(ABPC), Carbenicillin (CBPC), Surbenicillin (SBPC), Piperacillin (PIPC), Cephalexin (CEX), Cefaclor (CCL), Cephalothin (CET), Cefazolin (CEZ), Cefotia
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1 Key words: Blood culture, Trend of bacterial isolation, Increasing of staphylococcus, Use of new cephems
2 (ABPC), Carbenicillin (CBPC), Surbenicillin (SBPC), Piperacillin (PIPC), Cephalexin (CEX), Cefaclor (CCL), Cephalothin (CET), Cefazolin (CEZ), Cefotiam (CTM), Cefoperazone (CPZ), Cefsulodin (CFS), Cefotaxime (CTX), Ceftizoxime (CZX), Ceftazidime (CAZ), Ceftriaxone (CTRX), Cefmetazole (CMZ), Latamoxef (LMOX), Minocycline (MINO), Tiamphenicol (TP), Gentamicin (GM), Tobramycin (TOB), Amikacin (AMK), Erythromycin (EM), Lincomycin (LCM), Fosfomycin (FOM), ST &M(ST)
3 Table 1. Changes of frequency of bacterial positive cases on blood culture in 1980 to 1983 : Cases that same bacteria was isolated repeatedly were excepted from the total amount. Table 3. Gram positive bacteria isolated from blood culture in 1980 to 1983.
4 Table 4. Gram negative bacteria isolated from blood culture in 1980 to 1983
5 Fig. 1 Antimicrobial agents administered within 24hrs before blood culture to bacterial-positive cases
6 Table 5. Correlation of bacteria isolated from blood culture with the antimicrobial agents administered to patients within 24 hrs before the culture.
7 Table 6. Antimicrobial agents administered to patients at time of bacterial isolation from blood culture. Table 7. Species of genus Staphylococcus isolated from blood culture.
8 Fig. 2 Susceptibility distribution of Staphylococcus aureus to Antimicrobial agents. Fig. 3 Susceptibility distribution of coagulase negative Staphylococci to Antimicrobial agents51 strains
9 Fig. 4 Susceptibility of organisms isolated from blood culture to antimicrobial agents Fig. 5 Susceptibility of organisms isolated from blood culture to antimicrobial agents.
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13 coagulase-negative staphylococcal isolates from blood cultures. J. Clin. Microbiol., 15: 439 5) Marsik, F. J. & Brake, S.: Species identification and susceptibility to 17 antibiotics of coagulase nagative staphylococci isolated from clinical specimens. J. Clin. Microbiol., 15: 640 6) Swenson, F. J. & Rubin, S. J.: Clinical significance of viridans streptococci isolated from blood cultures. J. Clin. Microbiol., 15: , ) Moore, D. F., Hamada, S. S., Marso, E. & Mar- W. J.: Rapid identification and antimi- tin, crobial susceptibility testing of gram negative bacilli from blood cultures by the automicrobic system. J. Clin. Microbiol., 13: , ) Smith, E. G., Pritchard, J. K. & Mccarthy, L. R.: Four-hour presumptive identification of enterobacteriaceae from blood cultures. Am. J. Clin. Pathol., 75: 88-91, ) Rogers, D. E.: The changing pattern of lifethreatening microbial disease. New Eng. J. Med., 261: , ) Buchanan, R. E. & Gibbons, N. E.: Bergery's manual of determinative Bacteriology (Eighth edition), ) Myerowitz, R. R., Medeiros, A. A. & O'brien, T. F.: Recent experience with bacillemia due to gram-negative organisms. J. Inf. Dis., 124: ) Curtin, J. A., Petersdorf, R. G. & Bennett, I. L.: Pseudomonas bacteremia: Review of ninetyone cases. Ann. Int. Med., 54: , ) Eng, R. H. K., Wang, C., Person, A., Kiehn, T. E. & Armstrong, D.: Species identification of
