120 4 2018 255 ₂₆₁255 精神医学のフロンティア 統合失調症患者における認知機能障害の推定 : 多施設共同研究 藤野陽生 12 住吉チカ 3 安田由華 4 山森英長 4 藤本美智子 4 福永雅喜 5 三浦健一郎 6 竹林佑人 7 岡田直大 8 磯村周一 9 河野直子 1011 豊巻敦人 12 久我弘典 1314 磯部昌憲 815 大矢一登 16 岡久祐子 17 髙木学 17 橋本直樹 12 加藤正樹 18 鬼塚俊明 9 上野雄文 914 大沼徹 7 笠井清登 8 尾崎紀夫 11 住吉太幹 19 井村修 1 橋本亮太 420 COCORO Haruo Fujino Chika Sumiyoshi Yuka Yasuda Hidenaga Yamamori Michiko Fujimoto Masaki Fukunaga Kenichiro Miura Yuto Takebayashi Naohiro Okada Shuichi Isomura Naoko Kawano Atsuhito Toyomaki Hironori Kuga Masanori Isobe Kazuto Oya Yuko Okahisa Manabu Takaki Naoki Hashimoto Masaki Kato Toshiaki Onitsuka Takefumi Ueno Tohru Ohnuma Kiyoto Kasai Norio Ozaki Tomiki Sumiyoshi Osamu Imura Ryota Hashimoto COCORO(Cognitive Genetics Collaborative Research Organization) 11 446 686 WAIS JART 25 16.3 84.2 100.5 20 39.7 81.6 索引用語
256 2018 120 4 はじめに 1 1 2 SD 2328 4711 1 162129 IQ IQ 332 IQ 332 JART 1920 3 WAIS 23 12 JART IQ 25810131825 2731 Ⅰ. 研究の方法および結果 1 11 446 686 1 1 23 4 5 6 7 8 9 1011 1213 14 15 16 17 18 19 20 PCN 9 1
257 1 N 446 N 686 2 F P 228 218 340 346 0.26 0.61 35.8 12.0 35.5 13.7 0.12 0.73 13.7 2.4 14.5 1.9 35.6 3.2 10 9 IQ JART 100.5 10.7 108.2 7.6 196.5 2.8 10 41 IQ FSIQ 84.2 17.7 111.6 12.2 947.1 1.5 10 151 16.3 13.2 3.4 10.2 805.2 3.6 10 134 FSIQ full scale intelligence quotient FSIQ IQ 9 SCID NP WAIS IQ FSIQ IQ JART 25 1924 WAIS FSIQ IQ 1222 10 3151732 WAIS 30 2 IQ EIQ FSIQ 2 P 0.73 0.61 P 3.2 10 9 度数(%0-60 -50-40 -30-20 -10 0 10 20 30 40 30 20 )10 推定認知機能障害スコア 1 9 F 805.2 P 3.6 10 134 FSIQ IQ F 196.5 P 2.8 10 41 F 947.1 P 1.5 10 151 16.3 10 10 69.3 20 39.7 1 FSIQ EIQ Kruskal Wallis test 2 0.9 P 0.35 WAIS
258 2018 120 4 感度0.6 0.8 1.0 1.0 0.8 0.6 0.4 0.2 AUC=0.88 (95% Cl:0.86~0.90) 0.0 0.0 0.2 0.4 1- 特異度 2 ROC 9 EIQ FSIQ receiver operating characteristic ROC 81.6 0.79 0.83 AUC 0.88 2 Ⅱ. 考察 本論文の意義 苦労 工夫したことなどを含めて 1 16.3 IQ 10 3151732 70 30 40 20 14 30 1 30 13.5 20 30 26.315 20 15.910 15 13.710 30.7 FSIQ WAIS EIQ EIQ 30 14 3151732 JART JART IQ 10 EIQ FSIQ 0.9 1
259 2 3 1 3 9 WAIS 90 120 10 おわりに 今後の課題および方向性 6 JSPS JP25293250 JP16H05375 JP26860924 16H01689 16H06395 16H06399 16K21720 利益相反 MSD
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