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3 RI FIRST
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5 kg HDL HDL
6 From Bench to Bedside Science Art Humanity Physician Scientist Pharmacist Scientist
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8 Matthias Mann Technology-Driven Science Technology Science Science
9 AD AD B β kda β β B HBCPB AD β - C SELDI- TOF-MS MALDI-TOF-MS/MS HBCPB CPB-BPs AD AD
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11 FIRST: Funding Program for World-Leading Innovation R&D on Science and Technology Mass Spectrometry: MS MALDI -MS MALDI MS MS MS MS
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14 β Mild Cognitive Impairment MCI
15 という観点から 本プログラムに期待される創 と療の革新的進歩の重要性について示され 閉 会の辞となった 本講演会は多くの方にご出席頂き活発な質疑 応答が行われた 引き続き教育棟 1 階ホールに 会場を移して懇親会が開催された 懇親会では 学生 若手研究者と講演された先生方の活発な 意見交換がされていた また 名誉教授の先生 方 卒業生の方々 教職員並びに学生が講演会 の余韻を楽しみながら親睦を深め合い 本シン ポジウムは盛会のうちに終了した 最後に ご 講演頂いた先生方と参加者の皆さんに厚く御礼 を申し上げ報告を終えたい 13 平澤 明 薬理ゲノミクス分野 原 貴文 最先端創薬研究センター
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17 ISBN- - --
18 会員便り 第 37 回卒業生同窓会 西村 薬学部記念講堂で 薬学の未来を考える京都 シンポジウム が開催された 10 月 30 日に 私 達 37 回卒 23 名は京都岡崎に集まりました 近 畿に最接近した季節外れの台風 14 号も 私達 の熱い思いが南に押しやり 集合時間の午前 10 時過ぎには雨も止み 午後には晴れ間さえ 見えました 首都圏では年に数回 関西地区でも数年に一 度有志が集まってはいましたが 卒業生全員に 呼びかけての全体会は卒業後19年振り1995年3 月 阪神大震災の2ヶ月後に芝蘭会館で開催した のが初めてでした 2 回目は 9 年後の 2006 年 10 月京大会館で開催し 今回は3回目になります 卒業以来 日本全国 世界各地で活躍してい る仲間ですが 同窓会は懐かしい京大周辺でと いう声が多く 今回も岡崎 白河院 で同窓会 を行いました 前回までの会では卒業後 20 年以上経って初 めて会う人が多く 出席者の自己紹介だけで結 構盛り上がって終わりました 今回は趣向を変 えて同窓会の前に 岡崎に散在する有名な別荘 群の中のひとつ 住友家の別荘 有芳園 拝観 ツァーを計画しました 隣接した住友コレク ションを保有する 泉屋博古館 で数々の中国 青銅器や日本美術 屏風絵 襖絵 茶碗 磁器 等 を三々五々鑑賞した後 住友史料館の研究 員の方の案内で 雄大な別荘内を回遊しました 桂子 第 37 回卒 古の都の岡崎にひっそりと佇む別荘 内に能舞 台まである邸宅の縁側に座り 住友家の好むシ ンプルさを庭師の小川治兵衛さんが東山を借景 にし 疎水の流れを取り入れ 見事に築いた庭 を眺めて ひととき住友家の当主になったよう な気持ちになりました 普段私達が関わってい る医療と全く異次元の世界に触れて 暫し現実 を忘れた時間を過ごしました 同窓会場の白河院では同じ小川治兵衛さんの 築庭を眺めつつ 会席料理に舌鼓を打ちながら ひとり一人が前回から 4 年の間の近況報告をし ました 自分の事 子供の事 孫の事 4 年間 にそれぞれ波瀾万丈 変化に富んだ人生があり 感慨深く聴きました また 卒業時にはその存在すら知らなかった 京都大学 1976 年卒全理系学部卒卒業アルバム を藤吉彰君が持参してくれ 参加者は 34 年前 の自分の姿に驚愕の思いを抱きました 同窓会を終えて懐かしい京大周辺を散策しつ つ 10 月 1 日に約四半世紀振りに再オープンし た楽友会館の会議室で全員参加の二次会をし 同窓会の最後をしめくくりました 今回の参加者の近況報告で 皆が激動の時代 を生きており また 年齢的にも社会で 家庭 で 変化の大きな時期に来ていますので 次回 は早い目 2 4 年後の還暦前後に元気で再会出 来ることを約束して楽しい一日を終えました 有芳園門前にて 白河院庭園にて 16
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22 Fellow of the American Association of Pharmaceutical Scientists DMPK Award for the Most Frequently DownLoaded Review Article in Controlled Release Society, Fellow of the CRS International Pharmaceutical Federation, FIP Fellow Award
23 Effects of Additives on Physical and Chemical Stability of Drug in Solid State Formulation Synthesis of Nitrogen-Containing Polycyclic Compounds through Copper-Catalyzed Multi- Component Reaction Synthetic Studies on Nitrogen Heterocycles by Transition Metal-Catalyzed C-H Bond Functionalization and Their Synthetic Application to Biologically Active Compounds C H Au I Structural Biology Studies on the Overexpression and Translocation of Peroxisomal Membrane Protein Development of peptide inhibitors of the receptor tyrosine kinase activity in a novel inhibitory mechanism Spontaneous Reconstitution of Discoidal HDL from Model Membranes by Apolipoprotein A-I A-I HDL D, L- HNK- BMP Brorin Brorin-like Three Homologous ArfGAPs Participate in Coat Protein I-mediated Transport ArfGAP - ArfGAP COPI MAP Roles of angiotensin type 1 receptor signaling in neuroprotection
