NTBI = nontransferrin-bound iron NTBI DNA H DNA 2
NTBI NTBI NTBI NTBI NTBI NTBI (nta) (nta) (nta) NTBI (nta) (nta) NTBI (nta)ntbi Fe-(nta) (nta) N(CH 2 CH) 3 HCCH 2 NHCH 2 CH 2 NHCH 2 CH (HCCH 2 ) 2 NH (nta) (edda) (ida) 1. Effects of Iron Chelates on renal tubular injuries. (HCCH 2 ) 2 NCH 2 CH 2 N(CH 2 CH) 2 (edta) Iron chelates ph 6.2 ph 7.2 ph 8.2 Fe-(nta) + + + (HCCH 2 ) 2 NCH 2 (pac) Fe-(edda) + + + N Fe-(ida) + + (HCCH 2 ) 2 NCH 2 CH 2 H (hida) Fe-(edta) Fe-(pac) (HCCH 2 ) 2 NCH 2 (tfda) Fe-(hida) 3
Fe-(nta) Fe-(edda) Fe-(pac) zerofe-(ida) ph Fe-(nta) Fe-(pac) Fe-(nta) Fe-(pac) Fe-(nta) Fe-(pac) Fe-(nta) Fe-(pac) TBARSnm A: Fe-(nta) B:Fe-(edda) C: Fe-(pac) TBARS 4
(Å) Fe-(nta) Fe-(pac) Fe Fe Fe Fe Fe-Fe 3.188 3.186 C H 2 2 Fe-N 2.246 2.235 Fe-(oxo) 1.83 1.8 Fe-4(C 3 ) 2.005 1.984 [Fe 2 (nta) 2 (C 3 )] 4 Fe-6 Fe-8 2.025 2.02 2.061 2.02 Fe-10 2.082 Fe-N(py) 2.166 (nta) (pac) Fe-(pac) Fe-(nta) Fe-(pac) Fe-(pac) Fe-(edda) Fe-(nta) ESR Fe-(edda) B DNA Fe-(ida) ph Fe 2 (ida) 4 4 5
ida R R = 2 Fe(III)-(ida) R R TBARSnm TBARS R R Fe-(ida) TBARS TBARS R ph TBARS R ph ph Fe-(ida) (ida) Fe 2 (ida) 2 (H 2 ) 4 Fe 2 (ida) 2 (H 2 ) 4 Fe- Fe 2 (ida) 4-4 R R Fe 2 (ida) 4-4 Fe--Fe Fe 2 (ida) 4 4 Fe 2 (ida) 2 (H 2 ) 4 + 2(ida) 2 Fe-(ida) TBA 6
Fe ida Fe 2 (ida) 2 (H 2 ) 4 R ph phph R Fe 2 (ida) 2 (H 2 ) 4 PM5 Fe- H R (ida) R Fe 2 (ida) 4 4 Fe 2 (ida) 2 (H 2 ) 4 (Hedta) (epy) (Hedta) Fe 2 (ida) 4 4 (epy) Fe 2 (ida) 2 (H 2 ) 4 (Hedta) (epy) (Hedta) HCH 2 CH 2 HCCH 2 NCH 2 CH 2 N CH 2 CH CH 2 CH (Hedta) N CH 2 NCH 2 CH 2 CH 3 2 (epy) [Fe 2 (epy) 2 Cl 2 ] 2+ 7
Fe-(ida) Fe-(edda) Fe-(edda) NaHC 3 NaHC 3 (edda) NaHC 3 Fe-(pac) Fe-(nta) Fe-(edda) ESR (Hedta) (epy) Fe-(hida) [Fe 2 (hida) 2 (H 2 ) 2 ] Fe 2 (HPTP)Cl 4 Cl 4 Fe-(hida) 8
[Fe 2 (HPTP)Cl 4 ] + Fe-(nta) Fe Fe C Apo-Tf Intermediate Fe Fe Apo-Tf Transfer of iron atoms Fe-(nta) Fe-(nta) TBARS Fe-(nta), Fe-(ida) Fe 2 (HPTB), Fe 2 (HPTP) TMPD Fe 2 (HPTB)(H)(N 3 ) 2 2+ 9
Fe 2 (HPTB)(H)(N 3 ) 2 2+ Fe 2 (HPTB) TMPD N,N,N',N' p TMPD TMPD Fe-(nta) Fe-(nta) Fe C Fe Fe Fe Fe Fe glutathione cycle glutathione cycle 2 glutathione cycle Fe-(nta) 10
Fe-(nta) Fe-(nta) Fe-(edda) Fe-(pac) (edta) Fe-(nta) Fe-(ida) (R = 1) Fe(III) (III) Fe-(nta) Bates Fe-(nta) Fe-(nta) Fe-(edda) Fe-(pac) zerofe-(ida) ph Fe-(edda) Fe-(nta) Fe-(pac) 11
Fenton Fe-(nta) Fe-(ida) Fenton NTBI H L H L IRE iron response element A49U L HL L Fe-(ida) L H HL NTBI Fe-(nta) NTBI 12
CKD NTBI AGE Quality of Life NTBI 13
AGE Fe- (nta) AGEs NTBI NTBI NTBI 14
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