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- けいざぶろう すみい
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3 Table 1 Classification of female patients with vealcal irritating symptom by their signs Urination pain with other vesical irritability or not
4 Table 2 Serum levels of DL-8280 after a single oral administration (Mine healthy volunteers and outpatients with urinary tract infections In Sample was not collected. Case No. 1, 2, 3: Volunteers, Case No. 4, 5, 6: Outpatients Table 3-(1) Urinary levels of DL-8280 after a single oral administration (100mg) in healthy volunteers and outpatients with urinary tract infections (1) Urine volume was corrected to 1ml/min. Retention time (min) of urine in bladder Case No. 1, 2: Urine was collected in time schedule. Case No. 3, 4, 5: Urine was collected free. Table 3-(2) Urinary levels of DL-8280 after a single oral administration (100mg) in healthy volunteers and outpatients with urinary tract infections (2) Urine volume was corrected to lml/min. Retention time (min) of urine in bladder
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6 534 CHEMOTHERAPY FEB Table 5-(1) Distribution of clinical sings before treatment in cases of Group I
7 Table 5-(2) Distribution of clinical sings before treatment in cases of Group II
8 Table 5-(3) Distribution of clinical sings before treatment in cases of Group III
9 Table 5-(4) Distribution of clinical sings before treatment in cases of Group IV
10 CHEMOTHERAPY FEB Table 5-(5) Distribution of clinical signs before treatment in cases of Group V
11 Table 6 Distribution of strains isolated before DL-8280 treatment 4) SATO, K.; Y. MATSUURA, M. INOUE, T. UNE, Y. OSADA, H. OGAWA & S. MITSURASHI: In vitro and in vivo activity of DL-8280, a new oxazine derivative. Antimicr. Agents & Chemoth. 22: , 1982
12 Fig. 1-(1) Susceptibility of E. coli isolated before M-8280 treatment Fig. 2-(1) Susceptibility of gram rods except E. coli iso fore DL-8280 treatment Fig. 1-(2) Susceptibility of E. coil isolated before DL-8280 treatment Fig. 2-(2) Susceptibility of gram rods except E. coli ieola fore DL-8280 treatment
13 Fig. 3-(1) Susceptibility of grain positive cocci isolated before DL-8280 treatment Fig. 4-(1) Correlograma of MIC between DL-8280 and NFLX, PPA and NA: E. coil Fig. 3-(2) Susceptibility of gram positive cocci isolated before DL-8280 treatment
14 Fig. 4-(2) Correlograma of MIC between DL-8280 and NFLX, PPA and NA: S. fascalis Fig. 4-(3) Corr.lograms of MIC between DL-8280 and NFLX, PPA and NA: gram nega
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16 CHEMOTHERAPY FEB Table 7-(2) Bacteriological response to DL-8280 in acute simple cystitis fitting for criteria of UTI committee (78 cases) Table 842) Bacteriological response of Dli-8280 in acute simple cystitis unfitting for criteria of UTI committee (93 cases) -Group I: 3rd or 4th day judgement- * Regardless of bacterial count * Regardless of bacterial count Poly-microbial infection * Table 8-(1) Overall clinical efficacy of DL-8280 in acute simple cystitis unfitting for criteria of UTI committee Group - I: 3rd or 4th day judgement-
17 Table 9 Results of DL-8280 treatment 3rd or 4th day judgement- - Table 11-(1) Bacteriological response of DL-8280 in Group II (23 cases) -3 rd or 4th day judgement- Table 10 Relation of judgements between the original and UTI committee's criteria -3rd or 4th day judgement- Regardless of bacterial count Poly-microbial infection
18 Table 11-(2) Bacteriological response of DL-8280 in Group III (11 cases) -3rd or 4th day judgement- Table 12 Bacteriological response of DL-8280 in all cases (131 cases) - 3rd or 4th day judgement- Strains* appearing after treatment Regardless of bacterial count Table 11-(3) Bacteriological response of DL-8280 in Group IV (4 cases) - 3rd or 4th day judgement- Strains* appearing after treatment Strains* appearing after treatment Regardless of bacterial count Poly-microbial infection Regardless of bacterial count Poly-microbial infection
19 Table 13 Side effects Incidence of side effects: 10/167 (6.0%) Table 14 MIC50 and MICH values of E. coli, gram positive cocci and other gram negative rods isolated before DL-8280 treatment
20 COMPARATIVE STUDIES ON CLINICAL EFFICACY OF DL-8280 (100 MG/DAY, 3 DAYS TREATMENT) IN VARIOUS TYPES OF FEMALE ACUTE SIMPLE CYSTITIS YOSHIAKI KUMAMOTO, SHIGERU SAKAI, TSUGUO UMEHARA and Department of Urology, Sapporo Medical College TAKAOKI HIROSI SHOGO SHIMAMURA Department of Urology, Sapporo Teishin Hospital TAKAHIRO TAMIYA, KEIJI TAKATSUKA and SHINICHI MIYAMOTO Department of Urology, Sunagawa Municipal Hospital AKIO HONMA and TATSUO AOYAMA Department of Urology, Japan Red Cross Asahikawa Hospital SEIJI FURUYA and EIJI YOKOYAMA Department of Urology, Japan Red Cross Kitami Hospital CHOSHO ENATSU Department of Urology, Tomakomai Oji General Hospital HITOSHI TANDA and SHUJI KATO Department of Urology, Higashi Sapporo Sanjukai Hospital5 TSUNEAKI TORII and MASATAKA FUJITA Department of Urology, Hakodate Goryokaku Hospital KATSUYUKI MITOBE and AKIRA NISHIO Department of Urology, Sakata Municipal Hospital DL-8280, a new pyridone-carboxylic acid type synthetic antimicrobial agent for oral use, was studied fundamentally and clinically and the following conclusions were obtained. 1) The MICs of DL-8280 against clinical isolates were determined. The MICs against 80% of GNR and 30% of GPC were 0.10 pg/ml and less than 0.39 j g/ml, respectively. 2) The urinary concentration during hours after a single oral administration at the dose of 100 mg was over 10 Đg/ml and this result suggested DL-8280 was the long-acting drug. 3) Clinical effect and side effect in female patients with acute simple cystitis including the urethral syndrome treated with 100 mg for 3-17 days orally were evaluated. A new original criteria was established for judgement of cases unfitting for criteria of UTI committee. 4) The clinical response in 78 female patients with acute simple cystitis fitting for criteria of UTI committee was excellent in 64 cases, moderate in 14 cases, and clinical efficacy rate was 100%. 5) All cases were divided to group I, II, III, IV and V and therapeutic effect was evaluated in each group. No significant difference in clinical efficacy was observed among all groups, except cases having only subjective symptoms group V by the new original criteria. 6) As to side effects, eruption, itching, lip swelling and gastrointestinal disturbance were observed in 10 cases and rate of appearance was 6.0%. But those were not severe.
