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2 no.588 vol.57 no CODE CN1588

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7 Göteborg Kuopio Nun Göteborg leukoaraiosis Rotterdam CLINICIAN 10 NO

8 Skoog Snowdon Ott Kivipelto Solomon Bennet Göteborg study BP AD VD BP BP Nun study MMSE n AD Rotterdam study DM AD DM AD VD AD VD Kuopio studyad SBPTch AD AD Kuopio study Tch AD MCI Tch MCI Religious Orders study NIA/Reagan AD Stage ADVDMMSESBP TchMCI 5 CLINICIAN 10 NO. 588

9 ε4 Kuopio Göteborg CLINICIAN 10 NO

10 Kuopio Bennet Skoog, I., et al. : 15-year longitudinal study of blood pressure and dementia. Lancet, 347, (1996) Kivipelto, M., et al. : Midlife vascular risk factors and Alzheimer s disease in later life : longitudinal, population based study. BMJ, 322, (2001) Whitmer, R.A., et al. : Midlife cardiovascular risk factors and risk of dementia in late life. Neurology, 64, (2005) Snowdon, DA., et al. : Brain infarction and clinical expression of Alzheimer disease : the Nun study. JAMA, 277, (1997) 7 CLINICIAN 10 NO. 588

11 Solomon, A., et al. : Serum cholesterol changes after Med., 11, (2007) membrane rafts, isoprenoids and statins. J. Cell Mol. Reid, P. C., et al. : Alzheimer s disease : cholesterol, and aging. Am. J. Epidemiol., 156, (2002) a prospective analysis from the Canadian study of health Lindsay, J., et al. : Risk factors for Alzheimer s disease : nerve system. Neurosci. Biobehav., 25, (2001) Park, C. R. : Cognitive effects of insulin in the central 74(2006) 1942(1999) Biessels, G. J., et al. : Risk of dementia in diabetes mellitus : a systematic review. Lancet Neurol., 5, 64 dementia : the Rotterdam study. Neurology, 53, 1937 Ott, A., et al. : Diabetes mellitus and the risk of without cognitive impairment from two communitybased studies. Neurology, 66, (2006) Bennett, D. A., et al. : Neuropathology of older persons Neurol., 58, (2001) impairment and dementia in elderly persons. Arch. Laurin, D., et al. : Physical activity and risk of cognitive Neurology, 67, (2006) consumption with age-related cognitive change. Morris, M.C., et al. : Associations of vegetable and fruit Aging, 24, (2003) dementia : the Honolulu-Asia aging study. Neurobiaol. Tyas, S. L., et al. : Mid-life smoking and late-life midlife and late-life cognition : twenty-one-year followup study. Neurology, 86, (2007) CLINICIAN 10 NO

12 dementia depression delirium 9 CLINICIAN 10 NO. 588

13 abcd A A A A CLINICIAN 10 NO

14 α attenuation 11 CLINICIAN 10 NO. 588

15 American Psychiatric Association : Diagnostic and Statistical Manual of Mental Disorders-IV(DSM-IV). (1994) CLINICIAN 10 NO

16 13 CLINICIAN 10 NO. 588

17 T1 CLINICIAN 10 NO

18 secondary NPH : snph idiopathic NPH : inph CSH CSH 15 CLINICIAN 10 NO. 588

19 Evans Index0.3 Evans Index= aba b CLINICIAN 10 NO

20 inph 17 CLINICIAN 10 NO. 588

21 Iseki, C., et al. : Asymptomatic ventriculomegaly with features of idiopathic normal pressure hydrocephalus on MRI (AVIM) in the elderly : a prospective study in a Japanese population. J. Neurol. Sci., 277, 54 57(2009) Ogino, A., Kazui, H., et al. : Cognitive impairment in patients with idiopathic normal pressure hydrocephalus. Dement. Geriatr. Cogn. Disord., 21, (2006) Kitagaki, H., et al. : CSF spaces in idiopathic normal pressure hydrocephalus : morphology and volumetry. AJNR Am. J. Neuroradiol., 19, (1998) CLINICIAN 10 NO

22 Reisberg Global Deterioration Scale (GDS) Stage 3 Petersen 19 CLINICIAN 10 NO. 588

23 Petersen Dubois Va Dubois Va CLINICIAN 10 NO

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25 Dubois CLINICIAN 10 NO

26 Roman Mild Prichep, LS., et al. : Prediction of longitudinal cognitive decline in normal elderly with subjective complaints 23 CLINICIAN 10 NO. 588

