 (25 ) 2,4) 2.1 kpa (16 mmhg) (20 ) 3) 1ppm=1.31 mg/m 3 at 25, n- / -1.37 ( ) 3) 5) K b1 8.510-7 K b2 8.910-16