CHEMOTHERAPY FEB Table 1 Background of volunteers

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CHEMOTHERAPY FEB. 1985 Table 1 Background of volunteers

Table 3 Reproducibility of saisomicln In the EIA and the RIA Fig.1 Comparison of the EIA with the RIA or bioassay of sisomicin

Table 4 Blood levels of sisomicin Table 5 Pharmacokinetic parameters of sisomicin One compartment Two compartment model for I.M. model for D.I.

Fig.2 Serum concentrations of sisomicin after I. M.injection and I.V.drip infusion over 30 min. Fig.5 Simulation curves of serum sisomicin concentrations after I.V.drip infusion over various periods. Fig.3 Serum concentrations of sisomicin after I. M.injection and I.V.drip infusion over 60 min. Fig.6 Serum concentrations of sisomicin after L V.drip infusion of 1mg/kg over 30min. Fig.4 Serum concentrations of sisomicin after I. M.injection and I.V.drip infusion over 120 min. Fig.7 Serum concentrations of sisomicin after I. V.drip infusion of 1mg/kg over 120min. (Based on the results of 60min.I.V.drip infusion study)

Fig.8 Urinary excretion of sieomicin Fig.9 Changes on audiogram before and after administration of sisomicin.

CHEMOTHERAPY FEB. 1985

6) RITSCHEL, W. A.: Handbook of Basic Pharmacokinetics. 2 nd ED., Drug Intelligence publication, INC. 1980 7) BONOMINI, V. & A. ALBERTAZZI: Comparative pharmacokinetic of Sisomicin after Intravenous Injection, Intravenous Infusion and Intramuscular Injection in Man. Infection 4: S381-385, 1976 43) CHUNG, M.; J. J. SCHROGIE & S. SYMCHOWICZ: Pharmacokinetic Study of Sisomicin in Humans. J. Pharmacokinet. Biopharm. 9: 535 ` 551, 1981 9) LODE, H.; B. KEMMERICH & P. KOPPE: Comparative Clinical Pharmacology of Gentamicin, Sisomicin and Tobramycin. Antimicrob. Agents Chemother. 8: 396 `401, 1975 10) RODRIGUEZ, V.; G. P. BODEV, M. VALDIVIESO & R. FELD: Clinical Pharmacology of Sisomicin, Antimicrob. Agents Chemother. 7: 38 ` 41, 1975 11) RODOLFO, L. JAO & G. G. JACKSON: Gentamicin sulfate, new antibiotic against grain-negative bacilli. JAMA 189: 817 `822, 1964 12) ARCIERI, G. M.; F. G. FALCO, H. M. SMITH & L. B. HOBSON: Clinical Research Experience with Gentamicin Incidence of Adverse Reactions. Med. J. Austr., Suppl. June 13 ` 34, 1970 13) NORDSTROM, L.; G. BANCK, S. BELFRAGE, I. JUBLIN, O. TJERNSTROM & N. G. TOREMAIM: Prospective study of the ototoxity of gentamicin. Acta Path. Microb. Scand. Section B. Suppl 241: 58 `61, 1973 14) WINKEL, O.; M. M. HANSEN, K. KAABER & K. ROZARTH: A prospective study of gentamicin ototoxity. Acta Otolaryngol.86: 212 `216, 1978 PHARMACOKINETIC STUDY OF I.V.INFUSION VERSUS I.M.INJECTION OF SISOMICIN FUMIO MIKI Department of Internal Medicine,Tane General Hospital The serum concentration and urinary excretion of sisomicin after I.V.infusion(1mg/kg:120,60 and 30 minutes)were studied in comparison with those after intramuscular injection. The results are as follows. 1) The peak serum concentration after 2 hours I.V.infusion was 3.678ƒÊg/ml.This value was nearly equal to that obtained after I.M.injection(3.597ƒÊg/ml). 2) The peak serum concentration after 60 and 30 minutes I.V.infusion were 4.481 and 5.872ƒÊg/ml respectively.these values were higher than that obtained after I.M.injection,however,they are still much lower than 10 `12ƒÊg/ml which is regarded as toxic level of gentamicin. These results suggest that I.V.infusion of sisomicin is both effective and safe provided that care should be taken of the individual variance among patients. 3) 70% sisomicin administered by I.V.infusion was recovered from urine within 8 hours.no significant difference was found between I.V.infusion and I.M.injection.

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