Effect of Trimoprostil on Gastric Secretion Takeshi KAWAMURA * Hiroko EBINA * Fumiaki KOIZUMI * and Akira ISHIMORI * *Department of Clinical and Laboratory Medicine University School of Medicine, Tohoku The effects of trimoprostil, an analogue of PGE2, on gastric secretion was studied in 'healthy volunteers in comparison with those of cimetidine. Graded doses of 50, 250, 500, however. On the other hand, cimetidine inhibited gastrin-stimulated gastric acid and pepsin secretion remarkably. Some difference was also recognized between trimoprostil and cimetidine concerning the mechanism of inhibitory effect. Serum concentration of trimoprostil was measured at 60 min. after oral administration varied dose-dependently and dose-related anti-secretory effects were also found. Serum gastrin and pepsinogen 1 were not affected either by trimoprostil or cimetidine. These results indicate that Key words : trimoprostil, prostaglandin E2, gastric secretion, pepsinogen 1, gastrin
Tab. 1 Serum Concentration of Trimoprostil After a Single Oral Administration to Healthy Subjects. in Fasting State
350 Tab. 2 The Inhibitory Effects of Trimoprostil on Basal and AOC-Tetragastrin Stimulated Gastric Secretion
Fig. 2 Alteration of ph after oral dose of trimoprostil. Date were shown as mean of 8 Fig. 3 Alteration of acid concentration after oral dose of trimoprostil. Data were shown as mean of 8 subjects.
Fig. 4 Alteration of gastric volume after oral dose of trimoprostil. Data were shown as mean of 8 subjects. Fig. 5 Alteration of gastric acid secretion after oral dose of trimoprostil. Data were shown as mean of 8 subjects.
Tab. 3 The Inhibitory Effects of Trimoprostil on Cumulative Acid Output Fig. 6 Cumulative acid output after oral dose of trimoprostil. Data were shown as mean of 8 subjects.
Fig. 7 Alteration of pepsin concentration after oral dose of trimoprostil. Data were shown as mean of 8 subjects. Fig. 8 Alteration of gastric pepsin secretion after oral dose of trimoprostil. Data were shown as mean of 8 subjects.
Tab. 4 The Inhibitory Effects of Trimoprostil on Cumulative Pepsin Output Fig. 9 Cumulative pepsin output after oral dose of trimoprostil. Data were shown as mean of 8 subjects.
Tab. 5 Serum Gastrin Before and After Oral Dose of Trimoprostil Tab. 6 Serum Pepsinogen 1 Before and After Oral Dose of Trimoprostil
Fig. 10 Cumurative acid output (a) and pepsin output (b) after oral dose of cimetidine in 6 subjects. (b)
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