27 Dubois, B., et al. : Research criteria for the diagnosis of 352, 1 10(2005) treatment of mild cognitive impairment. N. Eng. J. Med., Petersen, RC., et al. : Vitamin E and donepezil for the Psychogeriatr., 1, 1 9(2008) disease in a community : The Osaki-Tajiri Project. Int. metabolism in converters from CDR 0.5to Alzheimer s Ishii, H., Meguro, K., et al. : Decreased cortical glucose Tajiri Project. Neuroepidemiology, 33, (2009) converters to dementia in a community : The Osaki- function tests can screen mild cognitive impairment and Nakata, E., et al. : Combined memory and executive Sci., 260, (2007) (2004) Meguro, K., et al. : Incidence of dementia and associated risk factors in Japan : The Osaki-Tajiri Project. J. Neurol. Alzheimer s disease? Lancet Neurol., 3, Dubois, B., Albert, ML. : Amnestic MCI or prodromal (1999) clinical characterization and outcome. Arch. Neurol., 56, Petersen, RC., et al. : Mild cognitive impairment : 27, (2006) using electrophysiological imaging. Neurobiol. Aging, 59, 23 30(2000) vascular dementia in clinical trials. J. Neural. Transm., Erkinjuntti, T., et al. : Research criteria for subcortical vascular dementia. J. Neurol. Sci., 226, 81 87(2004) 746(2007) Roman, GC., et al. : Vascular cognitive disorder : a new category updating vascular cognitive impairment and criteria-a Position Paper. Lancet Neurology, 6, 734 Alzheimer s disease : Revising the NINCDS-ADRDA CLINICIAN 10 NO

28 Mini-Mental State Examination MMSE Alzheimer s disease : AD Frontotemporal dementia : FTD Dementia with Lewy bodies : DLB Vas- 25 CLINICIAN 10 NO. 588

29 cular dementia : VaD Test Your Memory Verbal fluency category fluency semantic fluency letter fluency mild cognitive impairment : MCI DLB+VaD Alzheimer sdisease Assessment Scale cog Wechsler Memory Scale-revised verbal fluency Verbal fluency category fluency letter fluency category fluency CLINICIAN 10 NO

30 letter fluency category fluency letter fluency category fluency 27 CLINICIAN 10 NO. 588

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32 Folstein, MF., et al. : Mini-Mental State ; a practical method for grading the cognitive state for the clinician. J. Psychiatr. Res., 12, (1975) O Bryant, SE., et al. : Detecting dementia with the Mini- Mental State Examination in highly educated individuals. Arch. Neurol., 65, (2008) Hanyu, H., et al. : The 1-minute mental status examination in the memory clinic. J. Am. Geriat. Soc, 57, (2009) Hanyu, H., et al. : Differentiation of dementia with Lewy bodies from Alzheimer s disease using the Frontal Assessment Battery test. Int. J. Geriatr. Psychiatry, 24, (2009) Solomon, PR., et al. : A 7 minute neurocognitive screening battery highly sensitive to Alzheimer s disease. Arch. Neurol., 55, (1998) Brown, J., et al. : Self administered cognitive screening test (TYM) for detection of Alzheimer s disease : cross sectional study. Brit. Med. J., 338, (2009) 29 CLINICIAN 10 NO. 588

33 Alzheimer s disease Ach Ach CLINICIAN 10 NO

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35 pre synaptic neuron pre-sn pre-sn pre-sn Ach CLINICIAN 10 NO

36 pre-sn Honma, A., et al. : Donepezil treatments with severe Alzheimer s disease in a Japanese populations : results from a 24-week, double-blind, placebo-controlled, randomized trial. Dement. Geriatr. Cog. Disord., 25, (2008) Honma, A., et al. : Long-term safety and efficacy of Donepezil in patients with severe Alzheimer s disease : results from a 52-week, opne-label, multicenter, extension study in japan. Dement. Geriatr. Cog. Disord., 27, (2009) donepezil Nozawa, M., et al. : Clinical effects of high dose of donepezil for patients with Alzheimer s disease in Japan. Psychogeriatrics, 9, 50 55(2009) donepezil 33 CLINICIAN 10 NO. 588

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43 Clinical Dementia CLINICIAN 10 NO

44 Rating CDR CDR CDR very mild AD 41 CLINICIAN 10 NO. 588

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49 donepezil (Suppl 1)113(2009) CLINICIAN 10 NO

50 Neuropsychiatric Inventory NPI 47 CLINICIAN 10 NO. 588

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54 51 CLINICIAN 10 NO. 588

55 Rodda Lyketsos, C., et al. : Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment. Results from the cardiovascular health study. JAMA, 288, (2002) Lövheim, H., et al. : Sex differences in the prevalence of behavioral and psychological symptoms of dementia. International Psychogeriatrics, 21, (2009) Liperoti, R., et al. : Antipsychotics for the treatment of behavioral and psychological symptoms of dementia (BPSD). Current Neuropharmacology, 6, (2008) Gauthier, S., et al. : Improvement in behavioural symptoms in patients with moderate to severe Alzheimer s disease by memantine : a pooled data analysis. Int. J. Geriatr. Psychiatry, 23, (2008) CLINICIAN 10 NO

