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3 ProQuest Dialog / / MEDLINE EMBASE MEDLINE... 4 MEDLINE Embase... 5 Embase MEDLINE... 5 Embase MeSH EmtreeEmbase

4 SU MEDLINE MEDLINE Embase ProQuest Dialog

5 ProQuest Dialog ProQuest Dialog ProQuest Dialog MEDLINE / 1 Embase 1947 Embase Alert BIOSIS Previews 1926 Derwent Drug File 1964 International Pharmaceutical 1970 Abstracts (IPA) Adis Clinical Trials Insight 1990 Toxfile 1965 Adis Pharmacoeconomics & / Outcomes News 1 Adis Reactions Database 1983 Prous Science Daily Essentials ( ) IMS R&D Focus Drug News 1995 ESPICOM Pharmaceutical & 2000 Medical Device News ABI/INFORM Professional 1971 Advanced Adis R&D Insight / 1 IMS R&D Focus

6 ProQuest Dialog / Drug Information Fulltext / 1 Registry of Toxic Effects of Chemical Substances (RTECS ) 170, IMS New Product Focus /1 IMS Pharma Trademarks / /1 Incidence & Prevalence / Database 1 Gale Group PharmaBiomed / Business Journals 1 Business & Industry / 1 British Nursing Index / 1 EMCare / 1 Lancet Titles The Lancet / 1 New England Journal of The New England Journal of Medicine / Medicine 1 ProQuest Biological & Health Science Professional 26 1 / 1 KOSMET: Cosmetic Science / 1 FDAnews FDA / 1 IMS Company Profiles 1 / 1 Allied & Complementary Medicine / 1 ProQuest Dialog 2

7 MEDLINE EMBASE ProQuest Dialog ProQuest Dialog Dialog ProQuest Dialog MEDLINE Embase BIOSIS Derwent Drug IPA File ,600 8,500 5,400 1, ,500 NLM Elsevier Thomson Reuters Thomson Reuters Thomson Reuters ( ) ( 70) EMBASE MEDLINE ProQuest Dialog MEDLINE Embase MEDLINE Embase BIOSIS Embase Embase BIOSIS MEDLINE Embase Derwent Drug File IPA 3

8 ProQuest Dialog MEDLINE MEDLINE MEDLINE National Library of MedicineNLM 1946 MEDLINE 6 DSTATDSTAT(publisher) PUBLISHER IN-DATA-REVIEW IN-PROCESS MEDLINE OLDMEDLINE PUBMED-NOT-MEDLINE PubMed (MEDLINE ) MeSH NLM MeSH NLM MeSH MeSH MEDLINE PublisherIn-Data-ReviewIn-ProcessMEDLINE MeSH MeSH MEDLINE MEDLINE MeSH PublisherIn-Data-ReviewIn-Process MEDLINE 70 5, List of Serials Indexed for Online Users XML 4

9 ProQuest Dialog Embase Embase Embase Elsevier B.V , Embase MEDLINE 8,500 Embase MEDLINE MEDLINEOLDMEDLINEPublisher In-Data-ReviewIn-ProcessPubmed-not-MEDLINE Embase Alert 2 MEDLINE 5

10 ProQuest Dialog 6

11 ProQuest Dialog MEDLINE 7

12 ProQuest Dialog Embase 8

13 ProQuest Dialog Embase 9

14 ProQuest Dialog ProQuest Dialog AND Google Dialog TI TIO PUB JN clean robot TI( diabetes mellitus ) TIO( diabetes mellitus ) PUB(ophthalmology) PUB.EXACT(ophthalmology) AB AB(molecular n/0 clon) MeSH (MEDLINE ) MESH MESH(heart) MeSH MJMESH MJMESH( heart diseases ) Emtree (Embase ) EMB EMB(cancer) Emtree MJEMB MJEMB( abdominal cancer ) IF IF(antiepileptic and drug*) SUBST SUBST(sitagliptin) TI,AB,MESH,EMB( diabetes mellitus ) 10

