表紙1-4-A.4.0

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2 OSCE

3 1 59 IT IT GP() GP 3 6 OSCE Objective Structured Clinical Examination; CBT Computer Based Testing OSCE 21COE ( )

5 COE PK/PD in vitro in vivo 2121

6 Biologically Relevant Chemical Space GPCR To err is human, but errors can be prevented 4

7 5

8 OSCE Objective Structured Clinical Examination 1 OSCE 6 6 OSCE 6 CBTcomputer-based testing NPO OSCECBT OSCE OSCE OSCEOSCE OSCE OSCE OSCE 15

9 PNP 6SP; Simulated PatientOSCE OSCE 3 OSCE OSCE

10 8 2 OSCE TV OSCE OSCE 1OSCE OSCE

13 ,000m 2 20

14 mper

15 13 19

16 ab initio MO 15 in silico 6 in silico

17 GP GP COE IT 10 15

19 P

20 18 57

22 c COE CR Assistant Professor 20

23 HGCS Japan Award of Excellence Journal of Nuclear Medicine, Editors Choice Award Tetrahedron Letters Most Cited Paper Award Thomson Scientific Research Front Award DMPK Award for the Most Frequently Cited Review Article in

24 1923 PEPT Synthetic Studies on Chemokine Receptor CXCR4 and Its Specific Antagonists CXCR4 Synthesis of cis-xaa-pro type dipeptide isosteres with samarium (II) diiodide or organocopper reagents cis-xaa-pro Lipid Membrane Structure Modulated by Nonlamellar-forming Lipids and Interaction with Amphipathic Peptide Prediction of biodegradation pathways using knowledge base of enzymatic reactions Calumin, a novel Ca 2 -binding transmembrane protein on the endoplasmic reticulum TRIC channels essential for Ca 2 handling in intracellular stores. Fgf16 fibin Studies on Structure and Function of Tom1: Regulation of Membrane Traffic by Ubiquitin Tom1 Analysis of Interaction of Rab11- FIP/Arfophilin with Rab11 and ARFs and its Role in Membrane TrafficRab11 ARFRab11-FIP/Arfophilin Molecular mechanism of prostaglandin E2- EP2 signaling in ovulation and fertilization E2-EP2 Biodistribution Control of Catalase by Chemical Modification for Inhibition of 22

25 Cancer Metastasis catalase Informatics-based data acquisition and analysis of cytochrome P450-mediated drug metabolism P450 99m LDL Heat shock protein 70 hoat1 hoat3 P Development of Rapidly Disintegrating Tablets Using Crystalline Transition of Amorphous Sugar

26 1923 Pancratistatin HIV a, b Ligation X PMP22 2 CXCR4 c Adenosine Deaminase FIV / b COMBINE Apolipoprotein AIsphingomyelin HDL Enantiodivergent Development of in silico ligand screening approach of G-protein coupled receptors using chemical genomic information in silico SPR 24

27 Glucocorticoid-induced alternative promoter usage for a novel 5 variant of granzyme A A NC H Functional analysis of the interaction between Tom1L1 and clathrin in membrane traffic Tom1L1 HNK1ST Mechanisms of glutamate-induced intracellular clustering and trafficking of glial glutamate transporter GLT1 in astroglioneuronal cultures GLT1 Fgf16 SP24 Functional analysis of novel ARFGAPs in membrane traffic ARFGAP SP22 I Altered Calcium Currents in Cerebellar Purkinje Cells of the Ataxic Groggy Rat Groggy Ca 2 Fgf DNA Jacalin Coordination of contractile prostanoid receptors in the myometrial contraction for successful parturition SP23 c HNK1 The aromatic amino acid within intracellular loop 2 of the prostaglamdin EP2 receptor is 25

28 essential for association with Galpha-s EEP2 Gs Mechanisms underlying the neuronal death induced by TRPV1 stimulation in rat cortical culturestrpv1 Mechanisms of induction and maintenance of intrathecal ATP-elicited long-lasting allodynia in ratsatp Inhibitory effect of interferons on in vitro cell growth of mouse tumor cell lines in vitro Inhibition of cytokine production by NFkB decoy with antigen presenting cell-targeted carrier in rat acute cardiac allograft rejection model NFkB MAP OAT3 Evaluation of cytokine responses of linear PEI/Plasmid DNA complex in macrophage PEI/ 99mMT1 MMP sulforaphane b Cymserine hoat1 hoat3 PEPT1 Delivery of DNA-based chemo- and immunotherapeutic system to tumormacrophage interface for effective cancer therapydna - Enhancement of gene transfer into antigen presenting cells by novel ph-sensitive mannosylated cationic liposomesh Increased transgene expression by biological responses dependent on in vivo gene transfer methodin vivo H / MATE1 Targeted delivery of sirna to the liver by 26

29 galactosylated cationic liposomes sirna Transdifferentiation of microglia into neurons and astrocytes Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation Y Persistent interferon gene expression by plasmid desighn for cancer therapy a7 a MDR1CYP3A5 _ NMDA AChE a7 NMDA 27

30 COE 1DC9 MC6222 DC NMRIRMSGC HPLCCDDSC

31 DCMC 17 Thomson Scientific Research Front Award

32 30 DC MC12 G GPCR NMR 600MHz NMR 3 1DC5MC243 DC116 X 31) ABC 2) X3) X X

33 COE DC6MC DNA DNA in silico 3. G RNA 21 COE 4 HP( HDL NMR DSC 31

34 ( DCMC10 30 Ca 2 Ca 2 Ca 2 transverse tubuletriad junction j u n c t i o n a l sarcoplasmicreticulum longitudinal regionz-tubulez HNK-1 32

35 33 HNK- 2 GluAT-PGluAT-S GlcAT-P HNK-1 2HNK-1 LTP3 HNK-1 MC 1950 ( DC MC10 24

36 DCMC 24 () OB

37 35 DCMC10 25 Post Doc1DC8 2MC FIP DDS / DDS DC MC1124

38 36 DC MC PETSPECTMRI

39 DNA DNA RNA The First FIP-APSTJ Joint Workshop on Gene Delivery Best Presentation Award HP ( 37

40 38 19 MC Welcome PartyCongratulation Party ( MC 15 Fragment MOFMO FMOFKBPHIV-1

41 DCMC non coding RNA microrna

42 DC7 MC G ( DNA 3F 3

43 41 kozutsumi/ COEDC MC Brigham & Women's HospitalBonventre in vitro in vivo PDDC MC19 DNA

44 42 JR PDDCMC MHzNMR 19 PDDCMC DCMC KEGG 16 53

45 KEGG DNA RNA kuicr. kyoto-u. ac. jp/ projects_j. html GIW (Genome Informatics Workshop)ISMB (Intelligent Systems for Molecular Biology)PSB (the Pacific Symposium on Biocomputing) F PD 43

46 44

47 ,071,304 15,082,619 3,000,000 2,930,000 1,500,000 1,548, ,571,404 19,561,026 2,550,000 1,886,550 3,300,000 3,191, , , , ,170 12,298,404 14,071,304 18,571,404 19,561,026

48 ,000 1,

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