56 International Psychogeriatrics, 21, (2009) trials of donepezil, rivastigmine and galantamine. systematic review of randomized, placebo-controlled symptoms of dementia in Alzheimer s disease? A in the management of the behavioral and psychological Rodda, J., et al. : Are cholinesterase inhibitors effective 53 CLINICIAN 10 NO. 588

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58 amantadine Notch 55 CLINICIAN 10 NO. 588

59 Notch modulator Flurizan CLINICIAN 10 NO

60 active immunization passive immunization Bapineuzumab Vasogenic Edema 57 CLINICIAN 10 NO. 588

61 Solanezumab symptomatic treatment disease modification symptomatic treatment disease modification symptomatic treatment disease modification CLINICIAN 10 NO

62 disease modification 59 CLINICIAN 10 NO. 588

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64 Announcement by Neurochem and Ellan, The 8th International Montreal/Springfield Symposium on Advances in Alzheimer Therapy, April , Montreal, Canada http : //phx.corporate ir.net/phoenix.zhtml?c=78193&p= irol newsarticle&id= &highlight= Holmes, C., et al. : Long-term effects of Aβ42 immunisation in Alzheimer s disease : follow-up of a randomised, placebo-controlled phase I trial, Lancet, 372, (2008) 61 CLINICIAN 10 NO. 588

65 common disease Common disease CLINICIAN 10 NO

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68 common disease 65 CLINICIAN 10 NO. 588

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73 Cognition and Dementia Geriatric Medicine CLINICIAN 10 NO

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77 tap-test shunt LP-shunt VP-shunt shunt CLINICIAN 10 NO

78 shunt ope LP VP LP LP LP LP Tap test F.I. F.K. M.S. A.S. K.K. Y.K. I.D. A.Y. H.O. T.S. 75 CLINICIAN 10 NO. 588

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89 CLINICIAN 10 NO Airway HyperReactivity : AHR Umetsu CD1d /, Jα18 / alfa-galactosylceramide α-galcer Ig Holtzman

90 87 CLINICIAN 10 NO. 588 Umetsu CD1d tetramer invariant T New England Journal of Medicine NEJM

91 CLINICIAN 10 NO Dukanovic Fc α-galcer C-glycoside Akbari, O., et al. : Nat. Med., 9, (2003) Meyer, E.H., Goya, S., et al. : Proc. Natl. Acad. Sci. U. S. A., 103, (2005) Pichavant, M., Goya, S., et al. : J. Exp. Med., 205, 385

92 1422(2007) (2006) Vijayanand, P., et al. : N. Engl. J. Med., 356, 1410 Akbari, O., et al. : N. Engl. J. Med., 354, Kim, E.Y., et al. : Nat. Med., 14, (2008) 393(2008) 89 CLINICIAN 10 NO. 588

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108 MDCT MRI PCI CTOPCI PCI ACS PCIMDCT ST PCI ACLS CLINICIAN 10 NO

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113 JPS NEWS department/dgp/index-dgp-j.htm 111 CLINICIAN 10 NO. 588

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115 A BPSD A A B D ROT D Validation 113 CLINICIAN 10 NO. 588

116 p p p p p p p ns p p ns ns ns NA = not available ns ns NA ns NA NA NA ns ns ns p ns ns CLINICIAN 10 NO

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118 Geriatric Medicine, 45, (2007) CLINICIAN 10 NO

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121 FAST staged AD 119 CLINICIAN 10 NO. 588

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127 follow up follow up follow up 125 CLINICIAN 10 NO. 588

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131 Onozato, Y., et al. : Endoscopic submucosal dissection for early gastric cancers and large flat adenomas. Endoscopy, 38(10), (2006) Onozato, Y., et al. : Endoscopic submucosal dissection for rectal tumors. Endoscopy, 39(5), (2007) Onozato, Y., et al. : Endoscopic management of duodenal diverticular bleeding. Gastrointest. Endosc., 66(5), (2007) Onozato, Y., et al. : Feasibility of endoscopic submucosal dissection for elderly patients with early gastric cancers and adenomas. Digestive Endoscopy, 20, 12 16(2008) Prog. Digest. Endosc., 68, 62 66(2006) Prog. Digest. Endosc., 72, 94 95(2008) 129 CLINICIAN 10 NO. 588

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