Toshio HAMADA, M.D. and Tadao SAITO, M.D.

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1 Toshio HAMADA, M.D. and Tadao SAITO, M.D.

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8 皮 第9図癜 膚 第18巻 風 の褐 色 性 皮 疹 部 の 組織 像,PAS-premelanin反 応( 200) 第4号 369 昭 和51年11月 第10図 基 底 層 の メラ ニ ン顆 粒 同褐 色 性 皮 疹 の 辺 縁 健 常 部 の 組 織 像,PASpremelanin反 応( 200) 増 加,角 質 層 内に 軽 度菌 要 素,有 棘 層 の軽 度 肥 厚 を示 す 第11図癜 風 の 毛 嚢 一 致 性 脱 色 性 皮 疹 の 組 織 像, PAS-premelanin反 応( 120),毛 第12図 嚢上部 基 底 層 の メ ラ ニ ン顆 粒 の や や 減 少 を 示 す 第13図癜 風 の 褐 色 性 皮 疹 の 組 織 像,PAS-premelanin反 示す 応( 300) 角 栓 内の 胞 子 の集 落 を 同 毛 嚢 一 致 性 脱 色 性 皮 疹 の 組 織 像 の 拡 大, PAS-premelanin反 応( 800) 毛 嚢 内の 胞 子 の集 落 を示 す 第14図癜 風 の褐 色 性 皮 疹境 界 部 の 剥 離 表 皮 のdopa 反応( 40) 辺縁 健常 部 写 真 左 は褐 色性 皮疹 部,右 は

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10 histochemical and therapeutic studies, Internat. J. Derm., 14: , Charles, C. R., Sire, D. J., Johnson, and Beidler, J. G.: Hypopigmentation B. L. in tinea versicolor: a histochemical and electronmicroscopic study, Internat. J. Derm., 12: 48-58, Zimmermann, A. A. and Becker, S. W., Jr. Melanoblasts and melanocytes in fetal : Negro skin, Illinois Monographs in Medical 1. Gordon, M. A.: Lipophilic yeastlike organisms associated with tinea versicolor, J. Invest. Derm., 17: , Burke, R. C.: Tinea versicolor: susceptibility factors and experimental infection in human beings, J. Invest. Derm., 36: , Roberts, S. O. B.: Pityrosporum orbiculare: incidence and distribution on clinically normal skin, Brit. J. Derm., 81: , Beare, J. M., Gentles, J. C. and Mackenzie, D. W. R.: Pityriasis versicolor, Textbook of Dermatology (Rook, A., Wilkinson, D. S. and Ebling, F. J. G., Eds. ), Vol. 2, 2 nd Ed., Blackwell Scientific Publications. Oxford. 1972, Science, VI( 3 ), Univ. Illinois Press, Urbana, Illinois, 1959, Staricco, R. J. and Pinkus, H.: Quantitative and qualitative data on the pigment cells of adult human epidermis, J. Invest. Derm., 28: 33-45, Lii, S.: Cultivation and pathogenicity of Malassezia furfur with special respect to mycological studies on etiological fungus of tinea (pityriasis) versicolor, Tokushima J. Exper. Med., 16: , Roberts, S. O. B.: Pityriasis versicolor: a clinical and mycological investigation, Brit. J. Derm., 81: , Keddie, F. and Shadomy, S.: Etiological significance of Pityrosporum orbiculare in tinea versicolor, Sabouraudia, 3: 21-25, McGinley, K. J., Lantis, L. R. and Marples, R. R.: Microbiology of tinea versicolor, 6. Kistiakovsky, E. V.: Pityriasis versicolor and ultraviolet rays: achromic cutis postparasitaria, Arch. Derm. & Syph., 15: Arch. Derm., 102: , Hildick-Smith, G., Blank, H. and Sarkany, I.: Fungus Diseases and Their Tre , Lewis, G. M. and Hopper, M. E.: Pseudoachromia of tinea versicolor: clinical and 1964, p.5-9. æ èˆø p B atment, J. A., Churchill Ltd., London, experimental studies and observations on 18. Gotz, H.: Pityriasis versicolor, Jadassohn'- the use of filtered ultraviolet rays (Wood sche Handbuch d. Haut-u. Geschlekrkh., filter), Arch. Derm. & SyPh., 34: , Ergdnzungswerk, IV/3, Springer-Verlag, Berlin, 1962, Adamson, H. G.: Pityriasis versicolor with 19. Pinkus, H. and Mehregan, A. M.: Pigmentary disorders, A Guide to Dermatohistop- subsequent leucodermic patches, Brit. J. Derm., 61: , athology, 2 nd Ed., Appleton-Century- 9. El-Gothamy, Z., Abdel-Fattah, A, and Ghaly, Crofts, New York, 1974, A. F.: Tinea versicolor hypopigmentation :

11 Revised Ed., Harper & Row, Publishers, 21. Lewis, G. W., Hopper, M. E., Wilson, J. W. and Plunkett, 0. A.: Tinea versicolor, An Introduction to Medical Mycology, 4 th Ed., Year Book Publishers, Inc., Chicago, 1958, Wilson, J. W. and Plunkett, O. A.: Tinea versicolor, The Fungous Diseases of Man, 1st Ed., Univ. of California Press, Berkeley, California, 1965, Graham, J. H.: Tinea versicolor, Dermal Pathology (Graham, J. H., Johnson, W. C. and Helwig, E. B., Eds. ), 1 st Ed., Harper & Row, Publishers, Hagerstown, Maryland, 1972, Taplin, D. and Rebell, G.: Tinea versicolor (pityriasis versicolor), Clinical Dermatology, Vol. 3 (Demis, D. J., Crounse, R. G., Dobson, R. L. and McGuire, J., Eds.), Hagerstown, Maryland, 1975, Unit Papa, C. M. and Kligman, A. M.: The behavior of melanocytes in inflammation, J. Invest. Derm., 45: , Emmons, C. W., Binford, C. H. and Utz, J. P.: Pityriasis versicolor, Medical Mycology, 1 st Ed., Lea & Febiger, Philade 1phia, 1970,

12 Pigment Abnormality in Lesions of Tinea Versicolor Toshio Hamada and Tadao Saito Department of Dermatology, Osaka City University Medical School Out of 73 patients with tinea versicolor, hypopigmented lesions were observed in 34 cases (47 per cent), while hyperpigmented lesions in 16 cases (22 per cent). A combination of hypo- and hyperpigmented lesions was found in only three cases of them. The initial lesions generally appeared at the follicular portions, and gradually become hypopigmented as they enlarge. The older were the lesions, the more spores were found. Histopathologic studies of lesions of tinea versicolor revealed mild acanthosis and a tendency to vanish the dermal papillae. The amount of melanin granules of the basal layer either decreased or increased, depending upon the clinical appearance, that is, hypo- or hyperpigmentation. The appearance of Malassezia furfur in the horny layer and hyperkeratosis at the boundary of the lesion with the surrounding areas were first noticed, followed by changes of the amount of melanin granules at the basal layer, and acanthosis appeared a little later. In the hypopigmented lesions, the epidermal melanocytes were weaker in dopa reaction and less in number than in the surrounding normal areas (p<0.05). On the other hand, in the brownish pigmented lesions, they were stronger in dopa reaction and somewhat more in number than in the surrounding normal areas. It seems that the hypopigmention of the lesion is apt to occur in subjects with dark skin color, while the hyperpigmentation in ones with light skin color.

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