June 2014 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 193 47 1 1 1 1 3 3 4 1 5 6 1 2 5 5 1 2 4 1 6 1 3 7 2 1 1 2 3 4 5 6 7 2014 4 14 azithromycin; AZM 15 community-acquired pneumonia; CAP AZM A-DROP CAP AZM CAP AZM 500 mg 1 1 X AZM 64 61 62 61 AZM 88.5% A-DROP 85.2% 91.2% 91.7% 12 11 AZM 19 20 15 4 1 AZM AZM CAP
194 48 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 June 2014 azithromycin AZM, 500 mg 37.0 C communityacquired pneumonia; CAP C C-reactive protein; CRP 9,000/mm 3 X computed tomography CT 5 1 AZM A-DROP 2 AZM H23-148 3 2 A-DROP 23 12 AZM AZM 1 AZM 3 AUC 0 24 2.2 1 1 500 mg 2 2 AZM CAP 6 X 4 CRP CAP 30% 4 3 3 A-DROP 1 CAP AZM 1 1 AZM AZM AST, 1 2012 3 2014 2 ALT BUN, Scr AZM AZM
June 2014 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 195 49 64 2 AZM 2 1 62 61 1 61 1 61 31 50.8% 30 49.2% 68.8 15.6 37 60.7% 12 19.7% 6 4 AZM 6.2 2.0 A-DROP 27 44.3% 58.7 15.9 34 55.7% 76.7 9.6 AZM 61 54 88.5% 61 7 11.5% AZM A-DROP 23/27 85.2% 31/34 91.2% 11/12 91.7% AZM AZM 7 2 X 7 4 CRP 7 5 42 30 3 Streptococcus pneumoniae 6 4 Staphylococcus aureus 3 5 3 S. pneumoniae 6 4 AZM 1.
196 50 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 June 2014 1. n 61 AZM MIC 2 CLSI 2 4 AZM 4 AZM 62 19 30.6% 20 1 19 15 78.9% 3 4 AZM AZM 2 AST 8 2 ALT 12 1 BUN 1 0 Scr 0 0 AZM 2 ALT 2 3.2% 4 6.5% 1 1.6% AZM AZM A-DROP CAP AZM 88.5% VERGIS AZM AZM
June 2014 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 197 51 2. AZM n 61 91.0% 7 FELDMAN CAP AZM American Thoracic Society; ATS AZM 8 CAP AZM AZM AZM 84.5% 9 AZM CAP AZM CAP AZM ARNOLD CAP 10 AZM AZM CAP
198 52 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 June 2014 2. n 7
June 2014 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 199 53 3. n 61 4. 2 MIC 48.1% 70.6% P 0.07 33.3% 8.8% P 0.02 85.2% 91.2% P 0.37
200 54 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 June 2014 3. AZM n 62 4. AZM n 62 CAP S. pneumoniae Mycoplasma pneumoniae 11,12 30/61 49.2% S. pneumoniae 3 AZM
June 2014 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 201 55 3 S. pneumoniae 6 4 AZM AZM S. pneumoniae CAP 13 Prevotella Porphyromonas Fusobacterium MIC AZM 14 AZM 61 7 11.5% 7 / 4/3 A-DROP 4 3 6 2 4 2 3 AZM 4 S. pneumoniae AZM 30.6% 78.9% 15 grade 2 1 grade 1 VERGIS 11.9% 7.5% 6.0% 7 AZM Scr 42 CAP AZM AZM 2 1 22: 50 57, 2012 2 27: 521 529, 2013 3 YANAGIHARA, K.; K. IZUMIKAWA, F. HIGA, et al.: Streptococcus pneumoniae 535, 2009 4 MIYASHITA, N.; T. MATSUSHIMA & M. OKA: The 428, 2006 5 2007 6 60: 29 45, 2012
202 56 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 June 2014 7 VERGIS, E. N.; A. INDORF, T. M. FILE, et al.: Intern. Med. 160: 1294 1300, 2000 8 FELDMAN, R. B.; D. C. RHEW ONG, et al.: 163: 1718 1726, 2003 9) 10 ARNOLD UMMERGILL, A. S. LAJOIE, et al. in community-acquired pneumonia. Am. J. 1093, 2007 11 ISHIDA, T.; T. HASHIMOTO, M. ARITA, et al.: 1593, 1998 12 SAITO, A.; S. KOHNO, T. MATSUSHIMA, et al.: 63 69, 2006 13 YAMASAKI, K.; T. KAWANAMI, K. YATERA, et al.: community-acquired pneumonia. PLoS ONE 8: e63103, 2013 14 41: 489 493, 2007 15 JCOG
June 2014 THE JAPANESE JOURNAL OF ANTIBIOTICS 67 3 203 57 SHINGO NOGUCHI 1, KAZUHIRO YATERA 1, TOSHINORI KAWANAMI 1, KEI YAMASAKI 1, KEIGO UCHIMURA 3, RYOSUKE HATA 3, TAKASHI TACHIWADA 4, KEISHI ODA 1, KANAKO HARA 5, YU SUZUKI 6, KENTAROU AKATA 1, TAKAAKI OGOSHI 2, SUSUMU TOKUYAMA 5, NAOYUKI INOUE 5, CHINATSU NISHIDA 1, TAKESHI ORIHASHI 2, YUGO YOSHIDA 4, YUKIKO KAWANAMI 1, YUSUKE TAURA 6, HIROSHI ISHIMOTO 1, HIDETO OBATA 3, TORU TSUDA 7, CHIHARU YOSHII 2 and HIROSHI MUKAE 1 1 2 3 4 5 6 7 Azithromycin AZM CAP JRS