VOL. 23 NO. 1 CHEMOTHERAPY 399 Fig. 1 Stracture of cephradine Chemical name : 7-CD(-)-2-amino-2-(1,4-cyclohexadien-1-y1) -acetamido) -3-methyl-8-oxo-5-thia-1-aza- -bicyclo [4. 2. 0] oct-2-ene-2-carboxylic acid Molecular formula : C16H19N3O4S Molecular weight : 349. 4
400 CHEMOTHERAPY JAN. 1975 Table 1 Cases of drop outs
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402 CHEMOTHERAPY JAN. 1975
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404 CHEMOTHERAPY JAN: 1975 Table 3 Correlation between clinical results and dosage Table 4 Correlation between clinical results and basic diseases
VOL. 23 NO. 1 CHEMOTHERAPY 405 Table 5 Movements of urinary pathogens
406 CHEMOTHERAPY JAN. 1975 Table 6 Movements of laboratory findings
VOL. 23 NO. 1 CHEMOTHERAPY 407 Table 7 Correlation between cephradine sensitivity and clinical results 5) NEiss E. S. ; et al.: Cephradine : A summary of preclinical and clinical studies and clinical pharmacology. J. Irish Med. Ass. 66: (Suppl.) 1973 CLINICAL EXPERIENCE WITH CEPHRADINE IN URINARY TRACT INFECTIONS JYOICHI KUMAZAWA, SEIICHI NAKAMUTA and SHUNRO MOMOSE Department of Urology, Faculty of Medicine, Kyushu University (Director : Prof. SHUNRO MOMOSE) ASAMI ARIYOSHI, KAZUHIRO OSHIMA, YASUHITO FUJISAWA and YOSHIHARU HIRATSUKA Department of Urology, Faculty of Medicine, Fukuoka University Kozo HIRATA, ICHIKIRO MORITA and SADAMU HIEDA Department of Urology, Fukuoka National Central Hospital YASUHIRO OOTA, YUKIO OSADA and TETSURO TAKESUE Department of Urology, Fukuoka Red Cross Hospital CHUJI TAKAMATSU Department of Urology, Kyushu Cancer Center Hospital SEIICHIRO ANDO and HARUKA HIRANO Department of Urology, Kyushu Kosei Nenkin Hospital HIROYUKI NAGAYOSHI Department of Urology, Shin Nihon Seitetsu Yawata Hospital HIROSHI KIDA and HIROHIKO KIYOHARA Department of Urology, Kitakyushu City Kokura Hospital KOICHI OMARU, MASAAKI HIDAKA and KIMIYA FUJII Department of Urology, Miyazaki Prefectural Hospital HIROSHI NAKAYAMA and MOTONORI KANO Department of Urology, Beppu Nacional Hospital HIROSHI HIRATA and TAKUYA AMANO Department of Urology, Hiroshima Red Cross Hospital SANSHIN HARA, TAKAHIKO HARA, KAZUSHIGE NANRI and AKITO YAMAGUCHI Department of Urology, Iryohojin Sanshin-kai Hara Hospital
408 CHEMOTHERAPY JAN. 1975 1) Cephradine was administered in 115 cases of various urinary tract infections diagnozed byurological Departments of Kyushu Unversity and other allied hospitals. As 12 cases dropped out, examinations were possible in 18 cases of male and 85 cases of female, totalling 103 cases. 2) Among the group administered 1 g daily, the results obtained were excellent in 46 cases, good in 11 cases and poor in 2 cases out of 59 cases, effective ratio being 96. 6%. Among the group administered 2 g daily, the results were excellent in 33 cases, good in 8 cases and poor in 3 cases ratio being 93. 1%. out of 44 cases, effective 3) Among 81 cases of simple urinary tract infection, effective ratio of 100% was obtained in both 1 g group (51 cases) and 2 g group (30 cases). Among 22 cases of complicated urinary tract infection, no difference was noticed between 1 g group (8 cases) and 2 g group (14 cases), effective ratio being 75. 0% and 78. 5% respectively. 4) The largest number of cases was acute simple cystitis, being divided into 1 g group (49 cases) and 2 g group (23 cases). The administration was continued for 3-7 days (4. 9 days on an average), and effective ratio of 100% was obtained in both groups. 5) Gastric malaise was observed in 1 case of 1 g group and in 5 cases of 2 g group, including dropped out case. Leukopenia by receiving an adrenal cortical hormone. was recognized in 1 child of 1 g group, and the patient was released from this side effect 6) Cephradine was proved to be excellent for urinary tract infection, especially that of acute and simple. In these cases, the dosage of 1 g daily for less than 5 days seems to be sufficient in consideration of side effect with the drug.