14 Recent Trend of Organisms Isolated from Blood Cultures Masatoshi KONNO, Sayoko KAWAKAMI*, Ritsuko NONOGUCHI, Akira GOTO & Kimiko UBUKATA Department of Clinical Pathology, Teikyo University, School of Medicine, , Kaga, Itabashi-ku, Tokyo, Japan *Central Clinical Laboratory, Teikyo University Hospital Investigations for blood cultures from inpatients at Teikyo University Hospital between Oct and Mach 1983 were carried out and the following results were obtained. The incidence of bacterialpositive blood culture has been significantly increasing since Oct The species of organisms isolated from the culture with most rapidly increasing frequency were S. aureus and coagulase negative staphylococci. The time that isolation of the above organisms was increased coincided with the introduction to clinical side of new broad spectrum penicillins and cephems, so called third generation antibiotics. Retrospective study of the state of antibiotic administration with reference to the isolated organisms clarified that 86.5% of the bacterial-positive patients had been administered antimicrobial agents within 24hrs before the blood culture, and also 60% of these patients had been administered two or more antimicrobial agents. The majority of strains, 73.8%, were resistant to the antibiotics used to them. Among isolated organisms, sensitive to the antibiotics used intreatment was most frequently exhibited by staphylococci, and the sensitive strains were most frequently isolated from patients give IVH, etc. Sensitive strains were also frequently isolated from patients administered aminoglycosides, which suggested that the relationship of diseases indicating the use of aminoglycosides with the dosage must be re-investigated. As for the third generation cehems, that are now attracting attention, organisms, frequently resistant to these antibiotics, were isolated from the blood of many patients administered with them.
CHEMOTHERAPY Proteus mirabilis GN-79 Escherichia coli No. 35 Proteus vulgaris GN-76 Pseudomonas aeruginosa No. 11 Escherichia coli ML-1410 RGN-823 Kle
VOL. 29 NO.8 CHEMOTHERAPY 865 CHEMOTHERAPY Proteus mirabilis GN-79 Escherichia coli No. 35 Proteus vulgaris GN-76 Pseudomonas aeruginosa No. 11 Escherichia coli ML-1410 RGN-823 Klebsiella pneumoniae GN-69
Key words : R-plasmid, Urinary tract infection, E. coli Fig. 1. MIC distribution against E. coli isolated from urinary tract (366 strains) and isolation - frequencies of drug-resistant strains Table 1.
Staphylococcus epidermidis Streptococcus pneumoniae Staphylococcus epidermidis Streptococcus pneumontae S. epidermidis Table 1. Summary of the organis
Staphylococcus aureus S. aureus (MRSA) vancomycin (VCM), arbekacin (ABK) Streptococcus pneumoniae cefuzonam (CZON), cefpirome (CPR) S. pneumoniae Enterococcus faecalis ampicillin (ABPC), imipenem (IPM)
VOL. 43 NO. 4
VOL. 43 NO. 4 Fig. 1. Frequency of Enterococcus species from complicated UTI, 1988-1992. the number * of Enterococcus species/the number of cases with complicated UTI. Fig. 3 Epidemiologic characteristics
CHEMOTHERAPY AUG. 1982 VOL. 30 NO. 8 CHEMOTHERAPY Fig.1 Relation between various-closis of cefazolin and detection rate of organisms in heart blood of dying mice with E. coli and P. aeruginosa infection
1) i) Barber, M. et al.: Brit. Med J, 2, 565, 19'49. ii) Barber, M.F.G. J. Hayhoe and J. E. M. Whithead: Lancet, 1120 `1125, 1949.-2) Bergey: Bergey's Manual of Determinative Bacteriology 7 th Ed: (1958).-3)
Table 1 Survival rates of infected mice given antibiotic doses producing peak serum a) S. aurcus Smith Challenge dose :7 ~10 (5% mucin) CFU/mouse. LD50: 1 ~103 (5% mucin) CFU/mouse. Table 2 Survival rates
Fig.1 MICs of penicillins against 24 strains of B. pertussis Fig.2 MICs of cepherns against 24 strains of B. pertussis Fig.3 MICs of macrolides against 24 strains of B. pertussis Fig.4 MICs of nalidixic
CHEMOTHERAPY
CHEMOTHERAPY VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin CHEMOTHERAPY AUG. 1993 VOL.41 S-2 Laboratory and clinical evaluation of teicoplanin Table 1. Comparative in vitro activity of teicoplanin
Fig. 1 Chemical structure of DL-8280
Fig. 1 Chemical structure of DL-8280 Fig. 2 Susceptibility of cl in ical isolates to DL4280 Fig. 5 Susceptibility of clinical isolates to DL-8280 Fig. 3 Susceptibility of clinical isolates to DL-8280 Fig.
