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Kwansei Gakuin University Rep Title ヒトにおける 免 疫 反 応 の 古 典 的 条 件 づけ Author(s) Doe, Nobutaka, 土 江, 伸 誉 Citation 人 文 論 究, 51(4): 142-159 Issue Date 2002-02-10 URL http://hdl.handle.net/10236/4941 Right http://kgur.kawansei.ac.jp/dspace

514-11 1 3 psychoneuroimmunology Ader & Cohen, 1993 ; Ader, Felton, & Cohen, 1990, 20011998, 2001 e.g., Apanius, 1998 ; Baron, Cutrona, Hicklin, Russel, & Lubaroff, 1990 ; Calabrese, Kling, & Gold, 1987 ; Herbert & Cohen, 1993 ; Jemmott & Locke, 1984 ;

Jemmott & Magloire, 1988 ; O Leary, 1990 e.g., Ader & Cohen, 1975, 1982, 1985, 1986 ; Gorczynski, 1990 ; Krank & MacQueen, 1988 ; MacQueen, Marshall, Perdue, Siegel, & Bienenstock, 1989 ; MacQueen & Siegel, 1989 ; O Reilly & Exon, 1986 ; Solvason, Ghanta, & Hiramoto, 1988 ; Solvason, Ghanta, Lorden, Soong, & Hiramoto, 1991 ; Wayner, Flannery, & Singer, 1978 e.g., Buske-Kirschbaum, Kirschbaum, Stierle, Jabaij, & Hellhammer, 1994 ; Smith & McDaniel, 1983 2 2 Ader & Cohen 1975 conditioned stimulus, CSunconditioned stimulus, US

Solvason et al 1988 CS US natural killer, NK NK Ader & Cohen 1975e.g., Ader, et al., 1990 ; Alvarez-Borda, Ramiraez-Amaya, Perez-Montfort, & Bermudez-Rattoni, 1995 ; Dunn, 1989 ; Kelley & Dantzer, 1986 ; Kelley, Dantzer, Mormede, Salmon, & Aynaud, 1985 ; Rogers, Reich, Strom, & Carpenter, 1976 3 CS s-iga secretory immunoglobulin A TUA trimethylundecylenic aldehyde s-iga B

s-iga s-iga US TUA Kirk-Smith, Van Toller, & Dodd, 1983 CS TUA CSKirk-Smith, et al 1983 TUA Solvason, et al 1988 CS 4 1 s-iga s-iga US e.g., Dalahanty, Dougall, Schmitz, Hawken, Trakowski, Jenkins, & Baum, 1996 ; Naliboff, Benton, Solomon, Morley, Fahey, Bloom, Makinodan, & Gilmore, 1991 ; Ohira, Watanabe, Kobayashi, & Kawai, 1999 ; Pike, Smith, Hauger, Nicassio, Patterson, & McClintick, 1997 1995 e.g., Caudell & Gallucci, 1995 ; Landmann,

Muller, Perini, Wesp, Erna, & Buhler, 1984 e.g., Sieber, Rodin, Larson, Ortega, & Cummings, 1992e.g. 1998 e.g., Matthews, Caggiula, McAllister, Berga, Owens, Flory, & Miller, 1995 ; Mills, Dimsdale, Nelesen, & Dillon, 1996 1 s-iga 1 32 16 16 20.9 4 8 4 7 1 4 4 1 1 120 408 1 1 2 50 1 20 10 20 4 1 POMS Profile of Mood States

McNaire, Lorr, & Droppleman, 1992 1997 3 s-iga enzyme linked immunosorbent assey, ERISA s-iga Kvale & Brandtzaeg, 1986 2 Figure 1 s-iga s-iga ps.01 8 s-iga POMS D 2.21 4.60, A-H 0.93 2.71, F Figure 1 s-iga MT STATVTR

3.32 8.07, C 5.68 8.77 ps.05 D 2.51 5.42, F 2.43 9.45F 3.46 6.44 ps.05 s-iga 1 s-iga US s-iga US 5 2 s-iga 1 20 s-iga 20 2 s-iga 1 18 12 6 22.1 1 300

45 300 45 5 5, 15, 25, 35 6 10 POMS 1 2 Figure 2 s-iga 15, 25, 35 s-iga 5 ps.01 15 ps.05 s-iga 15 s-iga e.g., Graham, Bartholomeusz, Taboonpong, & LaBrooy, 1988 ; Jemmot & Magloire, 1988 45 s-iga POMS 1

Figure 2 s-iga 6 3 2 20 s-iga TUA CS US s-iga s-iga 3 2001 1 64 22 42 19.8

TUA CS-US 25 CS 20 TUA CS/US 19 3 1m 5 A4 TUA 0.2 ml TUA 50 cm TUA 1, 2 120 90 20 1 20 1 2 Kirk-Smith, et al 1983 2 30 1992 0 4 5 20 1 2 3.8 2 11 1

