JC43604

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1 J Cardiol 2004 Jun; 43 6 : Pheochromocytoma With Reversal of Tako-Tsubo-Like Transient Left Ventricular Dysfunction: A Case Report Yasuko Shin Tatsuya Keiji Naomi TAKENO, MD ENO, MD HONDO, MD MATSUDA,MD ZUSHI, MD Abstract A 59-year-old male was admitted to the emergency department because of sustained chest oppression. Electrocardiography revealed J type ST depression and peaked T wave in leads,, a F, and 4 6. No stenosis was found in the coronary arteries by urgent coronary angiography. Left ventricular abnormal wall movement with akinesis in the base and hyperkinesis in the apical area was observed and improved on the 12th day. Myocardial scintigraphy with iodine-123-metaiodobenzylguanidine showed completely defective images and decreased accumulation in the base with combined thallium-201 and iodine-123- beta-methyl-p-iodophenyl-pentadecanoic acid. Myocardial biopsy on the 12th day disclosed contraction band necrosis. The diagnosis was catecholamine-induced cardiomyopathy caused by pheochromocytoma. J Cardiol 2004 Jun ; 43 6 : Key Words Cardiomyopathies, other tako-tsubo-like left ventricular dysfunction, catecholamine-induced Neoplasms pheochromocytoma : : : mg : Department of Cardiology, Chugoku Rosai General Hospital, Hiroshima Address for correspondence: TAKENO Y, MD, Department of Cardiology, Chugoku Rosai General Hospital, Hirotagaya 1 5 1, Kure, Hiroshima Manuscript received January 29, 2004 ; revised March 17, 2004; accepted March 17,

2 282 竹野 榎野 本藤 ほか 覚したが 放置していた 翌 15 日午前 6 時 30 分から 前胸部圧迫感が出現して持続するため 午前 7 時 30 分 当院の救急外来を受診した 来院時理学的所見 : 身長 167 cm 体重 67 kg 血圧 応 を検索したが いずれも陰性であった 胸部 X 線写真所見 : 心胸郭比は 63% で 明らかな肺 うっ血像は認められなかった 心電図所見 Fig. 1 A : Ⅱ Ⅲ aⅤf Ⅴ4 Ⅴ6 で J 190/98 mmhg 脈拍 73/min 静脈血酸素飽和度 99% Table 1 Laboratory findings on admission 室内気 意識清明 心雑音はなく 肺野にラ音は認 められなかった 腹部は平坦軟で 腫瘤は触知しな かった 神経学的には異常はなかった 来院時検査成績 : 血液学的検査の結果を Table 1 に Complete blood count LDH 215 IU/l BUN 21 mg/dl WBC 17,600/μl RBC /μl Cr 1.35 mg/dl Hb 15.9 g/dl Na 140 meq/l 示す 白血球数の増多がみられたが C 反応性蛋白は Ht 42.8% K 3.2 meq/l 陰性であった クレアチンキナーゼは軽度上昇 血清 Plt /μl Cl 98 meq/l CK 324 IU/l K は低下していた ウイルス抗体価は アデノウイル ス 補体結合反応 インフルエンザウイルス A B Blood chemistry TP 8.0 g/dl CK-MB 0 IU/l Alb 5.0 g/dl Glu 357 mg/dl 補体結合反応 コクサッキーウイルス B1 B2 B3 AST 34 IU/l CRP 0.2 mg/dl B4 B5 補体結合反応 エコーウイルス 6 9 中和反 ALT 41 IU/l Troponin T Fig. 1 Electrocardiograms On admission, the ST-segment was depressed in Ⅱ, Ⅲ, aⅤf and Ⅴ4 Ⅴ6. A : On admission. B : After 3 days. J Cardiol 2004 Jun; 43 6 :