15 ProQuest Dialog (taller)(tallest) TOXIC 10 toxictoxicitytoxicology TOXIC / 10 toxictoxicitycytotoxicecotoxicology TOXIC 10 toxiccytotoxicnontoxicgenotoxic TOXC 10 toxictoxinictoxoplasmic TOXIC[3] TOXIC??? [3] 125 toxictoxicity toxicology? 1 toxicitytoxicanttoxicite toxic ANDORNOT AND OR AND > NEAR > PRE > AND > OR > NOT Dialog ProQuest Dialog W PRE/0 P/0 air p/0 filter nw PRE/n P/n n air p/3 filter N NEAR/0 N/0 air n/0 filter nn NEAR/n N/n n air n/3 filter L LNK MESH.EXACT(hypertension LNK dt) heart attack heart attack heart p/0 attack ((heart OR coeur OR cor) AND attack) OR "cardiac infarction" OR "myocardial infarction" "heart attack" OR "cardiac infarction" OR "myocardial infarction" (heart OR coeur OR cor) p/0 attack heart-attack heart-attack heartheart attack heart heart attack 11

16 ProQuest Dialog MEDLINE MeSHMedical Subject HeadingsEmbase EMTREE MEDLINE MeSH Neoplasms Embase Emtree Neoplasm MEDLINE cancer carcinoma tumor MeSHNeoplasms MeSHNeoplasms MeSHNeoplasms carcinomacancertumor Neoplasms carcino* OR cancer* OR tumor* OR tumour* MESH(neoplasms) EMB(neoplasm) MeSH Neoplasms NeoplasmsLIVER NEOPLASMSLUNG NEOPLASMS EXPLODE 12

17 ProQuest Dialog MeSH MEDLINE MeSH MeSH MeSHMedical Subject Headings NLM MeSH ProQuest Dialog NLM MeSH Browser MeSH MeSH ProQuest Dialog MeSH MEDLINE MeSH OLDMEDLINE MeSH NLM NLM MeSH Browser MeSH EmtreeEmbase MEDLINE MeSH Embase Emtree Elsevier Emtree Emtree ProQuest Dialog Emtree ProQuest Dialog Emtree Emtree 13

18 ProQuest Dialog STEP1 STEP2 search.proquest.com STEP3 MeSH 14

19 ProQuest Dialog STEP4 w vitamin c vitamin c vitamin c Vitamin C STEP5-1 STEP4 Vitamin C vitamin c Ascorbic Acid -Vitamin C Vitamin C MeSH Ascorbic Acid Ascorbic Acid Ascorbic Acid Ascorbic Acid Explode Dehydroascorbic Acid Major Major Ascorbic Acid 15

20 ProQuest Dialog STEP5-2 Ascorbic Acid STEP6 STEP5 MESH.EXACT("Ascorbic Acid") MESH.EXACT.EXPLODE("Ascorbic Acid ") MJMESH.EXACT("Ascorbic Acid") STEP7 16

21 MeSH ProQuest Dialog a. MEDLINEMeSH MESH(eye) MeSH eye Eye Eye Diseases Dry Eye Syndromes MeSH MESH.EXACT(eye) MESH.X(eye) MESH( eye injuries ) DialogS EYE/DE MeSH eye DialogS EYE/DF MeSH eye injuries Eye Eye Injuries Eye Injuries, Penetrating MESH.EXACT( eye injuries ) MESH.X( eye injuries ) DialogS EYE(W)INJURIES/DE MeSH eye injuries Eye Injuries MESH.EXACT.EXPLODE( eye injuries ) MESH.#( eye injuries ) MESH#( eye injuries ) MJMESH(eye) MJMESH.EXACT(eye) MJMESH.X(eye) MJMESH( eye injuries ) DialogS EYE INJURIES/DE MeSH DialogEYE INJURIES! MeSH eye DialogS EYE/MAJ MeSH eye MeSH eye injuries Eye Injuries Eye Burns Eye Injuries Corneal Perforation Eye Injuries Eye() Eye Diseases() Dry Eye Syndromes() Eye() Eye Injuries() Eye Injuries, Penetrating() MJMESH.EXACT( eye injuries ) MJMESH.X( eye injuries ) DialogS EYE(W)INJURIES/MAJ MeSH eye injuries Eye Injuries() MJMESH.EXACT.EXPLODE( eye injuries ) MJMESH.#( eye injuries ) MJMESH#( eye injuries ) DialogS EYE INJURIES/MAJ MeSH DialogS EYE INJURIES!/MAJ Eye Injuries() Eye Burns() (Eye Injuries Corneal Perforation() Eye Injuries b. EmbaseEMTREE a. MESH EMB MJMESH MJEMB c. MEDLINE Embase OR MeSH Emtree MESH,EMB(eye) MESH.EXACT(aspirin) OR EMB.EXACT("acetylsalicylic acid") SU.exact(aspirin OR acetylsalicylic acid ) MeSH Emtree eye MeSH aspirin Emtree acetylsalicylic acid SU aspirin acetylsalicylic acid SU MESHEMB 17