CS-US CS CS/US 1 2 2 CS/US 1 2 POMS 3 1, 2 2 Figure 3 1 CS-US s- IgA p.05 CS CS /US CS-US 1 s-iga 1, 2 TUA s-iga 2 CS-US Figure 3 s-iga

s-iga p.05cs-us CS/US CS CS/US 2 s-iga CS-US 2 s-iga POMS 2 CS-US A-H D C T-A CS- US 2 CS-US s-iga 2 2 POMS TUA CS-US CS/US TUA CS

7 Ader & Cohen 1975 US US s-iga s-iga

8 e.g., Buske-Kirschbaum et al., 1994 ; Ghanta, Hiramoto, Solvason, Soong, & Hiramoto, 1990 ; Halley, 1991 References Ader, R., & Cohen, N. 1975 Behaviorally conditioned immunosuppression. Psychosomatic Medicine, 37, 333 340. Ader, R., & Cohen, N. 1982 Behaviorally conditioned immunosuppression and murine systemic lupus erythematosus. Science, 215, 1534 1536. Ader, R., & Cohen, N. 1985 CNS-immune system interactions : Conditioning phenomena. Behavioral and Brain Science, 8, 379 394. Ader, R., & Cohen, N. 1986 Conditioned responses are indeed conditioned. Behavioral and Brain Science, 9, 760 763. Ader, R., & Cohen, N. 1993 Psychoneuroimmunology : Conditioning and stress. Annual Review of Psychology, 44, 53 85. Ader, R., Felten, D. L., & Cohen, N. 2001 Psychoneuroimmunology 3rd ed New York, Academic Press. Ader, R., Felten, D., & Cohen, N. 1990 Interactions between the brain and the immune system. Annual Review of Pharmacology and Toxicology, 30, 561 602. Alvarez-Borda, B., Ramirez-Amaya, V., Perez-Montfort, R., & Bermudez-Rattoni, F. 1995 Enhancement of antibody production by a learning paradigm. Neurobiology of Learning and Memory, 64, 103 105.

Apanius, V. 1998 Stress and immune defense. Advances in the study of behavior, 27, 133 153. Baron, R. S., Cutrona, C. E., Hicklin, D., Russel, D. W. & Lubaroff, D. M. 1990 Social support and immune function among spouses of cancer patients. Journal of Personality and Social Psychology, 59, 344 352. Buske-Kirschbaum, A., Kirschbaum, C., Stierle, H., Jabaij, L., & Hellhammer, D. 1994 Conditioned manipulation of natural killer NK cells in humans using a discriminative learning protocol. Biological Psychology, 38, 143 155. Caudell, K. A., & Gallucci, B. B. 1995 Neuroendocrine and immunological responses of women to stress. Western Journal of Nursing Research, 17, 672 692. Calabrese, J. R., Kling, M. A., & Gold, P. W. 1987 Alterrations in immunocompetence during stress, bereavement, and depression : Focus on neuroendocrine regulation. American Journal of Psychiatry, 144, 1123 1134. Dalahanty, D. L., Dougall, A. L., Schmitz, J. B., Hawken, L., Trakowski, J. H., Jenkins, F. J., & Baum, A. 1996 Time course of natural killer cell activity and lymphocyte poliferation in response to two acute stressors in healthy men. Health Psychology, 15, 48 55. 2001 65 380. Dunn, A. J. 1989 Psychoneuroimmunology for the psychoneuroendrocrinologist : A review of animal studies of nervous system-immune system interaction. Psychoneuroendrocrinology, 14, 251 274. Ghanta, V. K., Hiramoto, R. N., Solvason, H. B., Soong, S-J., & Hiramoto, R. N. 1990 Conditioning : A new approach to immunotherapy. Cancer Research, 50, 4295 4299. Gorczynski, R. M. 1990 Conditioned enhancement of skin allografts in mice. Brain, Behavior, and Immunity, 4, 85 92. Graham, N. M. H., Bartholomeusz, R. C. A., Taboonpong, N. & LaBrooy, J. T. 1988 Does anxiety reduce the secretion rate of secretory IgA in saliva? Medical Journal of Australia, 148, 131 133. Halley, F. M. 1991 Self-Regulation of the immune system through biobehavioral strategies. Biofeedback and Self-Regulation, 16, 55 74. Herbert, T. B., & Cohen, S. 1993 Stress and immunity in humans : a metaanalytic review. Psychosomatic Medicine, 55, 364 379. Jemmot, J. B. 3 rd. & Locke, S. E. 1984 Psychosocial factors, immunologic media-