VOL.30 NO.10 CHEMOTHERAPY 1123 Fig,1 Group B case 6 hepatolithiasis,e.k.66 y.0.,f.45kg Postoperative wound infection Fig.2 Group B case 15 gastric cancer,k.k.60 y.o.,m. Postoperative peritonitis Fig.3
CHEMOTHERAPY JUNE 1993 Table 1. Background of patients in pharmacokinetic study
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Table 1 Antibacterial spectra of CPM and other antimicrobials against anaerobes Fig. 1 In vitro activity of CPM and other antibiotics against B. fragilis (136 strains) Fig. 2 In vitro activity of CPM and
Key words: Antibiotics, Intestinal bacterial flora, Germfree mouse
Key words: Antibiotics, Intestinal bacterial flora, Germfree mouse Table 1 Susceptibility to various antibiotics Antibiotics Abbreviations ABPC: GM: CET: CEZ: CMZ: LMOX: CMX: Bacteriae used Ampicillin
Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile
Clostridium difficile ciprofloxacin, ofloxacin, norfloxacin Bifidobacterium Lactobacillus Lactobacillus Bacteroides fragilis B. fragilis C. difficile Key words: temafloxacin, TA-167, Bacteroides fragilis,
CHEMOTHERAPY DEC Table 1 Antibacterial spectra of T-1982, CTT, CMZ, CTX, CPZ and CEZ 106 CFU/ml Note: P; Peptococcus, S; Streptococcus, G; Gaffk
VOL. 30 S-3 CHEMOTHERAPY imeumoniae, Serratia marcescens, Proteus sp, CHEMOTHERAPY DEC. 1982 Table 1 Antibacterial spectra of T-1982, CTT, CMZ, CTX, CPZ and CEZ 106 CFU/ml Note: P; Peptococcus, S; Streptococcus,
Table 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone
Table 1. Antibacterial spectrum SBT ABPC ABPC CPZ : sulbactamiampicillin : ampicillin : cefoperazone (inoculum size= 106 CFU/ml) (Ĉ-lactamase producer : 2 strains) Fig. 1. Sensitivity distribution of
CHEMOTHERAPY JUN Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter cloacae 27, Proteus rettgeri 7, Proteus inconstans 20, Proteus
VOL. 32 S-4 CHEMOTHERAPY Fig. 1 Chemical structure of sodium cefoperazone Fig. 2 Chemical structure of sodium cefoperazone CHEMOTHERAPY JUN. 1984 Citrobacter freundii 27, Enterobacter aerogenes 26, Enterobacter
Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates
Table 1. Antibacterial activitiy of grepafloxacin and other antibiotics against clinical isolates Table 2-1. Summary of patients treated with grepafloxacin for respiratory infection 1) Out: outpatient,
Table 1.Resistance criteria Fig.1.The resistance rates of piperacillin,ceftazidime, cefsulodin,imipenem,aztreonam,gentamicin,tobramycin,amikacin,isepamicin,fosfomycin and ofloxacin against 2,793 strains
Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Ent
Fig.2. Sensitivity distribution of clinical isolates of S. epidermidis (24 strains, 106 CFU/ml) Staphylococcus aureus Staphylococcus epider- midis Enterococcus faecalis Klebsiella pneumoniae, Morganella
988 CHEMOTHERAPY NOV. 1971
988 CHEMOTHERAPY NOV. 1971 VOL. 19 NO. 8 CHEMOTHERAPY 989 Effect of medium-ph and inoculum size on activity of SB-PC heart infusion agar, mcg/ml Sensitivity distribution of Staphylococci to SB-PC in surgical
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b) Gram-negative bacteria Fig. 2 Sensitivity distribution of clinical isolates : E. coli Fig. 3 Sensitivity distribution of clinical isolates : Pseudomonas Fig. 1 Sensitivity distribution of clinical isolates
日本化学療法学会雑誌第61巻第6号
β Moraxella catarrhalis Escherichia coli Citrobacter Klebsiella pneumoniae Enterobacter cloacae Serratia marcescens Proteus Pseudomonas aeruginosa Acinetobacter Bacteroides fragilis β Haemophilus influenzae
