ALPHA ADRENERGIC MECHANISM ON THE REFLEX MICTURITION IN THE MALE DECEREBRATE DOG Tokuo Takahashi Department of Urology, Akita University School of Med

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1 ALPHA ADRENERGIC MECHANISM ON THE REFLEX MICTURITION IN THE MALE DECEREBRATE DOG Tokuo Takahashi Department of Urology, Akita University School of Medicine (Director: Prof. Seigi Tsuchida) We investigated the alterations of urodynamic parameters of reflex micturition evoked by filling the bladder with physiological saline prior to and after the administration of midodrine (alpha 1 agonist), terazosin (alpha 1 antagonist), clonidine (alpha 2 agonist) and yohimbine (alpha 2 antagonist) in 28 male decerebrate dogs. The significant finding produced by midodrine was an increase in contraction pressure, while terazosin produced a significant decrease in threshold pressure, contraction pressure and urethral pressure. Clonidine produced a decrease in threshold pressure, urethral pressure and external urethral sphincter activity, while yohimbine produced a significant increase in bladder volume and urethral pressure. It seems that alpha 1 adrenergic activity modulates urethral closing pressure via postsynaptic alpha 1 receptors, and that alpha 2 adrenergic activity mainly modulates urethral closing pressure via presynaptic alpha 2 receptors in the lower urinary tract function. Key words: 1-adrenarin, reflex micturition, decerebrate dog

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8 1) de Groat, W.C. and Saum, W.R.: Sympathetic inhibition of the urinary bladder and pelvic ganglionic transmission in the cat. J. Physiol. Lond., 220, , ) Nishizawa, 0., Fukuda, T., Matsuzaki, A. and Tsuchida, S.; Role of the sympathetic nerve in bladder and urethral sphincter function during the micturition cycle in the dog evaluated by pressure flow EMG study. J. Urol., 134, , ) de Groat, W.C. and Kawatani, M.: Reorganization of sympathetic pregangionic conections in cat bladder ganglia following parasympathetic denervation. J. Physiology, 409, , ) Nishizawa, 0., Fukuda, T., Matsuzaki, A., Moriya, I., Sato, S. and Tsuchida, S.; Adrener gic influences on the voiding cycle in the decerebrated dog. Neurourol. Urodyn., 5, ,

9 1986, 6) Khanna, OP.: Disoders of micturition. Neuropharmacologic basis and result of drug therapy. Urology, 8, , ) Caine, M.: The autonomic pharmacology of the urinary tract in the pharmacology of the urinary tract. Caine, M., p. 5-30, Springer- Verlag, Berlin, ) Kunisawa, Y., Kawabe, K., Kiijima, T., Honda, K, and Takenaka, T.: A pharmacological study of alpha adrenergic receptor subtypes in smooth muscle of human urinary bladder base and prostatic urethra. J. Urol., 134, , 1985, 9) Honda, K., Takenaka, T., Osawa, A., Terai, M. and Shiono, K.: Studies on YM-12617: A selective and potentantagonist of postsynaptic a 1-adrenoceptors. Arch. Pharmacol., 328, , 1985, 10) Honda, K., Momose, N. and Nakagawa, C.: In vitro characterization of a-adrenergic recepter in rabbit detrusor muscle. Jap. J. Pharmacol., 44, , ) Willete, R.N., Sauermelch, C.F. and Hieble, J. P.: Role of alpha"l and alpha-2 adrenoceptors in the sympathetic control of the proximal urethra. J. Pharmacol. Exp. Ther., 252, , 1990, 13) Imagawa, J., Akiima, M. and Sakai, K.: Functional evaluation of sympathetically mediated respnses in vivo lower uriary tract of dogs. J. Pharmacol. Methods, 22, , ) Keast, R.J., Kawatani, M. and De Groat, W.C. ; Sympathetic modulation of cholinergic transmission in cat vesical ganglia is mediated by al-and a2-adrenoceptors. Am. J. Physiol., 258, R44-50, ) Hedlund, H., Anderson, K.E. and Ek, A.: Effect of prazosin in patient with benign prostatic obstruction. J. Urol., 130, , 1983, 18) Levin, R.M., Ruggeier, M.R. and Wein, A.J.: Identification of receptor subtypes in the rabbit and human urinary bladder by selective radioligand binding. J. Urol., 139, , 1988, 19) Nordling, J., Meyhoff, H. and Hald, T.: Sympatholytic effect on striated urethral sphin. cter. A peripheal or central nervous system effect Scand. J. Urol. Nephrol., 15, , ) Morikawa, K., Ichihashi, M., Kakiuchi, M., Yamauchi, T., Kato, H., Ito, Y, and Gomi, Y.: Effects of various drugs on bladder function in conscious rats. Jap. J. Pharmacol., 50, , 1989, 21) Galeano, C., Corcos, M., Carmel, M. and Jubelin, B.: Action of clonidine on micturitional reflexes in decerebrate cats. Brain. Res., 491, 45-56, 1989, 22) Harada, T.: The effect of alpha"2 agonist and antagonists on the lower urianry tract of the rat. Akita J. Med., 18, , ) Felsen, D., Ernsberger, P., Nguyen, P., Sutaria, P., Breslin, D, and Vaughan, E.D.: A possible site for clonidines action in the canine prostate. J. Urol., 137, 147(part 2 abstract), ) Turusaki, M., Yoshida, M., Akasu, T. and N agatsu, I.: Alpha"2 adrenoceptors mediate the inhibition of cholinergic transmission in parasympathetic ganglia of the rabbit urianry bladder. Synapse, 5, , 1990.

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