tion, and human susceptibility to infectious disease : How much do we know? Psychological Bulletin, 95, 78 108. Jemmot, J. B. 3 rd. & Magloire, K. 1988 Academic stress, social support, and secretory immunoglobulin A. Journal of Personality and Social Psychology, 55, 803 810. Kelley, K. W., & Dantzer, R. 1986 Is conditioned immunosuppression truly conditioned? Behavioral and Brain Science, 9, 758 760. Kelley, K. W., Dantzer, R., Mormede, P., Salmon, H., & Aynaud, J. M. 1985 Conditioned taste aversion suppresses induction of delayed-type hypersensitivity immune reactions. Physiology and Behavior, 34, 189 193. Kirk-Smith, M. D., Van Toller, C., & Dodd, G. H. 1983 Unconscious odour conditioning in human subjects. Biological Psychology, 17, 221 231. Krank, M. D., & MacQueen, G. 1988 Conditioned compensatory responses elicited by environmental signals for cyclophosphamide-induced suppression of the immune system. Psychobiology, 16, 229 235. Kvale, D., & Brandtzaeg, P. 1986 An enzyme-linked immunosorbent assay for differential quantitation of secretory immunoglobulins of the A and M isotypes in human serum. Journal of Immunological Methods, 86, 107 114. 1998 2 s-iga 62 447. Landmann, R. M. A., Muller, F. B., Perini, C. H., Wesp, M., Erna, P., & Buhler, F. R. 1984 Changes of immunoregulatory cells induced by psychological and physical stress : Relationship to plasma catecholamines. Clinical and Experimental Immunology, 58, 127 135. MacQueen, G. M., Marshall, J., Perdue, M., Siegel, S., & Bienenstock, J. 1989 Pavlovian conditional of rat mucosal mast cells to secrete rat mast cell protease II. Science, 243, 83 85. MacQueen, G. M. & Siegel, S. 1989 Conditional immunomodulation following training with cyclophosphamide. Behavioral Neuroscience, 103, 638 647. Matthews, K. A., Caggiula, A. R., McAllister, C. G., Berga, S. L., Owens, J. F., Flory, J. D., & Miller, A. L. 1995 Sympathetic reactivity to acute stress and immune response in women. Psychosomatic Medicine, 57, 564 571. McNaire, D. M., Lorr, M., & Droppleman, L. F. 1992 Profile of Mood States. San Diego : Educational and industrial testing service. Mills, P. J., Dimsdale, J. E., Nelesen, R. A., & Dillon, E. 1996 Psychologic charac-

teristics associated with acute stressor-induced leukocyte subset redistribution. Journal of Psychosomatic Research, 40, 417 423. Naliboff, B. D., Benton, D., Solomon, G. F., Morley, J. E., Fahey, J. L., Bloom, E. T., Makinodan, T., & Gilmore, S. L. 1991 Immunological changes in young and old adults during brief laboratory stress. Psychosomatic Medicine, 53, 121 132. 1998 62 S 13. 2001 16, 16 28. Ohira, H., Watanabe, Y., Kobayashi, K., & Kawai, M. 1999 The type A behavior pattern and immune reactivity to brief stress : change of volume of secretory immunoglobulin A in saliva. Perceptual and Motor Skills, 89, 423 430. O Leary, A. 1990 Stress, emotion, and human immune function. Psychological Bulletin, 108, 363 382. O Reilly, C. A., & Exon, J. H. 1986 Cyclophosphamide-conditioned suppression of the natural killer cell response in rats. Physiology and Behavior, 37, 759 764. Pike, J. L., Smith, T. L., Hauger, R. L., Nicassio, P. M., Patterson, T. L., & McClintick, C. 1997 Chronic life stress alters sympathetic, neuroendocrine, and immune responsitivity to an acute psychological stressor in humans. Psychosomatic Medicine, 59, 447 457. Rogers, M. P., Reich, P., Strom, T. B., & Carpenter, C. B. 1976 Behaviorally conditioned immunosuppression : Replication of a recent study. Animal Learning and Behavior, 12, 439 441. Sieber, W. J., Rodin, J., Larson, L,. Ortega, S., & Cummings, N. 1992 Modulation of human natural killer cell activity by exposure to uncontrollable stress. Brain, Behavior, and Immunity, 6, 141 156. Smith, G. R., Jr., & McDaniel, S. M. 1983 Psychologically mediated effect on the delayed hypersensitivity reaction to tuberculin in humans. Psychosomatic Medicine, 45, 65 70. Solvason, H. B., Ghanta, V. K., & Hiramoto, R. N. 1988 Conditioned augmentation of natural killer cell activity : Independence from nociceptive effects and dependence on interferon-beta. Journal of Immunology, 15, 661 665. Solvason, H. B., Ghanta, V. K., Lorden, J. F., Soong, S. J. & Hiramoto, R. N. 1991 A behavioral augmentation of natural immunity : Odor specificity sup-

ports a Pavlovian conditioning model. International Journal of Neuroscience, 61, 277 288. 1992 62, 350 356. Wayner, E. A., Flannery, G. R., & Singer, G. 1978 The effects of taste aversion conditioning on the primary antibody response to sheep red blood cells and brucella abortus in the albino rat. Physiological Behavior, 21, 995 1000. 1995 IgA 1, 47 50. 1997 POMS