VOL.42 S-1
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VOL. 17 NO. 7 CHEMOTHERAPY 1305 1) W. BRumFirr et al. : Clinical and laboratory studies with carbenicillin. Lancet 1: 1289~ 1293, 1967 2) E. T. KNUDSEN et al. : A new semisynthetic penicillin active against
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Table1MIC of BAY o 9867 against standard strains
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VOL. 34 S-3 CHEMOTHERAPY Fig. 1 Structural formula of L-105 CHEMOTHERAPY JUNE 1986 VOL. 34 S-3 CHEMOTHERAPY Table 1 Antibacterial spectra of L-105 against gram negative anaerobic rods Inoculum 106 cells/ml
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2108 CHEMOTHERAPY SEPT Table 1 Antimicrobial spectrum Fig. 1
2108 CHEMOTHERAPY SEPT. 1977 Table 1 Antimicrobial spectrum Fig. 1 VOL. 25 NO. 7 CHEM 014 HERAPY 2109 Table 2 Susceptibility distribution of Staphylococcus aureus to aminoglycosides (54 strains) Table
Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S.
Key words : 7432-S, Oral cephem, Urinary tract infection Fig. 1. Chemical structure of 7432-S. Table 1. Clinical summary of acute uncomplicated cystitis patients treated with 7432-S UTI : Criteria by the
VOL.32 S-9 CHEMOTHERAPY Table 1 Minimum inhibitory concentrations of AC-1370, CPZ and CAZ Table 2 Efficacy of AC-1370 and CPZ against systemic infections in mice *Inoculum size: 106 cells/ml * 95% confidence
Table 1 Patients with various renal function * Ccr, Creatinine clearance ml/min per 1. 48 m2 ** C.V.D., Cerebral vascular disease ; C.R F., Chronic renal failure ; H.D., Hemoclialysis ; D., Dialyzer ;
epidermidis, Enterococcus faecalis, Enterococcus Klebsiella pneumoniae, Proteus mirabilis, indolepositive Proteus spp., Enterobacter spp., Serratia
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Table 1.Concentration of gatifloxacin (Middle-ear) Table 2.Concentration of gatifloxacin (Paranasal sinuses) Table 3.Concentration of gatifloxacin (Tonsil) Table 4.No.of patients studied Table 5.Background
1) University Group Diabetes Program: A study of hypoglycemic agents on vascular complica- in patients with adult-onset tions diabetes. I. Design, methods and baseline results. Diabetes 19 (suppl. 2):
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THE JAPANESE JOURNAL OF ANTIBIOTICS 57 1 33( 33 ) 2002 JA * 1 * 2 2003 12 15 * 1) * 2) 34( 34 ) THE JAPANESE JOURNAL OF ANTIBIOTICS 57 1 Feb. 1982 7 2002 (2002.4 2003.3) 1 174 131 (75.3%) 334 171 163 Staphylococcus
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日本 化 学療 法 学 会 雑 誌 262 JULY 血 球 数8,700/μl,CRP (症例2) 64歳 の男 性 1980年 ご ろ よ り慢 性 肺 気 腫 と診 断 さ れ て い る 本症 例 は まず1993年 に 喀 痰 細 胞 診Class皿 と 認 め られ た が,こ 5.0m
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2) Goetz, A., Tsuneishi, N.: Application of molecular filter membranes to the bacteriological analysis of water, J. Am. Water Works Assn., 43 (12): 943-969,1951. 3) Clark, H.F. et al.: The membrane filter
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400 46 THE JAPANESE JOURNAL OF ANTIBIOTICS 65 6 Dec. 2012 LVFX 100 mg 3 / 7 150 mg 2 / 7 2 2006 2008 9 LVFX PK PD 2009 7 100 mg 1 3 500 mg 1 1 AUC/MIC
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Fig. 1 Clinical findings and extent of inflammation area in female urethrocystitis Fig. 2 Classification and distribution of female patients with blad
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