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1 Feature Article Earozoru Kenkyu, 25, - Pharmaceutical Particulate Design by Spray-Drying Technique Hiromitsu YAMAMOTO Received April Accepted May Abstract Spray dry technique is one of the useful tools and is widely used for preparing pharmaceutical dosage forms and manufacturing pharmaceutical excipients. Spray drying of particles adds functions to the raw particles, e.g., flowability and compressibility. Other advantages of spray drying technique are to encapsulate drug in polymer matrix microcapsuleand prepare the composite particle by a simple process. Microcapsule shows the controlled release properties. In developing the drug delivery system, nano-drug carriers are paid recent attention. The spray dry technique can produce composite of nano-drug carrier and sugar alcohol in powder state. When the nano-composite powder is administered, the nano-drug carrier can promptly dissolve by the dissolution of sugar alcohol. The spray drying technique will be used more widely and more frequently in the future as a tool for hybridization of drug with functional materials so as to develop effective drug delivery systems. Key WordsSpray-Drying Technique, Composite Particle, Tabletting, Controlled Release, Nanoparticle, Spray Drying Fluidized Bed Granulator, Four-Fluid Nozzle. - - Department of Pharmaceutical Engineering, School of Pharmacy, Aichi Gakuin University - Kusumoto-cho, Chikusa-ku, Nagoya - Corresponding Author. hiromitu@dpc.agu.ac.jph. Yamamoto nm SupeerTab SDDMV-fonterra Excipients Japan Flowlac Meggle Cellactose MicroLac Vol. No.

2 StarLac Bromans Fig. 1 Tensile strength of various tablets. Spray-dried lactose Spray-dried composite particle of lactose-na alginate Physical mixture of lactose-na alginate Lactose for direct tabletting DCL Fig. 2 Dissolution profiles of acetaminophen from the matrix tablets.,spray-dried composite particle lactose Na alginate,physical mixture of lactose-na alginate,sodium alginate Closed symbolsjp No. medium ph., Open symbolsjp No. medium ph. Yasuji Fig. 1 ph. Fig. 2 ph.

Fig. 3 Scanning electron microphotograph of matrix made by spray-drying

4 Released of bulk drug from matrix made by spray-drying technique at ph.

3 Fig. 3 Scanning electron microphotograph of matrix made by spray-drying technique. Fig. 3 Yajima Fig. 4Fig. 5 NED.. Fig. 4 Released of bulk drug from matrix made by spray-drying technique at ph.. Matrix made by spray-drying technique Matrix treated with heat Intact drug Fig. 5 Dissolution profiles of theophylline from matrix tablet prepared from theophylline particle coated with acrylic polymer Eudragit NED. DrugPolymer:,,, Theophylline Vol. No.

4 . Ostwald ripening nm μm R, Fig. 6 Fig. 6 Granulation mechanism of spray drying fluidized bed granulator Agglomaster.

5 Fig. 7 μm μm Ozeki Fig. 8 Fig. 7 Scanning Electron Microphotograph of PLGA- Mannitol nanocomposite granules. Fig. 8 Schematic diagram of the four-fluid nozzle. Fig. 9 SEM photographs microsphere and dispersed nanoparticles and size distribution of dispersed nanoparticles. Vol. No.

6 Fig. 9 References Bromans, H., Bolhuis, G. K., Lerk, C. F., Van de Biggellar, H. and Bosch, H.: Studies on Tabletting Properties of Lactose. VII. The Effect of Variations in Primary Particle Size and Percentage of Amorphous Lactose in Spray Dried Lactose Particles, Int. J. Pharm., 35, - Takeuchi, H., Yasuji, T., Yamamoto, H., Hino, T. and Kawashima Y.: Spray-Dried Composite Particles of Lactose and Sodium Alginate for Direct Tabletting and Controlled Releasing, Int. J. Pharm., 174, - Liu, D., Ichikawa, H., Cui, F. and Fukumori, Y.: Short-Term Delayed-Release Microcapsules Spray Coated with Acrylic Terpolymers, Int. J. Pharm., 307, - Yajima, T., Nogata, A., Demachi, M., Umeki, N., Itai, S., Yunoki, N. and Nemoto M.: Particle Design for Taste-Masking Using a Spray- Cingealing Technique, Chem. Pharm. Bull., 44, - Takeuchi, H. and Kawashima, Y.: Aqueous Polymeric Coatings for Harmaceutical Dosage Forms. nd edition, p.-, Marcel Dekker Tahara, K., Sakai, T., Yamamoto, H., Takeuchi, H., Hirashima, N. and Kawashima Y.: Improved Cellular Uptake of Chitosan- Modified PLGA Nanospheres by A Cells, Int. J. Pharm., 382, - Lamprecht, A., Yamamoto, H., Takeuchi, H. and Kawashima, Y.: A ph-sensitive Microsphere System for the Colon Delivery of Tacrolimus Containing Nanoparticles, J. Control. Release, 104, - Yamamoto, H., Kuno, Y., Sugimoto, S., Takeuchi, H. and Kawashima, Y.: Surface-Modified PLGA Nanosphere with Chitosan Improved Pulmonary Delivery of Calcitonin by Mucoadhesion and Opening of the Intercellular Tight Junctions, J. Control. Release, 102, - Yamamoto, H., Hoshina, W., Kurashima, H., Takeuchi, H., Kawashima, Y., Yokoyama, T. and Tsujimoto, H.: Engineering of PolyDL-lactic-co-glycolic acidnanocomposite Particles for Dry Powder Inhalation Dosage Forms of Insulin with the Spray- Fluidized Bed Granulating System, Adv. Powder Technol., 18, - Ohashi, K., Kabasawa, T., Ozeki, T. and Okada, H.: One-Step Preparation of Rifampicin /Polylactic-co-glycolic acid Nanoparticle-Containing Mannitol Microspheres Using a Four- Fluid Nozzle Spray Drier for Inhalation Therapy of Tuberculosis, J. Control. Release, 135, -

Feature Article Earozoru Kenkyu, 26 1, Preparation of Nanoparticles by Ultrasonic Spray Pyrolysis 1 Takashi OGI 1 and Kikuo OKUYAMA 1 Rec

Feature Article Earozoru Kenkyu, 26, 36 4 20 Preparation of Nanoparticles by Ultrasonic Spray Pyrolysis Takashi OGI and Kikuo OKUYAMA Received 2 August 200 Accepted 29 September 200 Abstract In this review,