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ArteriosclerosisAtherosclerosis ArteriosclerosisAtherosclerosis arteriosclerosis atherosclerosis arteriosclerosis arteriosclerosis arteriosclerosis Lakatta 1, 2 glycosaminoglycan 1. 3 Schlatmann080 1346-8375/03/400//JCLS

4 5 140 6 2 5 2 2. 3 48 87 1 5 5

4 7 diffuse intimal thickeningdit DIT DIT DIT1883Thoma 8 normal intima 9 adaptive intima 10 adaptation French DIT 11 PDAY study 12 19781982 13 030 5 1991 1995 14 20 Sadoshima 4090 15 26 25 3 7 7

13 Leung 16 40 6 Sadoshima 15 Fabris 17 18 3

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