22 ProQuest Dialog a. MEDLINE MEDLINE Embase Embase b. MEDLINE Embase 2 0 c. MEDLINE 1966 Embase 1988 a. LNK Explode MESH.EXACT("Fatty Liver, Alcoholic" LNK (th OR dt OR dh)) MESH.EXACT("Fatty Liver, Alcoholic" LNK (therapy OR "drug therapy" OR "diet therapy")) 18 MeSH "Fatty Liver, Alcoholic" ththerapy dtdrug Therapy dhdiet Therapy

23 ProQuest Dialog [] STEP1 indometacin STEP2 Indomethacin Indomethacin Indomethacin STEP3 adverse effects (AE) contraindications (CT) poisoning (PO) toxicity (TO) 19

24 ProQuest Dialog STEP4: [] MESH.EXACT("Indomethacin -- toxicity") OR MESH.EXACT("Indomethacin -- adverse effects") OR MESH.EXACT("Indomethacin -- contraindications") OR MESH.EXACT("Indomethacin -- poisoning") MESH.EXACT(Indomethacin LNK (toxicity OR "adverse effects" OR contraindications OR poisoning)) MESH.EXACT(Indomethacin LNK (to OR ae OR ct OR po)) MESH.EXACT(indomethacin LNK qx) MEDLINE Embase ProQuest Dialog MEDLINE Embase QX PO TO AE CT AE TO QT TH DH DT NU PC RT RH SU TR DT RT SU TH QD DI PA RA RI US DI SU MEDLINE MESH MJMESH Embase EMB MJEMB BIOSIS SU MJSUB SU MJSUB MESHEMBIF 20

25 ProQuest Dialog Ziecik, Adam J Ziecik, Adam Ziecik, A J MEDLINE AU("ziecik, adam j") AU("ziecik adam j") AU(ziecik, adam j) AU(ziecik adam j) Ziecik, Adam J. Ziecik, A.J. Embase AU("ziecik, adam") AU("ziecik adam") AU(ziecik, adam) AU(ziecik adam) AU("ziecik, a") AU("ziecik a") AU(ziecik) au()au() au( A AND B) AND JR AU("ziecik a") OR AU("ziecik adam*") AU("ziecik adam*") OR (AU("ziecik a") and reproduct*) 21

26 ProQuest Dialog ProQuest Dialog FAU Ziecik, Adam J Ziecik, Adam Ziecik, A J MEDLINE FAU("ziecik, adam j") FAU("ziecik adam j") FAU("ziecik, adam") FAU("ziecik adam") FAU("ziecik, a") FAU("ziecik a") FAU(ziecik) Embase Ziecik, Adam J. Ziecik, A.J. MEDLINE MEDLINE PER( yamanaka s ) PER( yamanaka shinya ) 22

27 ProQuest Dialog AF("University of California Berkeley") AF("France") AF() MEDLINEEmbase ISSN NLM CODEN MEDLINE pub.exact("the Journal of clinical investigation") pub.exact("journal of clinical investigation") pub("journal of clinical investigation") International Journal of pub.exact("j clin invest") pub("j clin invest") International Journal of jn("the Journal of clinical investigation") jn("journal of clinical investigation") JC( ) The ISSN( ) ISSN( ) Embase CODEN(JCINA) exact 23