Fig. 1 Chemical structure of DL-8280
Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.
Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.
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Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Ent
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Fig. 1 Chemical structure of KW-1070
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Fig. 1 Chemical structure of norfioxacin (AM-715)
Fig. 1 Chemical structure of norfioxacin (AM-715) Table 1 Serum and biliary concentration of norfloxacin (AM-715) Table 2 Protocol for clinical evaluation of norfloxacin (AM-715) in the treatment of biliary
epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia
epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia Table 3. Overall clinical efficacy of cefozopran in
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Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad
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Staphylococcus sp. K.pneumoniae P.mirabilis C.freundii E. cloacae Serratia sp. P. aeruginosa ml, Enterococcus avium >100ƒÊg/ml
CHEMOTHERAPY SEPT. 1992 cefoperazone ceftazidime (CAZ), imipenem (IPM) Staphylococcus sp., Enterococcus (CPZ), faecalis, Escherichia coli, Klebsiella pneumoniae, Citrobacter freundii, Enterobacter cloacae,
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366 12 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 1 8 DNA 2,3 16 12 20 171 2008 12 2010 11 2 3,558 4.44% 1.65% 1.17% 90% 9 Escherichia coli -
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Table 1. Concentration of ritipenem in plasma, gallbladder tissue and bile after ritipenem acoxil administration (200 mg t.i.d., 3 days) N.D.: not detected *: time after last administration Table 2. Concentration
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1) Chemical name: Fig. 1 Chemical structure of TE-031 (-)-(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2, PYranosyl)oxy]-14-ethyl-12,13-dihydroxy-7-meth 6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexo- oxy-3,5,7,9,11,13-hexamethy1-6-[[3,4,6-trideoxy-3-
04-c-„FŒ{›xŒ¾-4.01
544( 56 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 Dec. 25 2003 2. * * Dec. THE JAPANESE JOURNAL OF ANTIBIOTICS 58 6 545( 57 ) 9 5 2003 8 2004 714 565 719 50 20 39 0 9 70 79 44.4 91.7% Escherichia coli
日本化学療法学会雑誌第59巻第5号
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1) University Group Diabetes Program: A study of hypoglycemic agents on vascular complica- in patients with adult-onset tions diabetes. I. Design, methods and baseline results. Diabetes 19 (suppl. 2):
Title 外傷性脊髄損傷患者の泌尿器科学的研究第 3 報 : 上部尿路のレ線学的研究並びに腎機能について Author(s) 伊藤, 順勉 Citation 泌尿器科紀要 (1965), 11(4): Issue Date URL
Title 外傷性脊髄損傷患者の泌尿器科学的研究第 3 報 : 上部尿路のレ線学的研究並びに腎機能について Author(s) 伊藤, 順勉 Citation 泌尿器科紀要 (1965), 11(4): 278-291 Issue Date 1965-04 URL http://hdl.handle.net/2433/112732 Right Type Departmental Bulletin Paper
CHEMOTHERAPY DEC Table 1 Antibacterial spectra of T-1982, CTT, CMZ, CTX, CPZ and CEZ 106 CFU/ml Note: P; Peptococcus, S; Streptococcus, G; Gaffk
VOL. 30 S-3 CHEMOTHERAPY imeumoniae, Serratia marcescens, Proteus sp, CHEMOTHERAPY DEC. 1982 Table 1 Antibacterial spectra of T-1982, CTT, CMZ, CTX, CPZ and CEZ 106 CFU/ml Note: P; Peptococcus, S; Streptococcus,
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VOL. 36 S-3 CHEMOTHERAPY 437 438 CHEMOTHERAPY JULY 1988 Fig. 1 Contractile response of gastrointestinal tract to intravenous administration of saline and EM in interdigestive state in dogs (a) : Saline,
CHEMOTHERAPY DEC phvlococcus aureus Staphylococcus Enterococcus faecalis Escherichia Klebsiella pneumoniae Serratia marcescens Pseudomonas cepac
CHEMOTHERAPY DEC. 1988 phvlococcus aureus Staphylococcus Enterococcus faecalis Escherichia Klebsiella pneumoniae Serratia marcescens Pseudomonas cepacia 1 Bacteroides bivius Propionibacterium granulosum
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VOL. 43 NO. 4
VOL. 43 NO. 4 Fig. 1. Frequency of Enterococcus species from complicated UTI, 1988-1992. the number * of Enterococcus species/the number of cases with complicated UTI. Fig. 3 Epidemiologic characteristics