3 283 Fig. 2 Left ventriculograms A : Left ventriculogram on admission showing the basal area was akinetic and the apical area was hyperkinetic. B : Left ventriculogram 12 days after admission showing normal wall motion. Left column: Diastolic phase. Right column: Systolic phase. ST T : : ST Fig. 2 A : Tl 123 I- beta-methyl-p-iodophenyl-pentadecanoic acid BMIPP Fig I-metaiodobenzylguanidine MIBG myomibg TM 2 3,804pg/ml 100pg/ml 2,406 pg/ml pg/ml computed tomography: CT Fig. 4 : 4 5cm J Cardiol 2004 Jun; 43 6 :

4 284 Fig. 3 Thallium-201 and iodine-123-beta-methyl-p-iodophenyl-pentadecanoic acid myocardial single photon emission computed tomography images 201 Tl upper and 123 I-BMIPP lower images demonstrating low-uptake in the basal. 201 Tl thallium-201; 123 I-BMIPP iodine-123-beta-methyl-p-iodophenyl-pentadecanoic acid. Fig. 4 Computed tomography scan of the abdomen A solid mass in the left adrenal gland is indicated by arrows. 131 I-MIBG pheomibg TM 12 Fig. 2 B Fig. 5 : 2 X 3 ST Fig. 1 B T pg/ml 808 pg/ml CT 131 I-MIBG pheomibg TM cm 50 g Tl 123 I-BMIPP 123 I-MIBG myomibg TM J Cardiol 2004 Jun; 43 6 :

5 285 Fig. 5 Photomicrograph of the endomyocardial biopsy specimen taken 12 days after admission Contraction band necrosis. 0.1% : , Ca I-MIBG 29,30 Van Vliet %Kline % J Cardiol 2004 Jun; 43 6 :

6 286 33, I-MIBG 59a F 4 6 J ST T Tl 123 I-BMIPP 123 I-MIBG 12 J Cardiol 2004 Jun; 43 6 : : 2001 ; 59 Suppl 8 : : 1991; 23 : : ; 32: : 1 Jpn Circ J 2003 ; 67 Suppl : 832 abstr 5 : Jpn Circ J 2001; 65 Suppl : 588 abstr 6 : Catecholamine-induced cardiomyopathy ; 10 : : ; 27 : : catecholamine crisis :ST ; 29: : Jpn Circ J 2001; 65 Suppl : 604 abstr 10 : ; 7: : ; 33 Suppl : 869 abstr 12 : 2002; 63: 1055 abstr J Cardiol 2004 Jun; 43 6 :

7 : ; 32 : : catecholamine-induced cardiomyopathy Jpn Circ J 2001; 65 Suppl : 804 abstr 15 : Jpn Circ J 2001 ; 65 Suppl : 762 abstr 16 : 1 : PCPS IABP 2001; 4 : : 1 Ther Res 1999 ; 5 : : ; 13 : : ; 26 : : 1990; 22 : : 1990; 66 : : PCPS ; 29 : : MEN- A ; 28: : ; 91 : James TN: De subitaneis mortibus:. On the cause of sudden death in pheochromocytoma, with special reference to the pulmonary arteries, the cardiac conduction system, and the aggregation of platelets. Circulation 1976 ; 54 : Haft JI, Gershengorn K, Kranz PD, Oestreicher R : Protection against epinephrin-induced myocardial necrosis by drugs that inhibit platelet aggregation. Am J Cardiol 1972; 30 : : Catecholamine 1973; 62 : : 1996 ; 54 Suppl 14 : Suga K, Tsukamoto K, Nishigauchi K, Kume N, Matsunaga N, Hayano T, Iwami T : Iodine-123-MIBG imaging in pheochromocytoma with cardiomyopathy and pulmonary edema. J Nucl Med 1996 ; 37: : I123MIBG Ther Res 1997 ; 18 : Van Vliet PD, Burchell HB, Titus JL : Focal myocarditis associated with pheochromocytoma. N Engl J Med 1966 ; 274: Kline IK : Myocardial alterations associated with pheochromocytoma. Am J Pathol 1961; 38 : : spasm stunned myocardium in : 1990; pp : Ampulla or Amphora 2000 ; 48: J Cardiol 2004 Jun; 43 6 :

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