C-reactive protein (CRP) and risk factors of atherosclerosis in chronic hemodialysis patients Kenji Yuasa, Hiroaki Sugiyama, Tetsuo Kouzi, Kazuhiro Ma
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1 C-reactive protein (CRP) and risk factors of atherosclerosis in chronic hemodialysis patients Kenji Yuasa, Hiroaki Sugiyama, Tetsuo Kouzi, Kazuhiro Matsushita, Kazumichi Oota, Shuusaku Mas uda, Hiroi Sawamura, Nobuaki Miyamoto, Naotami Terao Kidney Center, Kochi-Takasu Hospital In hemodialysis (HD) patients, elevated serum C-reactive protein (CRP) levels have significant associations with hypoalbuminemia, malnutrition, morbidity and mortality, and suggested to predictive markers of atherosclerosis. In this study, we assessed clinical significance of CRP especially the relationship between the serum CRP level and risk factors of atherosclerosis in HD outpatients without diabetes mellitus. We measured serum CRP levels and other parameters in 233 HD patients without acute infection in June Patients were divided into two groups based on serum CRP levels (high CRP group: CRP 0.3mg/dL, and low CRP group CRP<0.3mg/dL). White blood cell (WBC) and numbers f drugs prescribed for angina pectoris were signifi cantly greater in high CRP group than in the low CRP group. As risk factors for atherosclerosis, obesity (BMI 26.4), low dose dialysis (KT/V for urea<1.0), and low protein intake (PCR<0.9g/kg/day) showed a signifi cantly greater frequency in the high CRP group than in the low CRP group. In multiple regression analysis, obesity and low dose dialysis were risk factors of elevated CRP level. In conclusion, elevated CRP level may be associated with ishemic heart disease, obesity, and low dose dialysis.
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4 Hypertension: SBP 140mmHg and/or DBP 90mmHg, Hypercholesterolemia: TC 180mg/dL, Low HDL-cholester olemia: HDL-C<40mg/dL, High LDL-cholesterolemia: LDL-C 100mg/dL, Smoker: over 10 cigarettes, Obesity: BMI 26.4, Aging: M 45yrs, F 56yrs, Low dose dialysis: KT/V<1.0, Low protein intake: PCR<0.9, Anemia: Ht<30%, Hypoalbuminemia: Alb<3.5g/dL, Large weight gain: ƒ BW/DW 5%, Long duration of dialysis: over 15 years, Secon dary hyperparathyroidism: i-pth 720pg/mL, High level of serum phosphate: P 6.5mg/dL (Significan ce: chi-square test)
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