24 - m Development of DNA vaccine-based anti-tumor immunotherapeutic system DNA H+/ MATE Stabilization of a Formaldehyde-Sensitive Drug Substance by Meglumine and a Compression- Sensitive Drug Substance by a Wet-Granule Tableting Method Michael ADAM Development of histidine-modified gene carriers for improving transfection via enhanced endosomal escape Development of Efficient Methodologies for Construction of Bicyclic Heterocycles by Palladium-Catalyzed Domino Cyclization Transportin Molecular Clocks in Mouse Skin GPR120 Receptor-Ligand Interaction: Design and Pharmacological Characterization of Novel GPR120 Agonist GPR GPR
25 NMR GPP GPCR β -- Sp NMR Cryptochrome X D HDL 祏 Sec NHC α- β- D-Glucose calumin SynCAM TRIC-B BSRPs Analysis of the interferon system in mouse neuroblastoma C1300 cells
26 C Subcellular localization of flippases that determine phospholipid asymmetry in biological membranes Molecular mechanism of serotonin efflux induced by a psychostimulant, MDMA MDMA A critical role of TRPM2 channel in inflammatory and neuropathic pain TRPM Mechanisms of sustained MDMA-induced augmentation of 5-HT release in raphe serotonergic slice culture MDMA -HT Neudesin Wnt Neucrin Fgf zebrafish Fgf Arf BIG BIG Analysis of mechanisms that underlie TGN localization of BIG1 and BIG2, Arf-guanine nucleotide exchange factors GTPase Arf Localization and function of a small GTPase, Arf6, during cytokinesis in silico HIV Predicting target proteins of novel anti-hiv inhibitors using in silico method PGE -EP PGI - IP Different Roles of PGE 2 -EP3 and PGI 2 -IP Signaling in Acute Inflammation Sp GATA- zif Arg Development of in vivo long-term gene expression system in the kidney using ΦC31 integrase in mice ΦC integrase in vivo Development of primary mesenchymal stem cells with long-term expression of EmGFP using transposon EmGFP Investigation of transfection characteristics by pressure-mediated transfection method in rat kidney Evaluation of intratracheally instilled liposomal doxorubicin for inhibition of lung metastasis in mice Inhibition of bone metastasis by catalase delivery to the bone Development of anti-muc1 aptamer/amino acid dendrimer bioconjugates for tumor cell targeting
27 MUC / β sulforaphane naβ QAND AGHA NAZARI Evaluation of anti-oxidant activity of natural products using oxidative stress model induced by intrastriatal microinjection of sodium nitroprusside in mice Sodium nitroprusside Nrf -ARE β boron dipyrromethene BODIPY β GLP- F- MT -MMP Control of spatiotemporal distribution of IFN-γ for optimization of IFN-γ gene therapy IFN-γ IFN-γ Acceleration of wound healing by increasing survival of transplanted cells using adhesamine, a synthetic cell adhesion molecule adhesamine Role of inflammatory cytokines and reactive oxygen species on reactivation of transgene expression Improved dermal delivery of CpG oligodeoxynucleotides by cholesterol modification for the treatment of atopic dermatitis CpG Development and evaluation of polypodna, a polypod-like structure forming nucleic acid -polypodna- KANITTA WATCHARANURAK Effect of sustained interferon-γ gene expression on atopic and contact dermatitis in mice γ
28 GPR mirna CK CXCR HIV- gp /SA CXCR HIV Pachastrissamine Ca + C- HIF- α BEKIR ERGUNER Extracting Common Substructures of GPCR Ligands G
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52 gtsuji kazushmz hsugimot akirama jutsumi kazushmz fsato okuno eri.segi.nishida araki takeshim sakaedat mnegishi hirokato yasu htakema Fax - Fax - Fax - : : yakuyu@pharm.kyoto-u.ac.jp
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The most remarkable characteristic of the mammalian neocortex is its layered structure. Because all, but only the mammalian species, have this layered structure in the telencephalon, it has been accepted
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