28 ProQuest Dialog STEP1 STEP2 clinical investigation STEP3 MeSH Publication Type Embase Document Type 24

29 ProQuest Dialog DTYPE("journal article") DTYPE("clinical trial") clinical trial, phase II RTYPE.EXACT( clinical trial ) clinical trial DTYPE RTYPE DTYPE RTYPE.EXACT Embase 1989 遡 RTYPE.EXACT(review) OR EMB.EXACT(review) RTYPE,EMB.EXACT(review) MEDLINE Addresses Article Autobiography Bibliography Biography Case Reports Classical Article Clinical Conference Clinical Study Clinical Trial Clinical Trial, Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV Comment Comparative Study Congresses Consensus Development Conference Consensus Development Conference, NIH Controlled Clinical Trial Corrected And Republished Article Dataset Dictionary Directory Duplicate Publication Editorial English Abstract Evaluation Studies Festschrift Government Publications Guideline Historical Article Interactive Tutorial Interview Introductory Journal Article In Vitro Journal Article Lectures Legal Cases Legislation Letter Meta-Analysis Multicenter Study News Newspaper Article Observational Study Overall Patient Education Handout Periodical Index Personal Narratives Portraits Practice Guideline Published Erratum Randomized Controlled Trial Research Support, American Recovery And Reinvestment Act Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Retracted Publication Retraction Of Publication Review Scientific Integrity Review Technical Report Twin Study Validation Studies Video-Audio Media Webcasts Embase Abstract Report Article Article In Press Book Chapter Conference Abstract Conference Paper Conference Review Editorial Erratum Letter Note Patent Press Release Review Short Survey

30 ProQuest Dialog ProQuest Dialog ProQuest Dialog UD Dialog UD ProQuest Dialog 2009 ProQuest Dialog FAV UD LUPD FAV 1 UD LUPD FAV( ) FAV(201009) FAV(2010) FAV( ) FAV( ) FAV( ) FAV(>=2010) UD( ) UD(201009) UD(2010) UD( ) UD( ) UD( ) UD(>=2010) LUPD( ) LUPD(201009) LUPD(2010) LUPD( ) LUPD( ) LUPD( ) LUPD(>=2010) ProQuest Dialog ProQuest Dialog FAV LUPD UD 1 ProQuest Dialog FAV( )0 26

31 ProQuest Dialog MEDLINE DCRE( ) DCRE(201009) DCRE(2010) DCRE( ) DCRE( ) DCRE( ) DCRE(>=2010) DCOM( ) DCOM(201009) DCOM(2010) DCOM( ) DCOM( ) DCOM( ) DCOM(>=2010) DREV( ) DREV(201009) DREV(2010) DREV( ) DREV( ) DREV( ) DREV(>=2010) PD( ) PD(201301) PD(2013) PY(2013) YR(2013) MEDLINE MEDLINE Pubmed-not-MEDLINE PD PYYR HUMAN(YES) S1 AND HUMAN(YES) S1 NOT HUMAN(YES) ANIMAL(YES) S3 AND ANIMAL(YES) MALE(YES) FEMALE(YES) MEDLINE Embase ABANY(YES) S1 AND ABANY(YES) S3 NOT ABANY(YES) MEDL(YES) S1 AND MEDL(YES) S2 NOT MEDL(YES) Embase MEDLINE Embase 27

32 ProQuest Dialog STEP1 Embase EMBASE 2013 thesaurus STEP2 aspirin aspirin aspirin STEP3 aspirin acetylsalicylic acid 28

33 ProQuest Dialog STEP4 acetylsalicylic acid STEP5 STEP6 MEDLINE Embase MEDLINE MeSH 2013 Thesaurus 29

34 ProQuest Dialog STEP7 aspirin Aspirin Aspirin STEP8 Aspirin STEP9 ProQuest Dialog MEDLINE MESH Embase EMB Dialog FROM 30

35 ProQuest Dialog STEP10 OR STEP11 MESH.EXACT(aspirin LNK (AE or PO or CT or TO)) EMB.EXACT( acetylsalicylic acid LNK (AE or IT or TO)) (S1 or S2) and HUMAN(YES) 4 31

36 ProQuest Dialog Dialog Update ProQuest Dialog MEDLINE Embase Embase Embase MEDLINE Dialog MEDLINE MEDLINE Embase Embase Alert STEP1 STEP2 0 Biweekly 32

37 ProQuest Dialog STEP3 90 HTML HTML HTML ID ID ID ID 33

38 ProQuest Dialog 1MEDLINE 34

39 ProQuest Dialog 35

40 ProQuest Dialog 36

41 ProQuest Dialog 隙 37

42 ProQuest Dialog ( 38

43 ProQuest Dialog 2MEDLINE 39

44 ProQuest Dialog 3Embase MEDLINE MEDLINE 40

45 ProQuest Dialog 41 MEDLINE

46 ProQuest Dialog Embase 42

47 ProQuest Dialog ProQuest Dialog ProQuest Dialog ProQuest Dialog Loop-X G-Search Ltd.

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